Ian A. Graham

Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens (2010)

Maia, Margarida RG, Chaudhary, Lal C, Bestwick, Charles S, Richardson, Anthony J, McKain, Nest, Larson, Tony R, ...

Background Health-promoting polyunsaturated fatty acids (PUFA) are abundant in forages grazed by ruminants and in vegetable and fish oils used as dietary supplements, but only a small proportion of...

Potential of Jatropha curcas as a source of renewable oil and animal feed (2009)

King, Andrew J., He, Wei, Cuevas, Jesús A., Freudenberger, Mark, Ramiaramanana, Danièle, Graham, Ian A.

Jatropha curcas (L.) is a perennial plant of the spurge family (Euphorbiaceae). Recently, it has received much attention as a potential source of vegetable oil as a replacement for petroleum, and, in...

Is trehalose-6-phosphate a regulator of sugar metabolism in plants? (2003)

Eastmond, Peter J., Li, Yi, Graham, Ian A.

It has recently emerged that many higher plants can synthesize trace amounts of trehalose. In arabidopsis disruption of the first step of trehalose synthesis, catalysed by...

Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle

Eastmond, Peter J., Germain, Veronique, Lange, Peter R., Bryce, James H., Smith, Steven M., Graham, Ian A.

The glyoxylate cycle is regarded as essential for postgerminative growth and seedling establishment in oilseed plants. We have identified two allelic Arabidopsis mutants, icl-1 and icl-2, which lack...

Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression

Oswald, Oliver, Martin, Thomas, Dominy, Peter J., Graham, Ian A.

Feedback regulation of photosynthesis by carbon metabolites has long been recognized, but the underlying cellular mechanisms that control this process remain unclear. By using an Arabidopsis cell...

Arabidopsis Seedling Growth, Storage Lipid Mobilization, and Photosynthetic Gene Expression Are Regulated by Carbon:Nitrogen Availability1

Martin, Thomas, Oswald, Oliver, Graham, Ian A.

The objective of the current work was to establish the degree to which the effects of carbon and nitrogen availability on Arabidopsis seedling growth and development are due to these nutrients acting...

The Gluconeogenic Enzyme Phosphoenolpyruvate Carboxykinase in Arabidopsis Is Essential for Seedling Establishment

Rylott, Elizabeth L., Gilday, Alison D., Graham, Ian A.

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the gluconeogenic production of sugars from storage oil in germinating oilseeds. Here, we...

Stress induces peroxisome biogenesis genes

Lopez-Huertas, Eduardo, Charlton, Wayne L., Johnson, Barbara, Graham, Ian A., Baker, Alison

Peroxisomes are the cellular location of many antioxidants and are themselves significant producers of reactive oxygen species. In this report we demonstrate the induction of peroxisome biogenesis...

Reserve Mobilization in the Arabidopsis Endosperm Fuels Hypocotyl Elongation in the Dark, Is Independent of Abscisic Acid, and Requires PHOSPHOENOLPYRUVATE CARBOXYKINASE1

Penfield, Steven, Rylott, Elizabeth L., Gilday, Alison D., Graham, Stuart, Larson, Tony R., Graham, Ian A.

Arabidopsis thaliana is used as a model system to study triacylglycerol (TAG) accumulation and seed germination in oilseeds. Here, we consider the partitioning of these lipid reserves between embryo...

The Critical Role of Arabidopsis Electron-Transfer Flavoprotein:Ubiquinone Oxidoreductase during Dark-Induced StarvationW⃞

Ishizaki, Kimitsune, Larson, Tony R., Schauer, Nicolas, Fernie, Alisdair R., Graham, Ian A., Leaver, Christopher J.

In mammals, electron-transfer flavoprotein:ubiquinone oxidoreductase (ETFQO) and electron-transfer flavoprotein (ETF) are functionally associated, and ETF accepts electrons from at least nine...

Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle

Eastmond, Peter J., Germain, Veronique, Lange, Peter R., Bryce, James H., Smith, Steven M., Graham, Ian A.

The glyoxylate cycle is regarded as essential for postgerminative growth and seedling establishment in oilseed plants. We have identified two allelic Arabidopsis mutants, icl-1 and icl-2, which lack...

Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression

Oswald, Oliver, Martin, Thomas, Dominy, Peter J., Graham, Ian A.

Feedback regulation of photosynthesis by carbon metabolites has long been recognized, but the underlying cellular mechanisms that control this process remain unclear. By using an Arabidopsis cell...

Arabidopsis Seedling Growth, Storage Lipid Mobilization, and Photosynthetic Gene Expression Are Regulated by Carbon:Nitrogen Availability1

Martin, Thomas, Oswald, Oliver, Graham, Ian A.

The objective of the current work was to establish the degree to which the effects of carbon and nitrogen availability on Arabidopsis seedling growth and development are due to these nutrients acting...

The Gluconeogenic Enzyme Phosphoenolpyruvate Carboxykinase in Arabidopsis Is Essential for Seedling Establishment

Rylott, Elizabeth L., Gilday, Alison D., Graham, Ian A.

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the gluconeogenic production of sugars from storage oil in germinating oilseeds. Here, we...

Stress induces peroxisome biogenesis genes

Lopez-Huertas, Eduardo, Charlton, Wayne L., Johnson, Barbara, Graham, Ian A., Baker, Alison

Peroxisomes are the cellular location of many antioxidants and are themselves significant producers of reactive oxygen species. In this report we demonstrate the induction of peroxisome biogenesis...

Reserve Mobilization in the Arabidopsis Endosperm Fuels Hypocotyl Elongation in the Dark, Is Independent of Abscisic Acid, and Requires PHOSPHOENOLPYRUVATE CARBOXYKINASE1

Penfield, Steven, Rylott, Elizabeth L., Gilday, Alison D., Graham, Stuart, Larson, Tony R., Graham, Ian A.

Arabidopsis thaliana is used as a model system to study triacylglycerol (TAG) accumulation and seed germination in oilseeds. Here, we consider the partitioning of these lipid reserves between embryo...

The Critical Role of Arabidopsis Electron-Transfer Flavoprotein:Ubiquinone Oxidoreductase during Dark-Induced StarvationW⃞

Ishizaki, Kimitsune, Larson, Tony R., Schauer, Nicolas, Fernie, Alisdair R., Graham, Ian A., Leaver, Christopher J.

In mammals, electron-transfer flavoprotein:ubiquinone oxidoreductase (ETFQO) and electron-transfer flavoprotein (ETF) are functionally associated, and ETF accepts electrons from at least nine...

An Arabidopsis Mutant Impaired in Coenzyme A Biosynthesis Is Sugar Dependent for Seedling Establishment1

Rubio, Silvia, Larson, Tony R., Gonzalez-Guzman, Miguel, Alejandro, Santiago, Graham, Ian A., Serrano, Ramón, ...

Once the plant coenzyme A (CoA) biosynthetic pathway has been elucidated by comparative genomics, it is feasible to analyze the physiological relevance of CoA biosynthesis in plant life. To this end,...

Arabidopsis ABA INSENSITIVE4 Regulates Lipid Mobilization in the Embryo and Reveals Repression of Seed Germination by the Endosperm[W]

Penfield, Steven, Li, Yi, Gilday, Alison D., Graham, Stuart, Graham, Ian A.

Regulation of seed germination requires coordinate action by the embryo and surrounding endosperm. We used Arabidopsis thaliana to establish the relative roles of embryo and endosperm in the control...

Novel Insights into Seed Fatty Acid Synthesis and Modification Pathways from Genetic Diversity and Quantitative Trait Loci Analysis of the Brassica C Genome1[OA]

Barker, Guy C., Larson, Tony R., Graham, Ian A., Lynn, James R., King, Graham J.

Natural genetic variation in fatty acid synthesis and modification pathways determine the composition of vegetable oils, which are major components of human diet and renewable products. Based on...

The Coenzyme A Biosynthetic Enzyme Phosphopantetheine Adenylyltransferase Plays a Crucial Role in Plant Growth, Salt/Osmotic Stress Resistance, and Seed Lipid Storage1[W]

Rubio, Silvia, Whitehead, Lynne, Larson, Tony R., Graham, Ian A., Rodriguez, Pedro L.

Coenzyme A (CoA) is an essential cofactor in the metabolism of both prokaryotic and eukaryotic organisms and a universal five-step pathway is utilized to synthesize CoA from pantothenate. Null...