Anti-Melanocyte T Cell Responses – Methodology Versus Biology (9999)
Per Thor Straten, Per Guldberg, Ulrik Moerch, Jürgen C Becker
Uta B Hofmann, Johan R Westphal, Erwin T Waas, Jürgen C Becker, Dirk J Ruiter, Goos N P Van Muijen
Reinhard Dummer, Gerhard Posseckert, Frank Nestle, Ralph Witzgall, Mathias Burger, Jürgen C Becker, ...
Lack of Correlation between IGFBP7 Expression and BRAF Mutational Status in Melanoma (2009)
David Schrama, Hermann Kneitz, Christoph Willmes, Christian Adam, Roland Houben, Jürgen C Becker
Response to Imatinib Mesylate Depends on the Presence of the V559A-Mutated KIT Oncogene (2009)
Patrick Terheyden, Roland Houben, Parisa Pajouh, Christoph Thorns, Detlef Zillikens, Jürgen C Becker
Proliferation Arrest in B-Raf Mutant Melanoma Cell Lines upon MAPK Pathway Activation (2008)
Roland Houben, Sonja Ortmann, Astrid Drasche, Jakob Troppmair, Marco J Herold, Jürgen C Becker
MC Polyomavirus Is Frequently Present in Merkel Cell Carcinoma of European Patients (2008)
Jürgen C Becker, Roland Houben, Selma Ugurel, Uwe Trefzer, Claudia Pföhler, David Schrama
BRAFV600Emutations in malignant melanoma are associated with increased expressions of BAALC (2008)
Schrama, David, Keller, Gunhild, Houben, Roland, Ziegler, Christian G, Vetter-Kauczok, Claudia S, Ugurel, Selma, ...
Abstract Bachground Activating BRAF mutations are present in approximately 50% of melanomas. Although different downstream target genes of the most common mutant V600E have been identified, the...
Transport of Streptococcus pneumoniae Capsular Polysaccharide in MHC Class II Tubules (2007)
Tom Li Stephen, Mario Fabri, Laura Groneck, Till A. Röhn, Helena Hafke, Nirmal Robinson, ...
Bacterial capsular polysaccharides are virulence factors and are considered T cell–independent antigens. However, the capsular polysaccharide Sp1 from Streptococcus pneumoniae serotype 1 has been...
HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer (2006)
Andersen, Mads, Soerensen, Rikke B, Becker, Jürgen C, Thor Straten, Per
Abstract Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an...
HLA-B8 association with late-stage melanoma – an immunological lesson? (2006)
Fensterle, Joachim, Trefzer, Uwe, Berger, Thomas, Andersen, Mads, Ugurel, Selma, Becker, Jürgen C
Abstract Background Differences in HLA allele frequencies between the diseased and healthy populations may signify efficient immune responses, a notion that has been successfully tested for...
Becker, Jürgen C, Houben, Roland, Vetter, Claudia S, Bröcker, Eva B
Abstract Background Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA) as a promising treatment for atopic dermatitis, it has been approved in more than 30...
Houben, Roland, Becker, Jürgen C, Rapp, Ulf R
Abstract Background Activation of Ras or Raf contributes to tumorigenesis of melanoma. However, constitutive Raf activation is also a characteristic of the majority of benign melanocytic nevi and...
B-Raf specific antibody responses in melanoma patients (2004)
Fensterle, Joachim, Becker, Jürgen C, Potapenko, Tamara, Heimbach, Veronika, Vetter, Claudia S, Bröcker, Eva B, ...
Abstract Background Mutations of the BRAF gene are the most common genetic alteration in melanoma. Moreover, BRAF mutations are already present in benign nevi. Being overexpressed and mutated, B-Raf...
T-cell clonotypes in cancer (2004)
Thor Straten, Per, Schrama, David, Andersen, Mads, Becker, Jürgen C
Abstract Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our...
Houben, Roland, Becker, Jürgen C, Kappel, Andreas, Terheyden, Patrick, Bröcker, Eva-B, Goetz, Rudolf, ...
Abstract Background Genes of the Raf family encode kinases that are regulated by Ras and mediate cellular responses to growth signals. Recently, it was shown that activating mutations of BRaf are...
Andreas G. Niethammer, Rong Xiang, Jürgen C. Becker, Harald Wodrich, Ursula Pertl, Gabriele Karsten, ...
Maintenance of clonal anergy by endogenously produced IL-10 (1994)
Becker, Jürgen C., Czerny, Christian, Bröcker, Eva-Bettina
Inadequate co-stimulation of tumor reactive T cells may contribute to the fact that antigenlc tumors are not normally rejected by the immune system. We recently reported that the induction of...
Dummer, Reinhard, Nestle, Frank, Wiede, Johannes, Schäfer, Erwin, Röger, Jürgen, Becker, Jürgen C., ...
In 24 patients with cutaneous T-cell lymphomas (CTCL) the clinical course was documented by determination of a tumour burden index (TBI) on entering the study and six months later. In addition to the...
Activation of preexisting T cell clones by targeted interleukin 2 therapy
Thor Straten, Per, Guldberg, Per, Seremet, Tina, Reisfeld, Ralph A., Zeuthen, Jesper, Becker, Jürgen C.
The induction of an immunological antitumor response capable of eradicating metastatic tumors is the ultimate goal of immunotherapy. We have recently shown that this can be achieved by interleukin 2...
Thor Straten, Per, Schrama, David, Andersen, Mads Hald, Becker, Jürgen C
Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our...
Houben, Roland, Becker, Jürgen C, Kappel, Andreas, Terheyden, Patrick, Bröcker, Eva-B, Goetz, Rudolf, ...
Zhou, He, Luo, Yunping, Mizutani, Masato, Mizutani, Noriko, Becker, Jürgen C., Primus, F. James, ...
A lack of relevant animal models has hampered preclinical screening and critical evaluation of the efficacy of human vaccines in vivo. Carcinoembryonic antigen–A2Kb (CEA–A2Kb) double transgenic...
B-Raf specific antibody responses in melanoma patients
Fensterle, Joachim, Becker, Jürgen C, Potapenko, Tamara, Heimbach, Veronika, Vetter, Claudia S, Bröcker, Eva B, ...
DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor
Zhou, He, Luo, Yunping, Lo, Jeng-fan, Kaplan, Charles D., Mizutani, Masato, Mizutani, Noriko, ...
The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8+ T cells, and its ligands mediates stimulatory and costimulatory signals to these cells....
HLA-B8 association with late-stage melanoma – an immunological lesson?
Fensterle, Joachim, Trefzer, Uwe, Berger, Thomas, Andersen, Mads Hald, Ugurel, Selma, Becker, Jürgen C
HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer
Andersen, Mads Hald, Soerensen, Rikke B, Becker, Jürgen C, Thor Straten, Per
Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an HLA-A24...
Activation of preexisting T cell clones by targeted interleukin 2 therapy
Thor Straten, Per, Guldberg, Per, Seremet, Tina, Reisfeld, Ralph A., Zeuthen, Jesper, Becker, Jürgen C.
The induction of an immunological antitumor response capable of eradicating metastatic tumors is the ultimate goal of immunotherapy. We have recently shown that this can be achieved by interleukin 2...
Thor Straten, Per, Schrama, David, Andersen, Mads Hald, Becker, Jürgen C
Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our...
Houben, Roland, Becker, Jürgen C, Kappel, Andreas, Terheyden, Patrick, Bröcker, Eva-B, Goetz, Rudolf, ...
Zhou, He, Luo, Yunping, Mizutani, Masato, Mizutani, Noriko, Becker, Jürgen C., Primus, F. James, ...
A lack of relevant animal models has hampered preclinical screening and critical evaluation of the efficacy of human vaccines in vivo. Carcinoembryonic antigen–A2Kb (CEA–A2Kb) double transgenic...
B-Raf specific antibody responses in melanoma patients
Fensterle, Joachim, Becker, Jürgen C, Potapenko, Tamara, Heimbach, Veronika, Vetter, Claudia S, Bröcker, Eva B, ...
DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor
Zhou, He, Luo, Yunping, Lo, Jeng-fan, Kaplan, Charles D., Mizutani, Masato, Mizutani, Noriko, ...
The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8+ T cells, and its ligands mediates stimulatory and costimulatory signals to these cells....
HLA-B8 association with late-stage melanoma – an immunological lesson?
Fensterle, Joachim, Trefzer, Uwe, Berger, Thomas, Andersen, Mads Hald, Ugurel, Selma, Becker, Jürgen C
HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer
Andersen, Mads Hald, Soerensen, Rikke B, Becker, Jürgen C, Thor Straten, Per
Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an HLA-A24...
Ugurel, Selma, Thirumaran, Ranjit K., Bloethner, Sandra, Gast, Andreas, Sucker, Antje, Mueller-Berghaus, Jan, ...
In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulates tumor cell proliferation and survival. A varying mutation rate has been reported for B-RAF and...
Transport of Streptococcus pneumoniae Capsular Polysaccharide in MHC Class II Tubules
Stephen, Tom Li, Fabri, Mario, Groneck, Laura, Röhn, Till A, Hafke, Helena, Robinson, Nirmal, ...
Bacterial capsular polysaccharides are virulence factors and are considered T cell–independent antigens. However, the capsular polysaccharide Sp1 from Streptococcus pneumoniae serotype 1 has been...
Vetter-Kauczok, Claudia S, Ströbel, Philipp, Bröcker, Eva B, Becker, Jürgen C
Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor which usually occurs in infants. Clinically it appears as ill-defined red to purple indurated plaque. KHE is commonly...
BRAFV600E mutations in malignant melanoma are associated with increased expressions of BAALC
Schrama, David, Keller, Gunhild, Houben, Roland, Ziegler, Christian G, Vetter-Kauczok, Claudia S, Ugurel, Selma, ...
Cancer treatment: the combination of vaccination with other therapies
Andersen, Mads Hald, Sørensen, Rikke Bæk, Schrama, David, Svane, Inge Marie, Becker, Jürgen C., Thor Straten, Per
Harnessing of the immune system by the development of ‘therapeutic’ vaccines, for the battle against cancer has been the focus of tremendous research efforts over the past two decades. As an...
Identification of heme oxygenase-1–specific regulatory CD8+ T cells in cancer patients
Andersen, Mads Hald, Sørensen, Rikke Bæk, Brimnes, Marie K., Svane, Inge Marie, Becker, Jürgen C., Thor Straten, Per
Treg deficiencies are associated with autoimmunity. Conversely, CD4+ and CD8+ Tregs accumulate in the tumor microenvironment and are associated with prevention of antitumor immunity and anticancer...
The Immune System Strikes Back: Cellular Immune Responses against Indoleamine 2,3-dioxygenase
Sørensen, Rikke Bæk, Berge-Hansen, Linda, Junker, Niels, Hansen, Christina Aaen, Hadrup, Sine Reker, Schumacher, Ton N. M., ...
Quantitation of Human Seroresponsiveness to Merkel Cell Polyomavirus
Pastrana, Diana V., Tolstov, Yanis L., Becker, Jürgen C., Moore, Patrick S., Chang, Yuan, Buck, Christopher B.
Merkel cell carcinoma (MCC) is a relatively uncommon but highly lethal form of skin cancer. A majority of MCC tumors carry DNA sequences derived from a newly identified virus called Merkel cell...