Yang, IA, Ng, T, Molenaar, P, Fong, KM
Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway diseases characterized by airflow obstruction. The beta(2)-adrenoceptor mediates bronchodilatation in response to exogenous...
The role of Toll-like receptors and related receptors of the innate immune system in asthma (2006)
Yang, IA, Fong, KM, Holgate, ST, Holloway, JW
Purpose of review The biology of the innate immunity receptors is of central importance in the host response to the environment. Identifying genetic variants that alter the innate immune response is...
Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, KM, Barton, SJ, Holloway, JW, Yang, IA, Cakebread, JA, Cruikshank, W, ...
Background: IL-16, a multifunctional cytokine with increased expression in the airways of asthmatic subjects, inhibits allergic airway inflammation in animal models. A T -> C single nucleotide...
Yang, IA, Holz, O, Jorres, A, Magnussen, H, Barton, SJ, Rodriguez, S, ...
Ozone is a major air pollutant with adverse health effects which exhibit marked inter-individual variability. In mice, regions of genetic linkage with ozone-induced lung injury include the tumor...
Cochrane systematic reviews of treatments for lung cancer (2005)
Fong, KM, Yang, IA, Zimmerman, PV, Bowman, RV
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic...
Mucociliary clearance in patients with chronic asthma: Effects of beta(2) agonists (2005)
Daviskas, E, Anderson, SD, Shaw, J, Eberl, S, Seale, JP, Yang, IA, ...
Chronic asthma is characterized by airway inflammation, mucus hypersecretion and impaired mucociliary clearance (MCC). We investigated baseline MCC and the acute effect of terbutaline in chronic...
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism (2005)
Larsen, JE, Colosimo, ML, Yang, IA, Bowman, R, Zimmerman, PV, Fong, KM
Objective: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. Preliminary data suggesting a link between this polymorphism and lung cancer...
Effectiveness of hospital-based smoking cessation (2005)
Fung, PR, Snape-Jenkinson, SL, Godfrey, MT, Love, KW, Zimmerman, PV, Yang, IA, ...
Study objectives: Smoking cessation for current smokers is a health-care imperative. It is not clear which approaches to smoking cessation are the most effective in the hospital setting and which...
Cytokine gene polymorphisms in idiopathic pulmonary fibrosis (2004)
Riha, RL, Yang, IA, Rabnott, GC, Tunnicliffe, AM, Fong, KM, Zimmerman, PV
Pro- and anti-fibrotic cytokine gene polymorphisms may affect expression of idiopathic pulmonary fibrosis (IPF). The aims of the present case-control study were to examine polymorphisms in the IL-6,...
Toll-like receptor 4 polymorphism and severity of atopy in asthmatics (2004)
Yang, IA, Barton, SJ, Rorke, S, Cakebread, JA, Keith, TP, Clough, JB, ...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism in the Toll-like receptor 4 (TLR4) gene reduces responsiveness to endotoxin. This study determined...
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome (2003)
Child, NJA, Yang, IA, Pulletz, MCK, Andrews, AL, Pappachan, VJ, ...
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4...
TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis (2003)
Inflammation and innate immunity may play a role in the pathogenesis of atherosclerosis. The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces responsiveness to...