Perlecan is critical for heart stability (2008)
Sasse, Philipp, Malan, Daniela, Fleischmann, Michaela, Roell, Wilhelm, Gustafsson, Erika, Bostani, Toktam, ...
Aims Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function...
Leist, Marcel, Bremer, Susanne, Brundin, Patrik, Hescheler, Jürgen, Kirkeby, Agnete, Krause, Karl-Heinz, ...
Human embryonic stem cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In an ongoing ethical debate...
Doss, Michael, Chen, Shuhua, Winkler, Johannes, Hippler-Altenburg, Rita, Odenthal, Margareta, Wickenhauser, Claudia, ...
Abstract Background Bone morphogenetic protein (BMP)2 is a late mesodermal marker expressed during vertebrate development and plays a crucial role in early embryonic development. The nature of the...
Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes (2007)
Doss, Michael, Winkler, Johannes, Chen, Shuhua, Hippler-Altenburg, Rita, Sotiriadou, Isaia, Halbach, Marcel, ...
Abstract Background Characterization of gene expression signatures for cardiomyocytes derived from embryonic stem cells will help to define their early biologic processes. Results A transgenic...
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart (2007)
Reppel, Michael, Fleischmann, Bernd K., Reuter, Hannes, Sasse, Philipp, Schunkert, Heribert, Hescheler, Jürgen
Objective The Na+/Ca2+ exchanger (NCX) is involved in embryonic heart development and function demonstrated by the abnormal myofibrillar organization, defects in heartbeat, and early...
Küstermann, Ekkehard, Roell, W., Breitbach, M., Wecker, Stefan, Wiedermann, Dirk, Buehrle, Christian, ...
Nygren, Jens M, Jovinge, Stefan, Breitbach, Martin, Säwén, Petter, Röll, Wilhelm, Hescheler, Jürgen, ...
Abstract is not available
Wartenberg, Maria, Wolf, Sandra, Budde, Paula, Grünheck, Frank, Acker, Helmut, Hescheler, Jürgen, ...
Wartenberg, Maria, Ling, Frederike C., Müschen, Markus, Klein, Florian, Acker, Helmut, Gassmann, Max, ...
Cardiac specific differentiation of mouse embryonic stem cells (2003)
Sachinidis, Agapios, Fleischmann, Bernd K., Kolossov, Eugen, Wartenberg, Maria, Sauer, Heinrich, Hescheler, Jürgen
Embryonic stem (ES) cells may represent an alternative source of functionally intact cardiomyocytes for the causal treatment of cardiovascular diseases. However, this requires cardiac-specific...
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
Hopf,Carsten, Zuschratter,Werner, Jin,Shan, Guan,Kaomei, Pich,Uta, Rohwedel,Jürgen, ...
To analyze the formation of neuromuscular junctions, mouse pluripotent embryonic stem (ES) cells were differentiated via embryoid bodies into skeletal muscle and neuronal cells. The developmentally...
Hopf, Carsten, Zuschratter, Werner, Jin, Shan, Guan, Kaomei, Pich, Uta, Rohwedel, Jürgen, ...
To analyze the formation of neuromuscular junctions, mouse pluripotent embryonic stem (ES) cells were differentiated via embryoid bodies into skeletal muscle and neuronal cells. The developmentally...
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
Hoehn, Mathias, Küstermann, Ekkehard, Blunk, James, Wiedermann, Dirk, Trapp, Thorsten, Wecker, Stefan, ...
In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their regeneration potential. Migration of...
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
Hoehn, Mathias, Küstermann, Ekkehard, Blunk, James, Wiedermann, Dirk, Trapp, Thorsten, Wecker, Stefan, ...
In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their regeneration potential. Migration of...
Thalidomide Inhibits Angiogenesis in Embryoid Bodies by the Generation of Hydroxyl Radicals
Sauer, Heinrich, Günther, Julia, Hescheler, Jürgen, Wartenberg, Maria
Thalidomide is a teratogen with anti-angiogenic properties and causes stunted limb growth (dysmelia) during human embryogenesis. The molecular mechanisms of thalidomide action in embryopathy are...
Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes
Doss, Michael Xavier, Winkler, Johannes, Chen, Shuhua, Hippler-Altenburg, Rita, Sotiriadou, Isaia, Halbach, Marcel, ...
Microarray analysis reveals that the specific pattern of gene expression in cardiomyocytes derived from embryonic stem cells reflects the biological, physiological and functional processes occurring...
Local response of L-type Ca2+ current to nitric oxide in frog ventricular myocytes
Dittrich, Michael, Jurevičius, Jonas, Georget, Marie, Rochais, Francesca, Fleischmann, Bernd Kurt, Hescheler, Jürgen, ...
The regulation of L-type Ca2+ current (ICa) by the two nitric oxide (NO) donors sodium nitroprusside (SNP, 1 μm to 1 mm) and (±)-S-nitroso-N-acetylpenicillamine (SNAP, 3 or 10 μm) was investigated...
Silencing of B Cell Receptor Signals in Human Naive B Cells
Feldhahn, Niklas, Schwering, Ines, Lee, Sanggyu, Wartenberg, Maria, Klein, Florian, Wang, Hui, ...
To identify changes in the regulation of B cell receptor (BCR) signals during the development of human B cells, we generated genome-wide gene expression profiles using the serial analysis of gene...
Bloch, Wilhelm, Fan, Yun, Han, Ji, Xue, Sheng, Schöneberg, Torsten, Ji, Guanju, ...
β1 integrins play a crucial role as cytoskeletal anchorage proteins. In this study, the coupling of the cytoskeleton and intracellular signaling pathways was investigated in β1 integrin deficient...
Doss, Michael Xavier, Chen, Shuhua, Winkler, Johannes, Hippler-Altenburg, Rita, Odenthal, Margareta, Wickenhauser, Claudia, ...
Transcriptome analysis of BMP2+ cells in comparison to the undifferentiated BMP2 ES cells and the control population from 7-day old embryoid bodies led to the identification of 479 specifically...
Schneider, Annette, Spitkovsky, Dimitry, Riess, Peter, Molcanyi, Marek, Kamisetti, Naidu, Maegele, Marc, ...
A variety of embryonic and adult stem cell lines require an intial co-culturing with feeder cells for non-differentiated growth, self renewal and maintenance of pluripotency. However for many...
The FunGenES Database: A Genomics Resource for Mouse Embryonic Stem Cell Differentiation
Schulz, Herbert, Kolde, Raivo, Adler, Priit, Aksoy, Irène, Anastassiadis, Konstantinos, Bader, Michael, ...
Embryonic stem (ES) cells have high self-renewal capacity and the potential to differentiate into a large variety of cell types. To investigate gene networks operating in pluripotent ES cells and...