Current-dependent block of nerve membrane sodium channels by paragracine.
Seyama, I, Wu, C H, Narahashi, T
Paragracine, isolated from the coelenterate species Parazoanthus gracilis, selectively blocks sodium channels of squid axon membranes in a frequency-dependent manner. The blocking action depends on...
Grayanotoxin opens Na channels from inside the squid axonal membrane.
Seyama, I, Yamada, K, Kato, R, Masutani, T, Hamada, M
External application of alpha-dihydro-grayanotoxin II (alpha-H2-GTX II) to squid giant axon under nonperfused condition caused substantial membrane depolarization. Intracellular perfusion of the...
1. The effect of altering the extracellular pH (pHo) on the electrical activity of the isolated rabbit sino-atrial (s.a.) node was studied using the two-micro-electrode voltage-clamp technique. 2....
1. The generation of action potentials elicited from enzymatically dispersed ventricular cells from the frog, Rana catesbeiana, has been shown to be due to the influx of both Na+ and Ca2+. The...
Effect of alpha-dihydro-grayanotoxin-II on the electrical activity of the rabbit sino-atrial node.
The effect of alpha-dihydro-grayanotoxin-II (GTX) on the electrical activity of rabbit sino-atrial (s.a.) node cells was studied by the two-micro-electrode voltage-clamp technique. GTX, at...
Characteristics of the anion channel in the sino-atrial node cell of the rabbit.
1. The anion permeability of the sino-atrial node cell membranes was determined by substituting various anions for Cl and observing the resultant transient changes in membrane potential. The...
Characteristics of the rectifying properties of the sino-atrial node cell of the rabbit.
After confirming the region of the sino-atrial (S-A) node by its characteristic action potential, man-made strands including the pacemaker region of the rabbit heart were prepared and simple cable...
1. The effect of altering the extracellular pH (pHo) on the electrical activity of the isolated rabbit sino-atrial (s.a.) node was studied using the two-micro-electrode voltage-clamp technique. 2....
1. The generation of action potentials elicited from enzymatically dispersed ventricular cells from the frog, Rana catesbeiana, has been shown to be due to the influx of both Na+ and Ca2+. The...
Effect of alpha-dihydro-grayanotoxin-II on the electrical activity of the rabbit sino-atrial node.
The effect of alpha-dihydro-grayanotoxin-II (GTX) on the electrical activity of rabbit sino-atrial (s.a.) node cells was studied by the two-micro-electrode voltage-clamp technique. GTX, at...
Characteristics of the anion channel in the sino-atrial node cell of the rabbit.
1. The anion permeability of the sino-atrial node cell membranes was determined by substituting various anions for Cl and observing the resultant transient changes in membrane potential. The...
Characteristics of the rectifying properties of the sino-atrial node cell of the rabbit.
After confirming the region of the sino-atrial (S-A) node by its characteristic action potential, man-made strands including the pacemaker region of the rabbit heart were prepared and simple cable...
Current-dependent block of nerve membrane sodium channels by paragracine.
Seyama, I, Wu, C H, Narahashi, T
Paragracine, isolated from the coelenterate species Parazoanthus gracilis, selectively blocks sodium channels of squid axon membranes in a frequency-dependent manner. The blocking action depends on...
Grayanotoxin opens Na channels from inside the squid axonal membrane.
Seyama, I, Yamada, K, Kato, R, Masutani, T, Hamada, M
External application of alpha-dihydro-grayanotoxin II (alpha-H2-GTX II) to squid giant axon under nonperfused condition caused substantial membrane depolarization. Intracellular perfusion of the...