I. Tachtsidis

Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury (2008)

Tisdall, M.M., Tachtsidis, I., Leung, T.S., Elwell, C.E., Smith, M.

OBJECT: Traumatic brain injury (TBI) is associated with depressed aerobic metabolism and mitochondrial dysfunction. Normobaric hyperoxia (NBH) has been suggested as a treatment for TBI, but studies...

Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy (2007)

Leung, T., Tachtsidis, I., Tisdall, M., Smith, M., Delpy, D., Elwell, C.

To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were...

Near infrared spectroscopic quantification of changes in the concentration of oxidized cytochrome oxidase in the healthy human brain during hypoxemia (2007)

Tisdall, M.M., Tachtsidis, I., Leung, T.S., Elwell, C.E., Smith, M.

The near infrared cytochrome c oxidase (CCO) signal has potential as a clinical marker of changes in mitochondrial oxygen utilization. We examine the CCO signal response to reduced oxygen delivery in...

Investigation of in vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension (2007)

Tachtsidis, I., Tisdall, M., Leung, T.S., Cooper, C.E., Delpy, D.T., Smith, M., ...

We have previously used a continuous four wavelength near infrared spectrometer to measure changes in the cerebral concentrations of oxy- (Δ[HbO2] and deoxy- haemoglobin (Δ[HHb]) during head-up...

Measurement of the absolute optical properties and cerebral blood volume of the adult human head with hybrid differential and spatially resolved spectroscopy (2006)

Leung, T.S., Tachtsidis, I., Smith, M., Delpy, D.T., Elwell, C.E.

A hybrid differential and spatially resolved spectroscopy (SRS) technique has been developed to measure absolute absorption coefficient (μa), reduced scattering coefficient (μ's) and cerebral blood...

A physiological model of cerebral blood flow control (2005)

Banaji, M., Tachtsidis, I., Delpy, D., Baigent, S.

The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic...

A physiological model of cerebral blood flow control (2005)

Banaji, M., Tachtsidis, I., Delpy, D., Baigent, S.

The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic...