Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
Previous experiments using enzyme inhibitors, cell lysates, and purified enzyme have suggested that puromycin-sensitive aminopeptidase (PSA) plays a role in creating and destroying MHC class...
Towne, Charles Fenton, York, Ian A., Watkins, Levi B., Lazo, John S., Rock, Kenneth L.
Long oligopeptides (>10 residues) are generated during the catabolism of cellular proteins in the cytosol. To be presented to T cells, such peptides must be trimmed by aminopeptidases to the proper...
Towne, Charles Fenton, York, Ian A., Watkins, Levi B., Lazo, John S., Rock, Kenneth L.
Long oligopeptides (>10 residues) are generated during the catabolism of cellular proteins in the cytosol. To be presented to T cells, such peptides must be trimmed by aminopeptidases to the...
York, Ian A., Bhutani, Nidhi, Zendzian, Sophia, Goldberg, Alfred L., Rock, Kenneth L.
Recent reports concluded that tripeptidyl peptidase (TPPII) is essential for MHC class I Ag presentation and that the proteasome in vivo mainly releases peptides 16 residues or longer that require...
York, Ian A., Brehm, Michael A., Zendzian, Sophia, Towne, Charles Fenton, Rock, Kenneth L.
CD8(+) T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually...
Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
To detect viral infections and tumors, CD8+ T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are...
A mutant cell with a novel defect in MHC class I quality control (2005)
York, Ian A., Grant, Ethan P., Dahl, A. Maria, Rock, Kenneth L.
COS7 (African Green Monkey kidney) cells stably transfected with the mouse MHC class I allele H-2K(b) were mutagenized, selected for low surface expression of endogenous MHC class I products, and...
York, Ian A., Mo, Annie X. Y., Lemerise, Kristen, Zeng, Wanyong, Shen, Yuelei, Abraham, Carmela R., ...
Most antigenic peptides presented on MHC class I molecules are generated by proteasomes during protein breakdown. It is unknown whether these peptides are protected from destruction by cytosolic...
Evasion of the human cellular immune response by herpes simplex virus (1994)
Herpes simplex virus (HSV) is unusual in its ability to cause recurrent infection in a host with an ostensibly competent immune system. This thesis describes two mechanisms by which HSV evades the...
York, Ian A., Brehm, Michael A., Zendzian, Sophia, Towne, Charles F., Rock, Kenneth L.
CD8+ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate...
York, Ian A., Brehm, Michael A., Zendzian, Sophia, Towne, Charles F., Rock, Kenneth L.
CD8+ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate...
Evasion of the human cellular immune response by herpes simplex virus.
Thesis (Ph.D.)--McMaster University (Canada), 1994.