Ingemar Ernberg

Tumour Associated Herpesviruses The 11th Biennial Conference of The International Association for Research on Epstein-Barr Virus and Associated Diseases (2009)

Welcome To Regensburg, Richard Ambinder, Jen-yang Chen, Marilys Corbex, Dorothy Crawford, Riccardo Dolcetti, ...

You will find the venue close to the old town of Regensburg, one of the oldest townships of Germany with still visible portions of arches and walls from Roman times (100 – 200 AD) as integral part...

Epstein-Barr virus latency switch in human B-cells: a physico-chemical model (2007)

Werner, Maria, Ernberg, Ingemar, Zou, JieZhi, Almqvist, Jenny, Aurell, Erik

Abstract Background The Epstein-Barr virus is widespread in all human populations and is strongly associated with human disease, ranging from infectious mononucleosis to cancer. In infected cells the...

Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population (2006)

Cao, Yun, Miao, Xiao-Ping, Huang, Ma-Yan, Deng, Ling, Hu, Li-Fu, Ernberg, Ingemar, ...

Abstract Background Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China. In addition to environmental factors such as Epstein-Barr virus infection and diet, genetic...

Aberrant methylation of CDH13 gene in nasopharyngeal carcinoma could serve as a potential diagnostic biomarker (2006)

Van, Do Nguyen, Huang, Guangwu, Ernberg, Ingemar, Hu, Lifu

CDH13 encodes a cell adhesion molecule, H-cadherin. In this study, we examined CDH13 methylation in nasopharyngeal carcinoma (NPC). Methylation specific PCR results showed that CDH13 was methylated...

The molecular portrait of in vitrogrowth by meta-analysis of gene-expression profiles (2005)

Sandberg, Rickard, Ernberg, Ingemar

Abstract Background Cell lines as model systems of tumors and tissues are essential in molecular biology, although they only approximate the properties of in vivo cells in tissues. Cell lines have...

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE (2005)

Malin, Stephen, Linderson, Ylva, Almqvist, Jenny, Ernberg, Ingemar, Tallone, Tiziano, Pettersson, Sven

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in...

NotI passporting to identify species composition of complex microbial systems (2003)

Zabarovska, Veronika, Kutsenko, Alexey S., Petrenko, Lev, Kilosanidze, Gelena, Ljungqvist, Olle, Norin, Elisabeth, ...

We describe here a new method for large‐scale scanning of microbial genomes on a quantitative and qualitative basis. To achieve this aim we propose to create NotI passports: databases containing...

Restriction site tagged (RST) microarrays: a novel technique to study the species composition of complex microbial systems (2003)

Zabarovsky, Eugene R., Petrenko, Lev, Protopopov, Alexei, Vorontsova, Olga, Kutsenko, Alexey S., Zhao, Yanyan, ...

We have developed a new type of microarray, restriction site tagged (RST), for example NotI, microarrays. In this approach only sequences surrounding specific restriction sites (i.e. NotI linking...

A new approach to genome mapping and sequencing: slalom libraries (2002)

Zabarovska, Veronika I., Gizatullin, Rinat Z., Al-Amin, Ali N., Podowski, Raf, Protopopov, Alexei I., Löfdahl, Sven, ...

We describe here an efficient strategy for simultaneous genome mapping and sequencing. The approach is based on physically oriented, overlapping restriction fragment libraries called slalom...

NotI clones in the analysis of the human genome (2000)

Zabarovsky, Eugene R., Gizatullin, Rinat, Podowski, Raf M., Zabarovska, Veronika V., Xie, Li, Muravenko, Olga V., ...

NotI linking clones contain sequences flanking NotI recognition sites and were previously shown to be tightly associated with CpG islands and genes. To directly assess the value of NotI clones in...

A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4+ T lymphocytes (2000)

Rajnavölgyi, Éva, Nagy, Noémi, Thuresson, Britt, Dosztányi, Zsuzsa, Simon, Ágnes, Simon, István, ...

Most human adults carry the Epstein–Barr virus (EBV) and develop immunological memory against the structural and the virus-encoded cellular proteins. The EBV nuclear antigen 6 (EBNA6) elicits...

A new approach to genome mapping and sequencing: slalom libraries

Zabarovska, Veronika I., Gizatullin, Rinat Z., Al-Amin, Ali N., Podowski, Raf, Protopopov, Alexei I., Löfdahl, Sven, ...

We describe here an efficient strategy for simultaneous genome mapping and sequencing. The approach is based on physically oriented, overlapping restriction fragment libraries called slalom...

Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

Winberg, Gösta, Matskova, Liudmila, Chen, Fu, Plant, Pamela, Rotin, Daniela, Gish, Gerald, ...

The latent membrane protein (LMP) 2A of Epstein-Barr virus (EBV) is implicated in the maintenance of viral latency and appears to function in part by inhibiting B-cell receptor (BCR) signaling. The...

NotI clones in the analysis of the human genome

Zabarovsky, Eugene R., Gizatullin, Rinat, Podowski, Raf M., Zabarovska, Veronika V., Xie, Li, Muravenko, Olga V., ...

NotI linking clones contain sequences flanking NotI recognition sites and were previously shown to be tightly associated with CpG islands and genes. To directly assess the value of NotI clones in...

Specific Methylation Patterns in Two Control Regions of Epstein-Barr Virus Latency: the LMP-1-Coding Upstream Regulatory Region and an Origin of DNA Replication (oriP)

Falk, Kerstin I., Szekely, Laszlo, Aleman, Anna, Ernberg, Ingemar

The Epstein-Barr virus (EBV) can establish at least four different forms of latent infection. Previously, we have shown that the level of methylation of the EBV genome varies, depending on the form...

C-Terminal Domain of the Epstein-Barr Virus LMP2A Membrane Protein Contains a Clustering Signal

Matskova, Liudmila, Ernberg, Ingemar, Pawson, Tony, Winberg, Gösta

The latency-regulated transmembrane protein LMP2A interferes with signaling from the B-cell antigen receptor by recruiting the tyrosine kinases Lyn and Syk and by targeting them for degradation by...

NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes

Li, Jingfeng, Protopopov, Alexei, Wang, Fuli, Senchenko, Vera, Petushkov, Valentin, Vorontsova, Olga, ...

Methylation, deletions, and amplifications of cancer genes constitute important mechanisms in carcinogenesis. For genome-wide analysis of these changes, we propose the use of NotI clone microarrays...

NotI passporting to identify species composition of complex microbial systems

Zabarovska, Veronika, Kutsenko, Alexey S., Petrenko, Lev, Kilosanidze, Gelena, Ljungqvist, Olle, Norin, Elisabeth, ...

We describe here a new method for large-scale scanning of microbial genomes on a quantitative and qualitative basis. To achieve this aim we propose to create NotI passports: databases containing NotI...

Restriction site tagged (RST) microarrays: a novel technique to study the species composition of complex microbial systems

Zabarovsky, Eugene R., Petrenko, Lev, Protopopov, Alexei, Vorontsova, Olga, Kutsenko, Alexey S., Zhao, Yanyan, ...

We have developed a new type of microarray, restriction site tagged (RST), for example NotI, microarrays. In this approach only sequences surrounding specific restriction sites (i.e. NotI linking...

Capturing Whole-Genome Characteristics in Short Sequences Using a Naïve Bayesian Classifier

Sandberg, Rickard, Winberg, Gösta, Bränden, Carl-Ivar, Kaske, Alexander, Ernberg, Ingemar, Cöster, Joakim

Bacterial genomes have diverged during evolution, resulting in clearcut differences in their nucleotide composition, such as their GC content. The analysis of complete sequences of bacterial genomes...

RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies

Kashuba, Vladimir I., Li, Jingfeng, Wang, Fuli, Senchenko, Vera N., Protopopov, Alexey, Malyukova, Alena, ...

Chromosome 3p21.3 region is frequently (>90%) deleted in lung and other major human carcinomas. We subdivided 3p21.3 into LUCA and AP20 subregions and discovered frequent homozygous deletions...

Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI)

Sandberg, Rickard, Ernberg, Ingemar

The gene expression profiles of 60 cell lines, derived from nine different tissues, were compared with their corresponding in vivo tumors and tissues. Cell lines expressed few tissue-specific (2%) or...

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE

Malin, Stephen, Linderson, Ylva, Almqvist, Jenny, Ernberg, Ingemar, Tallone, Tiziano, Pettersson, Sven

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in...

WW Domains Provide a Platform for the Assembly of Multiprotein Networks†

Ingham, Robert J., Colwill, Karen, Howard, Caley, Dettwiler, Sabine, Lim, Caesar S. H., Yu, Joanna, ...

WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine-proline sites. To pursue the functional...

The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles

Sandberg, Rickard, Ernberg, Ingemar

A meta analysis comparing 60 tumor cell lines, 135 normal tissue samples and 176 tumor tissue samples in humans shows significant differential expression between cell lines and tissues of around 30%...

Genomic Sequence Analysis of Epstein-Barr Virus Strain GD1 from a Nasopharyngeal Carcinoma Patient†

Zeng, Mu-Sheng, Li, Da-Jiang, Liu, Qing-Lun, Song, Li-Bing, Li, Man-Zhi, Zhang, Ru-Hua, ...

To date, the only entire Epstein-Barr virus (EBV) genomic sequence available in the database is the prototype B95.8, which was derived from an individual with infectious mononucleosis. A causative...

A new approach to genome mapping and sequencing: slalom libraries

Zabarovska, Veronika I., Gizatullin, Rinat Z., Al-Amin, Ali N., Podowski, Raf, Protopopov, Alexei I., Löfdahl, Sven, ...

We describe here an efficient strategy for simultaneous genome mapping and sequencing. The approach is based on physically oriented, overlapping restriction fragment libraries called slalom...

Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

Winberg, Gösta, Matskova, Liudmila, Chen, Fu, Plant, Pamela, Rotin, Daniela, Gish, Gerald, ...

The latent membrane protein (LMP) 2A of Epstein-Barr virus (EBV) is implicated in the maintenance of viral latency and appears to function in part by inhibiting B-cell receptor (BCR) signaling. The...

NotI clones in the analysis of the human genome

Zabarovsky, Eugene R., Gizatullin, Rinat, Podowski, Raf M., Zabarovska, Veronika V., Xie, Li, Muravenko, Olga V., ...

NotI linking clones contain sequences flanking NotI recognition sites and were previously shown to be tightly associated with CpG islands and genes. To directly assess the value of NotI clones in...

Specific Methylation Patterns in Two Control Regions of Epstein-Barr Virus Latency: the LMP-1-Coding Upstream Regulatory Region and an Origin of DNA Replication (oriP)

Falk, Kerstin I., Szekely, Laszlo, Aleman, Anna, Ernberg, Ingemar

The Epstein-Barr virus (EBV) can establish at least four different forms of latent infection. Previously, we have shown that the level of methylation of the EBV genome varies, depending on the form...

C-Terminal Domain of the Epstein-Barr Virus LMP2A Membrane Protein Contains a Clustering Signal

Matskova, Liudmila, Ernberg, Ingemar, Pawson, Tony, Winberg, Gösta

The latency-regulated transmembrane protein LMP2A interferes with signaling from the B-cell antigen receptor by recruiting the tyrosine kinases Lyn and Syk and by targeting them for degradation by...

NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes

Li, Jingfeng, Protopopov, Alexei, Wang, Fuli, Senchenko, Vera, Petushkov, Valentin, Vorontsova, Olga, ...

Methylation, deletions, and amplifications of cancer genes constitute important mechanisms in carcinogenesis. For genome-wide analysis of these changes, we propose the use of NotI clone microarrays...

NotI passporting to identify species composition of complex microbial systems

Zabarovska, Veronika, Kutsenko, Alexey S., Petrenko, Lev, Kilosanidze, Gelena, Ljungqvist, Olle, Norin, Elisabeth, ...

We describe here a new method for large-scale scanning of microbial genomes on a quantitative and qualitative basis. To achieve this aim we propose to create NotI passports: databases containing NotI...

Restriction site tagged (RST) microarrays: a novel technique to study the species composition of complex microbial systems

Zabarovsky, Eugene R., Petrenko, Lev, Protopopov, Alexei, Vorontsova, Olga, Kutsenko, Alexey S., Zhao, Yanyan, ...

We have developed a new type of microarray, restriction site tagged (RST), for example NotI, microarrays. In this approach only sequences surrounding specific restriction sites (i.e. NotI linking...

Capturing Whole-Genome Characteristics in Short Sequences Using a Naïve Bayesian Classifier

Sandberg, Rickard, Winberg, Gösta, Bränden, Carl-Ivar, Kaske, Alexander, Ernberg, Ingemar, Cöster, Joakim

Bacterial genomes have diverged during evolution, resulting in clearcut differences in their nucleotide composition, such as their GC content. The analysis of complete sequences of bacterial genomes...

RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies

Kashuba, Vladimir I., Li, Jingfeng, Wang, Fuli, Senchenko, Vera N., Protopopov, Alexey, Malyukova, Alena, ...

Chromosome 3p21.3 region is frequently (>90%) deleted in lung and other major human carcinomas. We subdivided 3p21.3 into LUCA and AP20 subregions and discovered frequent homozygous deletions...

Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI)

Sandberg, Rickard, Ernberg, Ingemar

The gene expression profiles of 60 cell lines, derived from nine different tissues, were compared with their corresponding in vivo tumors and tissues. Cell lines expressed few tissue-specific (2%) or...

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE

Malin, Stephen, Linderson, Ylva, Almqvist, Jenny, Ernberg, Ingemar, Tallone, Tiziano, Pettersson, Sven

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in...

WW Domains Provide a Platform for the Assembly of Multiprotein Networks†

Ingham, Robert J., Colwill, Karen, Howard, Caley, Dettwiler, Sabine, Lim, Caesar S. H., Yu, Joanna, ...

WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine-proline sites. To pursue the functional...

The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles

Sandberg, Rickard, Ernberg, Ingemar

A meta analysis comparing 60 tumor cell lines, 135 normal tissue samples and 176 tumor tissue samples in humans shows significant differential expression between cell lines and tissues of around 30%...

Genomic Sequence Analysis of Epstein-Barr Virus Strain GD1 from a Nasopharyngeal Carcinoma Patient†

Zeng, Mu-Sheng, Li, Da-Jiang, Liu, Qing-Lun, Song, Li-Bing, Li, Man-Zhi, Zhang, Ru-Hua, ...

To date, the only entire Epstein-Barr virus (EBV) genomic sequence available in the database is the prototype B95.8, which was derived from an individual with infectious mononucleosis. A causative...

Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin’s Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells

Baumforth, Karl R.N., Birgersdotter, Anna, Reynolds, Gary M., Wei, Wenbin, Kapatai, Georgia, Flavell, Joanne R., ...

In ∼50% of patients with Hodgkin’s lymphoma (HL), the Epstein-Barr virus (EBV), an oncogenic herpesvirus, is present in tumor cells. After microarray profiling of both HL tumors and cell lines,...