Powley, M.W., Li, Y., Upton, P.B., Walker, V.E., Swenberg, J.A.
1,3-Butadiene (BD) is a confirmed rodent carcinogen and a suspect human carcinogen that forms mutagenic epoxide metabolites during biotransformation. Species differences in the roles of individual...
Powley, M. W., Li, Y., Upton, P. B., Walker, V. E., Swenberg, J. A.
1,3-butadiene (BD) is a confirmed rodent carcinogen and a suspect human carcinogen that forms mutagenic epoxide metabolites during biotransformation. Species differences in the roles of individual...
Biomarkers in Czech workers exposed to 1,3-butadiene: a transitional epidemiologic study (2003)
Albertini, R.J., Sram, R.J., Vacek, P.M., Lynch, J., Nicklas, J.A., Sittert, N.J. Van, ...
Farmer, Peter B., Bartsch, H., Boobis, A., Chipman, K., Gescher, A., Kadlubar, F.F., ...
Correspondence - no abstract available.
Genotoxic markers among butadiene polymer workers in China (2000)
Hayes, R.B., Zhang, L., Yin, S., Swenberg, J.A., Xi, L., Wiencke, J., ...
While 1,3-butadiene is carcinogenic in rodents, cancer causation in humans is less certain. We examined a spectrum of genotoxic outcomes in 41 butadiene polymer production workers and 38 non-exposed...
DIETRICH, D. R., SWENBERG, J. A.
NCI-Black-Reiler (NBR) Male Rats Fail to Develop Renal Disease following Exposure to Agents That Induce α2u-Globulin (α2u) Nephropathy. Dietrich, D. R., and Swenberg, J. A. (1991). Fundam. Appl....
Fedtke, N., Boucheron, J.A., Turner, M. J., Swenberg, J. A.
A sensitive assay for quantitative determination of the vinyl chloride (VC)-induced cyclic DNA adduct N2,3-ethenoguanine (EG) was developed. The method is based on the detection of EG as its...
Fedtke, N., Boucheron, J.A., Walker, V.E., Swenberg, J.A.
The formation and persistence of the DNA adducts 7-(2'-oxo-ethyl)guanine (OEG) and N2 ,3-ethenoguanine (EG) were investigated in preweanling Sprague–Dawley rats exposed to chloride (VC). Lactating...
BUCKLEY, L. A., MORGAN, K. T., SWENBERG, J. A., JAMES, R. A., HAMM, T. E., BARROW, C. S.
The Toxicity of Dimethylamine in F-344 Rats and B6C3F1 Mice following a 1-Year Inhalation Exposure (1985). BUCKLEY, L. A., MORGAN, K. T., SWENBERG, J. A., JAMES, R. A., HAMM, T. E., JR., and BARROW,...
A 13-Week Vapor Inhalation Study of n-Hexane in Rats with Emphasis on Neurotoxic Effects (1984)
CAVENDER, F. L., CASEY, H. W., SALEM, H., GRAHAM, D. G., SWENBERG, J. A., GRALLA, E. J.
A 13-Week Vapor Inhalation Study of n-Hexane in Rats with Emphasis on Neurotoxic Effects. CAVENDER, F. L., CASEY, H. W., SALEM, H., GRAHAM, D. G., SWENBERG, J. A., AND GRALLA, E. J. (1984). Fundam....
Richardson, K K, Richardson, F C, Crosby, R M, Swenberg, J A, Skopek, T R
Dideoxy chain-termination DNA sequencing was used to determine the specific DNA base changes induced after in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea (MNU) and...
Cariello, N F, Swenberg, J A, Skopek, T R
DNA synthesis fidelities of two thermostable DNA polymerases, Thermus aquaticus (Taq) and Thermococcus litoralis (Tli, also known as Vent), and a non-thermostable enzyme, a modified T7 DNA polymerase...
Swenberg, J A, Dyroff, M C, Bedell, M A, Popp, J A, Huh, N, Kirstein, U, ...
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the DNA of nonparenchymal cells...
Swenberg, J A, Bedell, M A, Billings, K C, Umbenhauer, D R, Pegg, A E
The activity of the alkyl acceptor protein (AAP) responsible for repair of DNA containing the promutagenic lesion O6-alkylguanine was determined in hepatocytes and nonparenchymal cells (NPC) obtained...
Contribution of formaldehyde to respiratory cancer.
Nelson, N, Levine, R J, Albert, R E, Blair, A E, Griesemer, R A, Landrigan, P J, ...
This article reviews the available data on the carcinogenicity of formaldehyde from experimental and epidemiologic studies and makes recommendations for further research. Two definitive chronic...
Swenberg, J A, Richardson, F C, Boucheron, J A, Deal, F H, Belinsky, S A, Charbonneau, M, ...
Recent investigations on mechanism of carcinogenesis have demonstrated important quantitative relationships between the induction of neoplasia, the molecular dose of promutagenic DNA adducts and...
This paper reviews what is known about the induction of alpha 2u-globulin nephropathy and carcinogenesis. This unique male-rat-specific disease is associated with exposure to an ever-increasing...
Comparative morphometry of the nasal cavity in rats and mice.
Gross, E A, Swenberg, J A, Fields, S, Popp, J A
The distribution of the various epithelial types lining the nasal cavity in normal 7 and 16 weeks old male Fischer-344 rats and male B6C3F1 mice has been mapped at the light microscopic level....
Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.
Walker, V E, Fennell, T R, Upton, P B, MacNeela, J P, Swenberg, J A
Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target tissues. The relationship between repeated...
Weight of the evidence on the human carcinogenicity of 2,4-D*
Ibrahim, M. A., Bond, G. G., Burke, T. A., Cole, P., Dost, F. N., Enterline, P. E., ...
The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the...
Relationships between DNA adduct formation and carcinogenesis.
Swenberg, J A, Richardson, F C, Boucheron, J A, Dyroff, M C
An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific...
Cell specificity in DNA binding and repair of chemical carcinogens.
Swenberg, J A, Rickert, D E, Baranyi, B L, Goodman, J I
Many animal models for organ specific neoplasia have been developed and used to study the pathogenesis of cancer. Morphologic studies have usually concentrated on the response of target cells,...
Richardson, K K, Richardson, F C, Crosby, R M, Swenberg, J A, Skopek, T R
Dideoxy chain-termination DNA sequencing was used to determine the specific DNA base changes induced after in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea (MNU) and...
Cariello, N F, Swenberg, J A, Skopek, T R
DNA synthesis fidelities of two thermostable DNA polymerases, Thermus aquaticus (Taq) and Thermococcus litoralis (Tli, also known as Vent), and a non-thermostable enzyme, a modified T7 DNA polymerase...
Swenberg, J A, Dyroff, M C, Bedell, M A, Popp, J A, Huh, N, Kirstein, U, ...
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the DNA of nonparenchymal cells...
Swenberg, J A, Bedell, M A, Billings, K C, Umbenhauer, D R, Pegg, A E
The activity of the alkyl acceptor protein (AAP) responsible for repair of DNA containing the promutagenic lesion O6-alkylguanine was determined in hepatocytes and nonparenchymal cells (NPC) obtained...
Comparative morphometry of the nasal cavity in rats and mice.
Gross, E A, Swenberg, J A, Fields, S, Popp, J A
The distribution of the various epithelial types lining the nasal cavity in normal 7 and 16 weeks old male Fischer-344 rats and male B6C3F1 mice has been mapped at the light microscopic level....
Contribution of formaldehyde to respiratory cancer.
Nelson, N, Levine, R J, Albert, R E, Blair, A E, Griesemer, R A, Landrigan, P J, ...
This article reviews the available data on the carcinogenicity of formaldehyde from experimental and epidemiologic studies and makes recommendations for further research. Two definitive chronic...
Swenberg, J A, Richardson, F C, Boucheron, J A, Deal, F H, Belinsky, S A, Charbonneau, M, ...
Recent investigations on mechanism of carcinogenesis have demonstrated important quantitative relationships between the induction of neoplasia, the molecular dose of promutagenic DNA adducts and...
This paper reviews what is known about the induction of alpha 2u-globulin nephropathy and carcinogenesis. This unique male-rat-specific disease is associated with exposure to an ever-increasing...
Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.
Walker, V E, Fennell, T R, Upton, P B, MacNeela, J P, Swenberg, J A
Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target tissues. The relationship between repeated...
Weight of the evidence on the human carcinogenicity of 2,4-D*
Ibrahim, M. A., Bond, G. G., Burke, T. A., Cole, P., Dost, F. N., Enterline, P. E., ...
The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the...
Relationships between DNA adduct formation and carcinogenesis.
Swenberg, J A, Richardson, F C, Boucheron, J A, Dyroff, M C
An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific...
Cell specificity in DNA binding and repair of chemical carcinogens.
Swenberg, J A, Rickert, D E, Baranyi, B L, Goodman, J I
Many animal models for organ specific neoplasia have been developed and used to study the pathogenesis of cancer. Morphologic studies have usually concentrated on the response of target cells,...