Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., ...
The differentiation of macrophages from their progenitors is controlled by macrophage colony-stimulating factor (CSF-1), which binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene. We...
Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., ...
The differentiation of macrophages from their progenitors is controlled by macrophage colony-stimulating factor (CSF-1), which binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene. We...
Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., ...
Neutrophilic lung inflammation is an essential component of host defense against diverse eukaryotic and prokaryotic pathogens, but in chronic inflammatory lung diseases, such as chronic obstructive...
Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., ...
Neutrophilic lung inflammation is an essential component of host defense against diverse eukaryotic and prokaryotic pathogens, but in chronic inflammatory lung diseases, such as chronic obstructive...
Hamilton, J.A., Wisniewski, M. *
Consumer protection law in the age of globalisation poses new challenges for policy-makers. The growth of international consumer transactions in the wake of technological change and the globalisation...
Hamilton, J.A., Wisniewski, M.
Consumer protection law in the age of globalisation poses new challenges for policy-makers. The growth of international consumer transactions in the wake of technological change and the globalisation...
Hamilton, J.A., Wisniewski, M.
Consumer protection law in the age of globalisation poses new challenges for policy-makers. The growth of international consumer transactions in the wake of technological change and the globalisation...
Tissue-type plasminogen activator deficiency exacerbates arthritis (2001)
Fibrin deposition, cell migration, and tissue remodeling are key components in the lesions of inflammatory joint diseases, such as rheumatoid arthritis. The plasminogen activators (PAs), namely,...
Exact solutions for transient spherical radiation (2001)
Closed-form, analytic solutions are derived for exterior wave fields generated by the transient, axisymmetric motion of a spherical boundary. These are intended for use as benchmark problems for...
Numerical studies of conjugated infinite elements for acoustical radiation (2000)
Aspects of conjugated infinite element schemes for unbounded wave problems are reviewed and a general formulation is presented for elements of variable order based on separable shape functions...
Hamilton, J. A., Iles, Ray K., Gunn, Lionel K., Wilson, C. M., Lower, Adrian M, Chard, Tim, ...
Concentrations of various proteins in uterine flushings have been described as a direct method for assessment of the secretory activity of the endometrium. We investigated levels of the endometrial...
Civelek, V N, Hamilton, J A, Tornheim, K, Kelly, K L, Corkey, B E
The main function of white adipose tissue is to store nutrient energy in the form of triglycerides. The mechanism by which free fatty acids (FFA) move into and out of the adipocyte has not been...
Hwang, S Y, Hertzog, P J, Holland, K A, Sumarsono, S H, Tymms, M J, Hamilton, J A, ...
To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a...
pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.
A central, unresolved question in cell physiology is how fatty acids move across cell membranes and whether protein(s) are required to facilitate transbilayer movement. We have developed a method for...
Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin.
Hamilton, J A, Era, S, Bhamidipati, S P, Reed, R G
Binding of 13C-enriched oleic acid to bovine serum albumin and to three large proteolytic fragments of albumin--two complementary fragments corresponding to the two halves of albumin and one fragment...
Hamilton, J A, Piccoli, D S, Leizer, T, Butler, D M, Croatto, M, Royston, A K
Transforming growth factor beta (TGF-beta) is usually associated with matrix formation and tissue repair; in contrast, cellular expression of the serine proteinase, urokinase-type plasminogen...
Hurley, T D, Bosron, W F, Hamilton, J A, Amzel, L M
The three-dimensional structure of human beta 1 beta 1 alcohol dehydrogenase (ADH; EC 1.1.1.1) complexed with NAD+ has been determined by x-ray crystallography to 3.0-A resolution. The amino acids...
Kanagasundaram, V., Jaworowski, A., Byrne, R., Hamilton, J. A.
Colony-stimulating factor 1 (CSF-1) triggers the activation of intracellular proteins in macrophages through selective assembly of signalling complexes. The separation of multimeric complexes of the...
Ho, J K, Moser, H, Kishimoto, Y, Hamilton, J A
Adrenoleukodystrophy (ALD) is an inherited disorder of fatty acid metabolism marked by accumulation of very long chain saturated fatty acids (VLCFA), especially the 26-carbon acid, hexacosanoic acid...
Young, I. G., Leppik, R. A., Hamilton, J. A., Gibson, F.
Three ubiquinone-deficient mutants of Escherichia coli unable to convert 4-hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate were isolated and examined. The results of genetic analysis suggest that...
Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers.
Temperature-dependent (5-42 degrees C) 13C NMR spectra of albumin complexes with 90% isotopically substituted [1-13C]decanoic acids (3 mol of fatty acid per mol of albumin) showed a single peak at...
Hart, P H, Vitti, G F, Burgess, D R, Whitty, G A, Piccoli, D S, Hamilton, J A
Stimulated human monocytes/macrophages are a source of mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), and prostaglandin E2 (PGE2), which can modulate inflammatory...
Transfer of oleic acid between albumin and phospholipid vesicles.
The net transfer of oleic acid between egg phosphatidylcholine unilamellar vesicles and bovine serum albumin has been monitored by 13C NMR spectroscopy and 90% isotopically substituted [1-13C]oleic...
A labile repressor acts through the NFkB-like binding sites of the human urokinase gene.
Novak, U, Cocks, B G, Hamilton, J A
Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF...
Interactions of myristic acid with bovine serum albumin: a 13C NMR study.
Hamilton, J A, Cistola, D P, Morrisett, J D, Sparrow, J T, Small, D M
Interactions of myristic acid with bovine serum albumin were studied by 13C NMR spectroscopy at 50.3 MHz using 90% isotopically substituted [1-13C]-, [3-13C]-, and [14-13C]myristic acids, either...
Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR study.
Cosonicated mixtures of egg phosphatidylcholine and small amounts (less than 5% wt/wt) of triolein have been studied by 13C NMR spectroscopy. The 50.3-MHz 13C NMR spectrum of vesicles preparations...
Musgrove, E A, Hamilton, J A, Lee, C S, Sweeney, K J, Watts, C K, Sutherland, R L
Cyclins and proto-oncogenes including c-myc have been implicated in eukaryotic cell cycle control. The role of cyclins in steroidal regulation of cell proliferation is unknown, but a role for c-myc...
Green, S P, Hamilton, J A, Phillips, W A
We have investigated the relationship between tyrosine phosphorylation and respiratory-burst activity in mouse bone-marrow-derived macrophages (BMM). We demonstrate that zymosan, an agent known to...
Fosang, A J, Last, K, Knäuper, V, Neame, P J, Murphy, G, Hardingham, T E, ...
The actions of recombinant human fibroblast collagenase (MMP1), purified polymorphonuclear leucocyte collagenase (MMP8) and their N-terminal catalytic domain fragments against cartilage aggrecan and...
Medcalf, R L, Richards, R I, Crawford, R J, Hamilton, J A
Suppression of plasminogen activator (PA) activity has been invoked as being part of the general anti-inflammatory action of glucocorticoids. Low concentrations of the synthetic glucocorticoid,...
Cell extracts of a multiple aromatic auxotroph of Escherichia coli K-12, strain AB2830, grown in the absence of precursors of the quinone rings of the ubiquinone and menaquinone molecules, converted...
The function of ubiquinone in Escherichia coli
Cox, G. B., Newton, N. A., Gibson, F., Snoswell, A. M., Hamilton, J. A.
1. The function of ubiquinone in Escherichia coli was studied by using whole cells and membrane preparations of normal E. coli and of a mutant lacking ubiquinone. 2. The mutant lacking ubiquinone,...
Kanagasundaram, V, Jaworowski, A, Hamilton, J A
Colony stimulating factor-1 (CSF-1) stimulation of the macrophage cell line BAC1.2F5 and murine bone marrow-derived macrophages resulted in tyrosine phosphorylation of phosphatidylinositol-3 kinase...
Jaworowski, A, Christy, E, Yusoff, P, Byrne, R, Hamilton, J A
To determine the relevance of mitogen-activated protein kinase activity to macrophage proliferation, we measured the stimulation of myelin basic protein (MBP) kinase and extracellular signal-related...
Csar, X F, Ward, A C, Hoffmann, B W, Guy, G G, Hamilton, J A
The cAMP analogue 8-bromo-cAMP (8BrcAMP) inhibits granulocyte-colony-stimulating factor (G-CSF)-stimulated DNA synthesis in myeloid NFS-60 cells. We examined the effect of 8BrcAMP addition on the...
Kanagasundaram, V, Christy, E, Hamilton, J A, Jaworowski, A
Phosphatidylinositol 3'(OH)-kinase (PI 3-kinase) is activated on stimulation of macrophages with colony-stimulating factor 1 (CSF-1). We studied its potential role in the internalization and...
Wilson, N J, Moss, S T, Csar, X F, Ward, A C, Hamilton, J A
Colony-stimulating factor 1 (CSF-1) is required for the development of monocytes/macrophages from progenitor cells and for the survival and activation of mature macrophages. The receptor for CSF-1 is...
Fowles, L F, Stacey, K J, Marks, D, Hamilton, J A, Hume, D A
Macrophage colony-stimulating factor (CSF-1) binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene and activates transcription of the urokinase plasminogen activator (uPA) gene in murine...
Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate.
Guo, W, Choi, J K, Kirkland, J L, Corkey, B E, Hamilton, J A
Medium-chain triacylglycerols (MCT) are present in milk, coconut oil and other foods, and are used therapeutically in special diets for certain disorders of lipid and glucose utilization. Recently,...
Hamilton, J A, Byrne, R, Jessup, W, Kanagasundaram, V, Whitty, G
Modification of low-density lipoprotein (LDL), for example by oxidation, could be involved in foam cell formation and proliferation observed in atherosclerotic lesions. Macrophage colony-stimulating...
Hamilton, J A, Jessup, W, Brown, A J, Whitty, G
Human atherosclerotic plaque contains a partially characterized range of normal and oxidized lipids formed mainly from free and esterified cholesterol and phospholipids, some of which can be located...
McMahon, K A, Wilson, N J, Marks, D C, Beecroft, T L, Whitty, G A, Hamilton, J A, ...
M1 myeloid cells transfected with the wild-type (WT) colony-stimulating factor-1 (CSF-1) receptor (CSF-1R; M1/WT cells) undergo CSF-1-dependent macrophage differentiation. By mutation studies, we...
13C MAS NMR studies of crystalline cholesterol and lipid mixtures modeling atherosclerotic plaques.
Cholesterol and cholesteryl esters are the predominant lipids of atherosclerotic plaques. To provide fundamental data for the quantitative study of plaque lipids in situ, crystalline cholesterol...
Six saturated acylglycerols (1-myristoyl-sn-glycerol, 1-palmitoyl-sn-glycerol, 1,2-dimyristoyl-sn-glycerol, 1,2-dipalmitoyl-sn-glycerol, 1,2-dipalmitoyl-rac-glycerol, and 1,3-dimyristoylglycerol)...
Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study.
Cholesteryl esters are a transport and storage form of cholesterol in normal physiology but also a significant lipid in atherosclerotic plaques. To understand better the molecular properties of...
Simard, J. R., Zunszain, P. A., Yang, J. S., Bhagavan, N. V., Petitpas, I., ...
Human serum albumin (HSA) is a versatile transport protein for endogenous compounds and drugs. To evaluate physiologically relevant interactions between ligands for the protein, it is necessary to...
Macrophage stimulation and the inflammatory response to asbestos.
Chrysotile fibers injected into the peritoneal cavity of mice elicit a cellular exudate. Macrophages appearing in this exudate produce high levels of the neutral protease, plasminogen activator, when...
Asbestos fibers, plasma and inflammation.
Fibrin clots have been detected at sites of inflammation, and kinins have been implicated as mediators of the vascular phenomena of acute inflammation, systemic shock, and disseminated intravascular...
Suppression of the neutral protease activity of macrophages treated with asbestos in vitro.
Macrophages are often conspicuous in asbestos-induced inflammatory lesions. Chrysotile type B elicits macrophages into the peritoneal cavity of mice which produce high levels of the neutral protease,...
Civelek, V N, Hamilton, J A, Tornheim, K, Kelly, K L, Corkey, B E
The main function of white adipose tissue is to store nutrient energy in the form of triglycerides. The mechanism by which free fatty acids (FFA) move into and out of the adipocyte has not been...
Hwang, S Y, Hertzog, P J, Holland, K A, Sumarsono, S H, Tymms, M J, Hamilton, J A, ...
To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a...
pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.
A central, unresolved question in cell physiology is how fatty acids move across cell membranes and whether protein(s) are required to facilitate transbilayer movement. We have developed a method for...
Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin.
Hamilton, J A, Era, S, Bhamidipati, S P, Reed, R G
Binding of 13C-enriched oleic acid to bovine serum albumin and to three large proteolytic fragments of albumin--two complementary fragments corresponding to the two halves of albumin and one fragment...
Hamilton, J A, Piccoli, D S, Leizer, T, Butler, D M, Croatto, M, Royston, A K
Transforming growth factor beta (TGF-beta) is usually associated with matrix formation and tissue repair; in contrast, cellular expression of the serine proteinase, urokinase-type plasminogen...
Hurley, T D, Bosron, W F, Hamilton, J A, Amzel, L M
The three-dimensional structure of human beta 1 beta 1 alcohol dehydrogenase (ADH; EC 1.1.1.1) complexed with NAD+ has been determined by x-ray crystallography to 3.0-A resolution. The amino acids...
Kanagasundaram, V., Jaworowski, A., Byrne, R., Hamilton, J. A.
Colony-stimulating factor 1 (CSF-1) triggers the activation of intracellular proteins in macrophages through selective assembly of signalling complexes. The separation of multimeric complexes of the...
Ho, J K, Moser, H, Kishimoto, Y, Hamilton, J A
Adrenoleukodystrophy (ALD) is an inherited disorder of fatty acid metabolism marked by accumulation of very long chain saturated fatty acids (VLCFA), especially the 26-carbon acid, hexacosanoic acid...
Young, I. G., Leppik, R. A., Hamilton, J. A., Gibson, F.
Three ubiquinone-deficient mutants of Escherichia coli unable to convert 4-hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate were isolated and examined. The results of genetic analysis suggest that...
Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers.
Temperature-dependent (5-42 degrees C) 13C NMR spectra of albumin complexes with 90% isotopically substituted [1-13C]decanoic acids (3 mol of fatty acid per mol of albumin) showed a single peak at...
Hart, P H, Vitti, G F, Burgess, D R, Whitty, G A, Piccoli, D S, Hamilton, J A
Stimulated human monocytes/macrophages are a source of mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), and prostaglandin E2 (PGE2), which can modulate inflammatory...
Transfer of oleic acid between albumin and phospholipid vesicles.
The net transfer of oleic acid between egg phosphatidylcholine unilamellar vesicles and bovine serum albumin has been monitored by 13C NMR spectroscopy and 90% isotopically substituted [1-13C]oleic...
A labile repressor acts through the NFkB-like binding sites of the human urokinase gene.
Novak, U, Cocks, B G, Hamilton, J A
Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF...
Interactions of myristic acid with bovine serum albumin: a 13C NMR study.
Hamilton, J A, Cistola, D P, Morrisett, J D, Sparrow, J T, Small, D M
Interactions of myristic acid with bovine serum albumin were studied by 13C NMR spectroscopy at 50.3 MHz using 90% isotopically substituted [1-13C]-, [3-13C]-, and [14-13C]myristic acids, either...
Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR study.
Cosonicated mixtures of egg phosphatidylcholine and small amounts (less than 5% wt/wt) of triolein have been studied by 13C NMR spectroscopy. The 50.3-MHz 13C NMR spectrum of vesicles preparations...
Musgrove, E A, Hamilton, J A, Lee, C S, Sweeney, K J, Watts, C K, Sutherland, R L
Cyclins and proto-oncogenes including c-myc have been implicated in eukaryotic cell cycle control. The role of cyclins in steroidal regulation of cell proliferation is unknown, but a role for c-myc...
Green, S P, Hamilton, J A, Phillips, W A
We have investigated the relationship between tyrosine phosphorylation and respiratory-burst activity in mouse bone-marrow-derived macrophages (BMM). We demonstrate that zymosan, an agent known to...
Fosang, A J, Last, K, Knäuper, V, Neame, P J, Murphy, G, Hardingham, T E, ...
The actions of recombinant human fibroblast collagenase (MMP1), purified polymorphonuclear leucocyte collagenase (MMP8) and their N-terminal catalytic domain fragments against cartilage aggrecan and...
Medcalf, R L, Richards, R I, Crawford, R J, Hamilton, J A
Suppression of plasminogen activator (PA) activity has been invoked as being part of the general anti-inflammatory action of glucocorticoids. Low concentrations of the synthetic glucocorticoid,...
Cell extracts of a multiple aromatic auxotroph of Escherichia coli K-12, strain AB2830, grown in the absence of precursors of the quinone rings of the ubiquinone and menaquinone molecules, converted...
The function of ubiquinone in Escherichia coli
Cox, G. B., Newton, N. A., Gibson, F., Snoswell, A. M., Hamilton, J. A.
1. The function of ubiquinone in Escherichia coli was studied by using whole cells and membrane preparations of normal E. coli and of a mutant lacking ubiquinone. 2. The mutant lacking ubiquinone,...
Kanagasundaram, V, Jaworowski, A, Hamilton, J A
Colony stimulating factor-1 (CSF-1) stimulation of the macrophage cell line BAC1.2F5 and murine bone marrow-derived macrophages resulted in tyrosine phosphorylation of phosphatidylinositol-3 kinase...
Jaworowski, A, Christy, E, Yusoff, P, Byrne, R, Hamilton, J A
To determine the relevance of mitogen-activated protein kinase activity to macrophage proliferation, we measured the stimulation of myelin basic protein (MBP) kinase and extracellular signal-related...
Csar, X F, Ward, A C, Hoffmann, B W, Guy, G G, Hamilton, J A
The cAMP analogue 8-bromo-cAMP (8BrcAMP) inhibits granulocyte-colony-stimulating factor (G-CSF)-stimulated DNA synthesis in myeloid NFS-60 cells. We examined the effect of 8BrcAMP addition on the...
Kanagasundaram, V, Christy, E, Hamilton, J A, Jaworowski, A
Phosphatidylinositol 3'(OH)-kinase (PI 3-kinase) is activated on stimulation of macrophages with colony-stimulating factor 1 (CSF-1). We studied its potential role in the internalization and...
Wilson, N J, Moss, S T, Csar, X F, Ward, A C, Hamilton, J A
Colony-stimulating factor 1 (CSF-1) is required for the development of monocytes/macrophages from progenitor cells and for the survival and activation of mature macrophages. The receptor for CSF-1 is...
Fowles, L F, Stacey, K J, Marks, D, Hamilton, J A, Hume, D A
Macrophage colony-stimulating factor (CSF-1) binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene and activates transcription of the urokinase plasminogen activator (uPA) gene in murine...
Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate.
Guo, W, Choi, J K, Kirkland, J L, Corkey, B E, Hamilton, J A
Medium-chain triacylglycerols (MCT) are present in milk, coconut oil and other foods, and are used therapeutically in special diets for certain disorders of lipid and glucose utilization. Recently,...
Hamilton, J A, Byrne, R, Jessup, W, Kanagasundaram, V, Whitty, G
Modification of low-density lipoprotein (LDL), for example by oxidation, could be involved in foam cell formation and proliferation observed in atherosclerotic lesions. Macrophage colony-stimulating...
Hamilton, J A, Jessup, W, Brown, A J, Whitty, G
Human atherosclerotic plaque contains a partially characterized range of normal and oxidized lipids formed mainly from free and esterified cholesterol and phospholipids, some of which can be located...
McMahon, K A, Wilson, N J, Marks, D C, Beecroft, T L, Whitty, G A, Hamilton, J A, ...
M1 myeloid cells transfected with the wild-type (WT) colony-stimulating factor-1 (CSF-1) receptor (CSF-1R; M1/WT cells) undergo CSF-1-dependent macrophage differentiation. By mutation studies, we...
13C MAS NMR studies of crystalline cholesterol and lipid mixtures modeling atherosclerotic plaques.
Cholesterol and cholesteryl esters are the predominant lipids of atherosclerotic plaques. To provide fundamental data for the quantitative study of plaque lipids in situ, crystalline cholesterol...
Six saturated acylglycerols (1-myristoyl-sn-glycerol, 1-palmitoyl-sn-glycerol, 1,2-dimyristoyl-sn-glycerol, 1,2-dipalmitoyl-sn-glycerol, 1,2-dipalmitoyl-rac-glycerol, and 1,3-dimyristoylglycerol)...
Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study.
Cholesteryl esters are a transport and storage form of cholesterol in normal physiology but also a significant lipid in atherosclerotic plaques. To understand better the molecular properties of...
Simard, J. R., Zunszain, P. A., Yang, J. S., Bhagavan, N. V., Petitpas, I., ...
Human serum albumin (HSA) is a versatile transport protein for endogenous compounds and drugs. To evaluate physiologically relevant interactions between ligands for the protein, it is necessary to...
Macrophage stimulation and the inflammatory response to asbestos.
Chrysotile fibers injected into the peritoneal cavity of mice elicit a cellular exudate. Macrophages appearing in this exudate produce high levels of the neutral protease, plasminogen activator, when...
Asbestos fibers, plasma and inflammation.
Fibrin clots have been detected at sites of inflammation, and kinins have been implicated as mediators of the vascular phenomena of acute inflammation, systemic shock, and disseminated intravascular...
Suppression of the neutral protease activity of macrophages treated with asbestos in vitro.
Macrophages are often conspicuous in asbestos-induced inflammatory lesions. Chrysotile type B elicits macrophages into the peritoneal cavity of mice which produce high levels of the neutral protease,...
Cheung, D L, Hart, P H, Vitti, G F, Whitty, G A, Hamilton, J A
Stimulated human monocytes/macrophages are a source of interleukin-6 (IL-6), which is a likely mediator involved in immune and inflammatory reactions. The means to control production of IL-6 by these...
Hart, P H, Whitty, G A, Burgess, D R, Hamilton, J A
Urokinase-type plasminogen activator (u-PA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) activities were measured for highly purified human monocytes cultured for 18 hr with...
Phillips, W A, Croatto, M, Hamilton, J A
Pre-exposure to bacterial lipopolysaccharide (LPS) or certain cytokines is known to enhance the ability of murine macrophages to generate a respiratory burst in response to subsequent stimulation, a...
Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.
Hart, P H, Whitty, G A, Piccoli, D S, Hamilton, J A
There have been suggestions that the production of pro-inflammatory mediators by human monocytes in response to interferon-gamma (IFN-gamma) may be controlled by changes in prostaglandins. Therefore...
Hamilton, J A, Whitty, G A, Royston, A K, Cebon, J, Layton, J E
Granulocyte colony-stimulating factor (G-CSF) was quantitated in the supernatants of lipopolysaccharide (LPS)-treated human monocytes by ELISA. Unlike previous reports, the lymphokines, interleukin-4...
Sewell, W A, De Moerloose, P A, Hamilton, J A, Schrader, J W, Mackay, I R, Vadas, M A
The effects of lymphokine production of two agents known to potentiate delayed-type hypersensitivity (DTH), pertussigen (pertussis toxin) (PT) and cyclophosphamide (CY) have been investigated. These...
Skinner, N A, MacIsaac, C M, Hamilton, J A, Visvanathan, K
Rapid overproduction of proinflammatory cytokines are characteristic of sepsis. CD14dimCD16+ monocytes are thought to be major producers of cytokine and have been shown to be elevated in septic...
Bischof, R J, Zafiropoulos, D, Hamilton, J A, Campbell, I K
CSF-1 and GM-CSF have been implicated in the pathogenesis of rheumatoid arthritis. We report the effects of CSF-1 and GM-CSF in the development of an acute methylated bovine serum albumin...
INDUCTION OF A PRIMARY ANTIHAPTEN RESPONSE IN VIVO BY A GRAFT-VS.-HOST REACTION
A primary anti-NIP PFC response can be elicited by a GVH reaction provided certain structural requirements of the NIP-carrier are met. NIP-coated F1 erythrocytes and NIP-coated parental erythrocytes...
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN.
Gray, I. C., Stewart, L. M., Phillips, S. M., Hamilton, J. A., Gray, N. E., Watson, G. J., ...
The chromosomal region 10q23-24 is frequently deleted in a number of tumour types, including prostate adenocarcinoma and glioma. A candidate tumour-suppressor gene at 10q23.3, designated PTENor...
The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers
Hamilton, J A, Stewart, L M D, Ajayi, L, Gray, I C, Gray, N E, Roberts, K G, ...
PTEN, a putative tumour suppressor gene associated with prostate and other cancers, is known to be located within the chromosomal region 10q23.3. Transcription of the PTEN gives rise to multiple mRNA...