Resolving the fast kinetics of cooperative binding: Ca²⁺ buffering by calretinin (2008)
Faas, Guido C., Schwaller, Beat, Vergara, Julio L., Mody, Istvan
Cooperativity is one of the most important properties of molecular interactions in biological systems. It is the ability to influence ligand binding at one site of a macromolecule by previous ligand...
Resolving the fast kinetics of cooperative binding: Ca²⁺ buffering by calretinin (2008)
Faas, Guido C., Schwaller, Beat, Vergara, Julio L., Mody, Istvan
Cooperativity is one of the most important properties of molecular interactions in biological systems. It is the ability to influence ligand binding at one site of a macromolecule by previous ligand...
Resolving the Fast Kinetics of Cooperative Binding: Ca2+ Buffering by Calretinin (2007)
Guido C. Faas, Beat Schwaller, Julio L. Vergara, Istvan Mody
Cooperativity is one of the most important properties of molecular interactions in biological systems. It is the ability to influence ligand binding at one site of a macromolecule by previous ligand...
Klaasen, Alwin, Glykys, Joseph, Maguire, Jamie, Labarca, Cesar, Mody, Istvan, Boulter, Jim
Selected mutations in the human α4 or β2 neuronal nicotinic acetylcholine receptor subunit genes cosegregate with a partial epilepsy syndrome known as autosomal dominant nocturnal frontal lobe...
A TinyOS-enabled MICA2-based wireless neural interface (2006)
Farshchi, Shahin, Nuyujukian, Paul H, Pesterev, Aleksey, Mody, Istvan, Judy, Jack W
Existing approaches used to develop compact low-power multichannel wireless neural recording systems range from creating custom-integrated circuits to assembling commercial-off-the-shelf (COTS)...
Gu, Xiaofeng, Li, Chenjian, Wei, Weizheng, Lo, Victor, Gong, Shiaoching, Li, Shi-Hua, ...
Expanded polyglutamine (polyQ) proteins in Huntington's disease (HD) as well as other polyQ disorders are known to elicit a variety of intracellular toxicities, but it remains unclear whether polyQ...
Gamma-hydroxybutyrate (GHB) is a drug of abuse which induces sedation and euphoria. However, overdoses can severely depress the level of consciousness or can be fatal especially when combined with...
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus
Sík, Attila, Hájos, Norbert, Gulácsi, Alexandra, Mody, Istvan, Freund, Tamás F.
The Ca2+/calmodulin-dependent protein phosphatase 2B or calcineurin (CN) participates in several Ca2+-dependent signal transduction cascades and, thus, contributes to the short and long term...
The GAD-given Right of Dentate Gyrus Granule Cells to Become GABAergic
Janus, the ancient Roman God of Gates and Doors had two faces: one looked into the past, and the other, into the future. Do neurons possess a Janus face when it comes to neurotransmitters, or a given...
Kinetic Properties of DM-Nitrophen Binding to Calcium and Magnesium
Faas, Guido C., Karacs, Kinga, Vergara, Julio L., Mody, Istvan
Caged-Ca2+ compounds such as nitrophenyl-EGTA (NP-EGTA) and DM-nitrophen (DMn) are extremely useful in biological research, but their use in live cells is hampered by cytoplasmic [Mg2+]. We...
Aspects of the homeostaic plasticity of GABAA receptor-mediated inhibition
Plasticity of ligand-gated ion channels plays a critical role in nervous system development, circuit formation and refinement, and pathological processes. Recent advances have mainly focused on the...
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus
Sík, Attila, Hájos, Norbert, Gulácsi, Alexandra, Mody, Istvan, Freund, Tamás F.
The Ca2+/calmodulin-dependent protein phosphatase 2B or calcineurin (CN) participates in several Ca2+-dependent signal transduction cascades and, thus, contributes to the short and long term...
The GAD-given Right of Dentate Gyrus Granule Cells to Become GABAergic
Janus, the ancient Roman God of Gates and Doors had two faces: one looked into the past, and the other, into the future. Do neurons possess a Janus face when it comes to neurotransmitters, or a given...
Kinetic Properties of DM-Nitrophen Binding to Calcium and Magnesium
Faas, Guido C., Karacs, Kinga, Vergara, Julio L., Mody, Istvan
Caged-Ca2+ compounds such as nitrophenyl-EGTA (NP-EGTA) and DM-nitrophen (DMn) are extremely useful in biological research, but their use in live cells is hampered by cytoplasmic [Mg2+]. We...
Aspects of the homeostaic plasticity of GABAA receptor-mediated inhibition
Plasticity of ligand-gated ion channels plays a critical role in nervous system development, circuit formation and refinement, and pathological processes. Recent advances have mainly focused on the...
Klaassen, Alwin, Glykys, Joseph, Maguire, Jamie, Labarca, Cesar, Mody, Istvan, Boulter, Jim
Selected mutations in the human α4 or β2 neuronal nicotinic acetylcholine receptor subunit genes cosegregate with a partial epilepsy syndrome known as autosomal dominant nocturnal frontal lobe...
Andrásfalvy, Bertalan K, Mody, Istvan
Anatomical studies have described inhibitory synaptic contacts on apical dendrites, and an abundant number of GABAergic synapses on the somata and proximal dendrites of CA1 pyramidal cells of the...
Resolving the Fast Kinetics of Cooperative Binding: Ca2+ Buffering by Calretinin
Faas, Guido C, Schwaller, Beat, Vergara, Julio L, Mody, Istvan
Cooperativity is one of the most important properties of molecular interactions in biological systems. It is the ability to influence ligand binding at one site of a macromolecule by previous ligand...
Nägerl, U Valentin, Mody, Istvan
Dentate gyrus granule cells acutely dissociated from hippocampal slices obtained from chronic temporal lobe epilepsy (TLE) patients displayed a high-voltage activated (HVA) Ca2+ conductance with a...
Williams, Stephen R, Buhl, Eberhard H, Mody, Istvan
The properties of GABAA receptor-mediated spontaneous IPSCs generated in hippocampal dentate granule neurones were analysed using whole-cell voltage-clamp techniques in order to explore the...
Properties of single NMDA receptor channels in human dentate gyrus granule cells
Lieberman, David N, Mody, Istvan
Cell-attached single-channel recordings of NMDA channels were carried out in human dentate gyrus granule cells acutely dissociated from slices prepared from hippocampi surgically removed for the...
Nusser, Zoltan, Sieghart, Werner, Mody, Istvan
It has been demonstrated that the regulation of recombinant GABAA receptors by phosphorylation depends on the subunit composition. Here we studied the regulation of synaptic GABAA receptor function...
“One Swallow Does Not Make a Summer” … or Does It?
A Single Episode of Neonatal Seizures Permanently Alters Glutamatergic SynapsesCornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA.Ann Neurol2007615:411–42617323345OBJECTIVE: The contribution...
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus
The extracellular space of the brain contains γ-aminobutyric acid (GABA) that activates extrasynaptic GABAA receptors mediating tonic inhibition. The source of this GABA is uncertain: it could be...
Silencing-Induced Metaplasticity in Hippocampal Cultured Neurons
Sokolova, Irina V., Mody, Istvan
Silencing-induced homeostatic plasticity is usually expressed as a change in the amplitude or the frequency of miniature postsynaptic currents. Here we report that, prolonged (∼24 h) silencing of...
Our insights into the basic characteristics of neuronal function were significantly advanced by combining the in vitro slice technique with the visualization of neurons and their processes. The...