Gelatinase B in vernal keratoconjunctivitis (2001)
Van Aelst, I, Al-Mansouri, S, Geboes, K
OBJECTIVES: To investigate the expression of gelatinase B in the conjunctiva of patients with vernal keratoconjunctivitis (VKC) and the cellular source of this enzyme. METHODS: Conjunctival biopsy...
Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle (2001)
Van Aelst, I, Vercauteren, R, Devos, R, ...
Chemokine production by tumors is a well-known phenomenon, but its role in tumor biology remains debatable. Although intratumoral injection of granulocyte chemotactic protein-2 (GCP-2) had no effect...
Stoops, G, Van Coillie, E, Lenaerts, J-P, ...
Chemokines are important mediators of cell migration during inflammation and normal leukocyte trafficking. Inflammatory chemokines are induced in multiple cell types at sites of infection. Here, we...
Human monocyte-derived dendritic cells produce bioactive gelatinase B: inhibition by IFN-beta (2001)
Van Aelst, I, Koyen, E, Kiss, R, Willems, F, Goldman, M, ...
We studied the secretion of gelatinase B by dendritic cells (DC) generated by culturing human peripheral blood monocytes in granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4...
Melief, M J, Markusse, H M, Van Aelst, I, Hazenberg, M P, ...
OBJECTIVES: Peptidoglycan (PG), a component of Gram-positive bacteria, may be involved in rheumatoid arthritis (RA) because of its ability to induce production of proinflammatory cytokines, to induce...
Schrijver, I. A., Markusse, H. M., Van Aelst, I., Opdenakker, G., Hazenberg, M. P., ...
Objectives. Peptidoglycan (PG), a component of Gram‐positive bacteria, may be involved in rheumatoid arthritis (RA) because of its ability to induce production of...
Human monocyte chemotactic protein-2 (MCP-2) is a member of the CC chemokine family. It is produced by mononuclear leukocytes, diploid fibroblasts, and tumor cells after induction with IL-1beta or...
Van Aelst, I, Polfliet, M, De Meester, I, ...
Human Monocyte Chemotactic Protein (MCP)-2 has originally been isolated from stimulated osteosarcoma cells as a chemokine coproduced with MCP-1 and MCP-3. Here, a 5'-end extended MCP-2 cDNA was...
Gelatinase B in proliferative vitreoretinal disorders (1998)
Veckeneer, M, Geboes, K, Van Aelst, I, ...
PURPOSE: To investigate whether gelatinases A and B are involved in the pathogenesis of proliferative vitreoretinal disorders. METHODS: In a prospective study of 101 consecutive patients, vitreous...
Nomiyama, H, Miura, R, Fiten, P, Van Aelst, I, ...
Stimulated MG-63 osteosarcoma cells have been used as a source to purify and identify the monocyte chemokines MCP-1, MCP-2 and MCP-3. In comparison with MCP-1, the production yields of MCP-2 and...
Paemen, L, Van Aelst, I, Fiten, P, ...
Gelatinase B is a matrix metalloproteinase involved in tissue remodelling. When mouse cells are triggered in vitro with interleukin-1, bacterial endotoxin, virus-mimicking double-stranded RNA or...
Extracellular matrix components as well as enzymes and enzyme-inhibitors controlling the turn-over of these components play an important role in the local control of testicular function. Zymographic...