Ritchie, Jennifer M., Brady, Michael J., Riley, Kathleen N., Ho, Theresa Deland, Campellone, Kenneth Geno, Herman, Ira M., ...
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 induces filamentous actin-rich 'pedestals' on intestinal epithelial cells. Pedestal formation in vitro requires translocation of bacterial effectors...
�cap73-ARF6 Interactions Modulate Cell Shape and Motility after Injury In Vitro (2002)
Kathleen N. Riley, Angel E. Maldonado, Patrice Tellier, Ira M. Herman
To understand the role that ARF6 plays in regulating isoactin dynamics and cell motility, we transfected endothelial cells (EC) with HA-tagged ARF6: the wild-type form (WT), a constitutively-active...
Sorting of beta-actin mRNA and protein to neurites and growth cones in culture (1998)
Bassell, Gary J., Zhang, Honglai, Byrd, Anne L., Femino, Andrea M., Singer, Robert H., Taneja, Krishan L., ...
The transport of mRNAs into developing dendrites and axons may be a basic mechanism to localize cytoskeletal proteins to growth cones and influence microfilament organization. Using isoform-specific...
βcap73-ARF6 Interactions Modulate Cell Shape and Motility after Injury In Vitro
Riley, Kathleen N., Maldonado, Angel E., Tellier, Patrice, D'Souza-Schorey, Crislyn, Herman, Ira M.
To understand the role that ARF6 plays in regulating isoactin dynamics and cell motility, we transfected endothelial cells (EC) with HA-tagged ARF6: the wild-type form (WT), a constitutively-active...
Collagenase Promotes the Cellular Responses to Injury and Wound Healing In Vivo
Riley, Kathleen N., Herman, Ira M.
Objective: This study focuses on the growth-promoting and migration-enhancing role that Clostridial collagenase plays in vitro and in vivo. Methods: For in vitro studies, biosynthesized extracellular...
βcap73-ARF6 Interactions Modulate Cell Shape and Motility after Injury In Vitro
Riley, Kathleen N., Maldonado, Angel E., Tellier, Patrice, D'Souza-Schorey, Crislyn, Herman, Ira M.
To understand the role that ARF6 plays in regulating isoactin dynamics and cell motility, we transfected endothelial cells (EC) with HA-tagged ARF6: the wild-type form (WT), a constitutively-active...
Collagenase Promotes the Cellular Responses to Injury and Wound Healing In Vivo
Riley, Kathleen N., Herman, Ira M.
Objective: This study focuses on the growth-promoting and migration-enhancing role that Clostridial collagenase plays in vitro and in vivo. Methods: For in vitro studies, biosynthesized extracellular...
Papetti, Michael, Herman, Ira M.
We have isolated a monoclonal antibody, clone βE11, which recognizes an antigen that is highly abundant on the surface of mitotic vascular endothelial cells and tumor cells. By sodium dodecyl...
Kutcher, Matthew E., Kolyada, Alexey Y., Surks, Howard K., Herman, Ira M.
Pericytes regulate microvascular development and maturation through the control of endothelial cell motility, proliferation, and differentiation. The Rho GTPases have recently been described as key...
Calpain Regulates Actin Remodeling during Cell Spreading
Potter, David A., Tirnauer, Jennifer S., Janssen, Richard, Croall, Dorothy E., Hughes, Christina N., Fiacco, Kerry A., ...
Previous studies suggest that the Ca2+-dependent proteases, calpains, participate in remodeling of the actin cytoskeleton during wound healing and are active during cell migration. To directly test...
Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone
Diefenbach, Thomas J., Latham, Vaughan M., Yimlamai, Dean, Liu, Canwen A., Herman, Ira M., Jay, Daniel G.
The myosin family of motor proteins is implicated in mediating actin-based growth cone motility, but the roles of many myosins remain unclear. We previously implicated myosin 1c (M1c; formerly myosin...
Intracellular Neutralization of Shiga Toxin 2 by an A Subunit-Specific Human Monoclonal Antibody▿ †
Krautz-Peterson, Greice, Chapman-Bonofiglio, Susan, Boisvert, Karen, Feng, Hanping, Herman, Ira M., Tzipori, Saul, ...
Infection of children with Shiga toxin (Stx)-producing Escherichia coli (STEC) is the leading cause of hemolytic-uremic syndrome (HUS). Stx2, one of two toxins liberated by the bacteria, is directly...