A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
Scimone, M. Lucila, Aifantis, Iannis, Apostolou, Irina, Von Boehmer, Harald, Von Andrian, Ulrich H.
Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell development. We have previously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2,...
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
Scimone, M. Lucila, Aifantis, Iannis, Apostolou, Irina, Von Boehmer, Harald, Von Andrian, Ulrich H.
Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell development. We have previously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2,...
Adoptively Transferred Allergen-Specific T Cells Cause Maternal Transmission of Asthma Risk
Hubeau, Cedric, Apostolou, Irina, Kobzik, Lester
In addition to genetics and environment, maternal asthma is an identified risk factor for developing the disease during childhood. The mechanisms of this maternal effect remain poorly understood. We...
In Vivo Instruction of Suppressor Commitment in Naive T Cells
Apostolou, Irina, Von Boehmer, Harald
The induction of antigen-specific tolerance in the mature immune system of the intact organism has met with limited success. Therefore, nonspecific immunosuppression has been the treatment of choice...
Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes
Apostolou, Irina, Hao, Zhenyue, Rajewsky, Klaus, Von Boehmer, Harald
In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in...
Verginis, Panayotis, McLaughlin, Katherine A., Wucherpfennig, Kai W., Von Boehmer, Harald, Apostolou, Irina
Antigen-specific transplantation tolerance in the absence of immunosuppressive drugs is a rarely achieved goal. Immune responses to Y chromosome-encoded transplantation antigens (HY) can have...