Research in Space Photogrammetry. (2005)
Axelrod,J., Ludwig,R., Nathan,Alan M.
This report gives the results of a study program to design experiments in atmospheric optics. The proposed program will provide a scientific study of those parameters of terrain and atmosphere which...
Octopamine: Presence in Single Neurons of Aplysia Suggests Neurotransmitter Function. (2002)
Saavedra,J. M., Brownstein,M. J., Carpenter,D. O., Axelrod,J.
Octopamine has been identified and measured in individual neurons (L7, L11, R14) from Aplysia californica. Neither dopamine nor norepinephrine was detected in these cells. Thus, in Aplysia, there may...
Coexistence of Several Putative Neurotransmitters in Single Identified Neurons of 'Aplysia'. (2002)
Brownstein,M. J., Saavedra,J. M., Axelrod,J., Zeman,G. H., Carpenter,D. O.
Recently very sensitive enzymatic assays have been developed for several neurotransmitters and putative transmitters which make it possible to assay these substances in single nerve cells of Aplysia....
Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Hampson, A. J., Grimaldi, M., Axelrod, J., Wink, D.
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate...
Collin, C, Devane, W A, Dahl, D, Lee, C J, Axelrod, J, Alkon, D L
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic...
Anandamide, an endogenous eicosanoid derivative (arachidonoylethanolamide), binds to the cannabinoid receptor, a member of the G protein-coupled superfamily. It also inhibits both adenylate cyclase...
Felder, C C, Briley, E M, Axelrod, J, Simpson, J T, Mackie, K, Devane, W A
Arachidonylethanolamide (anandamide), a candidate endogenous cannabinoid ligand, has recently been isolated from porcine brain and displayed cannabinoid-like binding activity to synaptosomal membrane...
Felder, C C, Williams, H L, Axelrod, J
ATP is copackaged and coreleased with adrenergic, serotonergic, and cholinergic neurotransmitters, suggesting a possible interaction between the signaling pathways for ATP and these coreleased...
Felder, C C, Kanterman, R Y, Ma, A L, Axelrod, J
Serotonin (5-HT) stimulated the release of arachidonic acid in hippocampal neurons cocultured with glial cells but not in glial cultures alone. Similar results were observed for the 5-HT-stimulated...
Făgărăşan, M O, Bishop, J F, Rinaudo, M S, Axelrod, J
Previous work has shown that prolonged pretreatment of a mouse anterior pituitary cell line, AtT-20 cells, with the cytokine interleukin 1 (IL-1) stimulates beta-endorphin release and potentiates the...
Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells.
Făgărăsan, M O, Aiello, F, Muegge, K, Durum, S, Axelrod, J
Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates beta-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior...
Nag, D K, Koonce, M P, Axelrod, J
During meiosis, a diploid cell undergoes two rounds of nuclear division following one round of DNA replication to produce four haploid gametes. In yeast, haploid meiotic products are packaged into...
Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.
Burch, R M, Connor, J R, Axelrod, J
Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner. Enhanced prostaglandin E2...
Conklin, B R, Brann, M R, Buckley, N J, Ma, A L, Bonner, T I, Axelrod, J
A family of genes encoding four distinct muscarinic receptors (designated m1-m4) has been cloned and stably expressed in A9 L cells. When the m1 and m3 receptors were stimulated with carbachol, there...
Făgăraşan, M O, Eskay, R, Axelrod, J
Previous work has shown that corticotropin releasing factor, vasoactive intestinal peptide, phorbol ester, and forskolin cause the secretion of adrenocorticotropic hormone and beta-endorphin from the...
In Swiss 3T3 fibroblasts bradykinin stimulated inositol phosphate (InsP) formation and prostaglandin E2 (PGE2) synthesis. The EC50 values for stimulation of PGE2 synthesis and InsP formation by...
In the rod outer segments (ROS) of bovine retina, light activation of phospholipase A2 has been shown to occur by a transducin-dependent mechanism. In this report, the transducin-mediated stimulation...
Hirata, F, Del Carmine, R, Nelson, C A, Axelrod, J, Schiffmann, E, Warabi, A, ...
The activity of phospholipase inhibitory protein, lipomodulin, partially purified from rabbit neutrophils, was markedly decreased after treatment with sera from patients with rheumatic diseases such...
Hoffman, T, Hirata, F, Bougnoux, P, Fraser, B A, Goldfarb, R H, Herberman, R B, ...
The role of phospholipid methylation and phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) in natural killer (NK) function by human peripheral blood mononuclear cells was studied....
Localization of triiodothyronine in nerve ending fractions of rat brain.
Dratman, M B, Crutchfield, F L, Axelrod, J, Colburn, R W, Thoa, N
Radioactive triiodothyronine reaching the rat brain after intravenous administration is rapidly and selectively taken up in the nerve ending fraction. A concentration gradient of radioactivity from...
Hook, V Y, Heisler, S, Axelrod, J
The 41-residue synthetic ovine corticotropin-releasing factor (CRF; corticoliberin) has been shown to stimulate release of corticotropin (adrenocorticotropic hormone; ACTH) and beta-endorphin from...
Heisler, S, Reisine, T D, Hook, V Y, Axelrod, J
The AtT-20/D16-16 mouse pituitary tumor cell secretes corticotropin (ACTH) in response to corticotropin-releasing factor (CRF), (-)-isoproterenol, and vasoactive intestinal peptide (VIP). These...
Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis.
Hirata, F, Toyoshima, S, Axelrod, J, Waxdal, M J
Phospholipid methylation in murine T lymphocytes but not B cells was stimulated by mitogenic lectins such as concanavalin A and phytohemagglutinin, and the methylation was then returned to the...
Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.
Mallorga, P, Tallman, J F, Henneberry, R C, Hirata, F, Strittmatter, W T, Axelrod, J
C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent...
Ishizaka, T, Hirata, F, Ishizaka, K, Axelrod, J
Normal rat mast cells were stimulated by antibodies against IgE receptors (anti-RBL) or by anti-IgE, and [3H]methyl group incorporation into phospholipids, 45Ca uptake, and histamine release were...
McGivney, A, Crews, F T, Hirata, F, Axelrod, J, Siraganian, R P
Variants of the rat basophilic leukemia (RBL) cell line were isolated and screened for phospholipid methyltransferase I and II activities, enzymes that convert phosphatidylethanolamine to...
A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.
Hirata, F, Schiffmann, E, Venkatasubramanian, K, Salomon, D, Axelrod, J
When rabbit peritoneal neutrophils were treated with glucocorticoids, their chemotactic response to stimulation by the chemoattractant fMet-Leu-Phe was markedly reduced. Preincubation of cells with...
Hirata, F, Strittmatter, W J, Axelrod, J
The beta-adrenergic agonist L-isoproterenol stimulated the enzymic synthesis of phosphatidyl-N-monomethylethanolamine and phosphatidylcholine in rat reticulocyte ghosts containing the methyl donor...
Hirata, F, Corcoran, B A, Venkatasubramanian, K, Schiffmann, E, Axelrod, J
When rabbit peritoneal leukocytes were treated with chemoattractants such as fMet-Leu-Phe, an apparent decrease of [3H]methyl incorporation into the lipid fraction from L-[methyl-3H]methionine was...
Burch, R M, Luini, A, Axelrod, J
In FRTL5 rat thyroid cells, norepinephrine, by interacting with alpha 1-adrenergic receptors, stimulates inositol phosphate formation, through activation of phospholipase C, and arachidonic acid...
Mezey, E, Reisine, T D, Palkovits, M, Brownstein, M J, Axelrod, J
Previous work in our laboratory has shown that stimulation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells causes the secretion of immunoreactive adrenocorticotropin (ACTH)....
Luini, A, Lewis, D, Guild, S, Corda, D, Axelrod, J
Corticotropin (ACTH)-releasing factor, vasoactive intestinal peptide, and catecholamines--hormones that stimulate ACTH secretion and cAMP generation--increased cytosolic calcium in AtT-20 cells. The...
Hirata, F, Viveros, O H, Diliberto, E J, Axelrod, J
Two methyltransferases involved in the methylation of phosphatidylethanolamine to form phosphatidylcholine were demonstrated in a microsomal fraction of bovine adrenal medulla. The first...
The synthesis of phosphatidylcholine from phosphatidylethanolamine is carried out by two methyltransferases in erythrocyte membranes. The first enzyme uses phosphatidylethanolamine as a substrate,...
Bareis, D L, Manganiello, V C, Hirata, F, Vaughan, M, Axelrod, J
The biochemical events that lead to bradykinin stimulation of cAMP accumulation in human fibroblasts were examined. Treatment of human fibroblasts with bradykinin increases phospholipid methylation,...
A mouse pituitary tumor cell line (AtT-20) releases corticotropin (ACTH) in response to a number of secretagogues, including corticotropin-releasing factor (CRF), beta-adrenergic agents,...
Hirata, F, Axelrod, J, Crews, F T
When histamine release from rat peritoneal mast cells is stimulated by concanavalin A, membrane phospholipids are methylated in the early stage of this process. Exogenously added phosphatidylserine...
Diliberto, D J, Veiveros, O H, Axelrod, J
Protein carboxymethylase (S-adenosyl-L-methionine:protein O-methyltransferase, EC 2.1.1.24) transfers a methyl group from S-adenoxyl-L-methionine to carboxyl side chains of proteins to form labile...
Schaeffer, J M, Brownstein, M J, Axelrod, J
Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and...
Regulation of sensitivity to beta-adrenergic stimulation in induction of pineal N-acetyltransferase.
Stimulation by isoproterenol causes large increases in the activity of rat pineal N-acetyltransferase (arylamine acetyltransferase or acetyl-CoA:arylamine N-acetyltransferase, EC 2.3.1.5) after a...
Romero, J A, Zatz, M, Axelrod, J
The lag period in the induction of rat pineal N-acetyltransferase (arylamine acetyltransferase or acetyl-CoA:arylamine N-acetyltransferase EC 2.3.1.5) by catecholamines via the beta-adrenergic...
Kebabian, J W, Zatz, M, Romero, J A, Axelrod, J
The properties of the beta-adrenergic receptor which regulates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)8 EC 4.6.1.1] in the pineal gland are similar to the properties of the sites which...
Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Hampson, A. J., Grimaldi, M., Axelrod, J., Wink, D.
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate...
Collin, C, Devane, W A, Dahl, D, Lee, C J, Axelrod, J, Alkon, D L
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic...
Anandamide, an endogenous eicosanoid derivative (arachidonoylethanolamide), binds to the cannabinoid receptor, a member of the G protein-coupled superfamily. It also inhibits both adenylate cyclase...
Felder, C C, Briley, E M, Axelrod, J, Simpson, J T, Mackie, K, Devane, W A
Arachidonylethanolamide (anandamide), a candidate endogenous cannabinoid ligand, has recently been isolated from porcine brain and displayed cannabinoid-like binding activity to synaptosomal membrane...
Felder, C C, Williams, H L, Axelrod, J
ATP is copackaged and coreleased with adrenergic, serotonergic, and cholinergic neurotransmitters, suggesting a possible interaction between the signaling pathways for ATP and these coreleased...
Felder, C C, Kanterman, R Y, Ma, A L, Axelrod, J
Serotonin (5-HT) stimulated the release of arachidonic acid in hippocampal neurons cocultured with glial cells but not in glial cultures alone. Similar results were observed for the 5-HT-stimulated...
Făgărăşan, M O, Bishop, J F, Rinaudo, M S, Axelrod, J
Previous work has shown that prolonged pretreatment of a mouse anterior pituitary cell line, AtT-20 cells, with the cytokine interleukin 1 (IL-1) stimulates beta-endorphin release and potentiates the...
Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells.
Făgărăsan, M O, Aiello, F, Muegge, K, Durum, S, Axelrod, J
Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates beta-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior...
Nag, D K, Koonce, M P, Axelrod, J
During meiosis, a diploid cell undergoes two rounds of nuclear division following one round of DNA replication to produce four haploid gametes. In yeast, haploid meiotic products are packaged into...
Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.
Burch, R M, Connor, J R, Axelrod, J
Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner. Enhanced prostaglandin E2...
Conklin, B R, Brann, M R, Buckley, N J, Ma, A L, Bonner, T I, Axelrod, J
A family of genes encoding four distinct muscarinic receptors (designated m1-m4) has been cloned and stably expressed in A9 L cells. When the m1 and m3 receptors were stimulated with carbachol, there...
Făgăraşan, M O, Eskay, R, Axelrod, J
Previous work has shown that corticotropin releasing factor, vasoactive intestinal peptide, phorbol ester, and forskolin cause the secretion of adrenocorticotropic hormone and beta-endorphin from the...
In Swiss 3T3 fibroblasts bradykinin stimulated inositol phosphate (InsP) formation and prostaglandin E2 (PGE2) synthesis. The EC50 values for stimulation of PGE2 synthesis and InsP formation by...
In the rod outer segments (ROS) of bovine retina, light activation of phospholipase A2 has been shown to occur by a transducin-dependent mechanism. In this report, the transducin-mediated stimulation...
Hirata, F, Del Carmine, R, Nelson, C A, Axelrod, J, Schiffmann, E, Warabi, A, ...
The activity of phospholipase inhibitory protein, lipomodulin, partially purified from rabbit neutrophils, was markedly decreased after treatment with sera from patients with rheumatic diseases such...
Hoffman, T, Hirata, F, Bougnoux, P, Fraser, B A, Goldfarb, R H, Herberman, R B, ...
The role of phospholipid methylation and phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) in natural killer (NK) function by human peripheral blood mononuclear cells was studied....
Localization of triiodothyronine in nerve ending fractions of rat brain.
Dratman, M B, Crutchfield, F L, Axelrod, J, Colburn, R W, Thoa, N
Radioactive triiodothyronine reaching the rat brain after intravenous administration is rapidly and selectively taken up in the nerve ending fraction. A concentration gradient of radioactivity from...
Hook, V Y, Heisler, S, Axelrod, J
The 41-residue synthetic ovine corticotropin-releasing factor (CRF; corticoliberin) has been shown to stimulate release of corticotropin (adrenocorticotropic hormone; ACTH) and beta-endorphin from...
Heisler, S, Reisine, T D, Hook, V Y, Axelrod, J
The AtT-20/D16-16 mouse pituitary tumor cell secretes corticotropin (ACTH) in response to corticotropin-releasing factor (CRF), (-)-isoproterenol, and vasoactive intestinal peptide (VIP). These...
Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis.
Hirata, F, Toyoshima, S, Axelrod, J, Waxdal, M J
Phospholipid methylation in murine T lymphocytes but not B cells was stimulated by mitogenic lectins such as concanavalin A and phytohemagglutinin, and the methylation was then returned to the...
Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.
Mallorga, P, Tallman, J F, Henneberry, R C, Hirata, F, Strittmatter, W T, Axelrod, J
C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent...
Ishizaka, T, Hirata, F, Ishizaka, K, Axelrod, J
Normal rat mast cells were stimulated by antibodies against IgE receptors (anti-RBL) or by anti-IgE, and [3H]methyl group incorporation into phospholipids, 45Ca uptake, and histamine release were...