Ifor Rhys Beacham

Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis (2009)

Owen, Suzzanne, Batzloff, Michael, Chehrehasa, Fatemeh, Meedeniya, Adrian Cuda Banda, Casart Quintero, Yveth, Logue, Carie-Anne, ...

BACKGROUND: Burkholderia pseudomallei, the causative agent of melioidosis, is generally considered to be acquired via inhalation of dust or water droplets from the environment. In this study, we show...

Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis (2009)

Owen, Suzzanne, Batzloff, Michael, Chehrehasa, Fatemeh, Meedeniya, Adrian Cuda Banda, Casart Quintero, Yveth, Logue, Carie-Anne, ...

BACKGROUND: Burkholderia pseudomallei, the causative agent of melioidosis, is generally considered to be acquired via inhalation of dust or water droplets from the environment. In this study, we show...

Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei (2008)

Choi, Kyoung-Hee, Mima, Takehiko, Casart Quintero, Yveth, Rholl, Drew, Kumar, Ayush, Beacham, Ifor Rhys, ...

Because of Burkholderia pseudomallei's classification as a select agent in the United States, genetic manipulation of this bacterium is strictly regulated. Only a few antibiotic selection markers,...

Evaluation of recombinant antigens for diagnosis of melioidosis. (2008)

Allwood, Elizabeth, Logue, Carie-Anne, Hafner, Gregory J., Ketheesan, Natkunam, Norton, Robert E., Peak, Ian, ...

Burkholderia pseudomallei, the causative agent of melioidosis, is endemic to Southeast Asia and northern Australia. Clinical manifestations of the disease are diverse, ranging from chronic localized...

Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei (2008)

Choi, Kyoung-Hee, Mima, Takehiko, Casart Quintero, Yveth, Rholl, Drew, Kumar, Ayush, Beacham, Ifor Rhys, ...

Because of Burkholderia pseudomallei's classification as a select agent in the United States, genetic manipulation of this bacterium is strictly regulated. Only a few antibiotic selection markers,...

Evaluation of recombinant antigens for diagnosis of melioidosis. (2008)

Allwood, Elizabeth, Logue, Carie-Anne, Hafner, Gregory J., Ketheesan, Natkunam, Norton, Robert E., Peak, Ian, ...

Burkholderia pseudomallei, the causative agent of melioidosis, is endemic to Southeast Asia and northern Australia. Clinical manifestations of the disease are diverse, ranging from chronic localized...

Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei (2008)

Choi, Kyoung-Hee, Mima, Takehiko, Casart Quintero, Yveth, Rholl, Drew, Kumar, Ayush, Beacham, Ifor Rhys, ...

Because of Burkholderia pseudomallei's classification as a select agent in the United States, genetic manipulation of this bacterium is strictly regulated. Only a few antibiotic selection markers,...

Evaluation of recombinant antigens for diagnosis of melioidosis. (2008)

Allwood, Elizabeth, Logue, Carie-Anne, Hafner, Gregory J., Ketheesan, Natkunam, Norton, Robert E., Peak, Ian, ...

Burkholderia pseudomallei, the causative agent of melioidosis, is endemic to Southeast Asia and northern Australia. Clinical manifestations of the disease are diverse, ranging from chronic localized...

The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells (2007)

Boddey, Justin Andrew, Day, Christopher, Flegg, Cameron, Ulrich, Ricky L., Stephens, Sebastien Robert, Beacham, Ifor Rhys, ...

Burkholderia pseudomallei is a facultative intracellular pathogen and the causative agent of melioidosis, a spectrum of potentially fatal diseases endemic in Northern Australia and South-East Asia....

Temperature-Regulated Microcolony Formation by Burkholderia pseudomallei Requires pilA and Enhances Association with Cultured Human Cells (2006)

Boddey, Justin Andrew, Flegg, Cameron, Day, Christopher, Beacham, Ifor Rhys, Peak, Ian

Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease that is endemic to Northern Australia and Southeast Asia and is acquired from soil or water. Adherence of...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

Identification of a novel two-partner secretion system from Burkholderia pseudomallei. (2004)

Brown, Nathaniel Francis, Logue, Carie-Anne, Boddey, Justin Andrew, Scott, R., Hirst, Robert G, Beacham, Ifor Rhys

Two adjacent genes, bpaA and bpaB, whose products display significant similarity to a number of two-partner secretion (TPS) systems have been identified in Burkholderia pseudomallei strain 08, but...

Regulation of the aprX-lipA operon of Pseudomonas fluorescens B52: differential regulation of the proximal and distal genes, encoding protease and lipase, by ompR-envZ. (2004)

McCarthy, Conor, Woods, Rickie, Beacham, Ifor Rhys

The production of lipase and protease from psychrotrophic strains of Pseudomonas fluorescens may result in spoilage of dairy products. The lipase (lipA) and alkaline metalloprotease (aprX) genes of...

Whole genome analysis reveals a high incidence of non-optimal codons in secretory signal sequences of Escherichia coli (2004)

Power, Peter M., Jones, Robert A., Beacham, Ifor Rhys, Bucholtz, Carolyn, Jennings, Michael P.

Translational pausing may occur due to a number of mechanisms, including the presence of non-optimal codons, and it is thought to play a role in the folding of specific polypeptide domains during...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

Cobalt activation of Escherichia coli 5'-nucleotidase is due to zinc ion displacement at only one of two metal-ion-binding sites. (2003)

McMillen, Lyle, Beacham, Ifor Rhys, Burns, Dennis Martin

Escherichia coli 5´-nucleotidase activity is stimulated 30- to 50-fold in vitro by the addition of Co2+. Seven residues from conserved sequence motifs implicated in the catalytic and...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nat, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

A strain of Pseudomonas fluorescens with two lipase-encoding genes, one of which possibly encodes cytoplasmic lipolytic activity. (2001)

Logue, Carie-Anne, Dieckelmann, Manuela, Beacham, Ifor Rhys

Aims: A lipase-encoding gene (lipA) from a psychrotrophic strain of Pseudomonas fluorescens C9 has previously been characterized. It was also shown that when this gene was insertionally-inactivated,...

A strain of Pseudomonas fluorescens with two lipase-encoding genes, one of which possibly encodes cytoplasmic lipolytic activity. (2001)

Logue, Carie-Anne, Dieckelmann, Manuela, Beacham, Ifor Rhys

Aims: A lipase-encoding gene (lipA) from a psychrotrophic strain of Pseudomonas fluorescens C9 has previously been characterized. It was also shown that when this gene was insertionally-inactivated,...

A strain of Pseudomonas fluorescens with two lipase-encoding genes, one of which possibly encodes cytoplasmic lipolytic activity. (2001)

Logue, Carie-Anne, Dieckelmann, Manuela, Beacham, Ifor Rhys

Aims: A lipase-encoding gene (lipA) from a psychrotrophic strain of Pseudomonas fluorescens C9 has previously been characterized. It was also shown that when this gene was insertionally-inactivated,...

A strain of Pseudomonas fluorescens with two lipase-encoding genes, one of which possibly encodes cytoplasmic lipolytic activity. (2001)

Logue, Carie-Anne, Dieckelmann, Manuela, Beacham, Ifor Rhys

Aims: A lipase-encoding gene (lipA) from a psychrotrophic strain of Pseudomonas fluorescens C9 has previously been characterized. It was also shown that when this gene was insertionally-inactivated,...