Isabelle Lebars

Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance. (2008)

Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo

In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...

Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance. (2008)

Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo

In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...

Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance. (2008)

Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo

In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...

NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer (2007)

Lebars, Isabelle, Richard, Tristan, Di Primo, Carmelo, Toulmé, Jean-Jacques

The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates...

Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing

Lebars, Isabelle, Lamontagne, Bruno, Yoshizawa, Satoko, Abou Elela, Sherif, Fourmy, Dominique

Rnt1p, the yeast orthologue of RNase III, cleaves rRNAs, snRNAs and snoRNAs at a stem capped with conserved AGNN tetraloop. Here we show that 9 bp long stems ending with AGAA or AGUC tetraloops bind...

Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII

Lebars, Isabelle, Yoshizawa, Satoko, Stenholm, Anne R., Guittet, Eric, Douthwaite, Stephen, Fourmy, Dominique

The bacterial rRNA methyltransferase RlmAII (formerly TlrB) contributes to resistance against tylosin-like 16-membered ring macrolide antibiotics. RlmAII was originally discovered in the...

Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing

Lebars, Isabelle, Lamontagne, Bruno, Yoshizawa, Satoko, Abou Elela, Sherif, Fourmy, Dominique

Rnt1p, the yeast orthologue of RNase III, cleaves rRNAs, snRNAs and snoRNAs at a stem capped with conserved AGNN tetraloop. Here we show that 9 bp long stems ending with AGAA or AGUC tetraloops bind...

Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII

Lebars, Isabelle, Yoshizawa, Satoko, Stenholm, Anne R., Guittet, Eric, Douthwaite, Stephen, Fourmy, Dominique

The bacterial rRNA methyltransferase RlmAII (formerly TlrB) contributes to resistance against tylosin-like 16-membered ring macrolide antibiotics. RlmAII was originally discovered in the...

NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer

Lebars, Isabelle, Richard, Tristan, Di Primo, Carmelo, Toulmé, Jean-Jacques

The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates...

Exploring TAR–RNA aptamer loop–loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance

Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo

In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5′ untranslated end of all...