Antibiotic susceptibility of Clostridium difficile (1979)
Burdon, D. W., Brown, J. D., Youngs, D. J., Arabi, Y., Shinagawa, N., Alexander-Williams, J., ...
Strains of Clostridium difficile isolated from patients with pseudomembranous colitis or diarrhoea were all sensitive to concentrations of vancomycin which are readily attained in faeces by oral...
Influence of neomycin and metronidazole on colonic microflora of volunteers (1979)
Arabi, Y., Dimock, Frances, Burdon, D. W., Alexander-Williams, J., Keighley, M. R. B.
The influence on colonic microflora of neomycin and metronidazole alone, or in combination, was studied in volunteers taking a normal diet. Bacterial counts on daily faecal samples revealed that...
Aspects of preventing sepsis in colo-rectal surgery: results of recent clinical trials (1978)
Keighley, M. R. B., Arabi, Y., Matheson, D., Alexander-Williams, J.
We have conducted four clinical trials to assess the value of antibiotic prophylaxis in colo-rectal surgery. Systemic lincomycin was shown to reduce the incidence of sepsis and non-sporing anaerobic...
Pseudomembranous colitis following prophylactic antibiotics in bowel surgery (1976)
Clark, C. E., Thompson, H., McLeish, A. R., Powis, S. J. A., Dorricott, N. J., Alexander-Williams, J.
Following the administration of lincomycin and various broad spectrum antibiotics as prophylaxis against post-operative sepsis, 6 patients who underwent elective operations for carcinoma of the large...
Faecal toxin and severity of antibiotic-associated pseudomembranous colitis.
Burdon, D W, George, R H, Mogg, G A, Arabi, Y, Thompson, H, Johnson, M, ...
The relationship between faecal toxin titre, histological evidence of pseudomembrane in the rectum, and severity of antibiotic-associated colitis has been analysed from data on 62 patients whose...
Lateral subcutaneous sphincterotomy: local or general anaesthetic?
Gatehouse, D, Arabi, Y, Alexander-Williams, J, Keighley, M R
Treatment of acute abscesses in the casualty department.
Simms, M H, Curran, F, Johnson, R A, Oates, J, Givel, J C, Chabloz, R, ...
In the treatment of acute pyogenic soft-tissue abscess incision, curettage, and primary suture was compared with incision and drainage alone in a randomised prospective trial. Operations were...
Influence of cholecystokinin on pyloric reflux after operation for gallstones and peptic ulcer.
Fleury, A, Poxon, V, Dorricott, N, Keighley, M, Alexander-Williams, J
Ambrose, N S, Hares, M M, Alexander-Williams, J, Keighley, M R
Two hundred and sixty eight patients with haemorrhoids were allocated at random to treatment by either photocoagulation (group 1, n=141) or rubber band ligation (group 2, n=127) and followed up for...
Appointment of Preregistration House Officers
Alexander-Williams, J., Stephenson, Ivor G.
A new programme to try and match the preferences of students and consultants in preregistration appointments has been designed after a survey of student opinion. It is based on five main principles:...
Prospective trials of minor surgical procedures and high-fibre diet for haemorrhoids.
Keighley, M R, Buchmann, P, Minervini, S, Arabi, Y, Alexander-Williams, J
Two hundred and sixteen consecutive patients seen for the first time with symptomatic haemorrhoids entered trials of conservative and minor surgical treatment. They were divided into two groups...
Diagnosis of pseudomembranous colitis.
Kappas, A, Shinagawa, N, Arabi, Y, Thompson, H, Burdon, D, Dimock, F, ...
Twenty-eight patients with histologically proved pseudomembranous colitis have been seen in one hospital since July 1975. All patients with the disease had received antibiotics, six for infections...
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
George, R H, Symonds, J M, Dimock, F, Brown, J D, Arabi, Y, Shinagawa, N, ...
Magnetic continent colostomy device.
Alexander-Williams, J, Amery, A H, Devlin, H B, Goligher, J C, Heald, R J, Parks, A G, ...
The effect of vagotomy on gastric emptying.
Alexander-Williams, J, Donovan, I A, Gunn, I F, Brown, A, Harding, L K
Recipe for success in international specialist meetings.
Alexander-Williams, J, Fielding, L P, Goldberg, S, Grace, R H
Letter: Postoperative pseudomembranous colitis.
Crapp, A R, Powis, J, Clark, C, Keighley, M R, Alexander-Williams, J
Faecal toxin and severity of antibiotic-associated pseudomembranous colitis.
Burdon, D W, George, R H, Mogg, G A, Arabi, Y, Thompson, H, Johnson, M, ...
The relationship between faecal toxin titre, histological evidence of pseudomembrane in the rectum, and severity of antibiotic-associated colitis has been analysed from data on 62 patients whose...
Lateral subcutaneous sphincterotomy: local or general anaesthetic?
Gatehouse, D, Arabi, Y, Alexander-Williams, J, Keighley, M R
Treatment of acute abscesses in the casualty department.
Simms, M H, Curran, F, Johnson, R A, Oates, J, Givel, J C, Chabloz, R, ...
In the treatment of acute pyogenic soft-tissue abscess incision, curettage, and primary suture was compared with incision and drainage alone in a randomised prospective trial. Operations were...
Influence of cholecystokinin on pyloric reflux after operation for gallstones and peptic ulcer.
Fleury, A, Poxon, V, Dorricott, N, Keighley, M, Alexander-Williams, J
Ambrose, N S, Hares, M M, Alexander-Williams, J, Keighley, M R
Two hundred and sixty eight patients with haemorrhoids were allocated at random to treatment by either photocoagulation (group 1, n=141) or rubber band ligation (group 2, n=127) and followed up for...
Appointment of Preregistration House Officers
Alexander-Williams, J., Stephenson, Ivor G.
A new programme to try and match the preferences of students and consultants in preregistration appointments has been designed after a survey of student opinion. It is based on five main principles:...
Prospective trials of minor surgical procedures and high-fibre diet for haemorrhoids.
Keighley, M R, Buchmann, P, Minervini, S, Arabi, Y, Alexander-Williams, J
Two hundred and sixteen consecutive patients seen for the first time with symptomatic haemorrhoids entered trials of conservative and minor surgical treatment. They were divided into two groups...
Diagnosis of pseudomembranous colitis.
Kappas, A, Shinagawa, N, Arabi, Y, Thompson, H, Burdon, D, Dimock, F, ...
Twenty-eight patients with histologically proved pseudomembranous colitis have been seen in one hospital since July 1975. All patients with the disease had received antibiotics, six for infections...
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
George, R H, Symonds, J M, Dimock, F, Brown, J D, Arabi, Y, Shinagawa, N, ...
Magnetic continent colostomy device.
Alexander-Williams, J, Amery, A H, Devlin, H B, Goligher, J C, Heald, R J, Parks, A G, ...
The effect of vagotomy on gastric emptying.
Alexander-Williams, J, Donovan, I A, Gunn, I F, Brown, A, Harding, L K
Recipe for success in international specialist meetings.
Alexander-Williams, J, Fielding, L P, Goldberg, S, Grace, R H
Letter: Postoperative pseudomembranous colitis.
Crapp, A R, Powis, J, Clark, C, Keighley, M R, Alexander-Williams, J
Influence of prophylaxis against bacteroides on incidence of sepsis after large-bowel surgery.
Keighley, M. R., Burdon, D. W., Cooke, W. T., Alexander-Williams, J.
Prophylactic antibiotics in bowel surgery.
Alexander-Williams, J., McLeish, A. R., Keighley, K. R., Burdon, D. W.
Morel, P, Alexander-Williams, J, Rohner, A
Patients with inflammatory and ischaemic bowel diseases seem to tolerate narrowing of the gut lumen to a critical degree of stenosis without obstructive symptoms. To determine the physical factors...
Keighley, M R, Asquith, P, Alexander-Williams, J
This study has investigated the possible association between duodenogastric reflux, gastritis, and symptoms in 35 patients with or without dyspepsia one to 15 years after gastric surgery. Five...
Symptomatic significance of gastric mucosal changes after surgery for peptic ulcer.
Hoare, A M, Jones, E L, Alexander-Williams, J, Hawkins, C F
Eighty-four patients who had undergone different types of operation for duodenal ulcer have been studied by endoscopy and gastric biopsy. Half suffered from dyspepsia and vomiting but the other half...
Hoare, A M, McLeish, A, Thompson, H, Alexander-Williams, J
Eighteen patients with dyspepsia and vomiting which followed surgery for peptic ulcer have completed a study to examine the role of diverting bile from the stomach by a Roux-en-Y procedure. Bile...
Hoare, A M, Keighley, M R, Starkey, B, Alexander-Williams, J
We measured the concentration of bile acids in gastric aspirates from patients who had had operations for peptic ulcer. Some patients were asymptomatic and some had postoperative symptoms of the type...
White, C M, Harding, L K, Keighley, M R, Dorricott, N J, Alexander-Williams, J
A consecutive series of 12 patients with stenosis secondary to duodenal ulceration were treated by proximal gastric vagotomy (PGV) and duodenoplasty or PGV and dilatation of the stenosis. Three...
Influence of inflammatory bowel disease on intestinal microflora.
Keighley, M R, Arabi, Y, Dimock, F, Burdon, D W, Allan, R N, Alexander-Williams, J
The microflora of the jejunum, ileum, and colon has been studied from operative samples in Crohn's disease (n = 30), ulcerative colitis (n = 15), and controls (n = 40). There was no significant...
Clarke, R. J., Allan, R. N., Alexander-Williams, J.
The result of a prospective trial of 40 patients with duodenal ulcer treated either by proximal gastric vagotomy (antrum innervated) or by selective vagotomy (antrum denervated) shows that they are...
A comparison of results of excision and bypass for ileal Crohn's disease
Alexander-Williams, J., Fielding, J. F., Cooke, W. T.
One hundred and ten patients presented with Crohn's disease confined to the terminal ileum, and indications for their surgical treatment are reviewed. Treatment was either by ileo-transverse...
Clarke, R. J., Alexander-Williams, J.
A prospective randomized trial of 40 duodenal ulcer patients is reviewed. The patients had one of four operations (selective vagotomy, proximal gastric vagotomy, selective vagotomy plus pyloroplasty,...
Free perforation in Crohn's disease
Steinberg, David M., Cooke, W. Trevor, Alexander-Williams, J.
Free perforation is a rare complication of Crohn's disease. Seven cases were found in a total series of 360 in Birmingham. It occurs during an acute exacerbation of chronic disease, particularly in...
Abscess and fistulae in Crohn's disease
Steinberg, David M., Cooke, W. Trevor, Alexander-Williams, J.
In a series of 360 patients with Crohn's disease 18% have developed a complication of abscess and/or fistula. Both complications can be spontaneous but more commonly occur in patients who have had a...
Steinberg, D. M., Allan, R. N., Thompson, H., Brooke, B. N., Alexander-Williams, J., Cooke, W. T.
This paper reports the indications for, and results of, excision of the large intestine with ileostomy in 73 patients with Crohn's colitis who have been followed for a mean of nine years since...
Relationship of proctitis and rectal capacity in Crohn's disease.
Buchmann, P, Mogg, G A, Alexander-Williams, J, Allan, R N, Keighley, M R
In patients with Crohn's disease involving the rectum (n=25), there was an inverse relationship between rectal capacity and the degree of proctitis. However, in patients with Crohn's disease not...
Management of enterocutaneous fistulae in Crohn's disease.
Hawker, P C, Givel, J C, Keighley, M R, Alexander-Williams, J, Allan, R N
The outcome among 39 patients with enterocutaneous fistulae complicating Crohn's disease has been reviewed. The patients were considered in two groups: (1) no disease - all were early postoperative...
Effects of nutrient liquids on human gastroduodenal motor activity.
White, C M, Poxon, V, Alexander-Williams, J
The effects of intragastric infusion of 10% Intralipid and 10% dextrose on the intraluminal pressures in the antrum, pylorus and duodenal bulb have been examined. Ten studies with each infusate have...
Clinical impact of colectomy and ileorectal anastomosis in the management of Crohn's disease.
Ambrose, N S, Keighley, M R, Alexander-Williams, J, Allan, R N
We report the outcome of 63 consecutive patients with Crohn's colitis treated by colectomy and ileorectal anastomosis between 1951-1981. There were no operative deaths. Serious postoperative...
Crohn's disease in the elderly.
Fabricius, P J, Gyde, S N, Shouler, P, Keighley, M R, Alexander-Williams, J, Allan, R N
The natural history of Crohn's disease in 47 patients, 60 years of age or older at the time of diagnosis has been defined, and their clinical management and long term prognosis reviewed. Distal...
Plasma fibronectin in Crohn's disease.
Allan, A, Wyke, J, Allan, R N, Morel, P, Robinson, M, Scott, D L, ...
The hypothesis that abnormal fibronectin metabolism in Crohn's disease could be an important mechanism leading to stricture formation or postoperative infection was tested in three related studies....
Ibbotson, J P, Lowes, J R, Chahal, H, Gaston, J S, Life, P, Kumararatne, D S, ...
Culture studies have suggested that Mycobacterium paratuberculosis may play a role in the aetiology of Crohn's disease. However, evidence of sensitization to mycobacterial antigens amongst patients...
Assessment and treatment of recurrent peptic ulceration.
Steinberg, D. M., Masselink, B. A., Alexander-Williams, J.
From the experience of treating 91 patients with a proven recurrent ulcer we consider that if a proven ulcer is shown to be present and a gastrin-secreting tumour is excluded an appropriate...
Comparison between general and local anaesthesia for repair of groin hernias.
Makuria, T., Alexander-Williams, J., Keighley, M. R.
A prospective study of 104 cases has been carried out to compare the use of local and general anaesthesia for the elective repair of groin hernias. There were no apparent disadvantages in using a...
Long saphenous vein stripping under local anaesthesia.
Taylor, E. W., Fielding, J. W., Keighley, M. R., Alexander-Williams, J.
Stripping of the long saphenous vein under femoral nerve block has been preformed on 21 patients (27 limbs). There has been no complication from the nerve block and this form of anaesthesia was found...
Dorricott, N. J., Baddeley, R. M., Keighley, M. R., Lee, J., Oates, G. D., Alexander-Williams, J.
The complications and results of rectal anastomoses carried out with the end-to-end anastomosis (EEA) stapling instrument on 50 patients by 5 consultant surgeons are recorded. There was a clinical...
The therapeutic dilatation of enteric strictures due to Crohn's disease.
Alexander-Williams, J., Allan, A., Morel, P., Hawker, P. C., Dykes, P. W., O'Connor, H.
The use of dilatation as a treatment of strictures due to Crohn's disease has hitherto received little attention. We report dilatation of small and large bowel strictures in twelve patients with...
The surgical treatment of gastroduodenal Crohn's disease.
Shepherd, A. F., Allan, R. N., Dykes, P. W., Keighley, M. R., Alexander-Williams, J.
Crohn's disease can affect any part of the gastrointestinal tract. Gastroduodenal involvement is uncommon and was not recognised until 1949 (1). Since then approximately 200 cases have been described...
Enterovesical fistulas in Crohn's disease.
Heyen, F., Ambrose, N. S., Allan, R. N., Dykes, P. W., Alexander-Williams, J., Keighley, M. R.
A total of 19 enterovesical fistulas were recorded in a series of 799 patients with Crohn's disease (2.4%). The origin of the fistulas was: ileum (9), colon (6) and four were complex involving the...
Non-steroidal anti-inflammatory drugs and stercoral perforation of the colon.
Hollingworth, J., Alexander-Williams, J.
Within 6 months, three constipated patients have been seen with stercoral perforation of the colon associated with the ingestion of non-steroidal anti-inflammatory drug medications (NSAIDs). These...
Early onset high grade dysplasia in ulcerative colitis.
Clements, D., Suarez, V., Thompson, H., Alexander-Williams, J., Allan, R. N.
We report a patient with ulcerative colitis who underwent colectomy when aged 25 years for multifocal high grade dysplasia which had developed within 2 years of diagnosis, and only 5 1/2 years after...