Quantitative transcription factor binding kinetics at the single-molecule level (2008)
Wang, Yufang, Guo, Ling, Golding, Ido, Cox, Edward C., Ong, N. P.
We have investigated the binding interaction between the bacteriophage lambda repressor CI and its target DNA using total internal reflection fluorescence microscopy. Large, step-wise changes in the...
Lambda-prophage induction modeled as a cooperative failure mode of lytic repression (2008)
Chia, Nicholas, Golding, Ido, Goldenfeld, Nigel
We analyze a system-level model for lytic repression of lambda-phage in E. coli using reliability theory, showing that the repressor circuit comprises 4 redundant components whose failure mode is...
A Quantitative Study of the Dynamics of Adaptive Mutation Appearance (2007)
Ido Golding, Barbara Drossel, Yoash Shapira, Eshel Ben-jacob
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Bacterial Cooperative Organization Under Antibiotic Stress (2007)
Physica A, Eshel Ben-jacob, Inon Cohen, Ido Golding, David L. Gutnick, ...
Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the e#ect of antibiotic stress on the colonial development of...
Studies of Bacterial Cooperative Organization (2007)
Ido Golding, Inon Cohen, Eshel Ben-jacob
Introduction During the course of evolution, bacteria have developed sophisticated cooperative behavior and intricate communication capabilities [1--3]. Utilizing these capabilities, bacterial...
Protein synthesis molecule by molecule (2006)
Abstract Since the earliest days of molecular biology it has been known that even a seemingly uniform culture of bacteria is made up of cells very different from each other in terms of their levels...
Protein synthesis molecule by molecule (2006)
Abstract Since the earliest days of molecular biology it has been known that even a seemingly uniform culture of bacteria is made up of cells very different from each other in terms of their levels...
Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses (2005)
Ying Chen, Ido Golding, Satoshi Sawai, Ling Guo, Edward C. Cox
Lysogenic bacteriophage such as lambda integrate into their host genome, but do they regulate specific host genes? This study shows that they do, thereby increasing the fitness of the lysogen.
Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses (2005)
Ying Chen, Ido Golding, Satoshi Sawai, Ling Guo, Edward C. Cox
Temperate bacteriophage parasitize their host by integrating into the host genome where they provide additional genetic information that confers higher fitness on the host bacterium by protecting it...
The artistry of bacterial colonies and the antibiotic crisis (2001)
Since the beginning of massive usage of antibiotics during World War II we have witnessed a dramatic evolutionary event-- the emergence of multiple drug resistant bacteria. The bacteria are capable...
A Quantitative Study of the Dynamics of Adaptive Mutation Appearance (2001)
Ido Golding, Barbara Drossel, Yoash Shapira, Eshel Ben-jacob
We present two dynamical models for the appearance of adaptive mutations, which permit a quantitative comparison with experimental observations. The models quantify two alternative pictures: The...
Modeling branching and chiral colonial patterning of lubricating bacteria (1999)
Ben-Jacob, Eshel, Cohen, Inon, Golding, Ido, Kozlovsky, Yonathan
In nature, microorganisms must often cope with hostile environmental conditions. To do so they have developed sophisticated cooperative behavior and intricate communication capabilities, such as:...
Spatio-selection in Expanding Bacterial Colonies (1999)
Ido Golding, Inon Cohen, Eshel Ben-jacob
Segregation of populations is a key question in evolution theory. One important aspect is the relation between spatial organization and the population 's composition. Here we study a specific...
Lubricating Bacteria Model for Branching growth of Bacterial Colonies (1999)
Yonathan Kozlovsky, Inon Cohen, Ido Golding, Eshel Ben-jacob
Various bacterial strains (e.g. strains belonging to the genera Bacillus, Paenibacillus, Serratia and Salmonella) exhibit colonial branching patterns during growth on poor semi-solid substrates....
Spatio-selection in Expanding Bacterial Colonies (1998)
Golding, Ido, Cohen, Inon, Ben-Jacob, Eshel
Segregation of populations is a key question in evolution theory. One important aspect is the relation between spatial organization and the population's composition. Here we study a specific example...
Lubricating Bacteria Model for Branching growth of Bacterial Colonies (1998)
Kozlovsky, Yonathan, Cohen, Inon, Golding, Ido, Ben-Jacob, Eshel
Various bacterial strains (e.g. strains belonging to the genera Bacillus, Paenibacillus, Serratia and Salmonella) exhibit colonial branching patterns during growth on poor semi-solid substrates....
Continuous and discrete models of cooperation in complex bacterial colonies (1998)
Cohen, Inon, Golding, Ido, Kozlovsky, Yonathan, Ben-Jacob, Eshel
We study the effect of discreteness on various models for patterning in bacterial colonies. In a bacterial colony with branching pattern, there are discrete entities - bacteria - which are only two...
Golding, Ido, Kozlovsky, Yonathan, Cohen, Inon, Ben-Jacob, Eshel
Various bacterial strains exhibit colonial branching patterns during growth on poor substrates. These patterns reflect bacterial cooperative self-organization and cybernetic processes of...
Physica A, Ido Golding, Yonathan Kozlovsky, Inon Cohen, Eshel Ben-jacob
Various bacterial strains exhibit colonial branching patterns during growth on poor substrates. These patterns re#ect bacterial cooperative self-organization and cybernetic processes of...
Modeling Branching and Chiral Colonial Patterning of Lubricating Bacteria (1998)
Eshel Ben-jacob, Inon Cohen, Ido Golding, Yonathan Kozlovsky
In nature, microorganisms must often cope with hostile environmental conditions. To do so they have developed sophisticated cooperative behavior and intricate communication capabilities, such as:...
Two-Dimensional Polymers with Random Short-Range Interactions (1997)
We use complete enumeration and Monte Carlo techniques to study two-dimensional self-avoiding polymer chains with quenched ``charges'' $\pm 1$. The interaction of charges at neighboring lattice sites...
RNA dynamics in live Escherichia coli cells
We describe a method for tracking RNA molecules in Escherichia coli that is sensitive to single copies of mRNA, and, using the method, we find that individual molecules can be followed for many hours...
Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses
Chen, Ying, Golding, Ido, Sawai, Satoshi, Guo, Ling, Cox, Edward C
Temperate bacteriophage parasitize their host by integrating into the host genome where they provide additional genetic information that confers higher fitness on the host bacterium by protecting it...
Single-molecule studies of repressor–DNA interactions show long-range interactions
Wang, Y. M., Tegenfeldt, Jonas O., Reisner, W., Riehn, R., Guan, Xiao-Juan, Guo, Ling, ...
We have performed single-molecule studies of GFP–LacI repressor proteins bound to bacteriophage λ DNA containing a 256 tandem lac operator insertion confined in nanochannels. An integrated photon...
RNA dynamics in live Escherichia coli cells
We describe a method for tracking RNA molecules in Escherichia coli that is sensitive to single copies of mRNA, and, using the method, we find that individual molecules can be followed for many hours...
Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses
Chen, Ying, Golding, Ido, Sawai, Satoshi, Guo, Ling, Cox, Edward C
Temperate bacteriophage parasitize their host by integrating into the host genome where they provide additional genetic information that confers higher fitness on the host bacterium by protecting it...
Single-molecule studies of repressor–DNA interactions show long-range interactions
Wang, Y. M., Tegenfeldt, Jonas O., Reisner, W., Riehn, R., Guan, Xiao-Juan, Guo, Ling, ...
We have performed single-molecule studies of GFP–LacI repressor proteins bound to bacteriophage λ DNA containing a 256 tandem lac operator insertion confined in nanochannels. An integrated photon...
Protein synthesis molecule by molecule
Even a seemingly uniform culture of bacteria is made up of cells very different from each other in terms of their levels of a given protein. This individuality has now finally been quantified at...