Jérôme N. Feige

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. (2009)

Heikkinen, Sami, Argmann, Carmen, Feige, Jérôme N, Koutnikova, Hana, Champy, Marie-France, Dali-Youcef, Nassim, ...

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a...

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008)

Feige, Jérôme N, Lagouge, Marie, Canto, Carles, Strehle, Axelle, Houten, Sander M, Milne, Jill C, ...

The NAD(+)-dependent deacetylase SIRT1 controls metabolic processes in response to low nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a specific and potent...

Transcriptional coregulators in the control of energy homeostasis. (2007)

Feige, Jérôme N, Auwerx, Johan

Metabolic programs controlling energy homeostasis are governed at the transcriptional level by the integrated action of several transcription factors. Among these, nuclear receptors including...