Building a semantically annotated corpus of clinical texts (2009)
Roberts, A., Gaizauskas, R., Hepple, M., Demetriou, G., Guo, Y., Roberts, I.
In this paper, we describe the construction of a semantically annotated corpus of clinical texts for use in the development and evaluation of systems for automatically extracting clinically...
Rowley, K. G., O'Dea, K., Anderson, I., McDermott, R., Saraswati, K., Tilmouth, R., ...
Objective: To examine mortality from all causes and from cardiovascular disease (CVD), and CVD hospitalisation rate for a decentralised Aboriginal community in the Northern Territory. Design and...
Taking age out of the workplace : putting older workers back in ? (2006)
This article suggests that much recent work that relates age to working life is mis-cast in looking at specific age groups in isolation. Rather than addressing the problem of younger or older...
Ginnelly, L., Sculpher, M., Bojke, C., Roberts, I., Wade, A., Diguiseppi, C.
BACKGROUND: In 2001, 486 deaths and 17 300 injuries occurred in domestic fires in the UK. Domestic fires represent a significant cost to the UK economy, with the value of property loss alone...
Developing Language Processing Components with GATE Version 3 (a User Guide) (2005)
Cunningham, H., Maynard, D., Bontcheva, K., Tablan, V., Ursu, C., Dimitrov, M., ...
A Large Scale Terminology Resource for Biomedical Text Processing (2004)
Harkema, H, Gaizauskas, R, Hepple, M, Roberts, A, Roberts, I, Davis, N, ...
Large-Scale Resource for Storing and Recognizing Technical Terminology (2004)
Harkema, H, Gaizauskas, R, Hepple, M, Davis, N, Guo, Y, Roberts, A, ...
Exploring the Performance of Boolean Retrieval Strategies for Open Domain Question Answering (2004)
Saggion, H, Gaizauskas, R, Hepple, M, Roberts, I, Greenwood, MA
Gribble, S.M., Reid, A.G., Roberts, I., Grace, C., Green, A.R., Nacheva, E.P.
The acute phase of chronic myeloid leukemia (CML) is accompanied by secondary chromosomal changes. The additional changes have a non-random pattern; however, highly abnormal (marker) chromosomes are...
DiGuiseppi, C., Roberts, I., Wade, A., Sculpher, M., Edwards, P., Godward, C., ...
OBJECTIVE: To measure the effect of giving out free smoke alarms on rates of fires and rates of fire related injury in a deprived multiethnic urban population. DESIGN: Cluster randomised controlled...
Rowland, D., DiGuiseppi, C., Roberts, I., Curtis, K., Roberts, H., Ginnelly, L., ...
OBJECTIVES: To identify which type of smoke alarm is most likely to remain working in local authority inner city housing, and to identify an alarm tolerated in households with smokers. DESIGN:...
Rowland, D., DiGuiseppi, C., Roberts, I., Curtis, K., Roberts, H., Ginnelly, L., ...
Objectives: To identify which type of smoke alarm is most likely to remain working in local authority inner city housing, and to identify an alarm tolerated in households with smokers. Design:...
DiGuiseppi, C., Roberts, I., Wade, A., Sculpher, M., Edwards, P., Godward, C., ...
Objective: To measure the effect of giving out free smoke alarms on rates of fires and rates of fire related injury in a deprived multiethnic urban population. Design: Cluster randomised controlled...
Working-class studies : memory, community, and activism. (2002)
It may seem strange to some people that I and several others travelled from England to the USA for a conference on social class and more especially the working-class. After all, we practically...
Shaw, J.M., Al-Shamkhani, A., Boxer, L.A., Buckley, C.D., Dodds, A.W., Klein, N., ...
Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports,...
Analysis of piecewise linear aeroelastic systems using numerical continuation (2001)
Roberts, I, Jones, DP, Lieven, NAJ, Di Bernardo, M, Champneys, AR
Preprint of a paper later published by Professional Engineering Publishing (2002), Proceedings of the Institution of Mechanical Engineers Part G : Journal of Aerospace Engineering, 216(G1), pp.1-11,...
Radicalism and respectability in the development of labour organisations. (1999)
Rosemary Aris, Trade Unions and the Management of Industrial Conflict. London: Macmillan, 1998, £42.50 (£15.99 pbk), vii+201 pp. (ISBN 0-333-65798-5 hbk; 0-333-65799-3 pbk). Huw Beynon and Terry...
Banff criteria as predictors of outcome following acute renal allograft rejection (1999)
Macdonald, F, Ashraf, S, Picton, M, Dyer, P, Parrott, N, Short, C, ...
Angiomyolipoma in a transplanted kidney (1999)
Lappin, D, Hutchison, A, Pearson, R, O'Donoghue, D, Roberts, I
An attempt to observe directly beauty particles in nuclear emulsions (1990)
Albanese, J P, Allasia, D, Armenise, N, Arnold, R, Baroni, Giustina, Barth, Monique, ...
An attempt to observe directly beauty particles in nuclear emulsions (1983)
Albanese, J.P., Arnold, R., Matteuzzi, C., Musset, P., Piuz, F., Poulard, G., ...
An attempt to observe directly beauty particles in nuclear emulsions (1983)
Albanese, J.P., Arnold, R., Matteuzzi, C., Musset, P., Piuz, F., Poulard, G., ...
In vivo regulatory responses of four Escherichia coli operons which encode leucyl-tRNAs.
Rowley, K B, Elford, R M, Roberts, I, Holmes, W M
Four Escherichia coli operons, the leuV operon which encodes tRNA(1Leu), the leuX operon which encodes tRNA(6Leu), the metT operon which encodes tRNA(3Leu), and the argT operon which encodes...
Development of a new shuttle plasmid system for Escherichia coli and Clostridium perfringens.
Roberts, I, Holmes, W M, Hylemon, P B
We constructed a 7.9-kilobase-pair recombinant shuttle plasmid, designated pHR106, by combining desired segments of three plasmids: an Escherichia coli plasmid (pSL100) which provides a multiple...
Modified plasmid isolation method for Clostridium perfringens and Clostridium absonum.
Roberts, I, Holmes, W M, Hylemon, P B
A rapid plasmid isolation procedure for Clostridium perfringens and C. absonum is described. The ratio of culture volume to lysis buffer volume was found to be crucial for efficient plasmid...
Homology among Escherichia coli K1 and K92 polysialytransferases.
Vimr, E R, Bergstrom, R, Steenbergen, S M, Boulnois, G, Roberts, I
The neuS-encoded polysialytransferase (polyST) in Escherichia coli K1 catalyzes synthesis of polysialic acid homopolymers composed of unbranched sialyl alpha 2,8 linkages. Subcloning and...
Kröncke, K D, Boulnois, G, Roberts, I, Bitter-Suermann, D, Golecki, J R, Jann, B, ...
The capsular K5 polysaccharide, a representative of group II capsular antigens of Escherichia coli, has been cloned previously, and three gene regions responsible for polymerization and surface...
Finke, A, Roberts, I, Boulnois, G, Pzzani, C, Jann, K
The activity of the cytoplasmic CMP-2-keto-3-deoxyoctulosonic acid synthetase (CMP-KDO synthetase), which is low in Escherichia coli rough strains such as E. coli K-12 and in uncapsulated strains...
Roberts, I, Mountford, R, High, N, Bitter-Suermann, D, Jann, K, Timmis, K, ...
With a DNA fragment from within the region encoding the transport functions for K1 production as a hybridization probe in Southern blot experiments, homologous DNA sequences were detected in the DNA...
Contribution of capsular polysaccharide and surface properties to virulence of Escherichia coli K1.
Allen, P M, Roberts, I, Boulnois, G J, Saunders, J R, Hart, C A
We examined the surface properties, susceptibility to the bactericidal activity of serum, and susceptibility to phagocytosis of Escherichia coli K1, a laboratory strain of E. coli (LE392), and strain...
DNA probes for K-antigen (capsule) typing of Escherichia coli.
Roberts, M, Roberts, I, Korhonen, T K, Jann, K, Bitter-Suermann, D, Boulnois, G J, ...
DNA restriction fragments derived from the polysaccharide biosynthesis regions of cloned Escherichia coli K1, K5, and K12 capsular antigen genes hybridized only with DNA of strains determined by...
Children's exposure to traffic and pedestrian injuries.
Macpherson, A, Roberts, I, Pless, I B
OBJECTIVES: The purpose of this study was to estimate children's exposure to traffic (number of streets crossed) and to determine the role of exposure in pedestrian injury. METHODS: Questionnaires...
Why have child pedestrian death rates fallen?
Pedestrian injuries are a leading cause of childhood mortality and disability. Over the past two decades in Britain child pedestrian death rates have fallen despite large increases in traffic volume....
In vivo regulatory responses of four Escherichia coli operons which encode leucyl-tRNAs.
Rowley, K B, Elford, R M, Roberts, I, Holmes, W M
Four Escherichia coli operons, the leuV operon which encodes tRNA(1Leu), the leuX operon which encodes tRNA(6Leu), the metT operon which encodes tRNA(3Leu), and the argT operon which encodes...
Development of a new shuttle plasmid system for Escherichia coli and Clostridium perfringens.
Roberts, I, Holmes, W M, Hylemon, P B
We constructed a 7.9-kilobase-pair recombinant shuttle plasmid, designated pHR106, by combining desired segments of three plasmids: an Escherichia coli plasmid (pSL100) which provides a multiple...
Modified plasmid isolation method for Clostridium perfringens and Clostridium absonum.
Roberts, I, Holmes, W M, Hylemon, P B
A rapid plasmid isolation procedure for Clostridium perfringens and C. absonum is described. The ratio of culture volume to lysis buffer volume was found to be crucial for efficient plasmid...
Homology among Escherichia coli K1 and K92 polysialytransferases.
Vimr, E R, Bergstrom, R, Steenbergen, S M, Boulnois, G, Roberts, I
The neuS-encoded polysialytransferase (polyST) in Escherichia coli K1 catalyzes synthesis of polysialic acid homopolymers composed of unbranched sialyl alpha 2,8 linkages. Subcloning and...
Kröncke, K D, Boulnois, G, Roberts, I, Bitter-Suermann, D, Golecki, J R, Jann, B, ...
The capsular K5 polysaccharide, a representative of group II capsular antigens of Escherichia coli, has been cloned previously, and three gene regions responsible for polymerization and surface...
Finke, A, Roberts, I, Boulnois, G, Pzzani, C, Jann, K
The activity of the cytoplasmic CMP-2-keto-3-deoxyoctulosonic acid synthetase (CMP-KDO synthetase), which is low in Escherichia coli rough strains such as E. coli K-12 and in uncapsulated strains...
Roberts, I, Mountford, R, High, N, Bitter-Suermann, D, Jann, K, Timmis, K, ...
With a DNA fragment from within the region encoding the transport functions for K1 production as a hybridization probe in Southern blot experiments, homologous DNA sequences were detected in the DNA...
Contribution of capsular polysaccharide and surface properties to virulence of Escherichia coli K1.
Allen, P M, Roberts, I, Boulnois, G J, Saunders, J R, Hart, C A
We examined the surface properties, susceptibility to the bactericidal activity of serum, and susceptibility to phagocytosis of Escherichia coli K1, a laboratory strain of E. coli (LE392), and strain...
DNA probes for K-antigen (capsule) typing of Escherichia coli.
Roberts, M, Roberts, I, Korhonen, T K, Jann, K, Bitter-Suermann, D, Boulnois, G J, ...
DNA restriction fragments derived from the polysaccharide biosynthesis regions of cloned Escherichia coli K1, K5, and K12 capsular antigen genes hybridized only with DNA of strains determined by...
Children's exposure to traffic and pedestrian injuries.
Macpherson, A, Roberts, I, Pless, I B
OBJECTIVES: The purpose of this study was to estimate children's exposure to traffic (number of streets crossed) and to determine the role of exposure in pedestrian injury. METHODS: Questionnaires...
Why have child pedestrian death rates fallen?
Pedestrian injuries are a leading cause of childhood mortality and disability. Over the past two decades in Britain child pedestrian death rates have fallen despite large increases in traffic volume....
Mast cells: the forgotten cells of renal fibrosis
Background/Aims—Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is...
Postmortem findings after fatal anaphylactic reactions
Aims—To determine the frequency at which classic manifestations of anaphylaxis are present at necropsy after fatal anaphylactic reactions.
Roberts, I, Gorodkin, L, Benbow, E
Aim—Many deaths fall in the "grey" area between those that are clearly natural and those that are unnatural. There are no guidelines to help doctors in dealing with such cases and death...
Small intestinal infarction: a fatal complication of systemic oxalosis
Johnson, J, Short, A, Hutchison, A, Parrott, N, Roberts, I
Primary hyperoxaluria is a rare genetic disorder characterised by calcium oxalate nephrolithiasis and nephrocalcinosis leading to renal failure, often with extrarenal oxalate deposition (systemic...
Shaw, J M, Al-Shamkhani, A, Boxer, L A, Buckley, C D, Dodds, A W, Klein, N, ...
Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports,...
Paracetamol metabolites in the neonate following maternal overdose.
Roberts, I, Robinson, M J, Mughal, M Z, Ratcliffe, J G, Prescott, L F
A case of paracetamol overdose in a 36 week pregnant woman is described. The baby was delivered by Caesarian section 6 h after the overdose. The mother but not the baby was treated with...
Influence of changing travel patterns on child death rates from injury: trend analysis.
DiGuiseppi, C., Roberts, I., Li, L.
OBJECTIVES: To examine trends in child mortality from unintentional injury between 1985 and 1992 and to find how changes in modes of travel contributed to these trends. DESIGN: Poisson regression...
Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials.
OBJECTIVE: To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury. DESIGN: Systematic review of randomised controlled trials of corticosteroids...
Genetic mapping of the FACC gene and linkage analysis in Fanconi anaemia families.
Gibson, R A, Ford, D, Jansen, S, Savoia, A, Havenga, C, Milner, R D, ...
Fanconi anaemia is an autosomal recessive disorder associated with increased chromosome breakage and progressive bone marrow failure. The gene for complementation group C (FACC) has been cloned and...
Sensory deficit and the risk of pedestrian injury.
OBJECTIVES: To examine the association between sensory deficit and the risk of child pedestrian-motor vehicle collisions. SETTING: The Auckland region of New Zealand. METHODS: A community based...
Methodologic issues in injury case-control studies.
In this paper some methodological problems particularly relevant to case-control studies of injury are illustrated by reference to previous childhood injury case-control studies. In contrast to...
Who's prepared for advocacy? Another inverse law.
OBJECTIVES: To examine the characteristics of parents responding to a petition calling for greater efforts to ensure the safety of children as pedestrians and to contrast factors predictive of...
Adult accompaniment and the risk of pedestrian injury on the school-home journey.
STUDY OBJECTIVE: To quantify the effect of adult accompaniment on the risk of pedestrian injury on the school-home journey. DESIGN: A community based case-control study. SETTING: The Auckland region...
Child and adolescent injury control activities: reports from the field.
Rivara, F. P., Roberts, I., Bass, D., Krishnan, R., Thein, M. M., Gallagher, S., ...
Smoke alarm use: prevalence and household predictors.
OBJECTIVE: To determine the prevalence of smoke alarm use among families with children and to identify household factors that predict the absence of a smoke alarm. DESIGN: Cross sectional analysis of...
An international study of the exposure of children to traffic.
Roberts, I., Carlin, J., Bennett, C., Bergstrom, E., Guyer, B., Nolan, T., ...
OBJECTIVES: To examine the extent of international differences in children's exposure to traffic as pedestrians or bicyclists. DESIGN: Children's travel patterns were surveyed using a parent-child...
Corticosteroids in head injury--the CRASH trial.
Yates, D, Farrell, B, Teasdale, G, Sandercock, P, Roberts, I
The "Let's Get Alarmed!" initiative: a smoke alarm giveaway programme
DiGuiseppi, C., Slater, S., Roberts, I., Adams, L., Sculpher, M., Wade, A., ...
Objectives—To reduce fires and fire related injuries by increasing the prevalence of functioning smoke alarms in high risk households.
Urban residential fire and flame injuries: a population based study
DiGuiseppi, C, Edwards, P, Godward, C, Roberts, I, Wade, A
Background—Fires are a leading cause of death, but non-fatal injuries from residential fires have not been well characterised.
Traffic calming for the prevention of road traffic injuries: systematic review and meta-analysis
Bunn, F, Collier, T, Frost, C, Ker, K, Roberts, I, Wentz, R
Objective: To assess whether area-wide traffic calming schemes can reduce road crash related deaths and injuries.
Toroyan, T., Roberts, I., Oakley, A.
Equipoise is widely regarded to be an essential prerequisite for the ethical conduct of a randomised controlled trial. There are some circumstances however, under which it is acceptable to conduct a...
Snapshot view of emergency neurolosurgical head injury care
SANDERCOCK, P., ROBERTS, I., FARRELL, B., YATES, D., WASSERBERG, J.
Edwards, P, Farrell, B, Lomas, G, Mashru, R, Ritchie, N, Roberts, I, ...
Objectives: To test the design and feasibility of a large scale multicentre randomised controlled trial evaluating the efficacy and safety of a high dose corticosteroid infusion after head injury. To...
Potential public health importance of the oven ready chip
Sample frame: 1073 of 2145 households participating in a randomised controlled trial.
Prophylactic antiepileptic agents after head injury: a systematic review
OBJECTIVE—To determine the effectiveness and safety of prophylactic antiepileptic agents in the management of acute traumatic head injury. METHODS—Systematic review of randomised controlled...
Roberts, I., Schierhout, G., Alderson, P.
OBJECTIVES—To assess the effectiveness of interventions routinely used in the intensive care management of severe head injury, specifically, the effectiveness of hyperventilation, mannitol, CSF...
Child pedestrian deaths: sensitivity to traffic volume--evidence from the USA.
STUDY OBJECTIVE--In case centred epidemiological studies, traffic volume has been shown to be a potent risk factor for child pedestrian injuries. Nevertheless, over the past two decades child...
Roberts, I, Norton, R, Taua, B
STUDY OBJECTIVE: To examine how child pedestrian exposure to risk, as measured by the mean number of streets crossed, varies according to indices of material disadvantage and ethnic group. DESIGN: A...
Limited role for nitric oxide in mediating cerebrovascular control of newborn piglets.
Patel, J, Pryds, O, Roberts, I, Harris, D, Edwards, A D
AIMS: To investigate the effects of the nitric oxide (NO) synthase inhibitor L-nitro-arginine methyl ester (L-NAME) on cerebral blood flow, and its response to alterations in arterial carbon dioxide...
Out-of-home day care and health.
Evidence from randomised trials indicates that out-of-home day care has important effects in domains that are integral to the health of mothers and children. The evidence that day care results in...
Injuries and the risk of disability in teenagers and young adults.
Barker, M, Power, C, Roberts, I
OBJECTIVE: To examine the risk of disability from unintentional injury in teenagers and young adults. METHODS: Analyses of data from the National Child Development Study, a follow up study of 98% of...
Smoke alarm installation and function in inner London council housing
DiGuiseppi, C., Roberts, I., Speirs, N.
AIM—To determine the prevalence of and predictors for installed, functioning smoke alarms in council (public) housing in a low income, multi-ethnic urban area. DESIGN—Cross sectional...
Randomised controlled trial of site specific advice on school travel patterns
Rowland, D, DiGuiseppi, C, Gross, M, Afolabi, E, Roberts, I
Aims: To evaluate the effect of site specific advice from a school travel coordinator on school travel patterns.
Roberts, H, Curtis, K, Liabo, K, Rowland, D, DiGuiseppi, C, Roberts, I
Study objectives: The UK government recommends that local authorities install battery operated smoke alarms to prevent fire related injury. However, a randomised controlled trial of smoke alarm...
Wiggins, M, Oakley, A, Roberts, I, Turner, H, Rajan, L, Austerberry, H, ...
Study objective: To evaluate the effect of two forms of postnatal social support for disadvantaged inner city mothers on maternal and child health outcomes.
Does home visiting prevent childhood injury? A systematic review of randomised controlled trials.
Roberts, I., Kramer, M. S., Suissa, S.
OBJECTIVE--To quantify the effectiveness of home visiting programmes in the prevention of child injury and child abuse. DESIGN--Systematic review of 11 randomised controlled trials of home visiting...
OBJECTIVE: To examine whether the decline in child injury death rates between 1981 and 1991 varied by social class. DESIGN: Comparison of class specific child injury death rates for 1979, 1980, 1982,...
Roberts, I., Campbell, F., Hollis, S., Yates, D.
OBJECTIVE: To assess the contribution of trauma care to the recent decline in accident death rates among children and young people. DESIGN: Logistic regression modelling of temporal trends in the...
Roberts, I., Norton, R., Jackson, R., Dunn, R., Hassall, I.
OBJECTIVE--To identify and assess contribution of environmental risk factors for injury of child pedestrians by motor vehicles. DESIGN--Community based case-control study. Environmental...
China is undergoing rapid motorisation--motor vehicle registrations are growing at a rate of 10%-20% a year. Road trauma is already a major public health problem, and road deaths, officially...
Social policy as a cause of childhood accidents: the children of lone mothers.
Almost one in five British mothers is a lone mother. Their children have injury rates that are twice those of children in two parent families. In this article the link between lone parenthood and...
Meta-analysis of randomised trials of monetary incentives and response to mailed questionnaires
Edwards, P., Cooper, R., Roberts, I., Frost, C.
Study objective: To quantify the increase in mailed questionnaire response attributable to a monetary incentive.
Hotchin, N. A., Wedderburn, N., Roberts, I., Thomas, J. A., Bungey, J. A., Naylor, B., ...
The respective roles of Epstein-Barr virus (EBV) and c-myc in the pathogenesis of endemic Burkitt's lymphoma (BL) are unclear. In order to help resolve the question whether constitutive expression of...
Malignant germ cell tumours of childhood: new associations of genomic imbalance
Palmer, R D, Foster, N A, Vowler, S L, Roberts, I, Thornton, C M, Hale, J P, ...
Malignant germ cell tumours (MGCTs) of childhood are a rare group of neoplasms that comprise many histological subtypes and arise at numerous different sites. Genomic imbalances have been described...
Molecular cytogenetic analysis of breast cancer cell lines
Davidson, J M, Gorringe, K L, Chin, S-F, Orsetti, B, Besret, C, Courtay-Cahen, C, ...
The extensive chromosome rearrangements of breast carcinomas must contribute to tumour development, but have been largely intractable to classical cytogenetic banding. We report here the analysis by...