Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch-Belgian Cohort (2009)
Stokkers, Pieter C. F, Wolfkamp, Simone C. S, Schreiber, Stefan, ...
OBJECTIVES: Inflammatory bowel diseases (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-are chronic gastrointestinal inflammatory disorders with a complex genetic background. A genome-wide...
Niens, Marijke, Visser, Lydia, Nolte, Ilja M., Steege, Gerrit Van Der, Diepstra, Arjan, Cordano, Pablo, ...
Hodgkin lymphoma (HL) is characterized by a minority of neoplastic Hodgkin-Reed Sternberg (HRS) cells surrounded by a non-neoplastic reactive infiltrate. As immunological mechanisms appear to be...
Association testing by haplotype-sharing methods applicable to whole-genome analysis (2007)
Nolte, Ilja M, De Vries, André R, Spijker, Geert T, Jansen, Ritsert C, Brinza, Dumitru, Zelikovsky, Alexander, ...
Abstract We propose two new haplotype-sharing methods for identifying disease loci: the haplotype sharing statistic (HSS), which compares length of shared haplotypes between cases and controls, and...
Diepstra, Arjan, Imhoff, Gustaaf W. Van, Karim-Kos, Henrike E., Berg, Anke Van Den, Meerman, Gerard J. Te, Niens, Marijke, ...
Purpose: The neoplastic Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin’s lymphoma (cHL) are derived from B cells. The frequency of HLA class II downregulation and its effect on prognosis...
Martens, Henk A., Nolte, Ilja M., Steege, Gerrit Van Der, Schipper, Martijn, Kallenberg, Cees G.M., Meerman, Gerard J. Te, ...
Niens, Marijke, Jarrett, Ruth F., Hepkema, Bouke, Nolte, Ilja M., Diepstra, Arjan, Platteel, Mathieu, ...
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV)–positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This...
Association testing by haplotype-sharing methods applicable to whole-genome analysis (2007)
Nolte, Ilja M., Vries, André R. De, Spijker, Geert T., Jansen, Ritsert C., Brinza, Dumitru, Zelikovsky, Alexander, ...
We propose two new haplotype-sharing methods for identifying disease loci: the haplotype sharing statistic (HSS), which compares length of shared haplotypes between cases and controls, and the CROSS...
Decorinand TGF-β1polymorphisms and development of COPD in a general population (2006)
Van Diemen, Cleo C, Postma, Dirkje S, Vonk, Judith M, Bruinenberg, Marcel, Nolte, Ilja M, Boezen, H Marike
Abstract Background Decorin, an extracellular matrix (ECM) proteoglycan, and TGF-β 1 are both involved in lung ECM turnover. Decorin and TGF-β 1 expression are decreased respectively increased in...
Oostenbrug, Liekele E., Dijkstra, Gerard, Nolte, Ilja M., Dullemen, Hendrik M. Van, Oosterom, Elvira, Faber, Klaas N., ...
Objective. The multidrug resistance (MDR1) gene encodes for P-glycoprotein, a drug efflux pump. Mice deficient for the MDR1a gene spontaneously develop colitis. In humans, a polymorphism in exon 26...
Niens, Marijke, Berg, Anke Van Den, Diepstra, Arjan, Nolte, Ilja M., Steege, Gerrit Van Der, Gallagher, Alice, ...
Various studies have indicated that the human leukocyte antigen (HLA) region is associated with Hodgkin’s lymphoma. We recently showed a specific association of the HLA class I region with...
The Human Leukocyte Antigen Region and Colorectal Cancer Risk (2005)
Jong, Mirjam M. De, Niens, Marijke, Nolte, Ilja M., Meerman, Gerard J. Te, Mulder, Marcel J., ...
Recently, we found a certain haplotype in the human leukocyte antigen Class III subregion to be associated with breast cancer. Epidemiologic studies have shown that breast cancer and colorectal...
Jong, Mirjam M. De, Nolte, Ilja M., Meerman, Gerard J. Te, Oosterom, Elvira, Bruinenberg, Marcel, ...
CHEK2 is low-penetrance breast cancer susceptibility gene. The 1100delC mutation may interact with variants/mutations in other breast cancer susceptibility loci. We identified a risk haplotype in the...
Colorectal Cancer and the CHEK2 1100delC Mutation (2005)
Jong, Mirjam M. De, Nolte, Ilja M., Meerman, Gerard J. Te, Mulder, Marcel J., Steege, Gerrit Van Der, ...
The CHEK2 1100delC mutation was recently identified as a low-penetrance breast cancer susceptibility allele. The mutation occurred more frequently in families with clustering of breast and colorectal...
Zoodsma, Margreet, Nolte, Ilja M., Schipper, Martin, Oosterom, Elvira, Steege, Gerrit Van Der, ...
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine. The potential influence of MTHFR activity on DNA methylation and on the...
Association Between Toll-like Receptor 4 and Inflammatory Bowel Disease (2005)
Oostenbrug, Liekele E., Drenth, Joost P.H., Jong, Dirk J. De, Nolte, Ilja M., Oosterom, Elvira, Dullemen, Hendrik M. Van, ...
Background: The human Toll-like receptor 4 (TLR4) participates in the innate response. Recently, the TLR4 variant Asp299Gly has been described to affect the response of this receptor to...
Polymorphisms in SPINK5 are not associated with asthma in a Dutch population (2005)
Jongepier, Hajo, Koppelman, Gerard H., Nolte, Ilja M., Bruinenberg, Marcel, Bleecker, Eugene R., Meyers, Deborah A., ...
Background: Asthma and allergic phenotypes are complex genetic diseases with known linkage to chromosome 5q. This region has many candidate genes, including serine protease inhibitor Kazal type 5...
Boon, Maartje, Nolte, Ilja M., Keyser, Jacques De, Meerman, Gerard J. Te
We previously identified on chromosome 6 an interval of 51 kb as the most likely interval in the HLA region for a disease-susceptibility locus for multiple sclerosis (MS). The interval was located...
The HLA class III subregion is responsible for an increased breast cancer risk (2003)
Jong, Mirjam M. De, Nolte, Ilja M., Schaapveld, Michael, Kleibeuker, Jan H., Oosterom, Elvira, ...
BRCA1 and BRCA2 germline mutations account for
The HLA class III subregion is responsible for an increased breast cancer risk (2003)
De Jong, Mirjam M., Nolte, Ilja M., Schaapveld, Michael, Kleibeuker, Jan H., Oosterom, Elvira, ...
BRCA1 and BRCA2 germline mutations account for
The HLA class III subregion is responsible for an increased breast cancer risk (2003)
De Jong, Mirjam M., Nolte, Ilja M., Schaapveld, Michael, Kleibeuker, Jan H., Oosterom, Elvira, ...
BRCA1 and BRCA2 germline mutations account for
The HLA class III subregion is responsible for an increased breast cancer risk (2003)
De Jong, Mirjam M., Nolte, Ilja M., Schaapveld, Michael, Kleibeuker, Jan H., Oosterom, Elvira, ...
The HLA class III subregion is responsible for an increased breast cancer risk (2003)
De Jong, Mirjam M., Nolte, Ilja M., Schaapveld, Michael, Kleibeuker, Jan H., Oosterom, Elvira, ...
BRCA1 and BRCA2 germline mutations account for
Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility (2002)
Jong, Mirjam M. De, Nolte, Ilja M., Meerman, Gerard J. Te, Sijmons, Rolf H., ...
This report focuses on low-penetrance genes that are associated with colorectal adenoma and/or cancer or that are in strong linkage disequilibrium with colorectal adenoma and/or cancer causing...
Testicular Carcinoma and HLA Class II Genes (2002)
Sonneveld, Dirk J.A., Lutke Holzik, Martijn F., Nolte, Ilja M., Sleijfer, Dirk Th., Bruinenberg, Marcel, ...
BACKGROUND. The association with histocompatibility antigens (HLA), in particular Class II genes (DQB1, DRB1), has recently been suggested to be one of the genetic factors involved in testicular germ...
Boon, Maartje, Nolte, Ilja M., Bruinenberg, Marcel, Spijker, Geert T., Terpstra, Peter, Raelson, John, ...
Multiple sclerosis (MS) is a complex disease that is partly genetic in origin. Although an association of MS with specific human leukocyte antigen (HLA) types has been known for almost 30 years, the...
Decorin and TGF-β1 polymorphisms and development of COPD in a general population
Van Diemen, Cleo C, Postma, Dirkje S, Vonk, Judith M, Bruinenberg, Marcel, Nolte, Ilja M, Boezen, H Marike
Identifying Candidate Hirschsprung Disease–Associated RET Variants
Burzynski, Grzegorz M., Nolte, Ilja M., Bronda, Agnes, Bos, Krista K., Osinga, Jan, Plaza Menacho, Ivan, ...
Patients with sporadic Hirschsprung disease (HSCR) show increased allele sharing at markers in the 5′ region of the RET locus, indicating the presence of a common ancestral RET mutation. In a...
Decorin and TGF-β1 polymorphisms and development of COPD in a general population
Van Diemen, Cleo C, Postma, Dirkje S, Vonk, Judith M, Bruinenberg, Marcel, Nolte, Ilja M, Boezen, H Marike
Association testing by haplotype-sharing methods applicable to whole-genome analysis
Nolte, Ilja M, De Vries, André R, Spijker, Geert T, Jansen, Ritsert C, Brinza, Dumitru, Zelikovsky, Alexander, ...
We propose two new haplotype-sharing methods for identifying disease loci: the haplotype sharing statistic (HSS), which compares length of shared haplotypes between cases and controls, and the CROSS...
Nolte, Ilja M., Wallace, Chris, Newhouse, Stephen J., Waggott, Daryl, Fu, Jingyuan, Soranzo, Nicole, ...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a...