Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna L., Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
D'Souza, Cletus A., Alspaugh, J. Andrew, Yue, Changli, Harashima, Toshiaki, Cox, Gary M., Perfect, John R., ...
Cryptococcus neoformans is an opportunistic fungal pathogen that infects the human central nervous system. This pathogen elaborates two specialized virulence factors: the antioxidant melanin and an...
Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna, Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP
Alspaugh, J. Andrew, Perfect, John R., Heitman, Joseph
This study explores signal transduction pathways that function during mating and infection in the opportunistic, human fungal pathogen Cryptococcus neoformans. The gene encoding a G-protein α...
Pukkila-Worley, Read, Gerrald, Quincy D., Kraus, Peter R., Boily, Marie-Josée, Davis, Matthew J., Giles, Steven S., ...
Cryptococcus neoformans is an opportunistic human fungal pathogen that elaborates several virulence attributes, including a polysaccharide capsule and melanin pigments. A conserved Gα protein/cyclic...
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans†
Fraser, James A., Huang, Johnny C., Pukkila-Worley, Read, Alspaugh, J. Andrew, Mitchell, Thomas G., Heitman, Joseph
Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to...
Vallim, Marcelo A., Nichols, Connie B., Fernandes, Larissa, Cramer, Kari L., Alspaugh, J. Andrew
The Cryptococcus neoformans Ras1 protein serves as a central regulator for several signaling pathways. Ras1 controls the induction of the mating pheromone response cascade as well as a distinct...
Cramer, Kari L., Gerrald, Quincy D., Nichols, Connie B., Price, Michael S., Alspaugh, J. Andrew
The Cryptococcus neoformans NRG1 gene was identified using gene microarrays to define putative transcription factor genes regulated by the cyclic AMP (cAMP) signal transduction pathway. Disruption of...
D'Souza, Cletus A., Alspaugh, J. Andrew, Yue, Changli, Harashima, Toshiaki, Cox, Gary M., Perfect, John R., ...
Cryptococcus neoformans is an opportunistic fungal pathogen that infects the human central nervous system. This pathogen elaborates two specialized virulence factors: the antioxidant melanin and an...
Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna, Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP
Alspaugh, J. Andrew, Perfect, John R., Heitman, Joseph
This study explores signal transduction pathways that function during mating and infection in the opportunistic, human fungal pathogen Cryptococcus neoformans. The gene encoding a G-protein α...
Pukkila-Worley, Read, Gerrald, Quincy D., Kraus, Peter R., Boily, Marie-Josée, Davis, Matthew J., Giles, Steven S., ...
Cryptococcus neoformans is an opportunistic human fungal pathogen that elaborates several virulence attributes, including a polysaccharide capsule and melanin pigments. A conserved Gα protein/cyclic...
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans†
Fraser, James A., Huang, Johnny C., Pukkila-Worley, Read, Alspaugh, J. Andrew, Mitchell, Thomas G., Heitman, Joseph
Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to...
Vallim, Marcelo A., Nichols, Connie B., Fernandes, Larissa, Cramer, Kari L., Alspaugh, J. Andrew
The Cryptococcus neoformans Ras1 protein serves as a central regulator for several signaling pathways. Ras1 controls the induction of the mating pheromone response cascade as well as a distinct...
Cramer, Kari L., Gerrald, Quincy D., Nichols, Connie B., Price, Michael S., Alspaugh, J. Andrew
The Cryptococcus neoformans NRG1 gene was identified using gene microarrays to define putative transcription factor genes regulated by the cyclic AMP (cAMP) signal transduction pathway. Disruption of...
The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense
Giles, Steven S., Stajich, Jason E., Nichols, Connie, Gerrald, Quincy D., Alspaugh, J. Andrew, Dietrich, Fred, ...
In the present study, we sought to elucidate the contribution of the Cryptococcus neoformans catalase gene family to antioxidant defense. We employed bioinformatics techniques to identify four...
Olson, Gillian M., Fox, Deborah S., Wang, Ping, Alspaugh, J. Andrew, Buchanan, Kent L.
Protein O mannosylation is initiated in the endoplasmic reticulum by protein O-mannosyltransferases (Pmt proteins) and plays an important role in the secretion, localization, and function of many...
Price, Michael S., Nichols, Connie B., Alspaugh, J. Andrew
Rho-GDP dissociation inhibitors (Rho-GDI) are repressors of Rho-type monomeric GTPases that control fundamental cellular processes, such as cytoskeletal arrangement, vesicle trafficking, and...
Characterization of the PMT Gene Family in Cryptococcus neoformans
Willger, Sven D., Ernst, Joachim F., Alspaugh, J. Andrew, Lengeler, Klaus B.
Fortwendel, Jarrod R., Juvvadi, Praveen Rao, Pinchai, Nadthanan, Perfect, B. Zachary, Alspaugh, J. Andrew, Perfect, John R., ...
Aspergillus fumigatus must be able to properly form hyphae and maintain cell wall integrity in order to establish invasive disease. Ras proteins and calcineurin each have been implicated as having...
Subcellular Localization Directs Signaling Specificity of the Cryptococcus neoformans Ras1 Protein▿
Nichols, Connie B., Ferreyra, Jessica, Ballou, Elizabeth R., Alspaugh, J. Andrew
In the human fungal pathogen Cryptococcus neoformans, Ras signaling mediates sexual differentiation, morphogenesis, and pathogenesis. By studying Ras prenylation and palmitoylation in this organism,...