Terrestrial Planet Finder Coronagraph (TPF-C) Flight Baseline Concept (2009)
Levine, Marie, Lisman, D., Shaklan, S., Kasting, J., Traub, W., Alexander, J., ...
The Terrestrial Planet Finder Coronagraph (TPF-C) mission presented here is an existence proof for a flagship-class internal coronagraph space mission capable of detecting and characterizing...
Maher, Barbara A., Watkins, S. J., Brunskill, G., Alexander, J., Fielding, C.
The sources and fluxes of sediment to the Great Barrier Reef lagoon from northeastern Australian rivers have been the subject of much concern and study, with the large catchments of the Burdekin and...
Mann, J.F.S., Shakir, E., Carter, K.C., Mullen, A., Alexander, J., Ferro, V.A.
Previous studies, using parenteral administration of antigen in lipid vesicles, have indicated a possible role for vesicle size in determining the Th1/Th2 bias of the resulting immune response. We...
Sex hormones and modulation of immunity against leishmaniasis (2009)
Snider, Heidi, Lezama-Davila, Claudio, Alexander, J., Satoskar, Abhay R.
Sex-associated hormones such as estradiol, testosterone and progesterone have all been shown to modulate immune responses, which can result in differential disease outcomes between males and females,...
Neuropsychiatric disease and toxoplasma gondii infection (2009)
Henriquez, S.A., Brett, Ros, Alexander, J., Pratt, Judith, Roberts, C.W.
Toxoplasma gondii infects approximately 30% of the world's population, but causes overt clinical symptoms in only a small proportion of people. In recent years, the ability of the parasite to...
Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent? (2008)
Alexander, J., McFarlane, Emma
While control of intracellular pathogens, such as the protozoan Leishmania, is dependent on the generation of type-1 immune responses, the role of T helper 2 cytokines in the disease process is more...
Alexander, J., McFarlane, E., Perez, C., Charmoy, M., Allenbach, C., Carter, K.C., ...
Neutrophils are key components of the inflammatory response and as such contribute to the killing of microorganisms. In addition, recent evidence suggests their involvement in the development of the...
Alexander, J., Bryson, K.J., Wei, X.
Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens...
Vaccination against toxoplasmosis: current status and future prospects (2007)
Schaap, D., Vermeulen, A.N., Roberts, C.W., Alexander, J.
Chapter focusing on vaccination against toxoplasmosis. Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately...
Alexander, J., Mann, J.F.S., Scales, H.E., Shakir, E., Carter, K.C., Mullen, A., ...
Protein antigens administered via the oral route are exposed to a hostile environment in the gastrointestinal tract, consisting of digestive enzymes and a range of pH (1-7.5). Using a delivery system...
New probes and optical spectroscopies for immune parasitological applications (2006)
The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately...
Ocular toxoplasmosis: in the storm of the eye (2006)
Alexander, J., Jones, L.A., Robertson, C.W.
Ocular toxoplasmosis (OT) can occur in the children of mothers infected with Toxoplasma gondii during pregnancy. It is not limited to the congenitally infected, but can also occur following...
Bryson, K.J., Besteiro, Sébastien, McGachy, H.A., Coombs, G.H., Mottram, J.C., Alexander, J.
Leishmania mexicana cysteine peptidases (CPs) have been identified as important parasite virulence factors. More recently, a natural inhibitor of CPs (ICP) from L. mexicana has been characterized,...
Rapid cell mapping using nanoparticles and SERRS
Stokes, Robert J., McKenzie, Fiona, McFarlane, Emma, Ricketts, Alastair, Tetley, L., Faulds, Karen, ...
Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced...
Functionalized nanoparticles for bioanalysis by SERRS
Graham, D., Faulds, Karen, Thompson, David, McKenzie, Fiona, Stokes, Robert J., Dalton, Colette, ...
Metallic nanoparticles can be used as basic materials for a wide variety of purposes including building blocks for nanoassemblies, substrates for enhanced spectroscopies such as fluorescence and...