Vogel, Carla IG, Greene, Brandon, Scherag, André, Müller, Timo D, Friedel, Susann, Grallert, Harald, ...
Abstract Background A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with obesity and increased...
Marquard, Vivien, Beckmann, Lars, Heid, Iris M, Lamina, Claudia, Chang-Claude, Jenny
Abstract Background We investigated the influence of genotyping errors on the type I error rate and empirical power of two haplotype based association methods applied to candidate regions. We...
Kollerits, Barbara, Coassin, Stefan, Beckmann, Noam D., Teumer, Alexander, Kiechl, Stefan, Döring, Angela, ...
Adiponutrin (PNPLA3) is a predominantly liver-expressed transmembrane protein with phospholipase activity that is regulated by fasting and feeding. Recent genome-wide association studies identified...
Common variants near MC4R are associated with fat mass, weight and risk of obesity (2008)
Loos, Ruth J.F., Lindgren, Cecilia M., Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, ...
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the...
Englert, Carsten, Blunk, Torsten, Müller, Rainer, Von Glasser, Sabine, Baumer, Julia, Fierlbeck, Johann, ...
Abstract After trauma, articular cartilage often does not heal due to incomplete bonding of the fractured surfaces. In this study we investigated the ability of chemical cross-linkers to facilitate...
Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI)[1]. The association between increased BMI and homozygosity for the...
Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
Lamina, Claudia, Meisinger, Christa, Heid, Iris M., Löwel, Hannelore, Rantner, Barbara, Koenig, Wolfgang, ...
Aims Peripheral arterial occlusive disease is associated with a high risk of cardiovascular morbidity and mortality. We prospectively examined the association of the ankle-brachial index (ABI) and...
Lamina, Claudia, Meisinger, Christa, Heid, Iris M., Löwel, Hannelore, Rantner, Barbara, Koenig, Wolfgang, ...
Aims Peripheral arterial occlusive disease is associated with a high risk of cardiovascular morbidity and mortality. We prospectively examined the association of the ankle-brachial index (ABI) and...
Schaeffer, Linda, Gohlke, Henning, Müller, Martina, Heid, Iris M., Palmer, Lyle J., Kompauer, Iris, ...
Fatty acid composition in membranes plays an important role in cellular processes and has shown to be associated with the aetiology of several complex diseases in humans. We report strong...
München, Univ., Diss., 2002 (Nur beschränkt für den Austausch).
Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
Englert, Carsten, Blunk, Torsten, Müller, Rainer, Von Glasser, Sabine Schulze, Baumer, Julia, Fierlbeck, Johann, ...
After trauma, articular cartilage often does not heal due to incomplete bonding of the fractured surfaces. In this study we investigated the ability of chemical cross-linkers to facilitate bonding of...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
On the Replication of Genetic Associations: Timing Can Be Everything!
Lasky-Su, Jessica, Lyon, Helen N., Emilsson, Valur, Heid, Iris M., Molony, Cliona, Raby, Benjamin A., ...
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study...
Vogel, Carla IG, Greene, Brandon, Scherag, André, Müller, Timo D, Friedel, Susann, Grallert, Harald, ...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...
Brandstätter, Anita, Kiechl, Stefan, Kollerits, Barbara, Hunt, Steven C., Heid, Iris M., Coassin, Stefan, ...
OBJECTIVE—High serum uric acid levels lead to gout and have been reported to be associated with an increased risk of hypertension, obesity, metabolic syndrome, type 2 diabetes, and cardiovascular...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
Heid, Iris M., Lamina, Claudia, Küchenhoff, Helmut, Fischer, Guido, Klopp, Norman, Kolz, Melanie, ...
Previously, estimation of genotype misclassification of single nucleotide polymorphisms (SNPs) as encountered in epidemiologic practice and involving thousands of subjects was lacking. The authors...
Heid, Iris M., Huth, Cornelia, Loos, Ruth J. F., Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S., ...
The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34...