Trafficking of spontaneously endocytosed MHC proteins
Chiu, Isaac, Davis, Daniel M., Strominger, Jack L.
Class I MHC protein primarily presents endogenous antigen but also may present exogenous antigen. Here, we investigated the intracellular pathway of spontaneously internalized class I MHC protein by...
The human natural killer cell immune synapse
Davis, Daniel M., Chiu, Isaac, Fassett, Marlys, Cohen, George B., Mandelboim, Ofer, Strominger, Jack L.
Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses...
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression
Deng, Lih-Wen, Chiu, Isaac, Strominger, Jack L.
MLL5 is a mammalian trithorax group (trx-G) gene identified within chromosome band 7q22, a frequently deleted element found in cytogenetic aberrations of acute myeloid malignancies. MLL5 cDNA was...
Zhang, Ming, Austen, William G., Chiu, Isaac, Alicot, Elisabeth M., Hung, Rachel, Ma, Minghe, ...
Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies...
Trafficking of spontaneously endocytosed MHC proteins
Chiu, Isaac, Davis, Daniel M., Strominger, Jack L.
Class I MHC protein primarily presents endogenous antigen but also may present exogenous antigen. Here, we investigated the intracellular pathway of spontaneously internalized class I MHC protein by...
The human natural killer cell immune synapse
Davis, Daniel M., Chiu, Isaac, Fassett, Marlys, Cohen, George B., Mandelboim, Ofer, Strominger, Jack L.
Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses...
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression
Deng, Lih-Wen, Chiu, Isaac, Strominger, Jack L.
MLL5 is a mammalian trithorax group (trx-G) gene identified within chromosome band 7q22, a frequently deleted element found in cytogenetic aberrations of acute myeloid malignancies. MLL5 cDNA was...
Zhang, Ming, Austen, William G., Chiu, Isaac, Alicot, Elisabeth M., Hung, Rachel, Ma, Minghe, ...
Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies...
Ma, Yinghua, Li, Jianxue, Chiu, Isaac, Wang, Yawen, Sloane, Jacob A., Lü, Jining, ...
Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential...
Identification of the target self-antigens in reperfusion injury
Zhang, Ming, Alicot, Elisabeth M., Chiu, Isaac, Li, Jinan, Verna, Nicola, Vorup-Jensen, Thomas, ...
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma....