J. A. Romijn

Publication List Details

Period

1997 - 2007

Number

146

Co-Authors

Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue (2006)

Berbee, J.F.P., Reiss, P., Valk, M., Voshol, P.J., Kuipers, F., ...

Objective - The use of the HIV protease inhibitor ritonavir (RTV) is frequently associated with hypertriglyceridemia and lipodystrophy. The aim of our study was to determine the mechanism underlying...

Differential effects of natural flavonoids on growth and iodide content in a human NA+/I_symporter-transfecred follicular thyroid carcinoma cell line (2004)

Romijn, J.A., Smit, J.W.A.

OBJECTIVE: Natural flavonoids (plant pigments) have been shown to inhibit thyroid peroxidase (TPO) in vitro and the growth of thyroid cancer cell lines. We have studied the role of flavonoids on the...

The future endocrine patient. Reflections on the future of clinical endocrinology (2003)

Lamberts, S.W., Romijn, J.A., Wiersinga, W.M.

In recent years the future position of clinical endocrinology has been extensively discussed by Western European endocrine societies. Clinical endocrinology seems to suffer from being too...

Iodide kinetics and experimental I-131 therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line (2002)

Smit, J.W.A., Karperien, M., Que, I., Stokkel, M., ...

Uptake of iodide is a prerequisite for radioiodide therapy in thyroid cancer. However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by...

Expression of the human sodium/iodide symporter (hNIS) in xenotransplanted human thyroid carcinoma (2001)

Smit, J.W.A., Karperien, M., Que, I., Romijn, J.A.

The uptake of iodide in thyroid epithelial cells is mediated by the sodium/iodide symporter (NIS). The uptake of iodide is of vital importance for thyroid physiology and is a prerequisite for...

Glucose production and gluconeogenesis in adults with cerebral malaria (2001)

Van Thien, H., Ackermans, M.T., Dekker, E., Chien, V.O. Thanh, Le, T., Endert, E., ...

Hypoglycaemia is an important complication in severe malaria, ascribed to an inhibition of gluconeogenesis. However, the only data available suggested that in severe malaria, total glucose production...

The decrease in nonsplenic interleukin-6 (IL-6) production after splenectomy indicates the existence of a positive feedback loop of IL-6 production during endotoxemia in dogs.

Moeniralam, H S, Bemelman, W A, Endert, E, Koopmans, R, Sauerwein, H P, Romijn, J A

The spleen is involved in endotoxin-induced interleukin-6 (IL-6) production. To quantitate the relative contribution of the spleen to endotoxin-induced IL-6 production, we studied the effect of...

Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes.

Sprangers, F, Sauerwein, H P, Romijn, J A, Van Woerkom, G M, Meijer, A J

There is increasing evidence for the existence of intrahepatic regulation of glucose metabolism by Kupffer cell products. Nitric oxide (NO) is known to inhibit gluconeogenic flux through pyruvate...

Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes.

Gustafson, L A, Neeft, M, Reijngoud, D J, Kuipers, F, Sauerwein, H P, Romijn, J A, ...

We studied the influence of glucose/glucose 6-phosphate cycling on glycogen deposition from glucose in fasted-rat hepatocytes using S4048 and CP320626, specific inhibitors of glucose-6-phosphate...

Effects of interferon-alpha (IFN-α) administration on leucocytes in healthy humans

CORSSMIT, E P M, HEIJLIGENBERG, R, HACK, C E, ENDERT, E, SAUERWEIN, H P, ROMIJN, J A

Plasma concentrations of IFN-α are increased in several inflammatory conditions. Several lines of evidence indicate that IFN-α has anti-inflammatory properties. To study the effects of IFN-α on...

Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity

Rentenaar, R J, De Metz, J, Bunders, M, Gouma, D J, Romijn, J A, ...

Antigen-induced activation of T cells is determined by many factors. Among these factors are (i) the number of T-cell receptors (TCRs) triggered by TCR ligands on antigen-presenting cells (APCs), and...

Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus

Maassen, J. A., Romijn, J. A., Heine, R. J.

Type 2 diabetes is associated with excessive food intake and a sedentary lifestyle. Local inflammation of white adipose tissue induces cytokine-mediated insulin resistance of adipocytes. This results...