Katagiri, Y.U., Sleeman, J., Fujii, H., Herrlich, P., Hotta, H., Tanaka, K., ...
Cancer Research, 59(1999) S.219-26
A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.
Sato, K, Yoo, Y C, Fukushima, A, Saiki, I, Takahashi, T A, Fujihara, M, ...
Bacterial endotoxin (lipopolysaccharide [LPS]) causes severe damage to the host organism as a result of excessive release of inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis...
Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives.
Nishimura, K, Okumura, H, Saiki, I, Okuyama, H, Azuma, I
The effect of N-acyl derivatives of muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine) on the activation of peritoneal adherent cells (PAC) in vivo and on the stimulation of nonspecific...
Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide.
Saiki, I, Tokushima, Y, Nishimura, K, Yamamura, Y, Azuma, I
The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. Mouse peritoneal macrophages, when treated either in...
Adjuvant activity of purified peptidoglycan of Listeria monocytogenes in mice and guinea pigs.
Saiki, I, Kamisango, K, Tanio, Y, Okumura, H, Yamamura, Y, Azuma, I
The immunological properties of peptidoglycan (L-PG) purified from the cell wall skeleton (L-CWS) of Listeria monocytogenes strain EGD were investigated and compared with the properties of L-CWS....
Effect of quinonyl-N-acetyl muramyl dipeptide on immune responses in tumor-bearing mice.
Saiki, I, Tanio, Y, Yamamoto, K I, Yamamura, Y, Azuma, I
The efficacy of 6-O-QS-10-N-acetyl muramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) for restoring impaired immune status was examined in mice bearing Lewis lung carcinoma....
Azuma, I, Okumura, H, Saiki, I, Kiso, M, Hasegawa, A, Tanio, Y, ...
The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was...
Adjuvant activities of quinonyl-N-acetyl muramyl dipeptides in mice and guinea pigs.
Saiki, I, Tanio, Y, Yamawaki, M, Uemiya, M, Kobayashi, S, Fukuda, T, ...
The adjuvant and tumor-suppressive activities of the quinonyl [2,3-dimethoxy-5-methyl-6-(9'-carboxynonyl)-1,4-benzoquinone (QS-10)] derivatives of N-acetyl muramyl dipeptides were examined. N-Acetyl...
Uemiya, M, Sugimura, K, Kusama, T, Saiki, I, Yamawaki, M, Azuma, I, ...
Adjuvant and antitumor activities of synthetic-6-O-mycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine and 6-O-mycoloyl-N-acetylmuramyl-glycyl-D-isoglutamine were examined in comparison with those of...
A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.
Sato, K, Yoo, Y C, Fukushima, A, Saiki, I, Takahashi, T A, Fujihara, M, ...
Bacterial endotoxin (lipopolysaccharide [LPS]) causes severe damage to the host organism as a result of excessive release of inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis...
Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives.
Nishimura, K, Okumura, H, Saiki, I, Okuyama, H, Azuma, I
The effect of N-acyl derivatives of muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine) on the activation of peritoneal adherent cells (PAC) in vivo and on the stimulation of nonspecific...
Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide.
Saiki, I, Tokushima, Y, Nishimura, K, Yamamura, Y, Azuma, I
The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. Mouse peritoneal macrophages, when treated either in...
Adjuvant activity of purified peptidoglycan of Listeria monocytogenes in mice and guinea pigs.
Saiki, I, Kamisango, K, Tanio, Y, Okumura, H, Yamamura, Y, Azuma, I
The immunological properties of peptidoglycan (L-PG) purified from the cell wall skeleton (L-CWS) of Listeria monocytogenes strain EGD were investigated and compared with the properties of L-CWS....
Effect of quinonyl-N-acetyl muramyl dipeptide on immune responses in tumor-bearing mice.
Saiki, I, Tanio, Y, Yamamoto, K I, Yamamura, Y, Azuma, I
The efficacy of 6-O-QS-10-N-acetyl muramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) for restoring impaired immune status was examined in mice bearing Lewis lung carcinoma....
Azuma, I, Okumura, H, Saiki, I, Kiso, M, Hasegawa, A, Tanio, Y, ...
The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was...
Adjuvant activities of quinonyl-N-acetyl muramyl dipeptides in mice and guinea pigs.
Saiki, I, Tanio, Y, Yamawaki, M, Uemiya, M, Kobayashi, S, Fukuda, T, ...
The adjuvant and tumor-suppressive activities of the quinonyl [2,3-dimethoxy-5-methyl-6-(9'-carboxynonyl)-1,4-benzoquinone (QS-10)] derivatives of N-acetyl muramyl dipeptides were examined. N-Acetyl...
Uemiya, M, Sugimura, K, Kusama, T, Saiki, I, Yamawaki, M, Azuma, I, ...
Adjuvant and antitumor activities of synthetic-6-O-mycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine and 6-O-mycoloyl-N-acetylmuramyl-glycyl-D-isoglutamine were examined in comparison with those of...
Saiki, I., Murata, J., Iida, J., Sakurai, T., Nishi, N., Matsuno, K., ...
We have investigated the inhibitory effect on experimental or spontaneous lung metastases of polypeptides which contain repetitive structures of the Arg-Gly-Asp (RGD) or Tyr-Ile-Gly-Ser-Arg (YIGSR)...
Ueno, Y, Sakurai, H, Matsuo, M, Choo, M K, Koizumi, K, Saiki, I
We have reported that the selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib (‘Iressa', ZD1839), suppressed intrahepatic metastasis of hepatocellular carcinoma...
Doki, Y, Murakami, K, Yamaura, T, Sugiyama, S, Misaki, T, Saiki, I
This study is designed to establish a pulmonary tumour model to investigate the biology and therapy of lung cancer in mice. Current methods for forming a solitary intrapulmonary nodule and subsequent...