Igor Mikaelian

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007)

Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...

Abstract Background Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To...

Systemic effects of Arctic pollutants in beluga whales indicated by CYP1A1 expression (2005)

Wilson, Joanna Y., Cooke, Suzy R., Moore, Michael J., Martineau, Daniel, Mikaelian, Igor, Metner, Donald A., ...

Author Posting. EHP is a publication of the United States government. Publication of EHP lies in the public domain and is therefore without copyright. The definitive version was published in...

Systemic effects of Arctic pollutants in beluga whales indicated by CYP1A1 expression (2005)

Wilson, Joanna Y., Cooke, Suzy R., Moore, Michael J., Martineau, Daniel, Mikaelian, Igor, Metner, Donald A., ...

Author Posting. EHP is a publication of the United States government. Publication of EHP lies in the public domain and is therefore without copyright. The definitive version was published in...

Proteotypic classification of spontaneous and transgenic mammary neoplasms (2004)

Mikaelian, Igor, Blades, Natalie, Churchill, Gary A, Fancher, Karen, Knowles, Barbara B, Eppig, Janan T, ...

Abstract Introduction Mammary tumors in mice are categorized by using morphologic and architectural criteria. Immunolabeling for terminal differentiation markers was compared among a variety of mouse...

SPONTANEOUS PROLIFERATIVE LESIONS AND TUMORS OF THE UTERUS OF CAPTIVE AFRICAN HEDGEHOGS (ATELERIX ALBIVENTRIS) (2004)

Igor Mikaelian, Drury R. Reavill

Fifteen captive female African hedgehogs (Atelerix albiventris), 3- to 5-yr-old, were diagnosed with proliferative uterine lesions (n = 28). Lesions were associated with vaginal bleeding in all...

Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada.

Martineau, Daniel, Lemberger, Karin, Dallaire, André, Labelle, Philippe, Lipscomb, Thomas P, Michel, Pascal, ...

A population of approximately 650 beluga (Delphinapterus leucas) inhabits a short segment of the St. Lawrence estuary (SLE). Over 17 years (1983-1999), we have examined 129 (or 49%) of 263 SLE beluga...

Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression

Wilson, Joanna Y., Cooke, Suzy R., Moore, Michael J., Martineau, Daniel, Mikaelian, Igor, Metner, Donald A., ...

Cytochrome P450 1A1 (CYP1A1) is induced by exposure to polycyclic aromatic hydrocarbons (PAHs) and planar halogenated aromatic hydrocarbons (PHAHs) such as non-ortho polychlorinated biphenyls (PCBs)....

Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada.

Martineau, Daniel, Lemberger, Karin, Dallaire, André, Labelle, Philippe, Lipscomb, Thomas P, Michel, Pascal, ...

A population of approximately 650 beluga (Delphinapterus leucas) inhabits a short segment of the St. Lawrence estuary (SLE). Over 17 years (1983-1999), we have examined 129 (or 49%) of 263 SLE beluga...

Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression

Wilson, Joanna Y., Cooke, Suzy R., Moore, Michael J., Martineau, Daniel, Mikaelian, Igor, Metner, Donald A., ...

Cytochrome P450 1A1 (CYP1A1) is induced by exposure to polycyclic aromatic hydrocarbons (PAHs) and planar halogenated aromatic hydrocarbons (PHAHs) such as non-ortho polychlorinated biphenyls (PCBs)....

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...

Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human...