Campese, Antonio F., Grazioli, Paola, Colantoni, Sara, Anastasi, Emanuela, Mecarozzi, Marco, Checquolo, Saula, ...
Dysregulated generation and/or function of naturally occurring ‘CD4+CD25+ regulatory T cells’ (Tregs) play key role in the development of autoimmune diseases, including type 1 diabetes. Recent...
Felli, Maria Pia, Maroder, Marella, Mitsiadis, Thimios A., Campese, Antonio F., Bellavia, Diana, Vacca, Alessandra, ...
The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the different members of the Notch family influence distinct steps in T...
Bellavia, Diana, Campese, Antonio F., Checquolo, Saula, Balestri, Anna, Biondi, Andrea, Cazzaniga, Giovanni, ...
Notch receptors are conserved regulators of cell fate and have been implicated in the regulation of T cell differentiation and lymphomagenesis. However, neither the generality of Notch involvement in...
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, ...
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4–8– thymocytes and is down-regulated across the...
RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
Di Marcotullio, Lucia, Ferretti, Elisabetta, De Smaele, Enrico, Argenti, Beatrice, Mincione, Claudia, Zazzeroni, Francesca, ...
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also...
Human MRE11 is inactivated in mismatch repair-deficient cancers
Giannini, Giuseppe, Ristori, Elisabetta, Cerignoli, Fabio, Rinaldi, Christian, Zani, Massimo, Viel, Alessandra, ...
Mutations of the ATM and NBS1 genes are responsible for the inherited Ataxia-Telangiectasia and Nijmegen Breakage Syndrome, both of which are associated with a predisposition to cancer. A related...
Talora, Claudio, Campese, Antonio F., Bellavia, Diana, Pascucci, Monica, Checquolo, Saula, Groppioni, Manuela, ...
Notch and basic helix–loop–helix E2A pathways specify cell fate and regulate neoplastic transformation in a variety of cell types. Whereas Notch enhances tumorigenesis, E2A suppresses it....
Bellavia, Diana, Campese, Antonio F., Checquolo, Saula, Balestri, Anna, Biondi, Andrea, Cazzaniga, Giovanni, ...
Notch receptors are conserved regulators of cell fate and have been implicated in the regulation of T cell differentiation and lymphomagenesis. However, neither the generality of Notch involvement in...
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, ...
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4–8– thymocytes and is down-regulated across the...
RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
Di Marcotullio, Lucia, Ferretti, Elisabetta, De Smaele, Enrico, Argenti, Beatrice, Mincione, Claudia, Zazzeroni, Francesca, ...
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also...
Human MRE11 is inactivated in mismatch repair-deficient cancers
Giannini, Giuseppe, Ristori, Elisabetta, Cerignoli, Fabio, Rinaldi, Christian, Zani, Massimo, Viel, Alessandra, ...
Mutations of the ATM and NBS1 genes are responsible for the inherited Ataxia-Telangiectasia and Nijmegen Breakage Syndrome, both of which are associated with a predisposition to cancer. A related...
Talora, Claudio, Campese, Antonio F., Bellavia, Diana, Pascucci, Monica, Checquolo, Saula, Groppioni, Manuela, ...
Notch and basic helix–loop–helix E2A pathways specify cell fate and regulate neoplastic transformation in a variety of cell types. Whereas Notch enhances tumorigenesis, E2A suppresses it....
Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia
Vacca, Alessandra, Felli, Maria Pia, Palermo, Rocco, Di Mario, Giuseppina, Calce, Angelica, Di Giovine, Monica, ...
Notch signaling plays a critical role in T-cell differentiation and leukemogenesis. We previously demonstrated that, while pre-TCR is required for thymocytes proliferation and leukemogenesis, it is...
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
Campese, Antonio F., Garbe, Annette I., Zhang, Fangrong, Grassi, Fabio, Screpanti, Isabella, Von Boehmer, Harald
Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required...
De Smaele, Enrico, Fragomeli, Caterina, Ferretti, Elisabetta, Pelloni, Marianna, Po, Agnese, Canettieri, Gianluca, ...
Medulloblastoma (MB) is the most common malignant brain tumor of childhood arising from deregulated cerebellar development. Sonic Hedgehog (Shh) pathway plays a critical role in cerebellar...
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival
Mandal, Malay, Borowski, Christine, Palomero, Teresa, Ferrando, Adolfo A., Oberdoerffer, Philipp, Meng, Fanyong, ...
The pre–T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR–expressing cells are selected to survive...
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing
Bellavia, Diana, Mecarozzi, Marco, Campese, Antonio F, Grazioli, Paola, Talora, Claudio, Frati, Luigi, ...
Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and...
Ren: a novel, developmentally regulated gene that promotes neural cell differentiation
Gallo, Rita, Zazzeroni, Francesca, Alesse, Edoardo, Mincione, Claudia, Borello, Ugo, Buanne, Pasquale, ...
Expansion and fate choice of pluripotent stem cells along the neuroectodermal lineage is regulated by a number of signals, including EGF, retinoic acid, and NGF, which also control the proliferation...
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis1
Mellone, Massimiliano, Rinaldi, Christian, Massimi, Isabella, Petroni, Marialaura, Veschi, Veronica, Talora, Claudio, ...
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in...
The coactivator CRTC1 promotes cell proliferation and transformation via AP-1
Canettieri, Gianluca, Coni, Sonia, Della Guardia, Michele, Nocerino, Valentina, Antonucci, Laura, Di Magno, Laura, ...
Regulation of gene expression in response to mitogenic stimuli is a critical aspect underlying many forms of human cancers. The AP-1 complex mediates the transcriptional response to mitogens, and its...
Giannini, Elisa, Lattanzi, Roberta, Nicotra, Annalisa, Campese, Antonio F., Grazioli, Paola, Screpanti, Isabella, ...
Neutrophil migration into injured tissues is invariably accompanied by pain. Bv8/prokineticin 2 (PK2), a chemokine characterized by a unique structural motif comprising five disulfide bonds, is...
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
Ferretti, Elisabetta, De Smaele, Enrico, Miele, Evelina, Laneve, Pietro, Po, Agnese, Pelloni, Marianna, ...
MicroRNAs (miRNA) are crucial post-transcriptional regulators of gene expression and control cell differentiation and proliferation. However, little is known about their targeting of specific...