Translation of the genetic message, IV. UAA as a chain termination codon.
Last, J A, Stanley, W M, Salas, M, Hille, M B, Wahba, A J, Ochoa, S
Sninsky, J J, Last, J A, Gilham, P T
Under the conditions that RNA ligase converts the tetranucleotide, pA-A2-A, to larger polynucleotides, no such polymerization can be detected with the derivative, pA-A2-A(MeOEt), that possesses a...
Lipid membrane reorganization induced by chemical recognition.
Last, J A, Waggoner, T A, Sasaki, D Y
Nanoscale structural reorganization of a lipid bilayer membrane induced by a chemical recognition event has been imaged using in situ atomic force microscopy (AFM). Supported lipid bilayers, composed...
Ozone, NO, and NO2: oxidant air pollutants and more.
Last, J A, Sun, W M, Witschi, H
This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled...
Effects of inhaled acids on lung biochemistry.
Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or...
Global atmospheric change: potential health effects of acid aerosol and oxidant gas mixtures.
Inhalation toxicology experiments in whole animals have demonstrated a remarkable lack of toxicity of sulfuric acid in the form of respirable aerosols, especially in rats and nonhuman primates. Thus,...
Collagen is the major structural protein of the lung. At least five genetically distinct collagen types have been identified in lung tissue. However, the precise role of collagen in nonrespiratory...
Mucus glycoprotein secretion by tracheal explants: effects of pollutants.
Tracheal slices incubated with radioactive precursors in tissue culture medium secrete labeled mucus glycoproteins into the culture medium. We have used an in vivtro approach, a combined method...
Biochemical alterations of lung structure as predictors of chronic lung disease.
This presentation reports on newer animal models and techniques that we and others have developed. These models attempt to predict in a reasonable experimental time frame the occurrence of structural...
Translation of the genetic message, IV. UAA as a chain termination codon.
Last, J A, Stanley, W M, Salas, M, Hille, M B, Wahba, A J, Ochoa, S
Sninsky, J J, Last, J A, Gilham, P T
Under the conditions that RNA ligase converts the tetranucleotide, pA-A2-A, to larger polynucleotides, no such polymerization can be detected with the derivative, pA-A2-A(MeOEt), that possesses a...
Lipid membrane reorganization induced by chemical recognition.
Last, J A, Waggoner, T A, Sasaki, D Y
Nanoscale structural reorganization of a lipid bilayer membrane induced by a chemical recognition event has been imaged using in situ atomic force microscopy (AFM). Supported lipid bilayers, composed...
Ozone, NO, and NO2: oxidant air pollutants and more.
Last, J A, Sun, W M, Witschi, H
This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled...
Effects of inhaled acids on lung biochemistry.
Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or...
Global atmospheric change: potential health effects of acid aerosol and oxidant gas mixtures.
Inhalation toxicology experiments in whole animals have demonstrated a remarkable lack of toxicity of sulfuric acid in the form of respirable aerosols, especially in rats and nonhuman primates. Thus,...
Collagen is the major structural protein of the lung. At least five genetically distinct collagen types have been identified in lung tissue. However, the precise role of collagen in nonrespiratory...
Mucus glycoprotein secretion by tracheal explants: effects of pollutants.
Tracheal slices incubated with radioactive precursors in tissue culture medium secrete labeled mucus glycoproteins into the culture medium. We have used an in vivtro approach, a combined method...
Biochemical alterations of lung structure as predictors of chronic lung disease.
This presentation reports on newer animal models and techniques that we and others have developed. These models attempt to predict in a reasonable experimental time frame the occurrence of structural...
Reiser, K. M., Hesterberg, T. W., Haschek, W. M., Last, J. A.
Rats were intratracheally instilled with 50 mg of silica as quartz (0.5-mu particles) at day 0. One and 2 weeks later, lungs were evaluated histologically and by a variety of biochemical...
Reiser, K. M., Haschek, W. M., Hesterberg, T. W., Last, J. A.
Rats received intratracheal instillations of 50 mg of silica (quartz, 0.5 mu particles). One, 2, 4, 5, 6, 9, and 12 months later, the lungs were evaluated histologically and by various biochemical...
Type I collagen content is increased in lungs of patients with adult respiratory distress syndrome.
Last, J A, Siefkin, A D, Reiser, K M
Collagen in lung tissue was examined from patients with adult respiratory distress syndrome, from patients who did not have this disease but required mechanical ventilation and oxygen treatment, and...