I. Takahashi

Publication List Details

Period

1988 - 2009

Number

84

Co-Authors

X-ray Diagnostics of Thermal Conditions of the Hot Plasmas in the Centaurus Cluster (2009)

Takahashi, I., Kawaharada, M., Makishima, K., Matsushita, K., Fukazawa, Y., Ikebe, Y., ...

X-ray data of the Centaurus cluster, obtained with {\it XMM-Newton} for 45 ksec, were analyzed. Deprojected EPIC spectra from concentric thin shell regions were reproduced equally well by a...

Prevalence of Adult-Onset Multifactorial Disease among Offspring of Atomic Bomb Survivors (2008)

S. Fujiwara, A. Suyama, J. B. Cologne, M. Akahoshi, M. Yamada, G. Suzuki, ...

Fujiwara, S., Suyama, A., Cologne, J. B., Akahoshi, M., Yamada, Y., Suzuki, G., Koyama, K., Takahashi, N., Kasagi, F., Grant, E. J., Lagarde, F., Hsu, W. L., Furukawa, K., Ohishi, W., Tatsukawa, Y. ,...

Dynamical Properties of Chaotic Wandering in Chaotic Neural Network Model (2008)

J. Kuroiwa, N. Masutani, S. Nara, I. Takahashi, T. Odaka, H. Shirai, ...

Abstract. In this paper, we investigate dynamical properties of chaotic wandering among memory-patterns space in chaotic neural network model, related with functional possibilities of chaotic...

Hard X-ray Detector (HXD) on Board Suzaku (2006)

Takahashi, T., Abe, K., Endo, M., Endo, Y., Ezoe, Y., Fukazawa, Y., ...

The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely...

In-Orbit Performance of the Hard X-ray Detector on board Suzaku (2006)

Kokubun, M., Makishima, K., Takahashi, T., Murakami, T., Tashiro, M., Fukazawa, Y., ...

The in-orbit performance and calibration of the Hard X-ray Detector (HXD) on board the X-ray astronomy satellite Suzaku are described. Its basic performances, including a wide energy bandpass of...

High resolution soft X-ray spectroscopy of the elliptical galaxy NGC 5044. Results from the reflection grating spectrometer on-board XMM-Newton (2002)

Tamura, T., Kaastra, J. S., Makishima, K., Takahashi, I.

The results from an X-ray spectroscopic study of the giant elliptical galaxy NGC5044 in the center of a galaxy group are presented. The line dominated soft X-ray spectra (mainly Fe-L and O VIII Ly_a)...

Properties of the background of EPIC-pn onboard XMM-Newton (2002)

Katayama, H., Takahashi, I., Ikebe, Y., Matsushita, K., Freyberg, M. J.

We have investigated the background properties of EPIC-pn onboard XMM-Newton to establish the background subtraction method. Count rates of the background vary violently by two orders of magnitude at...

Properties of the background of EPIC onboard XMM-Newton (2002)

Katayama, H., Takahashi, I., Ikebe, Y., Matsushita, K., Tanaka, Y., Freyberg, M.

Understanding a background is crucial in particular for a study of low surface brightness objects. In order to establish the background subtraction method, we have studied properties of the EPIC...

Simulation of the Concentrations and Distributions of Indoor Radon and Thoron (2001)

Zhou, W., Iida, T., Moriizumi, J., Aoyagi, T., Takahashi, I.

The technique of computational fluid dynamics (CFD) was used to study the concentrations and distributions of indoor radon (222Rn) and thoron (220Rn) as well as their progeny in three dimensions....

MAGNETOVOLUME EFFECT IN FERROMAGNETIC METALS : NUMERICAL RESULTS FOR BCC Fe AND FCC Ni (1988)

Takahashi, I., Shimizu, M.

The magnetovolume effect in ferromagnetic bcc Fe and fcc Ni is estimated numerically in the fixed moment method by using the LMTO method and the local spin density approximation. The obtained results...

MAGNETOVOLUME EFFECT IN FERROMAGNETIC METALS : NUMERICAL RESULTS FOR BCC Fe AND FCC Ni (1988)

Takahashi, I., Shimizu, M.

The magnetovolume effect in ferromagnetic bcc Fe and fcc Ni is estimated numerically in the fixed moment method by using the LMTO method and the local spin density approximation. The obtained results...

MAGNETOVOLUME EFFECT IN FERROMAGNETIC METALS : NUMERICAL RESULTS FOR BCC Fe AND FCC Ni (1988)

Takahashi, I., Shimizu, M.

The magnetovolume effect in ferromagnetic bcc Fe and fcc Ni is estimated numerically in the fixed moment method by using the LMTO method and the local spin density approximation. The obtained results...

Geoelectric potential changes: Possible precursors to earthquakes in Japan

Uyeda, S., Nagao, T., Orihara, Y., Yamaguchi, T., Takahashi, I.

Whether electromagnetic precursors to earthquakes (EQs) exist is an important question not only for EQ prediction but also for understanding the physical processes of EQ generation. Slow transient...

Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.

Takahashi, I, Kiyono, H, Jackson, R J, Fujihashi, K, Staats, H F, Hamada, S, ...

Linear B- and T-cell epitopes spanning all 103 amino acids of the Escherichia coli heat-labile toxin B subunit (LT-B) were assessed in mice orally immunized with native LT or with recombinant...

Diffusion of beta-lactam antibiotics through liposome membranes containing purified porins.

Kobayashi, Y, Takahashi, I, Nakae, T

A method to determine the diffusion of cephalosporins through porin pores in vitro was developed, using liposomes reconstituted from phospholipids, lipopolysaccharides, and purified porin trimers....

Molecular characterization of a negative regulator of Streptococcus sobrinus surface protein antigen gene.

Takahashi, I, Okahashi, N, Hamada, S

Mutans streptococci have been shown to give rise to variants in terms of expression of surface protein antigens by repeated subculturing of the organisms, which in turn induces changes in colonial...

Immunochemical comparison between an oxacillin-hydrolyzing penicillinase of Aeromonas hydrophila and those mediated by R plasmids.

Sawai, T, Takahashi, I, Nakagawa, H, Yamagishi, S

Antiserum against an oxacillin-hydrolyzing penicillinase of Aeromonas hydrophila did not show immunochemical cross-reaction with four oxacillin-hydrolyzing penicillinases mediated by R plasmids.

Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.

Rima, B K, Takahashi, I

In Bacillus subtilis, uracil (Ura), uridine (Urd), and deoxyuridine (dUrd) are metabolized through pathways similar to those of enteric bacteria. Ura is probably converted to uridine 5'-monophosphate...

Acid-Soluble Nucleotides in an Asporogenous Mutant of Bacillus subtilis

Chow, C. T., Takahashi, I.

An asporogenous mutant of Bacillus subtilis Sp−H12-3, which is considered to have a block at stage 0, showed general growth characteristics similar to those of sporulating cultures. However, a...

Genetic control of immune responses in mice to synthetic peptides of a Streptococcus mutans surface protein antigen.

Takahashi, I, Matsushita, K, Nisizawa, T, Okahashi, N, Russell, M W, Suzuki, Y, ...

The immune responses to a cell surface protein antigen (PAc) of Streptococcus mutans and a peptide corresponding to residues 301 to 319 of the protein antigen [PAc(301-319)] in various strains of...

Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.

Tokuda, M, Okahashi, N, Takahashi, I, Nakai, M, Nagaoka, S, Kawagoe, M, ...

The complete nucleotide sequence of the gene for a cell surface protein antigen (SpaA) of Streptococcus sobrinus MT3791 (serotype g) was determined. The spaA gene consisted of 4,698 bp and coded for...

Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c.

Koga, T, Okahashi, N, Takahashi, I, Kanamoto, T, Asakawa, H, Iwaki, M

The pac gene of the serotype c strain Streptococcus mutans MT8148 encodes a cell surface protein antigen (PAc) of approximate 190 kilodaltons. The serotype c strain S. mutans GS-5 does not produce...

Immunobiological activities of synthetic lipid A analogs with low endotoxicity.

Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...

Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...

Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficient manifestation of full endotoxic and associated bioactivities of lipid A.

Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...

Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...

Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta (1-6) glucosamine disaccharide 1,4'-bisphosphate.

Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...

A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...

Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule and of its analogs.

Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...

Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...

Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant.

Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...

A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...

Mechanism of plasma clotting by Erysipelothrix rhusiopathiae.

Takahashi, T, Takahashi, I, Tamura, Y, Sawada, T, Yoshida, T, Suzuki, S, ...

Experiments were performed to determine the mechanism by which Erysipelothrix rhusiopathiae clots plasma. Detection of plasma-clotting activity in four strains of E. rhusiopathiae was carried out by...

INCORPORATION OF BACTERIOPHAGE GENOME BY SPORES OF BACILLUS SUBTILIS1

Takahashi, I.

Takahashi, I. (Microbiology Research Institute, Ottawa, Ontario, Canada). Incorporation of bacteriophage genome by spores of Bacillus subtilis. J. Bacteriol. 87:1499–1502. 1964—The buoyant...

Localization of Spore Markers on the Chromosome of Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Localization of spore markers on the chromosome of Bacillus subtilis. J. Bacteriol. 89:1065–1067. 1965.—Attempts were made to...

Identification of antigenic epitopes in an alanine-rich repeating region of a surface protein antigen of Streptococcus mutants.

Okahashi, N, Takahashi, I, Nakai, M, Senpuku, H, Nisizawa, T, Koga, T

A surface protein antigen (PAc) of Streptococcus mutans with a molecular mass of 190 kDa is considered to play an important role in the initial attachment of this streptococcus to the tooth surface....

Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution.

Miyata, T, Kawabata, S, Iwanaga, S, Takahashi, I, Alving, B, Saito, H

Structural studies on a congenital abnormal coagulation factor XII (Hageman factor), factor XII Washington D.C., have been performed to identify the defect responsible for its lack of procoagulant...

Transduction of Sporogenesis in Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Transduction of sporogenesis in Bacillus subtilis. J. Bacteriol. 89:294–298. 1965.—A number of asporogenous mutants of Bacillus...

The reversible DNA-alkylating activity of duocarmycin and its analogues.

Asai, A, Nagamura, S, Saito, H, Takahashi, I, Nakano, H

Intact drugs with spirocyclopropylhexadienone moieties can be regenerated from the covalent DNA adducts induced by antitumor antibiotics duocarmycin (DUM) A, SA and some DUMA analogues in neutral...

Oral immunization with recombinant Streptococcus lactis carrying the Streptococcus mutans surface protein antigen gene.

Iwaki, M, Okahashi, N, Takahashi, I, Kanamoto, T, Sugita-Konishi, Y, Aibara, K, ...

A recombinant Streptococcus lactis strain which carries the structural gene for a surface protein antigen (PAc) of 190,000 daltons from Streptococcus mutans serotype c was constructed for development...

Joint Transfer of Genetic Markers in Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Joint transfer of genetic markers in Bacillus subtilis. J. Bacteriol. 91:101–105. 1966.—To compare the processes of genetic...

Bacteriophage transformation of PBS2 in Bacillus subtilis.

Herrington, M B, Takahashi, I

Transformation of temperature-sensitive mutants of bacteriophage PBS2 for Bacillus subtilis was demonstrated. The number of transformants was linearly related to the concentration of DNA within a...

DNase Specific for Uracil-Containing Bacteriophage DNA

Tomita, F., Takahashi, I.

A DNase from Bacillus subtilis which specifically hydrolyzes native DNA of phage PBS 1 has been purified and characterized. The mode of action of the enzyme is endonucleolytic, yielding deoxyuridine...

Sex hormone binding globulin as a reliable indicator of hormone dependence in human breast cancer.

Murayama, Y, Utsunomiya, J, Takahashi, I, Kitamura, M, Tominaga, T

One hundred nine pre- and postmenopausal mammary carcinoma cases were studied to elucidate the role of sex hormone binding globulin (SHBG) in the hormone dependence of human breast cancer. Our...

Geoelectric potential changes: Possible precursors to earthquakes in Japan

Uyeda, S., Nagao, T., Orihara, Y., Yamaguchi, T., Takahashi, I.

Whether electromagnetic precursors to earthquakes (EQs) exist is an important question not only for EQ prediction but also for understanding the physical processes of EQ generation. Slow transient...

Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.

Takahashi, I, Kiyono, H, Jackson, R J, Fujihashi, K, Staats, H F, Hamada, S, ...

Linear B- and T-cell epitopes spanning all 103 amino acids of the Escherichia coli heat-labile toxin B subunit (LT-B) were assessed in mice orally immunized with native LT or with recombinant...

Diffusion of beta-lactam antibiotics through liposome membranes containing purified porins.

Kobayashi, Y, Takahashi, I, Nakae, T

A method to determine the diffusion of cephalosporins through porin pores in vitro was developed, using liposomes reconstituted from phospholipids, lipopolysaccharides, and purified porin trimers....

Molecular characterization of a negative regulator of Streptococcus sobrinus surface protein antigen gene.

Takahashi, I, Okahashi, N, Hamada, S

Mutans streptococci have been shown to give rise to variants in terms of expression of surface protein antigens by repeated subculturing of the organisms, which in turn induces changes in colonial...

Immunochemical comparison between an oxacillin-hydrolyzing penicillinase of Aeromonas hydrophila and those mediated by R plasmids.

Sawai, T, Takahashi, I, Nakagawa, H, Yamagishi, S

Antiserum against an oxacillin-hydrolyzing penicillinase of Aeromonas hydrophila did not show immunochemical cross-reaction with four oxacillin-hydrolyzing penicillinases mediated by R plasmids.

Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.

Rima, B K, Takahashi, I

In Bacillus subtilis, uracil (Ura), uridine (Urd), and deoxyuridine (dUrd) are metabolized through pathways similar to those of enteric bacteria. Ura is probably converted to uridine 5'-monophosphate...

Acid-Soluble Nucleotides in an Asporogenous Mutant of Bacillus subtilis

Chow, C. T., Takahashi, I.

An asporogenous mutant of Bacillus subtilis Sp−H12-3, which is considered to have a block at stage 0, showed general growth characteristics similar to those of sporulating cultures. However, a...

Genetic control of immune responses in mice to synthetic peptides of a Streptococcus mutans surface protein antigen.

Takahashi, I, Matsushita, K, Nisizawa, T, Okahashi, N, Russell, M W, Suzuki, Y, ...

The immune responses to a cell surface protein antigen (PAc) of Streptococcus mutans and a peptide corresponding to residues 301 to 319 of the protein antigen [PAc(301-319)] in various strains of...

Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.

Tokuda, M, Okahashi, N, Takahashi, I, Nakai, M, Nagaoka, S, Kawagoe, M, ...

The complete nucleotide sequence of the gene for a cell surface protein antigen (SpaA) of Streptococcus sobrinus MT3791 (serotype g) was determined. The spaA gene consisted of 4,698 bp and coded for...

Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c.

Koga, T, Okahashi, N, Takahashi, I, Kanamoto, T, Asakawa, H, Iwaki, M

The pac gene of the serotype c strain Streptococcus mutans MT8148 encodes a cell surface protein antigen (PAc) of approximate 190 kilodaltons. The serotype c strain S. mutans GS-5 does not produce...

Immunobiological activities of synthetic lipid A analogs with low endotoxicity.

Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...

Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...

Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficient manifestation of full endotoxic and associated bioactivities of lipid A.

Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...

Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...

Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta (1-6) glucosamine disaccharide 1,4'-bisphosphate.

Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...

A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...

Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule and of its analogs.

Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...

Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...

Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant.

Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...

A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...

Mechanism of plasma clotting by Erysipelothrix rhusiopathiae.

Takahashi, T, Takahashi, I, Tamura, Y, Sawada, T, Yoshida, T, Suzuki, S, ...

Experiments were performed to determine the mechanism by which Erysipelothrix rhusiopathiae clots plasma. Detection of plasma-clotting activity in four strains of E. rhusiopathiae was carried out by...

INCORPORATION OF BACTERIOPHAGE GENOME BY SPORES OF BACILLUS SUBTILIS1

Takahashi, I.

Takahashi, I. (Microbiology Research Institute, Ottawa, Ontario, Canada). Incorporation of bacteriophage genome by spores of Bacillus subtilis. J. Bacteriol. 87:1499–1502. 1964—The buoyant...

Localization of Spore Markers on the Chromosome of Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Localization of spore markers on the chromosome of Bacillus subtilis. J. Bacteriol. 89:1065–1067. 1965.—Attempts were made to...

Identification of antigenic epitopes in an alanine-rich repeating region of a surface protein antigen of Streptococcus mutants.

Okahashi, N, Takahashi, I, Nakai, M, Senpuku, H, Nisizawa, T, Koga, T

A surface protein antigen (PAc) of Streptococcus mutans with a molecular mass of 190 kDa is considered to play an important role in the initial attachment of this streptococcus to the tooth surface....

Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution.

Miyata, T, Kawabata, S, Iwanaga, S, Takahashi, I, Alving, B, Saito, H

Structural studies on a congenital abnormal coagulation factor XII (Hageman factor), factor XII Washington D.C., have been performed to identify the defect responsible for its lack of procoagulant...

Transduction of Sporogenesis in Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Transduction of sporogenesis in Bacillus subtilis. J. Bacteriol. 89:294–298. 1965.—A number of asporogenous mutants of Bacillus...

The reversible DNA-alkylating activity of duocarmycin and its analogues.

Asai, A, Nagamura, S, Saito, H, Takahashi, I, Nakano, H

Intact drugs with spirocyclopropylhexadienone moieties can be regenerated from the covalent DNA adducts induced by antitumor antibiotics duocarmycin (DUM) A, SA and some DUMA analogues in neutral...

Oral immunization with recombinant Streptococcus lactis carrying the Streptococcus mutans surface protein antigen gene.

Iwaki, M, Okahashi, N, Takahashi, I, Kanamoto, T, Sugita-Konishi, Y, Aibara, K, ...

A recombinant Streptococcus lactis strain which carries the structural gene for a surface protein antigen (PAc) of 190,000 daltons from Streptococcus mutans serotype c was constructed for development...

Joint Transfer of Genetic Markers in Bacillus subtilis

Takahashi, I.

Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Joint transfer of genetic markers in Bacillus subtilis. J. Bacteriol. 91:101–105. 1966.—To compare the processes of genetic...

Bacteriophage transformation of PBS2 in Bacillus subtilis.

Herrington, M B, Takahashi, I

Transformation of temperature-sensitive mutants of bacteriophage PBS2 for Bacillus subtilis was demonstrated. The number of transformants was linearly related to the concentration of DNA within a...

DNase Specific for Uracil-Containing Bacteriophage DNA

Tomita, F., Takahashi, I.

A DNase from Bacillus subtilis which specifically hydrolyzes native DNA of phage PBS 1 has been purified and characterized. The mode of action of the enzyme is endonucleolytic, yielding deoxyuridine...

Sex hormone binding globulin as a reliable indicator of hormone dependence in human breast cancer.

Murayama, Y, Utsunomiya, J, Takahashi, I, Kitamura, M, Tominaga, T

One hundred nine pre- and postmenopausal mammary carcinoma cases were studied to elucidate the role of sex hormone binding globulin (SHBG) in the hormone dependence of human breast cancer. Our...

Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4+ CD45RB+ T cells

Kweon, M-N, Takahashi, I, Yamamoto, M, Jang, M H, Suenobu, N, Kiyono, H

Background and aims: Enteric bacterial and/or food antigens may be crucial in the development of colitis but little is known of the exact mechanism of antigen specific reactions in this condition....

Sequence dependence of the hyperthermic potentiation of carboplatin-induced cytotoxicity and intracellular platinum accumulation in HeLa cells.

Kusumoto, T., Maehara, Y., Baba, H., Takahashi, I., Kusumoto, H., Ohno, S., ...

We have examined the enhancement of cytotoxic effects of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) (carboplatin) by hyperthermia in HeLa cells using different regimes of timing and...

Combined evaluation of preoperative serum sialyl-Tn antigen and carcinoembryonic antigen levels is prognostic for gastric cancer patients.

Takahashi, I., Maehara, Y., Kusumoto, T., Kohnoe, S., Kakeji, Y., Baba, H., ...

We have found that elevation of preoperative serum sialyl-Tn antigen (STN) levels is associated with a poor prognosis for gastric cancer patients, and these high levels remain in the advanced stage...

Interaction of human serum albumin with anticancer agents in vitro.

Takahashi, I., Ohnuma, T., Kavy, S., Bhardwaj, S., Holland, J. F.

The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological...

Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma.

Kakeji, Y., Maehara, Y., Morita, M., Matsukuma, A., Furusawa, M., Takahashi, I., ...

The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the...

Time trends of surgical treatment and the prognosis for Japanese patients with gastric cancer

Maehara, Y, Kakeji, Y, Oda, S, Takahashi, I, Akazawa, K, Sugimachi, K

The incidence of gastric cancer is much higher in Japan than in other countries even though diagnostics and treatments of such patients have improved. The objective of this study was to present an...