Isao Miyoshi

Studies on Leukemia in the C3Hf Strain of Mice I. Ori­gin, Transmission and Morphology of Spontaneous Lymphatic Leukemia (2007)

Miyoshi, Isao

The ongm and characteristics in transmission and morphology of spontaneous lymphatic leukemia in a low-leukemic strain C3Hf have been described. The leukemia line is being currently subjected to a...

A study on the isolation of leukemia virus of AKR mouse by fluorocarbon (2007)

Okada, Koichi, Miyoshi, Isao

The authors have succeeded in isolating a biologically-active leukemia virus from leukemic tissues of AKR mice with a fluorocarbon. From the chemical analysis of the biologically-active virus...

Brachet Test (Urine Hydrolysis Test) as an Aid to Differentiation of Leukemic Cells (2007)

Miyoshi, Isao, Sanada, Hiroshi

Our experience with Brachet test on twenty-four leukemic patients has shown a high degree of reliability of the test for differentiating acute leukemias. A standard method has been described which is...

Sheehan's syndrome (postpartum hypopituitarism), report of a case (2007)

Miyoshi, Isao, Kibata, Masayoshi

A case of postpartum necrosis of the anterior lobe of the pituitary, known as Sheehan's syndrome, is presented. The patient has done well on a combined replacement therapy with cortisone and thyroid....

Acceleration of the development of leukemia and induc­tion of tumors in AKR mice by neo-natal injection of 20-methy-Icholanthrene (2007)

Miyoshi, Isao

A single subcutaneous injection of 20-methylcholanthrene into newborn AKR mice less than 24 hours old resulted in the acceleration of the development of lymphocytic leukemia, and induction of...

Studies on leukemia in the CsHf strain of mice II. hete-rologous transplantation of mouse leukemia into newborn wistar rats (2007)

Miyoshi, Isao

Spontaneous C3Hf lymphatic leukemia maintained in an ascites form was transplanted into newborn Wistar rats less than 24 hours old. Single subcutaneous or intraperitoneal inoculation of the...

Tissue culture of spleen : Studies on the growing pattern and its evaluation for clinical diagnosis of leukemias and other hematologic disorders (2007)

Hiraki, Kiyoshi, Ofuji, Tadashi, Sunami, Hiroshi, Ota, Zensuke, Kitajima, Koichi, Shinagawa, Koji, ...

It has been found that the clinical tissue culture method devised in our laboratory for bone marrow is satisfactorily applicable to the in vitro study of human and animal splenic tissues. The present...

Absence of C-type virus production in human leukemic B cell, T cell and null cell lines. (2007)

Ogura, Hajime, Hiraki, Shunkichi, Omura, Sachiko, Miyoshi, Isao, Oda, Takuzo

Electron microscope observation of cultured human leukemic B cell, T cell and null cell lines and reverse transcriptase assay of the culture supernatants were all negative for the presence of C-type...

8-14 translocation in a Japanese Burkitt's lymphoma. (2007)

Miyamoto, Kanji, Sato, Jiro, Miyoshi, Isao, Nishihara, Ryuji, Terao, Seiya, Hara, Masamichi, ...

Chromosome analysis was performed on cells obtained from the pleural effusion of a Japanese patient with Burkitt's lymphoma. Two modal chromosomal numbers were found: 45 and 46. Five different...

Chromosome 14q+ in a Japanese patient with Burkitt's lymphoma. (2007)

Miyamoto, Kanji, Miyano, Keiko, Miyoshi, Isao, Hamasaki, Kazuhide, Nishihara, Ryuji, Terao, Seiya, ...

Cytogenetic studies were performed on a biopsy specimen of a jaw tumor and on a bone marrow aspirate from a Japanese patient with Epstein-Barr virus-negative Burkitt's lymphoma. A 14q + chromosome...

Heterotransplantation of human leukemic B-cell, T-cell and null-cell lines in hamsters. (2007)

Hiraki, Shunkichi, Miyoshi, Isao, Nakamura, Kazuo, Ohta, Takamasa, Tsubota, Teruhiko, Uno, Junzaburo, ...

Human leukemic B-cell (BALL-1), T-cell (TALL-1) and null-cell (NALL-1) lines have been established from three patients with acute lymphoblastic leukemia (ALL). To study the heterotransplantability...

Characterization of xenoantiserum produced against B cell acute lymphoblastic leukemia cell line (2007)

Akagi, Tadaatsu, Sonobe, Hiroshi, Miyoshi, Isao, Yoshimoto, Shizuo

Antiserum was produced in white rabbit by intravenously injecting living cells of a B cell acute lymphoblastic leukemia (ALL) line (BALL-1). The reactivity of the antiserum against various lymphoid...

Cryptococcal pleural effusion in an HTLV-I carrier with Waldenstroem's macroglobulinemia. (2007)

Taguchi, Hirokuni, Kotani, Shigemitsu, Sugito, Sawa, Kobayashi, Makoto, Kubonishi, Ichiro, Miyoshi, Isao

A 70-year-old woman with Waldenstroem's macroglobulinemia developed bilateral pleural effusions due to Cryptococcus neoformans. She was found to be a carrier of HTLV-I. It is speculated that the...

Immune suppression in HTLV-I carriers: a predictive sign of adult T-cell leukemia. (2007)

Taguchi, Hirokuni, Miyoshi, Isao

Suppression of the cellular immune system appears to be a prerequisite for the manifestation of adult T-cell leukemia (ATL). In other words, ATL will develop when impairment of the immune system is...

Transformation of human fetal thymus and spleen lymphocytes by human t-cell leukemia virus type Ι (2007)

Akagi, Tadaatsu, Ohtsuki, Yuji, Shiraishi, Yukimasa, Miyoshi, Isao

Co-cultivation of human thymus and spleen lymphocytes, which were obtained from 26-week and 27-week fetuses, with a lethally-irradiated human cord T-cell line harboring human T-cell leukemia virus...

Detection of HLA-D-region-associated antigens on the surface of adult T-cell leukemia virus particles by immunoelectron microscopy. (2007)

Ohtsuki, Yuji, Akagi, Tadaatsu, Takeda, Isao, Miyoshi, Isao

To search for lymphocyte marker antigens on the surface of human T-cell leukemia virus (HTLV), an immunoelectron microscopic study was performed on a HTLV-producing human T-cell line, MT-2, using...

Trichosporon beigelii Pneumonia in a Patient with Malignant Histiocytosis (1986)

KOBAYASHI, MAKOTO, MATSUOKA, TOMOKO, TAGUCHI, HIROKUNI, MORIKI, TOSHIAKI, ENZAN, HIDEAKI, HARA, HIROSHI, ...

A 30-year-old previously healthy housewife presented with bilateral pulmonary infiltrates. She was treated with various antibiotics but died with disseminated intravascular coagulation. Cultures of...

Japanese Burkitt's Lymphoma: Clinicopathological Review of 14 Cases (1983)

MIYOSHI, ISAO

The clinicopathological features of 14 Japanese patients with Burkitt's lymphoma (seven studied by us and seven reported by others) are reviewed. Five patients were 12 years of age or younger. Six...

Induction of Lytic Epstein-Barr Virus (EBV) Infection by Synergistic Action of Rituximab and Dexamethasone Renders EBV-Positive Lymphoma Cells More Susceptible to Ganciclovir Cytotoxicity In Vitro and In Vivo

Daibata, Masanori, Bandobashi, Kentaro, Kuroda, Masayuki, Imai, Shosuke, Miyoshi, Isao, Taguchi, Hirokuni

The purposeful induction of the lytic form of Epstein-Barr virus (EBV) infection combined with ganciclovir (GCV) treatment has been advocated as a novel strategy for EBV-positive B-cell lymphoma. We...

Induction of Lytic Epstein-Barr Virus (EBV) Infection by Synergistic Action of Rituximab and Dexamethasone Renders EBV-Positive Lymphoma Cells More Susceptible to Ganciclovir Cytotoxicity In Vitro and In Vivo

Daibata, Masanori, Bandobashi, Kentaro, Kuroda, Masayuki, Imai, Shosuke, Miyoshi, Isao, Taguchi, Hirokuni

The purposeful induction of the lytic form of Epstein-Barr virus (EBV) infection combined with ganciclovir (GCV) treatment has been advocated as a novel strategy for EBV-positive B-cell lymphoma. We...

BRD4 Bromodomain Gene Rearrangement in Aggressive Carcinoma with Translocation t(15;19)

French, Christopher A., Miyoshi, Isao, Aster, Jon C., Kubonishi, Ichiro, Kroll, Todd G., Dal Cin, Paola, ...

Translocation t(15;19)(q13;p13.1) defines a lethal midline carcinoma arising adjacent to respiratory tract in young people. To characterize molecular alterations responsible for the distinctly...

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

Gu, Ting-lei, Mercher, Thomas, Tyner, Jeffrey W., Goss, Valerie L., Walters, Denise K., Cornejo, Melanie G., ...

Activated tyrosine kinases have been frequently implicated in the pathogenesis of cancer, including acute myeloid leukemia (AML), and are validated targets for therapeutic intervention with...