R. M. Haralick, E. Dougherty, J. Ha, T. Kanungo, S. Karasu, C. K. Lee, ...
This paper first introduces a parametric model for the generation of stationary random correlated binary sequences. The parameters of the model include the probability that a pixel is a binary one...
Stagnitti, F, Li, L, Allinson, G, Phillips, I, Lockington, D, Zeiliguer, A, ...
Multiple sampling is widely used in vadose zone percolation experiments to investigate the extent in which soil structure heterogeneities influence the spatial and temporal distributions of water and...
Stagnitti, F, Sherwood, J, Allinson, G, Evans, L, Allinson, M, Li, L, ...
A multisegment percolation system (MSPS) consisting of 25 individual collection wells was constructed to study the effects of localised soil heterogeneities on the transport of solutes in the vadose...
CP violating observables in e$^{-}$e$^{+}$ --> W$^{-}$W$^{+}$ (1993)
Chang, D, Keung, W Y, Phillips, I
We consider various integrated lepton charge-energy asymmetries and azimuthal asymmetries as tests of CP violation in the process $e^-e^+ \to W^-W^+$. These asymmetries are sensitive to different...
Chang, D, Keung, W Y, Phillips, I
We investigate the possibility of detecting CP--odd angular correlations in the various decay modes of the neutral Higgs boson including the modes of a $ZZ$ pair, a $W^+W^-$ pair, or a heavy quark...
CP violation in top pair production at an e+e- collider (1992)
Chang, D, Keung, W Y, Phillips, I
We investigate possible CP violating effects in $e^+e^-$ annihilation into top quark pairs. One of the interesting observable effects is the difference in production rates between the two CP...
R-matrix Approach to Quantum Superalgebras su_{q}(m|n) (1992)
Chang, D., Phillips, I., Rozansky, Lev
Quantum superalgebras $su_{q}(m\mid n)$ are studied in the framework of $R$-matrix formalism. Explicit parametrization of $L^{(+)}$ and $L^{(-)}$ matrices in terms of $su_{q}(m\mid n)$ generators are...
Stapleton, P, Wu, P J, King, A, Shannon, K, French, G, Phillips, I
Among Escherichia coli organisms isolated at St. Thomas's Hospital during the years 1990 to 1994, the frequency of resistance to amoxicillin-clavulanic acid (tested by disk diffusion in a ratio of...
DNA sequence differences of ampD mutants of Citrobacter freundii.
Stapleton, P, Shannon, K, Phillips, I
Three groups of mutants with increased levels of beta-lactamase synthesis were selected from Citrobacter freundii 382010 by beta-lactam antibiotics at concentrations just above the MIC. Uninduced...
Antibacterial action of ciprofloxacin.
Mason, D J, Power, E G, Talsania, H, Phillips, I, Gant, V A
The mechanisms by which quinolones rapidly kill are ill defined. We have investigated the action of ciprofloxacin on Escherichia coli KL16 with a combination of traditional and flow cytometric...
Isoelectric focusing of Bacteroides melaninogenicus group beta-lactamases.
Timewell, R M, Phillips, I, Söderholm, J, Nord, C E
beta-Lactamases extracted by sonication from the Bacteroides melaninogenicus group organisms (B. asaccharolyticus, B. melaninogenicus, B. bivius, and B. oralis) were found to be in the form of...
In vitro antibacterial activity of norfloxacin (MK-0366).
King, A, Warren, C, Shannon, K, Phillips, I
The in vitro activity of norfloxacin (MK-0366) compared with that of beta-lactam antibiotics and, where appropriate of gentamicin or metronidazole was assessed against recent clinical isolates of...
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
King, A, Bethune, L, Phillips, I
The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of...
Laboratory diagnosis of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Ludlam, H A, Price, T N, Berry, A J, Phillips, I
The clinical course and laboratory diagnosis of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis was studied in 32 consecutive episodes. Peritonitis was associated with a...
Staff carriage of epidemic methicillin-resistant Staphylococcus aureus.
Cookson, B, Peters, B, Webster, M, Phillips, I, Rahman, M, Noble, W
Twenty-six nurses were repeatedly screened for carriage of epidemic methicillin-resistant Staphylococcus aureus (EMRSA) immediately before and after duty periods in which they solely attended six...
King, A, Shannon, K, Phillips, I
Cefsulodin sodium (SCE-129, CGP-7174/E), active in minimum inhibitory concentrations (MICs) of 0.5 to 64 microgram/ml, was about 16- to 32-fold more active than carbenicillin against Psuedomonas...
Shannon, K, King, A, Warren, C, Phillips, I
The in vitro activity of Ro 13-9904 was assessed against clinical isolated of common bacteria. Its activity against most enterobacteria was similar to that of cefotaxime and moxalactam, but it was...
Wu, P J, Shannon, K, Phillips, I
The susceptibility of 173 TEM-1-producing isolates of Escherichia coli was assessed by determination of MICs by the agar dilution method. MICs of amoxicillin, mezlocillin, cephaloridine, and, to a...
Detke, S, Lichtler, A, Phillips, I, Stein, J, Stein, G
The representation of H4 histone mRNA sequences in RNAs isolated from G1 and S phase HeLa cells was assessed by use of a homologous H4 histone cDNA. S phase cells were obtained by double thymidine...
Sensitivity of Citrobacter freundii and Citrobacter koseri to cephalosporins and penicillins
Holmes, B., King, Anna, Phillips, I., Lapage, S. P.
An examination of 99 field and reference strains of Citrobacter freundii showed 79% of them to be resistant to cephaloridine and sensitive to carbenicillin, while 96% of 45 field and reference...
Serological grouping of streptococci by a slide coagglutination method.
A new method for the serological grouping of streptococci by coagglutination with specific antibodies absorbed to protein A-containing staphylococci has been assessed. A total of 242 strains of...
API ZYM: a simple rapid system for the detection of bacterial enzymes.
Humble, M W, King, A, Phillips, I
The API ZYM system of detection of enzymes has been applied to 81 bacteria belonging to several species. It was found to be easy to use and has produced results that may be useful in the...
Serum gentamicin assay: A comparison and assessment of different methods
Phillips, I., Warren, Christine, Smith, S. E.
We have compared, in a clinical laboratory, three methods for estimating the concentration of gentamicin in serum. The adenylase method is most accurate, but requires considerable skilled technical...
Wills, A, Taylor, E, Pantosti, A, Phillips, I, Tabaqchali, S
Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera...
The use of an anaerobic incubator for the isolation of anaerobes from clinical samples.
Berry, P L, Taylor, E, Phillips, I
An anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. Seventy specimens were selected as likely to yield anaerobes: 342 different...
Comparison of radiometric and gas capture system for blood cultures.
A single bottle blood culture system that detects the gas produced by micro-organisms from substrates in a specially formulated medium was compared with the Bactec radiometric system. A total of 725...
Performance of converted pressure cookers and two conventional jars for anaerobic bacterial culture.
The simple conversion of commercial pressure cookers into inexpensive anaerobic jars is described. These containers were shown to be as good as the small conventional BBL polycarbonate GasPak and...
Determination of antibiotic sensitivities by the Sensititre system.
Phillips, I, Warren, C, Waterworth, P M
The Sensititre system provides antibiotics dried in microtitre trays in appropriate concentrations for the determination of minimum inhibitory concentrations (MIC) when organisms are added in liquid...
Unsworth, P F, Heatley, F W, Phillips, I
Ten patients undergoing total hip replacement for osteoarthritis were each given intramuscular flucloxacillin about two hours preoperatively; bone and serum were sampled simultaneously at operation....
Food as a source of Klebsiella species for colonisation and infection of intensive care patients.
Food prepared for intensive care patients was frequently contaminated with Klebsiella species. Sixty-eight per cent of nasogastric feeds were contaminated with up to 10(4) klebsiellae per ml....
A computer system for clinical microbiology.
Williams, K N, Davidson, J M, Lynn, R, Rice, E, Phillips, I
The Department of Clinical Microbiology at St Thomas' Hospital has been producing bacteriological reports on a computer for more than three years and is now producing some 2300 reports per week. The...
Pneumococcal bacteraemia: 325 episodes diagnosed at St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Three hundred and twenty five episodes of pneumococcal bacteraemia occurred at St Thomas's Hospital during 1970-84, accounting for 13.3% of all episodes of bacteraemia. Twice as many cases occurred...
Necrobacillosis: a forgotten disease.
Moore-Gillon, J, Lee, T H, Eykyn, S J, Phillips, I
Over four years five previously healthy young adults developed necrobacillosis , a severe septicaemic illness caused by Fusobacterium necrophorum. The infections were characterised by sore throat...
Staphylococcus aureus bacteraemia: 400 episodes in St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Four hundred episodes of Staphylococcus aureus bacteraemia occurred in St Thomas's Hospital from 1969 to 1983, accounting for 17.5% of all episodes of bacteraemia. The mortality was 24%, half...
Microbiology of pyogenic liver abscess.
Moore-Gillon, J C, Eykyn, S J, Phillips, I
Sixteen patients with pyogenic liver abscesses were studied over 10 years to discover the causative organisms of the condition. Pus was subjected to Gram-negative smear or gas-liquid chromatography...
Prosthetic valve endocarditis.
Moore-Gillon, J, Eykyn, S J, Phillips, I
During 1965 to 1982, 32 episodes of infective endocarditis on prosthetic valves in 30 patients were treated at this hospital. In early endocarditis (presenting within four months of operation)...
Spectinomycin resistant gonococci.
Ison, C A, Littleton, K, Shannon, K P, Easmon, C S, Phillips, I
A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St Mary's and St Thomas's Hospitals, London. All of the...
Leach, R D, Eykyn, S J, Phillips, I, Corrin, B, Taylor, E A
Fifty-two patients with axillary abscesses were seen during two years. Staphylococcus aureus was isolated from 34, anaerobic bacteria from 12, and skin flora from five; in one case the pus was...
Staphylococcal bacteraemia, fusidic acid, and jaundice.
Humble, M W, Eykyn, S, Phillips, I
Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given to the 119 remaining patients. Thirty-seven patients were...
Hands as route of transmission for Klebsiella species.
Seventeen per cent of the staff of an intensive care ward were found to have Klebsiella spp contaminating their hands, and these strains could be related to serotypes infecting or colonising patients...
Group B streptococci in the female genital tract.
Finch, R G, French, G L, Phillips, I
Vaginal carriage rates of group B streptococci among 250 women attending a clinic for sexually transmitted diseases, 123 attending family planning clinics, and 110 in labour wages were 36.0%, 17-1%...
Metronidazole and anaerobic sepsis.
Fifty patients with anaerobic sepsis were treated with intravenous and oral metronidazole. In 26 cases this was combined with other antimicrobial agents. Highly satisfactory clinical results were...
Stapleton, P, Wu, P J, King, A, Shannon, K, French, G, Phillips, I
Among Escherichia coli organisms isolated at St. Thomas's Hospital during the years 1990 to 1994, the frequency of resistance to amoxicillin-clavulanic acid (tested by disk diffusion in a ratio of...
DNA sequence differences of ampD mutants of Citrobacter freundii.
Stapleton, P, Shannon, K, Phillips, I
Three groups of mutants with increased levels of beta-lactamase synthesis were selected from Citrobacter freundii 382010 by beta-lactam antibiotics at concentrations just above the MIC. Uninduced...
Antibacterial action of ciprofloxacin.
Mason, D J, Power, E G, Talsania, H, Phillips, I, Gant, V A
The mechanisms by which quinolones rapidly kill are ill defined. We have investigated the action of ciprofloxacin on Escherichia coli KL16 with a combination of traditional and flow cytometric...
Isoelectric focusing of Bacteroides melaninogenicus group beta-lactamases.
Timewell, R M, Phillips, I, Söderholm, J, Nord, C E
beta-Lactamases extracted by sonication from the Bacteroides melaninogenicus group organisms (B. asaccharolyticus, B. melaninogenicus, B. bivius, and B. oralis) were found to be in the form of...
In vitro antibacterial activity of norfloxacin (MK-0366).
King, A, Warren, C, Shannon, K, Phillips, I
The in vitro activity of norfloxacin (MK-0366) compared with that of beta-lactam antibiotics and, where appropriate of gentamicin or metronidazole was assessed against recent clinical isolates of...
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
King, A, Bethune, L, Phillips, I
The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of...
Laboratory diagnosis of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Ludlam, H A, Price, T N, Berry, A J, Phillips, I
The clinical course and laboratory diagnosis of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis was studied in 32 consecutive episodes. Peritonitis was associated with a...
Staff carriage of epidemic methicillin-resistant Staphylococcus aureus.
Cookson, B, Peters, B, Webster, M, Phillips, I, Rahman, M, Noble, W
Twenty-six nurses were repeatedly screened for carriage of epidemic methicillin-resistant Staphylococcus aureus (EMRSA) immediately before and after duty periods in which they solely attended six...
King, A, Shannon, K, Phillips, I
Cefsulodin sodium (SCE-129, CGP-7174/E), active in minimum inhibitory concentrations (MICs) of 0.5 to 64 microgram/ml, was about 16- to 32-fold more active than carbenicillin against Psuedomonas...
Shannon, K, King, A, Warren, C, Phillips, I
The in vitro activity of Ro 13-9904 was assessed against clinical isolated of common bacteria. Its activity against most enterobacteria was similar to that of cefotaxime and moxalactam, but it was...
Wu, P J, Shannon, K, Phillips, I
The susceptibility of 173 TEM-1-producing isolates of Escherichia coli was assessed by determination of MICs by the agar dilution method. MICs of amoxicillin, mezlocillin, cephaloridine, and, to a...
Detke, S, Lichtler, A, Phillips, I, Stein, J, Stein, G
The representation of H4 histone mRNA sequences in RNAs isolated from G1 and S phase HeLa cells was assessed by use of a homologous H4 histone cDNA. S phase cells were obtained by double thymidine...
Sensitivity of Citrobacter freundii and Citrobacter koseri to cephalosporins and penicillins
Holmes, B., King, Anna, Phillips, I., Lapage, S. P.
An examination of 99 field and reference strains of Citrobacter freundii showed 79% of them to be resistant to cephaloridine and sensitive to carbenicillin, while 96% of 45 field and reference...
Serological grouping of streptococci by a slide coagglutination method.
A new method for the serological grouping of streptococci by coagglutination with specific antibodies absorbed to protein A-containing staphylococci has been assessed. A total of 242 strains of...
API ZYM: a simple rapid system for the detection of bacterial enzymes.
Humble, M W, King, A, Phillips, I
The API ZYM system of detection of enzymes has been applied to 81 bacteria belonging to several species. It was found to be easy to use and has produced results that may be useful in the...
Serum gentamicin assay: A comparison and assessment of different methods
Phillips, I., Warren, Christine, Smith, S. E.
We have compared, in a clinical laboratory, three methods for estimating the concentration of gentamicin in serum. The adenylase method is most accurate, but requires considerable skilled technical...
Wills, A, Taylor, E, Pantosti, A, Phillips, I, Tabaqchali, S
Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera...
The use of an anaerobic incubator for the isolation of anaerobes from clinical samples.
Berry, P L, Taylor, E, Phillips, I
An anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. Seventy specimens were selected as likely to yield anaerobes: 342 different...
Comparison of radiometric and gas capture system for blood cultures.
A single bottle blood culture system that detects the gas produced by micro-organisms from substrates in a specially formulated medium was compared with the Bactec radiometric system. A total of 725...
Performance of converted pressure cookers and two conventional jars for anaerobic bacterial culture.
The simple conversion of commercial pressure cookers into inexpensive anaerobic jars is described. These containers were shown to be as good as the small conventional BBL polycarbonate GasPak and...
Determination of antibiotic sensitivities by the Sensititre system.
Phillips, I, Warren, C, Waterworth, P M
The Sensititre system provides antibiotics dried in microtitre trays in appropriate concentrations for the determination of minimum inhibitory concentrations (MIC) when organisms are added in liquid...
Unsworth, P F, Heatley, F W, Phillips, I
Ten patients undergoing total hip replacement for osteoarthritis were each given intramuscular flucloxacillin about two hours preoperatively; bone and serum were sampled simultaneously at operation....
Food as a source of Klebsiella species for colonisation and infection of intensive care patients.
Food prepared for intensive care patients was frequently contaminated with Klebsiella species. Sixty-eight per cent of nasogastric feeds were contaminated with up to 10(4) klebsiellae per ml....
A computer system for clinical microbiology.
Williams, K N, Davidson, J M, Lynn, R, Rice, E, Phillips, I
The Department of Clinical Microbiology at St Thomas' Hospital has been producing bacteriological reports on a computer for more than three years and is now producing some 2300 reports per week. The...