Caloric restriction, SIRT1 and longevity (2009)
More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease....
Dietary manipulation of mouse metabolism (2008)
Feige, J.N., Lagouge, M., Auwerx, J.
The maintenance of metabolic homeostasis relies on the balanced intake of nutrients from food. Consequently, diet composition strongly impacts whole-body physiology. Dietary formulations with strong...
SIRT1/PGC-1: A neuroprotective axis? [SIRT1/PGC-1: Un axe neuroprotecteur?] (2007)
Rasouri, S., Lagouge, M., Auwerx, J.
Neurodegenerative diseases are more and more prevalent in our aging societies. A rapid overview of the etiology of many neurodegenerative diseases like Alzheimer, Parkinson, Huntington disease and...
Evaluation of glucose homeostasis (2007)
Heikkinen, S., Argmann, C.A., Auwerx, J.
Obesity and dyslipidemia are often found in association with insulin resistance (IR). These components combined with hypertension characterize the most common endocrine disorder in humans, the...
Histopathology in mouse metabolic investigations (2007)
Mark, M., Teletin, M., Antal, C., Wendling, O., Auwerx, J., Heikkinen, S., ...
Due to the small size of the mouse, evaluating its clinical phenotype is sometimes problematic. In contrast, mouse models are readily accessible to post-mortem analyses at any time during the course...
Tissue collection for systematic phenotyping in the mouse (2007)
Antal, C., Teletin, M., Wendling, O., Dgheem, M., Auwerx, J., Mark, M.
In this unit, a procedure for post-mortem examination of mice and tissue collection is provided. This procedure is performed for post-mortem analysis of anatomical defects (necropsy) and histological...
Endocrine functions of bile acids (2006)
Houten, S.M., Watanabe, M., Auwerx, J.
Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in...
Lipid and bile acid analysis (2006)
Argmann, C.A., Houten, S.M., Auwerx, J.
Lipids are important body constituents that are vital for cellular, tissue, and whole-body homeostasis. Lipids serve as crucial membrane components, constitute the body's main energy reservoir, and...
Evaluation of energy homeostasis (2006)
Body mass and composition reflect the combined effects of three processes: energy intake, energy partitioning (storage), and energy expenditure. Energy is released from food as it is combusted to...
Uses of forward and reverse genetics in mice to study gene function (2006)
Argmann, C.A., Dierich, A., Auwerx, J.
As the focus of human genetics shifts from Mendelian traits to complex diseases, a sophisticated genetic tool kit—with space for genetics (classical, molecular, statistical, and quantitative),...
Minimizing variation due to genotype and environment (2006)
Mouse models are increasingly popular tools to study and characterize the molecular and physiological bases for human diseases. Due to the readily available genetic tools to construct mouse models of...
Collection of blood and plasma from the mouse (2006)
There are many elements in plasma that can act as surrogate markers of the physiological well-being of a mouse, thus making the collection of blood and plasma a general technique with many...
Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population (2005)
Meirhaeghe, A., Tanck, M.W.T., Fajas, L., Janot, C., Helbecque, N., Cottel, D., ...
Peroxisome proliferator-activated receptor gamma: the more the merrier? (2005)
Argmann, C A, Cock, T-A, Auwerx, J
The consequence of activating the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), which coordinates adipocyte differentiation, validates the concept, 'you are...
Debril, M-B, Dubuquoy, L, Feige, J-N, Wahli, W, Desvergne, B, Auwerx, J, ...
Transcriptional activity relies on coregulators that modify the chromatin structure and serve as bridging factors between transcription factors and the basal transcription machinery. Using the DE...
The European dimension for the mouse genome mutagenesis program (2004)
Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., ...
The European Mouse Mutagenesis Consortium is the European initiative contributing to the international effort on functional annotation of the mouse genome. Its objectives are to establish and...
This review highlights the presentations and discussions held during the 2003 Stock Conference in Lisbon focussed on the identification of new therapeutic targets for the treatment of obesity and...
Larval rearing of burbot (Lota lota L.) using Brachionus calyciflorus rotifer as starter food (2003)
HARZEVILI, AS, CHARLEROY, D, AUWERX, J, VUGHT, I, SLYCKEN, J, DHERT, P, ...
The pleiotropic functions of peroxisome proliferator-activated receptor gamma. (2001)
Debril, M B, Renaud, J P, Fajas, L, Auwerx, J
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds that induce peroxisome proliferation. PPARgamma is...
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. (2001)
Fajas, L, Debril, M B, Auwerx, J
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the...
PPAR gamma: an essential role in metabolic control. (2001)
Fajas, L, Debril, M B, Auwerx, J
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic...
Xol INXS: role of the liver X and the farnesol X receptors. (2001)
Fayard, E, Schoonjans, K, Auwerx, J
Cholesterol and bile acid metabolism is tightly controlled by nuclear receptors. The liver X receptor, an oxysterol-activated nuclear receptor, limits cholesterol accumulation in the body both by...
Regulation of adipocyte differentiation. (2001)
Once multipotent mesenchymal cells become committed to the adipoblast lineage, adipogenesis, the process of preadipocytes differentiation into adipocytes is initiated. This process starts with a...
The peroxisome proliferator-activated receptor gamma (PPARgamma) is nuclear receptor that controls the expression of a large number of genes involved in adipocyte differentiation, lipid storage and...
Akiyama, T E, Nicol, C J, Fievet, C, Staels, B, Ward, J M, Auwerx, J, ...
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in obesity. Two purebred congenic strains of PPARalpha-null mice were developed...
Claudel, T, Leibowitz, M D, Fiévet, C, Tailleux, A, Wagner, B, Repa, J J, ...
A common feature of many metabolic pathways is their control by retinoid X receptor (RXR) heterodimers. Dysregulation of such metabolic pathways can lead to the development of atherosclerosis, a...
Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity. (2001)
Davies, P J, Berry, S A, Shipley, G L, Eckel, R H, Hennuyer, N, Crombie, D L, ...
Hypertriglyceridemia is a frequent complication accompanying the treatment of patients with either retinoids or rexinoids, [retinoid X receptor (RXR)-selective retinoids]. To investigate the cellular...
Desreumaux, P, Dubuquoy, L, Nutten, S, Peuchmaur, M, Englaro, W, Schoonjans, K, ...
The peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied the involvement of...
Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. (2001)
Hanley, K, Kömüves, L G, Ng, D C, Schoonjans, K, He, S S, Lau, P, ...
The isoprenoids farnesol and juvenile hormone III (JH), metabolites of the cholesterol biosynthetic pathway, have been shown to stimulate fetal epidermal development in rodents. In this study we...
Rieusset, J, Chambrier, C, Bouzakri, K, Dusserre, E, Auwerx, J, Riou, J P, ...
AIMS/HYPOTHESIS: Thiazolidinediones are new oral antidiabetic drugs that activate the nuclear receptor PPARgamma. Our aim was to identify potential target genes of PPARgamma in the human adipocyte in...
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. (2001)
Rocchi, S, Picard, F, Vamecq, J, Gelman, L, Potier, N, Zeyer, D, ...
FMOC-L-Leucine (F-L-Leu) is a chemically distinct PPARgamma ligand. Two molecules of F-L-Leu bind to the ligand binding domain of a single PPARgamma molecule, making its mode of receptor interaction...
Tarrade, A, Schoonjans, K, Guibourdenche, J, Bidart, J M, Vidaud, M, Auwerx, J, ...
Recent studies performed with null mice suggested a role of either RXR alpha or PPAR gamma in murine placental development. We report here that both PPAR gamma and RXR alpha are strongly expressed in...
PPARgamma/RXRalpha heterodimers control human trophoblast invasion. (2001)
Tarrade, A, Schoonjans, K, Pavan, L, Auwerx, J, Rochette-Egly, C, Evain-Brion, D, ...
The ligand-dependent nuclear receptors PPARgamma and RXRalpha/beta were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we...
Thiazolidinediones: an update. (2000)
Thiazolidinediones, which are being developed for the treatment of insulin resistance and type 2 diabetes mellitus, bind and activate peroxisome proliferator-activated receptor gamma, a nuclear...
Binnert, C, Koistinen, H A, Martin, G, Andreelli, F, Ebeling, P, Koivisto, V A, ...
Fatty acid transporter protein (FATP)-1 mRNA expression was investigated in skeletal muscle and in subcutaneous abdominal adipose tissue of 17 healthy lean, 13 nondiabetic obese, and 16 obese type 2...
Dubois, M, Pattou, F, Kerr-Conte, J, Gmyr, V, Vandewalle, B, Desreumaux, P, ...
AIMS/HYPOTHESIS: Thiazolidinediones are reported to improve pancreatic islet morphology and beta-cell function in rodents, supporting the hypothesis of a direct action of thiazolidinediones on...
Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. (2000)
Kömüves, L G, Hanley, K, Lefebvre, A M, Man, M Q, Ng, D C, Bikle, D D, ...
Our recent studies have demonstrated that PPARalpha activators stimulate differentiation and inhibit proliferation in cultured human keratinocytes and accelerate epidermal development and...
Activation of PPARdelta alters lipid metabolism in db/db mice. (2000)
Leibowitz, M D, Fiévet, C, Hennuyer, N, Peinado-Onsurbe, J, Duez, H, Bergera, J, ...
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which heterodimerize with the retinoid X receptor and bind to peroxisome proliferator response elements in the promoters of...
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. (2000)
Lu, T T, Makishima, M, Repa, J J, Schoonjans, K, Kerr, T A, Auwerx, J, ...
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway's rate-limiting enzyme cholesterol 7alpha-hydroxylase...
Martin, G, Nemoto, M, Gelman, L, Geffroy, S, Najib, J, Fruchart, J C, ...
Uptake of fatty acids into cells is a controlled process in part regulated by fatty acid transport proteins (FATPs), which facilitate the transport of fatty acids across the cell membrane. In this...
Martin, G, Poirier, H, Hennuyer, N, Crombie, D, Fruchart, J C, Heyman, R A, ...
The intracellular fatty acid content of insulin-sensitive target tissues determines in part their insulin sensitivity. Uptake of fatty acids into cells is a controlled process determined in part by a...
Meirhaeghe, A, Fajas, L, Helbecque, N, Cottel, D, Auwerx, J, Deeb, S S, ...
OBJECTIVE: The Pro12Ala polymorphism of the Peroxisome Proliferator Activated Receptor gamma2 (PPARgamma2) gene has been inconsistently associated with body mass index variations and...
Meirhaeghe, A, Martin, G, Nemoto, M, Deeb, S, Cottel, D, Auwerx, J, ...
Fatty acids play important biological roles in cells. The precise mechanism whereby fatty acids cross the plasma membrane is still poorly understood. They can cross membranes because of their...
Pihlajamäki, J, Miettinen, R, Valve, R, Karjalainen, L, Mykkänen, L, Kuusisto, J, ...
Dyslipidemias and insulin resistance often present simultaneously, as in familial combined hyperlipidemia (FCHL), and therefore may have a common genetic background. In our previous study the...
Schoonjans, K, Gelman, L, Haby, C, Briggs, M, Auwerx, J
Overexpression of the adipocyte differentiation and determination factor-1 (ADD-1) or sterol regulatory element binding protein-1 (SREBP-1) induces the expression of numerous genes involved in lipid...
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. (2000)
Tobin, K A, Steineger, H H, Alberti, S, Spydevold, O, Auwerx, J, Gustafsson, J A, ...
LXR alpha (liver X receptor, also called RLD-1) is a nuclear receptor, highly expressed in tissues that play a role in lipid homeostasis. In this report we show that fatty acids are positive...
PPARgamma, the ultimate thrifty gene. (1999)
The peroxisome proliferator-activated receptor gamma (PPARgamma) quickly evolved over the last decade from a new orphan receptor to one of the best characterized nuclear receptors. This fast pace in...
Peroxisome proliferator-activated receptors are nuclear receptors with pleiotropic effects on intra- and extracellular lipid metabolism, glucose homeostasis, inflammation control, and cell...
Gelman, L, Fruchart, J C, Auwerx, J
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and have been initially described as molecular targets for compounds which induce peroxisome proliferation. The interest of...
Peroxisome proliferator-activated receptor-gamma: a versatile metabolic regulator. (1999)
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that controls the expression of a large array of genes involved in adipocyte differentiation, lipid storage and...
Brendel, C., Auwerx, J., Schoonjans, K.
Sterols and cholesterol in particular are lipids that have been studied exhaustively in view of their vital role in diverse cellular functions. Recently, it has been recognized that cholesterol is...
Inflammatory alterations in mesenteric adipose tissue in Crohn's disease. (1999)
Desreumaux, P, Ernst, O, Geboes, K, Gambiez, L, Berrebi, D, Müller-Alouf, H, ...
BACKGROUND & AIMS: Abnormalities of fat in the mesentery including adipose tissue hypertrophy and fat wrapping have been long recognized on surgical specimens as characteristic features of Crohn's...
Ek, J, Urhammer, S A, Sørensen, T I, Andersen, T, Auwerx, J, Pedersen, O
AIMS/HYPOTHESIS: The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with...
Fajas, L, Schoonjans, K, Gelman, L, Kim, J B, Najib, J, Martin, G, ...
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor implicated in adipocyte differentiation and insulin sensitivity. We investigated whether PPARgamma expression is...
Gelman, L, Zhou, G, Fajas, L, Raspé, E, Fruchart, J C, Auwerx, J
The nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) activates the transcription of multiple genes involved in intra- and extracellular lipid metabolism. Several cofactors are...
Lefebvre, M, Paulweber, B, Fajas, L, Woods, J, McCrary, C, Colombel, J F, ...
Peroxisome proliferator-activated receptor gamma (PPARgamma), a fatty acid-activated nuclear receptor, is implicated in adipocyte differentiation and insulin sensitisation. In view of the association...
Rieusset, J, Andreelli, F, Auboeuf, D, Roques, M, Vallier, P, Riou, J P, ...
Peroxisome proliferator-activated receptor (PPAR)-gamma is one of the key actors of adipocyte differentiation. This study demonstrates 1) that PPAR-gamma mRNA expression is not altered in...
Rieusset, J, Auwerx, J, Vidal, H
To better define the mechanism of action of the thiazolidinediones, we incubated freshly isolated human adipocytes with rosiglitazone and investigated the changes in mRNA expression of genes encoding...
Saladin, R, Fajas, L, Dana, S, Halvorsen, Y D, Auwerx, J, Briggs, M
Adipocyte differentiation is driven by the expression and activation of three transcription factor families: the differentially expressed CAAT/enhancer binding proteins (C/EBPs) alpha, beta, and...
Schoonjans, K, Peinado-Onsurbe, J, Fruchart, J C, Tailleux, A, Fiévet, C, Auwerx, J
Statins are hypolipidemic drugs which not only improve cholesterol but also triglyceride levels. Whereas their cholesterol-reducing effect involves inhibition of de novo biosynthesis of cellular...
Valve, R, Sivenius, K, Miettinen, R, Pihlajamäki, J, Rissanen, A, Deeb, S S, ...
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates adipocyte differentiation. Variations in the PPARgamma gene may affect the function of the PPARgamma...
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has...
Transcriptional control of adipogenesis. (1998)
Fajas, L, Fruchart, J C, Auwerx, J
Adipocyte differentiation is coordinatedly regulated by several transcription factors. C/EBP beta, C/EBP delta and ADD-1/SREBP-1 are active early during the differentiation process and induce the...
Martin, G, Schoonjans, K, Staels, B, Auwerx, J
It is currently thought that the effects of PPARgamma activation on glucose homeostasis may be due to the effect of this nuclear receptor on the production of adipocyte-derived signalling molecules,...
Mechanism of action of fibrates on lipid and lipoprotein metabolism. (1998)
Staels, B, Dallongeville, J, Auwerx, J, Schoonjans, K, Leitersdorf, E, Fruchart, J C
Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL cholesterol...
Sirtori, C.R., Lovati, M.R., Manzoni, C., Gianazza, E., Bondioli, A., Staels, B., ...
The major components of soybean flour (ie, proteins, fibres, and isoflavones) have been investigated as possibly responsible for the cholesterol-lowering effects of soy-based diets. The evidence for...
Buscà, R, Martínez, M, Vilella, E, Peinado, J, Gelpi, J L, Deeb, S, ...
Certain missense substitutions on the human lipase (hLPL) gene produce mutated proteins that are retained in different compartments along the secretory pathway. The purpose of the present study was...
Dallongeville, J, Hecquet, B, Lebel, P, Edmé, J L, Le Fur, C, Fruchart, J C, ...
OBJECTIVE: To investigate whether acute feeding induces changes in circulating leptin levels in humans and whether these changes vary according to nycthemeral cycle. METHODS: First experiment....
De Vos, P, Lefebvre, A M, Shrivo, I, Fruchart, J C, Auwerx, J
Leptin is a hormone which is produced in adipose tissue and which plays a role in the regulation of energy homeostasis. The expression of the ob gene, encoding leptin, is under multi-hormonal...
Deeb, S S, Fajas, L, Nemoto, M, Pihlajamäki, J, Mykkänen, L, Kuusisto, J, ...
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a transcription factor that has a pivotal role in adipocyte differentiation and expression of adipocyte-specific genes. The...
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter. (1998)
Fajas, L, Fruchart, J C, Auwerx, J
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We...
Lefebvre, A M, Chen, I, Desreumaux, P, Najib, J, Fruchart, J C, Geboes, K, ...
The development of colorectal cancer, one of the most frequent cancers, is influenced by prostaglandins and fatty acids. Decreased prostaglandin production, seen in mice with mutations in the...
Depot-specific differences in adipose tissue gene expression in lean and obese subjects. (1998)
Lefebvre, A M, Laville, M, Vega, N, Riou, J P, Van Gaal, L, Auwerx, J, ...
Intra-abdominal and subcutaneous adipose tissue display important metabolic differences that underlie the association of visceral, but not subcutaneous, fat with obesity-related cardiovascular and...
Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin. (1998)
Lepercq, J, Cauzac, M, Lahlou, N, Timsit, J, Girard, J, Auwerx, J, ...
Leptin, a small peptide produced by adipocytes, is implicated in an increasing number of endocrine regulations, including adiposity, satiety, puberty, and fertility. Although the factors involved in...
Meirhaeghe, A, Fajas, L, Helbecque, N, Cottel, D, Lebel, P, Dallongeville, J, ...
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a transcription factor implicated in adipocyte differentiation, lipid and glucose metabolism. A polymorphism corresponding to a silent...
Ricote, M, Huang, J, Fajas, L, Li, A, Welch, J, Najib, J, ...
The peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcription factor that has been demonstrated to regulate fat cell development and glucose homeostasis....
Vigouroux, C, Fajas, L, Khallouf, E, Meier, M, Gyapay, G, Lascols, O, ...
[Familial combined hyperlipidemia] (1997)
Martin, G, Shviro, I, Staels, B, Auwerx, J
Familial combined hyperlipidemia is a common inherited disorder characterized by a hepatic overproduction of apo B particles and an elevated risk for the development of atherosclerosis. LDL particles...
Peroxisome proliferator-activated receptors, orphans with ligands and functions. (1997)
Schoonjans, K, Martin, G, Staels, B, Auwerx, J
The three peroxisome proliferator-activated receptors (PPARs), PPAR alpha, delta and gamma, form a subfamily of the nuclear hormone receptor gene family. PPAR alpha has been shown to bind and be...
Staels, B, Schoonjans, K, Fruchart, J C, Auwerx, J
The hypolipidemic fibrates and antidiabetic thiazolidinediones display potent triglyceride-lowering activities. Studies on the molecular action mechanisms of these compounds indicate that...
Gelman, L., Staels, B., Auwerx, J.
Members of the nuclear receptor family are involved in an increasing number of processes in the cell. These receptors can directly regulate gene expression by binding to DNA. The molecular basis for...
The peroxisome proliferator activated receptors or PPARs constitute a subfamily of the nuclear hormone receptor superfamily of transcription factors. PPARs form heterodimeric complexes with the 9-cis...
Auboeuf, D, Rieusset, J, Fajas, L, Vallier, P, Frering, V, Riou, J P, ...
Members of the peroxisome proliferator-activated receptor (PPAR) family might be involved in pathologies with altered lipid metabolism. They participate in the control of the expression of genes...
The organization, promoter analysis, and expression of the human PPARgamma gene. (1997)
Fajas, L, Auboeuf, D, Raspé, E, Schoonjans, K, Lefebvre, A M, Saladin, R, ...
PPARgamma is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of the human PPARgamma cDNA and gene was determined, and its promoters and tissue-specific expression...
Frøyland, L, Madsen, L, Vaagenes, H, Totland, G K, Auwerx, J, Kryvi, H, ...
Fish oil polyunsaturated fatty acids and fibrate hypolipidemic drugs are potent hypotriglyceridemic agents that act by increasing fatty acid catabolism and decreasing triglyceride synthesis and...
Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. (1997)
Hallakou, S, Doaré, L, Foufelle, F, Kergoat, M, Guerre-Millo, M, Berthault, M F, ...
Thiazolidinediones are potent antidiabetic compounds, in both animal and human models, which act by enhancing peripheral sensitivity to insulin. Thiazolidinediones are high-affinity ligands for...
Jarvik, G P, Goode, E L, Austin, M A, Auwerx, J, Deeb, S, Schellenberg, G D, ...
We previously reported that change, with age, in plasma levels of total cholesterol (TC) and LDL cholesterol (LDL-C) differed between apolipoprotein E (APOE) genotypes epsilon 3 epsilon 3 and epsilon...
Lefebvre, A M, Peinado-Onsurbe, J, Leitersdorf, I, Briggs, M R, Paterniti, J R, Fruchart, J C, ...
Thiazolidinediones are antidiabetic agents, which not only improve glucose metabolism but also reduce blood triglyceride concentrations. These compounds are synthetic ligands for PPAR gamma, a...
Martin, G, Schoonjans, K, Lefebvre, A M, Staels, B, Auwerx, J
Intracellular fatty acid (FA) concentrations are in part determined by a regulated import/export system that is controlled by two key proteins, i.e. fatty acid transport protein (FATP) and acyl-CoA...
Peters, J M, Hennuyer, N, Staels, B, Fruchart, J C, Fievet, C, Gonzalez, F J, ...
The peroxisome proliferator-activated receptor-alpha (PPARalpha) controls gene expression in response to a diverse class of compounds collectively referred to as peroxisome proliferators. Whereas...
Transcription, adipocyte differentiation, and obesity. (1996)
Auwerx, J, Martin, G, Guerre-Millo, M, Staels, B
Differentiation of adipogenic precursor cells into mature adipocytes is a complex phenomenon, characterized by an ordered expression of adipocyte-specific genes, triggered by a set of interacting...
Auwerx, J, Schoonjans, K, Fruchart, J C, Staels, B
The development of atherosclerosis is often associated with altered concentrations of systemic lipoproteins, which are determined by the concentration and/or activity of three groups of different...
Auwerx, J, Schoonjans, K, Fruchart, J C, Staels, B
The molecular mechanism by which hypolipidemic fibrates and antidiabetic thiazolidinediones exert their hypotriglyceridemic action are discussed. Increased activity of lipoprotein lipase (LPL), a key...
PPAR tissue distribution and interactions with other hormone-signaling pathways. (1996)
Lemberger, T, Braissant, O, Juge-Aubry, C, Keller, H, Saladin, R, Staels, B, ...
Regulation of ob gene expression in rodents and humans. (1996)
Saladin, R, Staels, B, Auwerx, J, Briggs, M
The discovery of the obese gene in the mouse and its conserved homologue in humans has led to important discoveries in energy metabolism. One of the chief findings was the fact that the expression of...
Schoonjans, K, Staels, B, Auwerx, J
The three types of peroxisome proliferator activated receptor (PPAR), alpha, beta (or delta), and gamma, each with a specific tissue distribution, compose a subfamily of the nuclear hormone receptor...
Schoonjans, K, Staels, B, Auwerx, J
The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta (or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome proliferators,...
Staels, B, Van Tol, A, Fruchart, J C, Auwerx, J
Since plasma high density lipoprotein (HDL) concentrations are inversely related to the development of atherosclerosis, induction of HDL after pharmacological treatment is considered of benefit. To...
Martin, G., Staels, B., Guerre-Millo, M., Auwerx, J.
Differentiation of adipogenic precursor cells into mature adipocytes is a complex process. Adipocyte differentiation is characterized by the expression of several adipocyte-specific genes, which...
Berthou, L, Duverger, N, Emmanuel, F, Langouët, S, Auwerx, J, Guillouzo, A, ...
The regulation of liver apolipoprotein (apo) A-I gene expression by fibrates was studied in human apo A-I transgenic mice containing a human genomic DNA fragment driving apo A-I expression in liver....
Bossu, J P, Chartier, F L, Fruchart, J C, Auwerx, J, Staels, B, Laine, B
Recent reports indicate that apolipoprotein (apo) A-II, the second most abundant protein of high-density lipoproteins, plays a crucial role in counteracting the beneficial effect of apo A-I against...
Buscà, R, Martínez, M, Vilella, E, Pognonec, P, Deeb, S, Auwerx, J, ...
While the molecular characterization of lipoprotein lipase (LPL) activation is progressing, the intracellular processing, transport, and secretion signals of LPL are still poorly known. The aim of...
Lipoprotein lipase in highly vascularized structures of the eye. (1996)
Casaroli-Marano, R P, Peinado-Onsurbe, J, Reina, M, Staels, B, Auwerx, J, Vilaró, S
Ocular tissues are highly dependent on lipid turnover and metabolism, which requires an uptake mechanism for fatty acids from lipoproteins. We studied the activity and expression of lipoprotein...
De Vos, P, Lefebvre, A M, Miller, S G, Guerre-Millo, M, Wong, K, Saladin, R, ...
The ob gene product, leptin, is a signaling factor regulating body weight and energy balance. ob gene expression in rodents is increased in obesity and is regulated by feeding patterns and hormones,...
Lemberger, T, Saladin, R, Vázquez, M, Assimacopoulos, F, Staels, B, Desvergne, B, ...
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by fatty acids and peroxisome proliferators. The PPAR alpha subtype mediates the pleiotropic...
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression. (1996)
Miller, S G, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, ...
The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance. ob gene expression is increased in obese...
Sabugal, R, Robert, M Q, Julve, J, Auwerx, J, Llobera, M, Peinado-Onsurbe, J
We examined the expression of lipoprotein lipase (LPL) gene and LPL activity following a two-thirds hepatectomy and during liver regeneration. In most of the tissues studied, LPL activity increased a...
Saladin, R, Vu-Dac, N, Fruchart, J C, Auwerx, J, Staels, B
Treatment with glucocorticoids increases the concentration of plasma high-density lipoprotein (HDL), which is inversely correlated to the development of atherosclerosis. Previously, we demonstrated...
Schoonjans, K, Peinado-Onsurbe, J, Lefebvre, A M, Heyman, R A, Briggs, M, Deeb, S, ...
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of the various...
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex. (1996)
Staels, B, Martin, G, Martinez, M, Albert, C, Peinado-Onsurbe, J, Saladin, R, ...
Lipoprotein lipase (LPL), an enzyme which hydrolyzes triglycerides and participates in the catabolism of remnant lipoproteins, plays a crucial role in energy and lipid metabolism. The goal of this...
Vidal, H, Auboeuf, D, De Vos, P, Staels, B, Riou, J P, Auwerx, J, ...
The regulation of ob gene expression in abdominal subcutaneous adipose tissue was investigated using a reverse transcription-competitive PCR method to quantify the mRNA level of leptin. Leptin mRNA...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Heyman, R A, Staels, B, ...
Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids...
Apolipoprotein C-III, an important player in lipoprotein metabolism (1996)
Fruchart, J.C., Clavey, V., Luc, G., Dallongeville, J., Staels, B., Auwerx, J.
Staels, B., Saladin, R., Auwerx, J.
Despite the complex regulation of the expression of these genes, some general conclusions seem to be warranted. First, nearly all the studied genes are regulated in a tissue-specific fashion....
Aperlo, C, Pognonec, P, Saladin, R, Auwerx, J, Boulukos, K E
We have isolated a cDNA corresponding to the hamster peroxisome proliferator-activated receptor haPPAR gamma, a member of the steroid nuclear hormone receptor superfamily of transcription factors....
Berthou, L, Saladin, R, Yaqoob, P, Branellec, D, Calder, P, Fruchart, J C, ...
The regulation by fibrates and dietary fatty acids of the hepatic gene expression of apolipoproteins (apo) A-I and A-II, the major protein constituents of high-density lipoproteins, as well as of...
Buscà, R, Peinado, J, Vilella, E, Auwerx, J, Deeb, S S, Vilaró, S, ...
Lipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the catabolism of triglyceride-rich lipoprotein particles. LPL performs its hydrolytic action attached to heparan...
Buscá, R, Pujana, M A, Pognonec, P, Auwerx, J, Deeb, S S, Reina, M, ...
Lipoprotein lipase (LPL) is the enzyme responsible for the hydrolysis of plasma triglycerides from apolipoprotein C-II-containing lipoproteins at the capillary endothelium and it is synthesized in...
De Vos, P, Saladin, R, Auwerx, J, Staels, B
Genetic studies in mice have identified the ob gene product as a potential signaling factor regulating body weight homeostasis and energy balance. It is suggested that modulation of ob gene...
Transient increase in obese gene expression after food intake or insulin administration. (1995)
Saladin, R, De Vos, P, Guerre-Millo, M, Leturque, A, Girard, J, Staels, B, ...
Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have...
Schoonjans, K, Watanabe, M, Suzuki, H, Mahfoudi, A, Krey, G, Wahli, W, ...
The long-chain acyl-coenzyme A synthetase (ACS) gene gives rise to three transcripts containing different first exons preceded by specific regulatory regions A, B, and C. Exon-specific...
Staels, B, Vu-Dac, N, Kosykh, V A, Saladin, R, Fruchart, J C, Dallongeville, J, ...
Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Fruchart, J C, Staels, B, ...
In view of the evidence linking plasma high density lipoprotein (HDL)-cholesterol levels to a protective effect against coronary artery disease and the widespread use of fibrates in the treatment of...
Jarvik, G P, Austin, M A, Fabsitz, R R, Auwerx, J, Reed, T, Christian, J C, ...
This study addressed the possible influence of apolipoprotein E (apo E) genotype on age-related changes in total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG)...
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. (1994)
Lemberger, T, Staels, B, Saladin, R, Desvergne, B, Auwerx, J, Wahli, W
This study demonstrates that the expression of the peroxisome proliferator-activated receptor alpha (PPAR alpha) is regulated by glucocorticoid hormones in hepatocytes. Hydrocortisone, dexamethasone,...
Reed, T, Carmelli, D, Swan, G E, Breitner, J C, Welsh, K A, Jarvik, G P, ...
OBJECTIVE: Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 with late-onset Alzheimer dementia or multi-infarct dementia, we tested whether normal older adult men with at...
Vu-Dac, N, Schoonjans, K, Laine, B, Fruchart, J C, Auwerx, J, Staels, B
Fibrates have been reported to modulate plasma high density lipoprotein cholesterol and apolipoprotein (apo) A-I concentrations. Therefore, the molecular mechanisms underlying the regulation of human...
De Groot, R P, Auwerx, J, Bourouis, M, Sassone-Corsi, P
Transcription factor AP-1 is constituted by the products of the various fos and jun genes. AP-1 activity is modulated by second messengers and appears to involve post-translational modifications of...
Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat. (1993)
Peinado-Onsurbe, J, Staels, B, Vanderschueren, D, Bouillon, R, Auwerx, J
In humans, sex steroids have been implicated in the regulation of hepatic and lipoprotein lipase activity. Therefore, the effects of orchidectomy and subsequent androgen or estrogen administration on...
Schoonjans, K, Staels, B, Devos, P, Szpirer, J, Szpirer, C, Deeb, S, ...
The molecular mechanism underlying the extinction of lipoprotein lipase (LPL) expression in rat liver during development was investigated. A mouse (BWTG3) and a rat (7777) hepatoma, both of which...
Schoonjans, K, Staels, B, Grimaldi, P, Auwerx, J
Several enzymes of the beta-oxidation pathway have been shown to be induced after stimulation with peroxisomal proliferators, including several hypolipidemic drugs. We investigated the regulation of...
A Fos-Jun element in the first intron of an alpha 2u-globulin gene. (1993)
Van Dijck, P, Schoonjans, K, Sassone-Corsi, P, Auwerx, J, Verhoeven, G
The hepatic expression of the alpha-2u-globulin gene family is controlled by a variety of hormones including steroids, growth hormone and insulin. The mechanisms by which these hormones affect alpha...
A group of receptors termed peroxisome proliferator activated receptors (PPAR), belonging to the nuclear hormone receptor supergene family, might be crucial in explaining how a diverse group of...
Lipoprotein lipase: recent contributions from molecular biology. (1992)
Auwerx, J, Leroy, P, Schoonjans, K
Lipoprotein lipase (LPL) is a glycoprotein enzyme that is produced in several cells and tissues. LPL belongs to a large lipase gene family that includes, among others, hepatic lipase and pancreatic...
Auwerx, J, Bouillon, R, Kesteloot, H
In a survey of cardiovascular risk factors in 185 men and 173 women of a Belgian population group, an independent and highly significant positive correlation was found between the serum...
AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth. (1992)
Transcription factor AP-1 is constituted by the various products of the fos and jun proto-oncogene family members, which associate as dimers to bind with variable efficiency to 12-O-tetradecanoyl...
Auwerx, J, Staels, B, Van Vaeck, F, Ceuppens, J L
We studied changes in the three types of Fc gamma receptor (FcR) on the THP-1 human monocytic leukemia cells, after incubation with the phorbol ester, PMA, which has been shown to alter the...
Descheemaeker, K A, Wyns, S, Nelles, L, Auwerx, J, Ny, T, Collen, D
Phorbol 12-myristate 13-acetate induces a 3- and 10-fold induction of chloramphenicol acetyltransferase (CAT) activity in HT1080 and HeLa cells, respectively, following transient transfection of a...
Jansen, H, Van Tol, A, Auwerx, J, Skretting, G, Staels, B
Rats were treated with hydrocortisone, dexamethasone or triamcinolone for 4 days. The effect of treatment on hepatic lipase and lecithin:cholesterol acyltransferase (LCAT) mRNA levels and catalytic...
Peinado-Onsurbe, J, Staels, B, Deeb, S, Auwerx, J
Recently, it was shown that lipoprotein lipase (LPL) was produced in neonatal but not in adult rat liver. In an attempt to further define the mechanism involved in liver LPL expression, we identified...
Neonatal extinction of liver lipoprotein lipase expression. (1992)
Peinado-Onsurbe, J, Staels, B, Deeb, S, Ramirez, I, Llobera, M, Auwerx, J
In contrast to the complete absence of lipoprotein lipase (LPL) mRNA in adult rat liver, fetal and neonatal rat liver contain substantial amounts of LPL mRNA, which is translated in active LPL...
Liver lipoprotein lipase (LPL) and alpha-fetoprotein (AFP) gene expression show similar developmental patterns. Both mRNAs are abundantly expressed in neonatal rat liver and gradually disappear upon...
Down-regulation of hepatic lipase gene expression and activity by fenofibrate. (1992)
Staels, B, Peinado-Onsurbe, J, Auwerx, J
The influence of the hypolipidemic drug, fenofibrate, on hepatic lipase (HL) gene expression and activity was investigated in the rat. Fenofibrate treatment provoked a dose-dependent decrease in HL...
Staels, B, Van Tol, A, Andreu, T, Auwerx, J
The influence of different fibrates on apolipoprotein metabolism was investigated. Administration of fenofibrate provoked a dose-dependent decrease in plasma cholesterol concentration that was...
Staels, B, Van Tol, A, Skretting, G, Auwerx, J
Plasma lipoprotein metabolism is influenced by several factors that may act by regulating the expression of proteins involved in lipoprotein metabolism, such as lecithin:cholesterol acyltransferase...
THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1 cells differentiate into macrophage-like cells which mimic native monocyte-derived macrophages in several...
IP-1: a dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation. (1991)
Transcription factor AP-1 is inducible by phorbol esters and thus could be considered to be one final target of the protein kinase C signal transduction pathway. AP-1 consists of the products of the...
Activation of junB by PKC and PKA signal transduction through a novel cis-acting element. (1991)
De Groot, R P, Auwerx, J, Karperien, M, Staels, B, Kruijer, W
The product of the junB gene, a gene homologous to the proto-oncogene c-jun, is a component of transcription factor AP-1. JunB expression is modulated by a wide variety of extracellular stimuli, such...
Demacker, P N, Staels, B, Stalenhoef, A F, Auwerx, J
The mechanism by which ethinyl estradiol (EE) decreases the concentration of lipids in the d less than 1.019 g/ml fraction (beta-very low density lipoprotein [beta-VLDL]) of homozygous Watanabe...
Staels, B, Van Tol, A, Chan, L, Verhoeven, G, Auwerx, J
Treatment of male rats with hydrocortisone provoked a dose- and time-dependent decrease in plasma cholesterol concentration without a change in plasma triglyceride levels. In contrast, administration...
The effects of probucol on lipoprotein metabolism in the rat. (1991)
Staels, B, Van Tol, A, Jansen, H, Auwerx, J
The effects of probucol on liver and intestinal apolipoprotein, LDL-receptor and hepatic lipase gene expression, as well as plasma lipid and apolipoprotein levels and liver lipase activity were...
Van Ranst, M, Norga, K, Masure, S, Proost, P, Vandekerckhove, F, Auwerx, J, ...
The induction of proteolytic enzymes is an important mechanism in the migration of monocytes into tissues and body fluids. The monocytic cell line THP-1 was used as a model system to study the...
Auwerx, J, Staels, B, Sassone-Corsi, P
The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the...
Naranjo, J R, Mellström, B, Auwerx, J, Mollinedo, F, Sassone-Corsi, P
Induction of PC12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor (NGF) is accompanied by a coupled stimulation of c-fos and c-jun oncogene transcription. We...
Staels, B, Jansen, H, Van Tol, A, Stahnke, G, Will, H, Verhoeven, G, ...
The influence of development and ethinylestradiol on low density lipoprotein (LDL)-receptor mRNA and hepatic triglyceride lipase (HTGL) activity and mRNA levels was studied in rat liver and...
Staels, B, Van Tol, A, Chan, L, Will, H, Verhoeven, G, Auwerx, J
The influence of altered thyroid state is investigated on plasma apolipoprotein-A-I (apo-A-I), apo-B, and apo-E levels and on apo-A-I, apo-A-II, apo-B, apo-E, hepatic triglyceride lipase (HTGL), and...
Staels, B, Van Tol, A, Verhoeven, G, Auwerx, J
The influence of development and estrogen, thyroid hormone, corticosteroid, and fibrate administration on apolipoprotein (apo) A-IV mRNA levels in the liver and intestine and on serum or plasma...
Staels, B, Auwerx, J, Chan, L, Van Tol, A, Rosseneu, M, Verhoeven, G
The influence of development and ethinylestradiol (EE) on apolipoprotein (apo) A-I, A-II, and E mRNA in rat liver and intestine was studied by dot blot hybridization and Northern blot analysis....
Auwerx, J, Bouillon, R, Collen, D, Geboers, J
Parameters of fibrinolysis, including euglobulin fibrinolytic activity, tissue-type plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PA-inhibitor) activity, and plasmin-alpha...
Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus. (1988)
Auwerx, J, Dequeker, J, Bouillon, R, Geusens, P, Nijs, J
Bone mineral content (BMC), mineral homeostasis, and diabetes control were evaluated in 31 Caucasian insulin-dependent diabetic patients (disease duration 18.3 +/- 7.7 yr, mean +/- SD) with normal...
Mineral and bone metabolism in thyroid disease: a review. (1986)
This review discusses the abnormalities in bone and mineral metabolism encountered in thyroid disorders. Thyroid hormones probably stimulate bone resorption directly, thereby increasing serum calcium...
Decreased free 1,25-dihydroxycholecalciferol index in patients with the nephrotic syndrome. (1986)
Auwerx, J, De Keyser, L, Bouillon, R, De Moor, P
The serum concentrations of calcium, phosphorus, parathyroid hormone, vitamin D3 metabolites and their transport protein (DBP) were measured in 18 patients with the nephrotic syndrome (mean daily...
Pancreatic secretion in man with subclinical vitamin D deficiency. (1986)
Nyomba, B L, Auwerx, J, Bormans, V, Peeters, T L, Pelemans, W, Reynaert, J, ...
The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic...
Mineral and Bone Metabolism in Thyroid Disease: A Review (1986)
This review discusses the abnormalities in bone and mineral metabolism encountered in thyroid disorders. Thyroid hormones probably stimulate bone resorption directly, thereby increasing serum calcium...
Auwerx, J, Boogaerts, M, Ceuppens, J L, Demedts, M
An extensive in vitro investigation of the host defence system was performed in 11 sibs of a large kindred with unexplained combination of familial hypocalciuric hypercalcaemia (FHH), interstitial...
Auwerx, J, Demedts, M, Bouillon, R, Desmet, J
In a prospective investigation, a large kindred (twenty-one subjects) with unexplained association of familial hypocalciuric hypercalcaemia and idiopathic interstitial lung disease was studied. Serum...
Demedts, M, Auwerx, J, Goddeeris, P, Bouillon, R, Gyselen, A, Lauweryns, J
The history and pulmonary histopathology of 3 siblings, presenting with the association of idiopathic interstitial lung disease, hypocalciuric hypercalcemia, and an intrinsic defect in granulocyte...
Cobalt-induced bronchial asthma in diamond polishers. (1985)
Gheysens, B, Auwerx, J, Demedts, M
Three diamond workers had occupational asthma attributed to the inhalation of cobalt powder. The exposure originated from high speed polishing disks with an abrasive consisting of microdiamonds...
Altered parathyroid set point to calcium in familial hypocalciuric hypercalcaemia. (1984)
Auwerx, J, Demedts, M, Bouillon, R
Changes in calcium concentration were induced by an infusion of disodium-EDTA or calcium in 2 members of a family suffering from hypocalciuric hypercalcaemia ( FHH ) associated with interstitial lung...
Serum vitamin D metabolites and their binding protein in patients with liver cirrhosis. (1984)
Bouillon, R, Auwerx, J, Dekeyser, L, Fevery, J, Lissens, W, De Moor, P
Serum parameters of calcium metabolism were measured in 32 consecutive patients with biopsy-proven cirrhosis due to either hepatitis (n = 13), alcohol abuse (n = 11), Wilson's disease (n = 3), or...
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
Miller, S G, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, ...
The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance. ob gene expression is increased in obese...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Fruchart, J C, Staels, B, ...
In view of the evidence linking plasma high density lipoprotein (HDL)-cholesterol levels to a protective effect against coronary artery disease and the widespread use of fibrates in the treatment of...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Heyman, R A, Staels, B, ...
Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids...
Staels, B, Vu-Dac, N, Kosykh, V A, Saladin, R, Fruchart, J C, Dallongeville, J, ...
Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was...
Auwerx, J, Staels, B, Sassone-Corsi, P
The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the...
Naranjo, J R, Mellström, B, Auwerx, J, Mollinedo, F, Sassone-Corsi, P
Induction of PC12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor (NGF) is accompanied by a coupled stimulation of c-fos and c-jun oncogene transcription. We...
Activation of junB by PKC and PKA signal transduction through a novel cis-acting element.
De Groot, R P, Auwerx, J, Karperien, M, Staels, B, Kruijer, W
The product of the junB gene, a gene homologous to the proto-oncogene c-jun, is a component of transcription factor AP-1. JunB expression is modulated by a wide variety of extracellular stimuli, such...
Schoonjans, K, Peinado-Onsurbe, J, Lefebvre, A M, Heyman, R A, Briggs, M, Deeb, S, ...
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of the various...
Berthou, L, Duverger, N, Emmanuel, F, Langouët, S, Auwerx, J, Guillouzo, A, ...
The regulation of liver apolipoprotein (apo) A-I gene expression by fibrates was studied in human apo A-I transgenic mice containing a human genomic DNA fragment driving apo A-I expression in liver....
Vidal, H, Auboeuf, D, De Vos, P, Staels, B, Riou, J P, Auwerx, J, ...
The regulation of ob gene expression in abdominal subcutaneous adipose tissue was investigated using a reverse transcription-competitive PCR method to quantify the mRNA level of leptin. Leptin mRNA...
De Vos, P, Lefebvre, A M, Miller, S G, Guerre-Millo, M, Wong, K, Saladin, R, ...
The ob gene product, leptin, is a signaling factor regulating body weight and energy balance. ob gene expression in rodents is increased in obesity and is regulated by feeding patterns and hormones,...
Bossu, J P, Chartier, F L, Fruchart, J C, Auwerx, J, Staels, B, Laine, B
Recent reports indicate that apolipoprotein (apo) A-II, the second most abundant protein of high-density lipoproteins, plays a crucial role in counteracting the beneficial effect of apo A-I against...
Sabugal, R, Robert, M Q, Julve, J, Auwerx, J, Llobera, M, Peinado-Onsurbe, J
We examined the expression of lipoprotein lipase (LPL) gene and LPL activity following a two-thirds hepatectomy and during liver regeneration. In most of the tissues studied, LPL activity increased a...
Jarvik, G P, Goode, E L, Austin, M A, Auwerx, J, Deeb, S, Schellenberg, G D, ...
We previously reported that change, with age, in plasma levels of total cholesterol (TC) and LDL cholesterol (LDL-C) differed between apolipoprotein E (APOE) genotypes epsilon 3 epsilon 3 and epsilon...
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
Miller, S G, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, ...
The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance. ob gene expression is increased in obese...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Fruchart, J C, Staels, B, ...
In view of the evidence linking plasma high density lipoprotein (HDL)-cholesterol levels to a protective effect against coronary artery disease and the widespread use of fibrates in the treatment of...
Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Heyman, R A, Staels, B, ...
Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids...
Staels, B, Vu-Dac, N, Kosykh, V A, Saladin, R, Fruchart, J C, Dallongeville, J, ...
Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was...
Auwerx, J, Staels, B, Sassone-Corsi, P
The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the...
Naranjo, J R, Mellström, B, Auwerx, J, Mollinedo, F, Sassone-Corsi, P
Induction of PC12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor (NGF) is accompanied by a coupled stimulation of c-fos and c-jun oncogene transcription. We...
Activation of junB by PKC and PKA signal transduction through a novel cis-acting element.
De Groot, R P, Auwerx, J, Karperien, M, Staels, B, Kruijer, W
The product of the junB gene, a gene homologous to the proto-oncogene c-jun, is a component of transcription factor AP-1. JunB expression is modulated by a wide variety of extracellular stimuli, such...
Schoonjans, K, Peinado-Onsurbe, J, Lefebvre, A M, Heyman, R A, Briggs, M, Deeb, S, ...
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of the various...
Berthou, L, Duverger, N, Emmanuel, F, Langouët, S, Auwerx, J, Guillouzo, A, ...
The regulation of liver apolipoprotein (apo) A-I gene expression by fibrates was studied in human apo A-I transgenic mice containing a human genomic DNA fragment driving apo A-I expression in liver....
Vidal, H, Auboeuf, D, De Vos, P, Staels, B, Riou, J P, Auwerx, J, ...
The regulation of ob gene expression in abdominal subcutaneous adipose tissue was investigated using a reverse transcription-competitive PCR method to quantify the mRNA level of leptin. Leptin mRNA...
De Vos, P, Lefebvre, A M, Miller, S G, Guerre-Millo, M, Wong, K, Saladin, R, ...
The ob gene product, leptin, is a signaling factor regulating body weight and energy balance. ob gene expression in rodents is increased in obesity and is regulated by feeding patterns and hormones,...
Bossu, J P, Chartier, F L, Fruchart, J C, Auwerx, J, Staels, B, Laine, B
Recent reports indicate that apolipoprotein (apo) A-II, the second most abundant protein of high-density lipoproteins, plays a crucial role in counteracting the beneficial effect of apo A-I against...
Sabugal, R, Robert, M Q, Julve, J, Auwerx, J, Llobera, M, Peinado-Onsurbe, J
We examined the expression of lipoprotein lipase (LPL) gene and LPL activity following a two-thirds hepatectomy and during liver regeneration. In most of the tissues studied, LPL activity increased a...
Jarvik, G P, Goode, E L, Austin, M A, Auwerx, J, Deeb, S, Schellenberg, G D, ...
We previously reported that change, with age, in plasma levels of total cholesterol (TC) and LDL cholesterol (LDL-C) differed between apolipoprotein E (APOE) genotypes epsilon 3 epsilon 3 and epsilon...
Auwerx, J, Boogaerts, M, Ceuppens, J L, Demedts, M
An extensive in vitro investigation of the host defence system was performed in 11 sibs of a large kindred with unexplained combination of familial hypocalciuric hypercalcaemia (FHH), interstitial...