Functional Analysis of Interactions Between 53BP1, BRCA1 and p53 (1998)
53BP1 has been reported to interact with the central DNA-binding domain of the tumor suppressor p53 and to enhance p53-dependent transcription. The C-terminus of 53BP1 contains a tandem BRCT motif....
Functional Analysis of Interactions Between 53BP1, BRCA1 and p53 (1998)
53BP1 has been suggested to play a role in DNA damage recognition and/or repair. We could show that upon exposure of cells to ionizing radiation, 53BPl rapidly colocalizes with phosphorylated H2Ax...
Functional Analysis of Interactions Between 53BP1, BRCA1 and p53 (1998)
The ability to sense DNA damage and activate response pathways that coordinate cell cycle progression and DNA repair is essential for the maintenance of genomic integrity. Based on its conserved BRCT...
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
Ward, Irene M., Minn, Kay, Van Deursen, Jan, Chen, Junjie
53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
Ward, Irene M., Minn, Kay, Van Deursen, Jan, Chen, Junjie
53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Sengupta, Sagar, Robles, Ana I., Linke, Steven P., Sinogeeva, Natasha I., Zhang, Ran, Pedeux, Remy, ...
Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal...
53BP1 is required for class switch recombination
Ward, Irene M., Reina-San-Martin, Bernardo, Olaru, Alexandru, Minn, Kay, Tamada, Koji, Lau, Julie S., ...
53BP1 participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of mice and cells deficient in 53BP1 suggests a defect in DNA repair...