Douglas, C M, Foor, F, Marrinan, J A, Morin, N, Nielsen, J B, Dahl, A M, ...
In Saccharomyces cerevisiae, mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer resistance to the cell-wall-active...
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.
Douglas, C M, Marrinan, J A, Li, W, Kurtz, M B
A novel, potent, semisynthetic pneumocandin, L-733,560, was used to isolate a resistant mutant in Saccharomyces cerevisiae. This compound, like other pneumocandins and echinocandins, inhibits...
Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans.
Monk, B C, Kurtz, M B, Marrinan, J A, Perlin, D S
The Candida albicans PMA1 gene was isolated from a genomic library by using a hybridization probe obtained from the PMA1 gene of Saccharomyces cerevisiae. The gene was localized to chromosome III of...
Douglas, C M, Foor, F, Marrinan, J A, Morin, N, Nielsen, J B, Dahl, A M, ...
In Saccharomyces cerevisiae, mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer resistance to the cell-wall-active...
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.
Douglas, C M, Marrinan, J A, Li, W, Kurtz, M B
A novel, potent, semisynthetic pneumocandin, L-733,560, was used to isolate a resistant mutant in Saccharomyces cerevisiae. This compound, like other pneumocandins and echinocandins, inhibits...
Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans.
Monk, B C, Kurtz, M B, Marrinan, J A, Perlin, D S
The Candida albicans PMA1 gene was isolated from a genomic library by using a hybridization probe obtained from the PMA1 gene of Saccharomyces cerevisiae. The gene was localized to chromosome III of...