Igor A. Sidorov

SNAD: sequence name annotation-based designer (2009)

Sidorov, Igor A, Reshetov, Denis A, Gorbalenya, Alexander E

Abstract Background A growing diversity of biological data is tagged with unique identifiers (UIDs) associated with polynucleotides and proteins to ensure efficient computer-mediated data storage,...

CHAPTER 21 Computational Biology (2008)

Dimiter S. Dimitrov, Igor A. Sidorov, Nikola Kasabov

2. Computational Genomics and Proteomics................ 3 2.1. DNA Sequencing............................. 3

Correlation between binding rate constants and individual information of E. coli Fis binding sites (2007)

Shultzaberger, Ryan K., Roberts, Lindsey R., Lyakhov, Ilya G., Sidorov, Igor A., Stephen, Andrew G., Fisher, Robert J., ...

Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics...

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes

Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., ...

HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that...

Concordant Modulation of Neutralization Resistance and High Infectivity of the Primary Human Immunodeficiency Virus Type 1 MN Strain and Definition of a Potential gp41 Binding Site in gp120

Leavitt, Maria, Park, Eun Ju, Sidorov, Igor A., Dimitrov, Dimiter S.

Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been...

Multiple Interactions across the Surface of the gp120 Core Structure Determine the Global Neutralization Resistance Phenotype of Human Immunodeficiency Virus Type 1

Bouma, Peter, Leavitt, Maria, Zhang, Peng Fei, Sidorov, Igor A., Dimitrov, Dimiter S., Quinnan, Gerald V.

Resistance to neutralization is an important characteristic of primary isolates of human immunodeficiency virus type 1 (HIV-1) that relates to the potential for successful vaccination to prevent...

Identification and Characterization of a New Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody

Zhang, Mei-Yun, Xiao, Xiaodong, Sidorov, Igor A., Choudhry, Vidita, Cham, Fatim, Zhang, Peng Fei, ...

The identification and characterization of new human monoclonal antibodies (hMAbs) able to neutralize primary human immunodeficiency virus type 1 (HIV-1) isolates from different subtypes may help in...

Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients

Kovacs, Joseph A., Lempicki, Richard A., Sidorov, Igor A., Adelsberger, Joseph W., Sereti, Irini, Sachau, William, ...

HIV infection leads to decreases in the number of CD4+ T lymphocytes and an increased risk for opportunistic infections and neoplasms. The administration of intermittent cycles of IL-2 to...

Naïve T-Cell Dynamics in Human Immunodeficiency Virus Type 1 Infection: Effects of Highly Active Antiretroviral Therapy Provide Insights into the Mechanisms of Naïve T-Cell Depletion

Di Mascio, Michele, Sereti, Irini, Matthews, Lynn T., Natarajan, Ven, Adelsberger, Joseph, Lempicki, Richard, ...

Both naïve CD4+ and naïve CD8+ T cells are depleted in individuals with human immunodeficiency virus type 1 (HIV-1) infection by unknown mechanisms. Analysis of their dynamics prior to and after...

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes

Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., ...

HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that...

Concordant Modulation of Neutralization Resistance and High Infectivity of the Primary Human Immunodeficiency Virus Type 1 MN Strain and Definition of a Potential gp41 Binding Site in gp120

Leavitt, Maria, Park, Eun Ju, Sidorov, Igor A., Dimitrov, Dimiter S.

Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been...

Multiple Interactions across the Surface of the gp120 Core Structure Determine the Global Neutralization Resistance Phenotype of Human Immunodeficiency Virus Type 1

Bouma, Peter, Leavitt, Maria, Zhang, Peng Fei, Sidorov, Igor A., Dimitrov, Dimiter S., Quinnan, Gerald V.

Resistance to neutralization is an important characteristic of primary isolates of human immunodeficiency virus type 1 (HIV-1) that relates to the potential for successful vaccination to prevent...

Identification and Characterization of a New Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody

Zhang, Mei-Yun, Xiao, Xiaodong, Sidorov, Igor A., Choudhry, Vidita, Cham, Fatim, Zhang, Peng Fei, ...

The identification and characterization of new human monoclonal antibodies (hMAbs) able to neutralize primary human immunodeficiency virus type 1 (HIV-1) isolates from different subtypes may help in...

Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients

Kovacs, Joseph A., Lempicki, Richard A., Sidorov, Igor A., Adelsberger, Joseph W., Sereti, Irini, Sachau, William, ...

HIV infection leads to decreases in the number of CD4+ T lymphocytes and an increased risk for opportunistic infections and neoplasms. The administration of intermittent cycles of IL-2 to...

Naïve T-Cell Dynamics in Human Immunodeficiency Virus Type 1 Infection: Effects of Highly Active Antiretroviral Therapy Provide Insights into the Mechanisms of Naïve T-Cell Depletion

Di Mascio, Michele, Sereti, Irini, Matthews, Lynn T., Natarajan, Ven, Adelsberger, Joseph, Lempicki, Richard, ...

Both naïve CD4+ and naïve CD8+ T cells are depleted in individuals with human immunodeficiency virus type 1 (HIV-1) infection by unknown mechanisms. Analysis of their dynamics prior to and after...

Correlation between binding rate constants and individual information of E. coli Fis binding sites

Shultzaberger, Ryan K., Roberts, Lindsey R., Lyakhov, Ilya G., Sidorov, Igor A., Stephen, Andrew G., Fisher, Robert J., ...

Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics...

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

Zhu, Zhongyu, Chakraborti, Samitabh, He, Yuxian, Roberts, Anjeanette, Sheahan, Tim, Xiao, Xiaodong, ...

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an independent animal-to-human...

Identification of Dynamically Distinct Subpopulations of T Lymphocytes That Are Differentially Affected by HIV

Kovacs, Joseph A., Lempicki, Richard A., Sidorov, Igor A., Adelsberger, Joseph W., Herpin, Betsey, Metcalf, Julia A., ...

We examined the effects of human immunodeficiency virus infection on the turnover of CD4 and CD8 T lymphocytes in 17 HIV-infected patients by 30 min in vivo pulse labeling with bromodeoxyuridine...