Hydro-geochemical Modelling of Bauxite Residue: Managing the legacy of alumina production (2007)
Wissmeier, L., Barry, D.A., Phillips, I., Carter, Ch.
In the bauxite refining Bayer’s process, about 8 x 107 t/y of problematic residue is produced worldwide by extraction of alumina from bauxite earth. The bauxite refining industry requires...
Antibiotic use in animals (2004)
Phillips, I., Casewell, M., Cox, T., De Groot, B., Friis, C., Jones, R., ...
Antibiotic use in animals (2004)
Phillips, I., Casewell, M., Cox, T., De Groot, B., Friis, C., Jones, R., ...
Koeth, L. M., King, A., Knight, H., May, J., Miller, L. A., Phillips, I., ...
Comparison of MIC results obtained in different parts of the world is currently difficult because of variations in methods. In this study, cation-adjusted Mueller–Hinton broth, the...
Stagnitti, F, Li, L, Allinson, G, Phillips, I, Lockington, D, Zeiliguer, A, ...
Multiple sampling is widely used in vadose zone percolation experiments to investigate the extent in which soil structure heterogeneities influence the spatial and temporal distributions of water and...
Stagnitti, F, Li, L, Allinson, G, Phillips, I, Lockington, D, Zeiliguer, A, ...
Multiple sampling is widely used in vadose zone percolation experiments to investigate the extent in which soil structure heterogeneities influence the spatial and temporal distributions of water and...
Stagnitti, F, Sherwood, J, Allinson, G, Evans, L, Allinson, M, Li, L, ...
A multisegment percolation system (MSPS) consisting of 25 individual collection wells was constructed to study the effects of localised soil heterogeneities on the transport of solutes in the vadose...
Stagnitti, F, Sherwood, J, Allinson, G, Evans, L, Allinson, M, Li, L, ...
A multisegment percolation system (MSPS) consisting of 25 individual collection wells was constructed to study the effects of localised soil heterogeneities on the transport of solutes in the vadose...
Phillips, I., Dimian, C., Barlow, D., Moi, H., Stolz, E., Weidner, W., ...
A multicentre, double-blind, randomised study comparing the efficacy and safety of oral sparfloxacin (200 mg on day 1 followed by 100 mg daily for 2 or 6 additional days) with doxycycline (200 mg...
Yeo, S. F., Akalln, E., Arikan, S., Auckenthaler, R., Bergan, T., Dornbusch, K., ...
In order to compare the prevalence of antibiotic resistance in different geographical areas, it is necessary to ensure that agreement is achieved between laboratories on the assignment of strains to...
Septicaemia in the newborn and elderly (1994)
Gransden, W. R., Eykyn, S. J., Phillips, I.
Analysis of 5304 episodes of septicaemia at St Thomas' Hospital showed that both the elderly (> 65 years) and neonates accounted for increasing proportions between 1969 and 1992. In particular the...
CP violating observables in e$^{-}$e$^{+}$ --> W$^{-}$W$^{+}$ (1993)
Chang, D, Keung, W Y, Phillips, I
We consider various integrated lepton charge-energy asymmetries and azimuthal asymmetries as tests of CP violation in the process $e^-e^+ \to W^-W^+$. These asymmetries are sensitive to different...
Chang, D, Keung, W Y, Phillips, I
We investigate the possibility of detecting CP--odd angular correlations in the various decay modes of the neutral Higgs boson including the modes of a $ZZ$ pair, a $W^+W^-$ pair, or a heavy quark...
Baillie, L. W. J., Power, E. G. M., Phillips, I.
Examination of 67 ciprofloxacin-resistant dones of Pseudomonas aeruginosa PAO (ciprofloxacin MIC >0·5 mg/L) yielded four isolates that were hypersensitive to chiorhexidine (MIC 5 mg/L); none...
MIC audit for routine ciprofloxacin sensitivity testing (1993)
KING, A., PHILLIPS, I., AMYES, S., LEWIN, C., PATON, R., TILLOTSON, G.
MIC audit for routine ciprofloxacin sensitivity testing (1993)
King, A, Phillips, I, Amyes, S, Lewin, C, Paton, R, Tillotson, G
CP violation in top pair production at an e+e- collider (1992)
Chang, D, Keung, W Y, Phillips, I
We investigate possible CP violating effects in $e^+e^-$ annihilation into top quark pairs. One of the interesting observable effects is the difference in production rates between the two CP...
R-matrix Approach to Quantum Superalgebras su_{q}(m|n) (1992)
Chang, D., Phillips, I., Rozansky, Lev
Quantum superalgebras $su_{q}(m\mid n)$ are studied in the framework of $R$-matrix formalism. Explicit parametrization of $L^{(+)}$ and $L^{(-)}$ matrices in terms of $su_{q}(m\mid n)$ generators are...
Detection of ciprofloxadn resistance in Gram-negative bacteria due to alterations in gyrA (1992)
Power, E. G. M., Bellido, J. L. Mnfioz, Phillips, I.
Two plasmids containing the cloned Escherichia coli wild-type gyrA gene were used to transform ciprofloxacin-resistant Gram-negative clinical isolates to screen for DNA gyrase A-mediated quinolone...
Reeves, D. S., Holt, H. A., Phillips, I., King, Anna, Miles, R. S., Paton, R., ...
MICs of penicillin, methicillin, clindamycin, erythromycin, sodium fusidate and gentamicin were determined by an agar dilution method for 300 current isolates of Staphylococcus aureus and 100 of S....
Dryden, M. S., Wing, A. J., Phillips, I.
Ciprofloxacin at a dose of 25 mg/L of dialysate was administered intraperitoneally for five days as a single agent for the empirical treatment of CAPD peritonitis. One hundred and seventeen...
Ludlam, H. A., Barton, I., White, L., McMullin, C., King, A., Phillips, I.
Ciprofloxacin was evaluated as single-agent therapy for the empirical treatment of patients presenting with CAPD peritonitis in an open, uncontrolled trial. Seventy-five episodes of peritonitis in 44...
Shannon, K. P., King, A., Phillips, I., Nicolas, M. H., Philippon, A.
We report the isolation of three strains of Klebsiella pneumoniae sensu lato, brought into the United Kingdom by patients from Greece and Egypt, that showed plasmid-determined resistance to...
Multiresolution morphology (1987)
R. M. Haralick, E. Dougherty, J. Ha, T. Kanungo, S. Karasu, C. K. Lee, ...
This paper first introduces a parametric model for the generation of stationary random correlated binary sequences. The parameters of the model include the probability that a pixel is a binary one...
Degener, J. E., Naidoo, J. L., Noble, W. C., Phillips, I., Marples, R. R.
Gentamicin-resistant coagulase-negative staphylococci were found on various sites of the skin of 20 of 27 patients on continuous ambulatory peritoneal dialysis (CAPD). In 12 cases isolates with...
The antibiotic sensitivity of the Bacteroides fragilis group in the United Kingdom (1987)
Eight hundred and sixty-two cultures of penicillin-resistant anaerobic Gramnegative bacilli collected from 14 centres in the United Kingdom were identified. Six hundred and fifty-one were members of...
A comparison was made of three methods for gentamicin assay; (i) a modification of the radioenzymatic transferase technique, which was used as the reference method; (ii) EMIT autocarousel; and (iii)...
Flucloxacillin concentration in serum and wound exudate during open heart surgery (1985)
Farrington, M., Fenn, A., Phillips, I.
Per-operative serum and wound fluid concentrations achieved by two flucloxacillin dosage regimens were measured in twelve patients undergoing open heart surgery. One 500 mg bolus dose given after the...
Of 118 patients infected with β-lactamase producing Neisseria gonorrhoeae treated with cefotaxime 0-5 g, 95 returned for at least one assessment. There were no failures to eradicate genital or...
Cooke, Deborah M., Salter, A.J., Phillips, I.
To assess current antibiotic use and the impact on prescribing of hospital antibiotic policy, a prospective one-day prevalence survey of antibiotic use in both in-patients and out-patients was...
Infective Endocarditis, 1970-1979: A STUDY OF CULTURE-POSITIVE CASES IN ST. THOMAS' HOSPITAL (1980)
MOULSDALE, M. T., EYKYN, S. J., PHILLIPS, I.
Ninety-three episodes of culture-positive endocarditis occurred in 88 patients in the years 1970 to 1979. Streptococci caused two-thirds of the cases, with Streptococcus mitior and Streptococcus...
Warren, C. A., King, B. A., Shannon, K. P., Eykyn, S. J., Phillips, I.
The in vitro activity of LY127935 (6059S) was assessed against recent clinical isolates of common bacteria. It was highly active against the Enterobacteriaceae, with nearly all isolates inhibited by...
The susceptibility of Neisseria gonorrhoeae to cefoxitin sodium (1978)
Minimum inhibitory concentrations (MICs) of cefoxitin sodium and benzylpenicillin for 48 gonococci were compared. Although benzylpenicillin was much more active on sensitive strains, the two agents...
An assay for gentamicin in serum, plasma or urine is described. The method uses aminoglycoside 2′-N-acetyltransferase, an enzyme which acetylates all 3 components of commercially available...
Stapleton, P, Wu, P J, King, A, Shannon, K, French, G, Phillips, I
Among Escherichia coli organisms isolated at St. Thomas's Hospital during the years 1990 to 1994, the frequency of resistance to amoxicillin-clavulanic acid (tested by disk diffusion in a ratio of...
DNA sequence differences of ampD mutants of Citrobacter freundii.
Stapleton, P, Shannon, K, Phillips, I
Three groups of mutants with increased levels of beta-lactamase synthesis were selected from Citrobacter freundii 382010 by beta-lactam antibiotics at concentrations just above the MIC. Uninduced...
Antibacterial action of ciprofloxacin.
Mason, D J, Power, E G, Talsania, H, Phillips, I, Gant, V A
The mechanisms by which quinolones rapidly kill are ill defined. We have investigated the action of ciprofloxacin on Escherichia coli KL16 with a combination of traditional and flow cytometric...
Isoelectric focusing of Bacteroides melaninogenicus group beta-lactamases.
Timewell, R M, Phillips, I, Söderholm, J, Nord, C E
beta-Lactamases extracted by sonication from the Bacteroides melaninogenicus group organisms (B. asaccharolyticus, B. melaninogenicus, B. bivius, and B. oralis) were found to be in the form of...
In vitro antibacterial activity of norfloxacin (MK-0366).
King, A, Warren, C, Shannon, K, Phillips, I
The in vitro activity of norfloxacin (MK-0366) compared with that of beta-lactam antibiotics and, where appropriate of gentamicin or metronidazole was assessed against recent clinical isolates of...
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
King, A, Bethune, L, Phillips, I
The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of...
Laboratory diagnosis of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Ludlam, H A, Price, T N, Berry, A J, Phillips, I
The clinical course and laboratory diagnosis of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis was studied in 32 consecutive episodes. Peritonitis was associated with a...
Staff carriage of epidemic methicillin-resistant Staphylococcus aureus.
Cookson, B, Peters, B, Webster, M, Phillips, I, Rahman, M, Noble, W
Twenty-six nurses were repeatedly screened for carriage of epidemic methicillin-resistant Staphylococcus aureus (EMRSA) immediately before and after duty periods in which they solely attended six...
King, A, Shannon, K, Phillips, I
Cefsulodin sodium (SCE-129, CGP-7174/E), active in minimum inhibitory concentrations (MICs) of 0.5 to 64 microgram/ml, was about 16- to 32-fold more active than carbenicillin against Psuedomonas...
Shannon, K, King, A, Warren, C, Phillips, I
The in vitro activity of Ro 13-9904 was assessed against clinical isolated of common bacteria. Its activity against most enterobacteria was similar to that of cefotaxime and moxalactam, but it was...
Wu, P J, Shannon, K, Phillips, I
The susceptibility of 173 TEM-1-producing isolates of Escherichia coli was assessed by determination of MICs by the agar dilution method. MICs of amoxicillin, mezlocillin, cephaloridine, and, to a...
Detke, S, Lichtler, A, Phillips, I, Stein, J, Stein, G
The representation of H4 histone mRNA sequences in RNAs isolated from G1 and S phase HeLa cells was assessed by use of a homologous H4 histone cDNA. S phase cells were obtained by double thymidine...
Sensitivity of Citrobacter freundii and Citrobacter koseri to cephalosporins and penicillins
Holmes, B., King, Anna, Phillips, I., Lapage, S. P.
An examination of 99 field and reference strains of Citrobacter freundii showed 79% of them to be resistant to cephaloridine and sensitive to carbenicillin, while 96% of 45 field and reference...
Serological grouping of streptococci by a slide coagglutination method.
A new method for the serological grouping of streptococci by coagglutination with specific antibodies absorbed to protein A-containing staphylococci has been assessed. A total of 242 strains of...
API ZYM: a simple rapid system for the detection of bacterial enzymes.
Humble, M W, King, A, Phillips, I
The API ZYM system of detection of enzymes has been applied to 81 bacteria belonging to several species. It was found to be easy to use and has produced results that may be useful in the...
Serum gentamicin assay: A comparison and assessment of different methods
Phillips, I., Warren, Christine, Smith, S. E.
We have compared, in a clinical laboratory, three methods for estimating the concentration of gentamicin in serum. The adenylase method is most accurate, but requires considerable skilled technical...
Wills, A, Taylor, E, Pantosti, A, Phillips, I, Tabaqchali, S
Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera...
The use of an anaerobic incubator for the isolation of anaerobes from clinical samples.
Berry, P L, Taylor, E, Phillips, I
An anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. Seventy specimens were selected as likely to yield anaerobes: 342 different...
Comparison of radiometric and gas capture system for blood cultures.
A single bottle blood culture system that detects the gas produced by micro-organisms from substrates in a specially formulated medium was compared with the Bactec radiometric system. A total of 725...
Performance of converted pressure cookers and two conventional jars for anaerobic bacterial culture.
The simple conversion of commercial pressure cookers into inexpensive anaerobic jars is described. These containers were shown to be as good as the small conventional BBL polycarbonate GasPak and...
Determination of antibiotic sensitivities by the Sensititre system.
Phillips, I, Warren, C, Waterworth, P M
The Sensititre system provides antibiotics dried in microtitre trays in appropriate concentrations for the determination of minimum inhibitory concentrations (MIC) when organisms are added in liquid...
Unsworth, P F, Heatley, F W, Phillips, I
Ten patients undergoing total hip replacement for osteoarthritis were each given intramuscular flucloxacillin about two hours preoperatively; bone and serum were sampled simultaneously at operation....
Food as a source of Klebsiella species for colonisation and infection of intensive care patients.
Food prepared for intensive care patients was frequently contaminated with Klebsiella species. Sixty-eight per cent of nasogastric feeds were contaminated with up to 10(4) klebsiellae per ml....
A computer system for clinical microbiology.
Williams, K N, Davidson, J M, Lynn, R, Rice, E, Phillips, I
The Department of Clinical Microbiology at St Thomas' Hospital has been producing bacteriological reports on a computer for more than three years and is now producing some 2300 reports per week. The...
Pneumococcal bacteraemia: 325 episodes diagnosed at St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Three hundred and twenty five episodes of pneumococcal bacteraemia occurred at St Thomas's Hospital during 1970-84, accounting for 13.3% of all episodes of bacteraemia. Twice as many cases occurred...
Necrobacillosis: a forgotten disease.
Moore-Gillon, J, Lee, T H, Eykyn, S J, Phillips, I
Over four years five previously healthy young adults developed necrobacillosis , a severe septicaemic illness caused by Fusobacterium necrophorum. The infections were characterised by sore throat...
Staphylococcus aureus bacteraemia: 400 episodes in St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Four hundred episodes of Staphylococcus aureus bacteraemia occurred in St Thomas's Hospital from 1969 to 1983, accounting for 17.5% of all episodes of bacteraemia. The mortality was 24%, half...
Microbiology of pyogenic liver abscess.
Moore-Gillon, J C, Eykyn, S J, Phillips, I
Sixteen patients with pyogenic liver abscesses were studied over 10 years to discover the causative organisms of the condition. Pus was subjected to Gram-negative smear or gas-liquid chromatography...
Prosthetic valve endocarditis.
Moore-Gillon, J, Eykyn, S J, Phillips, I
During 1965 to 1982, 32 episodes of infective endocarditis on prosthetic valves in 30 patients were treated at this hospital. In early endocarditis (presenting within four months of operation)...
Spectinomycin resistant gonococci.
Ison, C A, Littleton, K, Shannon, K P, Easmon, C S, Phillips, I
A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St Mary's and St Thomas's Hospitals, London. All of the...
Leach, R D, Eykyn, S J, Phillips, I, Corrin, B, Taylor, E A
Fifty-two patients with axillary abscesses were seen during two years. Staphylococcus aureus was isolated from 34, anaerobic bacteria from 12, and skin flora from five; in one case the pus was...
Staphylococcal bacteraemia, fusidic acid, and jaundice.
Humble, M W, Eykyn, S, Phillips, I
Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given to the 119 remaining patients. Thirty-seven patients were...
Hands as route of transmission for Klebsiella species.
Seventeen per cent of the staff of an intensive care ward were found to have Klebsiella spp contaminating their hands, and these strains could be related to serotypes infecting or colonising patients...
Group B streptococci in the female genital tract.
Finch, R G, French, G L, Phillips, I
Vaginal carriage rates of group B streptococci among 250 women attending a clinic for sexually transmitted diseases, 123 attending family planning clinics, and 110 in labour wages were 36.0%, 17-1%...
Metronidazole and anaerobic sepsis.
Fifty patients with anaerobic sepsis were treated with intravenous and oral metronidazole. In 26 cases this was combined with other antimicrobial agents. Highly satisfactory clinical results were...
Stapleton, P, Wu, P J, King, A, Shannon, K, French, G, Phillips, I
Among Escherichia coli organisms isolated at St. Thomas's Hospital during the years 1990 to 1994, the frequency of resistance to amoxicillin-clavulanic acid (tested by disk diffusion in a ratio of...
DNA sequence differences of ampD mutants of Citrobacter freundii.
Stapleton, P, Shannon, K, Phillips, I
Three groups of mutants with increased levels of beta-lactamase synthesis were selected from Citrobacter freundii 382010 by beta-lactam antibiotics at concentrations just above the MIC. Uninduced...
Antibacterial action of ciprofloxacin.
Mason, D J, Power, E G, Talsania, H, Phillips, I, Gant, V A
The mechanisms by which quinolones rapidly kill are ill defined. We have investigated the action of ciprofloxacin on Escherichia coli KL16 with a combination of traditional and flow cytometric...
Isoelectric focusing of Bacteroides melaninogenicus group beta-lactamases.
Timewell, R M, Phillips, I, Söderholm, J, Nord, C E
beta-Lactamases extracted by sonication from the Bacteroides melaninogenicus group organisms (B. asaccharolyticus, B. melaninogenicus, B. bivius, and B. oralis) were found to be in the form of...
In vitro antibacterial activity of norfloxacin (MK-0366).
King, A, Warren, C, Shannon, K, Phillips, I
The in vitro activity of norfloxacin (MK-0366) compared with that of beta-lactam antibiotics and, where appropriate of gentamicin or metronidazole was assessed against recent clinical isolates of...
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
King, A, Bethune, L, Phillips, I
The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of...
Laboratory diagnosis of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Ludlam, H A, Price, T N, Berry, A J, Phillips, I
The clinical course and laboratory diagnosis of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis was studied in 32 consecutive episodes. Peritonitis was associated with a...
Staff carriage of epidemic methicillin-resistant Staphylococcus aureus.
Cookson, B, Peters, B, Webster, M, Phillips, I, Rahman, M, Noble, W
Twenty-six nurses were repeatedly screened for carriage of epidemic methicillin-resistant Staphylococcus aureus (EMRSA) immediately before and after duty periods in which they solely attended six...
King, A, Shannon, K, Phillips, I
Cefsulodin sodium (SCE-129, CGP-7174/E), active in minimum inhibitory concentrations (MICs) of 0.5 to 64 microgram/ml, was about 16- to 32-fold more active than carbenicillin against Psuedomonas...
Shannon, K, King, A, Warren, C, Phillips, I
The in vitro activity of Ro 13-9904 was assessed against clinical isolated of common bacteria. Its activity against most enterobacteria was similar to that of cefotaxime and moxalactam, but it was...
Wu, P J, Shannon, K, Phillips, I
The susceptibility of 173 TEM-1-producing isolates of Escherichia coli was assessed by determination of MICs by the agar dilution method. MICs of amoxicillin, mezlocillin, cephaloridine, and, to a...
Detke, S, Lichtler, A, Phillips, I, Stein, J, Stein, G
The representation of H4 histone mRNA sequences in RNAs isolated from G1 and S phase HeLa cells was assessed by use of a homologous H4 histone cDNA. S phase cells were obtained by double thymidine...
Sensitivity of Citrobacter freundii and Citrobacter koseri to cephalosporins and penicillins
Holmes, B., King, Anna, Phillips, I., Lapage, S. P.
An examination of 99 field and reference strains of Citrobacter freundii showed 79% of them to be resistant to cephaloridine and sensitive to carbenicillin, while 96% of 45 field and reference...
Serological grouping of streptococci by a slide coagglutination method.
A new method for the serological grouping of streptococci by coagglutination with specific antibodies absorbed to protein A-containing staphylococci has been assessed. A total of 242 strains of...
API ZYM: a simple rapid system for the detection of bacterial enzymes.
Humble, M W, King, A, Phillips, I
The API ZYM system of detection of enzymes has been applied to 81 bacteria belonging to several species. It was found to be easy to use and has produced results that may be useful in the...
Serum gentamicin assay: A comparison and assessment of different methods
Phillips, I., Warren, Christine, Smith, S. E.
We have compared, in a clinical laboratory, three methods for estimating the concentration of gentamicin in serum. The adenylase method is most accurate, but requires considerable skilled technical...
Wills, A, Taylor, E, Pantosti, A, Phillips, I, Tabaqchali, S
Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera...
The use of an anaerobic incubator for the isolation of anaerobes from clinical samples.
Berry, P L, Taylor, E, Phillips, I
An anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. Seventy specimens were selected as likely to yield anaerobes: 342 different...
Comparison of radiometric and gas capture system for blood cultures.
A single bottle blood culture system that detects the gas produced by micro-organisms from substrates in a specially formulated medium was compared with the Bactec radiometric system. A total of 725...
Performance of converted pressure cookers and two conventional jars for anaerobic bacterial culture.
The simple conversion of commercial pressure cookers into inexpensive anaerobic jars is described. These containers were shown to be as good as the small conventional BBL polycarbonate GasPak and...
Determination of antibiotic sensitivities by the Sensititre system.
Phillips, I, Warren, C, Waterworth, P M
The Sensititre system provides antibiotics dried in microtitre trays in appropriate concentrations for the determination of minimum inhibitory concentrations (MIC) when organisms are added in liquid...
Unsworth, P F, Heatley, F W, Phillips, I
Ten patients undergoing total hip replacement for osteoarthritis were each given intramuscular flucloxacillin about two hours preoperatively; bone and serum were sampled simultaneously at operation....
Food as a source of Klebsiella species for colonisation and infection of intensive care patients.
Food prepared for intensive care patients was frequently contaminated with Klebsiella species. Sixty-eight per cent of nasogastric feeds were contaminated with up to 10(4) klebsiellae per ml....
A computer system for clinical microbiology.
Williams, K N, Davidson, J M, Lynn, R, Rice, E, Phillips, I
The Department of Clinical Microbiology at St Thomas' Hospital has been producing bacteriological reports on a computer for more than three years and is now producing some 2300 reports per week. The...
Pneumococcal bacteraemia: 325 episodes diagnosed at St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Three hundred and twenty five episodes of pneumococcal bacteraemia occurred at St Thomas's Hospital during 1970-84, accounting for 13.3% of all episodes of bacteraemia. Twice as many cases occurred...
Necrobacillosis: a forgotten disease.
Moore-Gillon, J, Lee, T H, Eykyn, S J, Phillips, I
Over four years five previously healthy young adults developed necrobacillosis , a severe septicaemic illness caused by Fusobacterium necrophorum. The infections were characterised by sore throat...
Staphylococcus aureus bacteraemia: 400 episodes in St Thomas's Hospital.
Gransden, W R, Eykyn, S J, Phillips, I
Four hundred episodes of Staphylococcus aureus bacteraemia occurred in St Thomas's Hospital from 1969 to 1983, accounting for 17.5% of all episodes of bacteraemia. The mortality was 24%, half...
Microbiology of pyogenic liver abscess.
Moore-Gillon, J C, Eykyn, S J, Phillips, I
Sixteen patients with pyogenic liver abscesses were studied over 10 years to discover the causative organisms of the condition. Pus was subjected to Gram-negative smear or gas-liquid chromatography...
Prosthetic valve endocarditis.
Moore-Gillon, J, Eykyn, S J, Phillips, I
During 1965 to 1982, 32 episodes of infective endocarditis on prosthetic valves in 30 patients were treated at this hospital. In early endocarditis (presenting within four months of operation)...
Spectinomycin resistant gonococci.
Ison, C A, Littleton, K, Shannon, K P, Easmon, C S, Phillips, I
A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St Mary's and St Thomas's Hospitals, London. All of the...
Leach, R D, Eykyn, S J, Phillips, I, Corrin, B, Taylor, E A
Fifty-two patients with axillary abscesses were seen during two years. Staphylococcus aureus was isolated from 34, anaerobic bacteria from 12, and skin flora from five; in one case the pus was...
Staphylococcal bacteraemia, fusidic acid, and jaundice.
Humble, M W, Eykyn, S, Phillips, I
Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given to the 119 remaining patients. Thirty-seven patients were...
Hands as route of transmission for Klebsiella species.
Seventeen per cent of the staff of an intensive care ward were found to have Klebsiella spp contaminating their hands, and these strains could be related to serotypes infecting or colonising patients...
Group B streptococci in the female genital tract.
Finch, R G, French, G L, Phillips, I
Vaginal carriage rates of group B streptococci among 250 women attending a clinic for sexually transmitted diseases, 123 attending family planning clinics, and 110 in labour wages were 36.0%, 17-1%...
Metronidazole and anaerobic sepsis.
Fifty patients with anaerobic sepsis were treated with intravenous and oral metronidazole. In 26 cases this was combined with other antimicrobial agents. Highly satisfactory clinical results were...
Lactate UV-system: a rapid method for diagnosis of septic arthritis.
Behn, A R, Mathews, J A, Phillips, I
The concentration of lactic acid in synovial fluid was estimated in 43 specimens from patients with an acute monoarthritis by a simple enzyme method. In 9 patients with 10 episodes of septic...
Stagnitti, F, Sherwood, J, Allinson, G, Evans, L, Allinson, M, Li, L, ...
A multisegment percolation system (MSPS) consisting of 25 individual collection wells was constructed to study the effects of localised soil heterogeneities on the transport of solutes in the vadose...
Stagnitti, F, Li, L, Allinson, G, Phillips, I, Lockington, D, Zeiliguer, A, ...
Multiple sampling is widely used in vadose zone percolation experiments to investigate the extent in which soil structure heterogeneities influence the spatial and temporal distributions of water and...
Martin, K. F., Hannon, S., Phillips, I., Heal, D. J.
1. Intracerebral microdialysis was used to determine whether 5-hydroxytryptamine (5-HT) release in the ventral hippocampus of rats anaesthetized with chloral hydrate was modulated by 5-HT3 receptors....
Martin, K. F., Phillips, I., Hearson, M., Prow, M. R., Heal, D. J.
1. 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) dose-dependently induced hypothermia in mice. 2. The 5-HT1A receptor partial agonists, buspirone, gepirone and ipsapirone, also dose-dependently...
Brucella melitensis endocarditis: successful treatment of an infected prosthetic mitral valve
O'Meara, J. B., Eykyn, Susannah, Jenkins, B. S., Braimbridge, M. V., Phillips, I.
O'Meara, J. B., Eykyn, Susannah, Jenkins, B. S., Braimbridge, M. V., and Phillips, I. (1974).Thorax, 29, 377-381. Brucella melitensis endocarditis: successful treatment of an infected prosthetic...
Two regimens of sultamicillin in treating uncomplicated gonorrhoea.
Farthing, C, Thin, R N, Smith, S, Phillips, I
Sultamicillin is a covalent union of ampicillin and the beta lactamase inhibitor, sulbactam (CP-45,899). Two studies were conducted to assess its efficacy in treating uncomplicated gonorrhoea. In the...
Ciprofloxacin for treating urethral gonorrhoea in men.
Shahmanesh, M, Shukla, S R, Phillips, I, Westwood, A, Thin, R N
The effectiveness of a single oral dose of ciprofloxacin in eradicating urethral gonorrhoea was assessed in 18 men who received 250 mg and 26 men who were given 100 mg. All patients, including two...
Diagnosis of gonorrhoea in women.
Barlow, D, Nayyar, K, Phillips, I, Barrow, J
250 consecutive female contacts of men with gonorrhoea were examined in Lydia Department of Genito-urinary Medicine, St Thomas' Hospital, London, and 165 (66 per cent.) were found to be positive for...
An assessment of the Microcult-GC culture test.
Unsworth, P F, Talsania, H, Phillips, I
Microcult-GC, a miniaturised culture test, was compared with an established selective culture method for laboratory confirmation of gonorrhoea. Microcult-GC correlated 94% with the control method in...
Assessment of a selective medium for the isolation of Neisseria gonorrhoeae.
Specimens of urethral pus from 312 men with gonorrhoea were diluted and inoculated on to non-selective and selective media, the latter containing vancomycin, colistin, nystatin, and trimethoprim....
Assessment of transport and isolation methods for gonococci.
Urethral discharge from men was diluted to give heavy and light inocula and cultured on seven different solid culture media, including two transport/isolation media, or held in three types of...
In-vitro antigonococcal activity of rosoxacin (WIN 35213).
Warren, C A, Shannon, K P, Phillips, I
The in-vitro activity of rosoxacin against 173 isolates of Neisseria gonorrhoeae, including 17 beta-lactamase-producers, was tested by an agar dilution method. Of the isolates, 167 (including 16 of...
Imported penicillinase producing Neisseria gonorrhoeae becomes endemic in London.
Thin, R N, Barlow, D, Eykyn, S, Phillips, I
We review all cases of gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) seen between 1976 and 1983 at the sexually transmitted disease (STD) clinic of this hospital, which...
OBJECTIVE--To examine the penicillinase producing N. gonorrhoeae (PPNG) collected at St Thomas' Hospital from 1976-1990 and, by determination of antibiotic susceptibility pattern and application of...