under a Creative Commons License. Atmospheric Chemistry and Physics Discussions (2009)
E. J. Jensen, L. Pfister, T. V. Bui, P. Lawson, B. Baker, Q. Mo, ...
Formation of large (�100 µm) ice crystals near the tropical tropopause
St. Clair, J. M., Hanisco, T. F., Weinstock, E. M., Moyer, E. J., Sayres, D. S., Keutsch, F. N., ...
We present a new instrument, Hoxotope, for the in situ measurement of H2O and its heavy deuterium isotopologue (HDO) in the upper troposphere and lower stratosphere aboard the NASA WB-57. Sensitive...
Formation of large (?100 ?m) ice crystals near the tropical tropopause (2008)
Jensen, E. J., Pfister, L., Bui, T. V., Lawson, P., Baker, B., Mo, Q., ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (?100 ?m length), thin (aspect ratios of ?6:1 or larger) hexagonal plate ice...
Formation of large (?100 ?m) ice crystals near the tropical tropopause (2008)
Jensen, E. J., Pfister, L., Bui, T. V., Lawson, P., Baker, B., Mo, Q., ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (?100 ?m length), thin (aspect ratios of ?6:1 or larger) hexagonal plate ice...
Formation of large (≃100 μm) ice crystals near the tropical tropopause (2008)
E. J. Jensen, L. Pfister, T. V. Bui, P. Lawson, B. Baker, Q. Mo, ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (≃100 μm length), thin (aspect ratios of ≃6:1 or larger)...
E. J. Jensen, L. Pfister, T. V. Bui, P. Lawson, B. Baker, Q. Mo, ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (≃100 μm length), thin (aspect ratios of ≃6:1 or larger) hexagonal plate...
Formation of large (≃100 μm) ice crystals near the tropical tropopause (2008)
E. J. Jensen, L. Pfister, T. V. Bui, P. Lawson, B. Baker, Q. Mo, ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (≃100 μm length), thin (aspect ratios of ≃6:1 or larger)...
Gensch, I.V., Bunz, H., Baumgardner, D.G., Christensen, L.E., Fahey, D.W., Herman, R.L., ...
Environmental Research Letters, 3(2008) S.035003/1-9
Condensed-phase nitric acid in a tropical subvisible cirrus cloud (2007)
Popp, P. J., Marcy, T. P., Watts, L. A., Gao, R. S., Fahey, D. W., Weinstock, E. M., ...
In situ observations in a tropical subvisible cirrus cloud during the Costa Rica Aura Validation Experiment on 2 February 2006 show the presence of condensed-phase nitric acid. The cloud was observed...
Formation of large (?100 ?m) ice crystals near the tropical tropopause (2007)
Jensen, E. J., Pfister, L., Bui, T. V., Lawson, P., Baker, B., Mo, Q., ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (?100 ?m length), thin (aspect ratios of ?6:1 or larger) hexagonal plate ice...
Formation of large (?100 ?m) ice crystals near the tropical tropopause (2007)
Jensen, E. J., Pfister, L., Bui, T. V., Lawson, P., Baker, B., Mo, Q., ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (?100 ?m length), thin (aspect ratios of ?6:1 or larger) hexagonal plate ice...
Formation of large (≃100 μm) ice crystals near the tropical tropopause (2007)
E. J. Jensen, L. Pfister, T. V. Bui, P. Lawson, B. Baker, Q. Mo, ...
Recent high-altitude aircraft measurements with in situ imaging instruments indicated the presence of relatively large (≃100 μm length), thin (aspect ratios of ≃6:1 or larger)...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2006)
P. J. Popp, T. P. Marcy, E. J. Jensen, B. Kärcher, D. W. Fahey, R. S. Gao, ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2006)
Popp, P.J., Marcy, T.P., Jensen, E.J., Kärcher, B., Fahey, D.W., Gao, R.S., ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2006)
Popp, P. J., Marcy, T. P., Jensen, E. J., Kärcher, B., Fahey, D. W., Gao, R. S., ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2006)
Popp, P. J., Marcy, T. P., Jensen, E. J., Kärcher, B., Fahey, D. W., Gao, R. S., ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
John Henry Smith was an LDS Church apostle and father of church president George Albert Smith. He also served as president of Utah's Constitutional Convention in 1895.
John Henry Smith was an LDS Church apostle and father of church president George Albert Smith. He also served as president of Utah's Constitutional Convention in 1895.
E. J. Jensen, J. B. Smith, L. Pfister, J. V. Pittman, E. M. Weinstock, D. S. Sayres, ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
FIRE TESTS OF TWO REMOTE AREA FIRE SUPPRESSION SYSTEM CONCEPTS. (2005)
Two packaged, self-contained fire suppression systems were fire tested to determine which would best meet the remote area fire protection needs. Results of 31 tests indicate that the multi-cycle,...
Smith, J. B., Cousins, E. W., Slicer, J. S., Miller, M. J.
Five packaged, self-contained fire suppression systems were devised after a comprehensive review of pertinent material. Eighty-one references are attached. The two most promising concepts, as...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2005)
Popp, P. J., Marcy, T. P., Jensen, E. J., Kärcher, B., Fahey, D. W., Gao, R. S., ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
Jensen, E. J., Smith, J. B., Pfister, L., Pittman, J. V., Weinstock, E. M., Sayres, D. S., ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
The observation of nitric acid-containing particles in the tropical lower stratosphere (2005)
Popp, P. J., Marcy, T. P., Jensen, E. J., Kärcher, B., Fahey, D. W., Gao, R. S., ...
Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the tropical lower stratosphere. These...
Jensen, E. J., Smith, J. B., Pfister, L., Pittman, J. V., Weinstock, E. M., Sayres, D. S., ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
Nitric Acid Uptake on Subtropical Cirrus Cloud Particles (2004)
Popp, P.J., Gao, R.S., Marcy, T.P., Fahey, D.W., Hudson, P.K., Thompson, T.L., ...
FIRE HAZARD TO FALLOUT SHELTER OCCUPANTS: A CLASSIFICATION GUIDE (2004)
Smith, J. B., Cousins, E. W., Newman, R. M.
This classification guide was prepared for the use of architects and engineers. The guide was field-tested by several architects and a consulting engineer. Trial surveys were made at existing...
Jensen, E., Smith, J. B., Pfister, L., Pitman, J. V., Weinstock, E. M., Sayres, D. S., ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
Jensen, E., Smith, J. B., Pfister, L., Pitman, J. V., Weinstock, E. M., Sayres, D. S., ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
E. Jensen, J. B. Smith, L. Pfister, J. V. Pitman, E. M. Weinstock, D. S. Sayres, ...
Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to...
Vulnerability to climate change and reasons for concern: a synthesis (2001)
Smith, J.B., Schellnhuber, H.J., Fankhauser, S., Leemans, R., Erda, L., ...
Low Cost 2-D Heatshield Materials (2000)
Burns, Robert L., Smith, J. B., Dara, P.
Heatshield materials were manufactured using braided and prepregged rubber-modified-silica-phenolic (RMSP) tapes as opposed to bias-cut broad-goods. This program demonstrated the manufacturing...
ASSEMBLY OF PORTABLE MAINTENANCE PLATFORM (7-97000), (1998)
The purpose of the field test procedure is to provide instructions for positioning and securing the Portable Maintenance Platform Assembly, Drawing No. 7-97000, and four contour curved ladders, with...
Morphodynamics and Stratigraphy of Essex River EBB-Tidal Delta: Massachusetts. (1998)
The Essex River Inlet ebb-tidal delta system is a well-formed delta along a barrier island chain in the Merrimack Embayment. Sediments comprising this barrier island chain have been supplied...
Literature Review on the Geologic Aspects of Inner Shelf Cross-Shore Sediment Transport. (1998)
This report reviews literature concerning the geological aspects of inner continental shelf physical processes, sediment transport, and stratigraphy. Although surf zone and nearshore processes and...
Parson, Larry E., Smith, J. B.
The accurate representation of native beach characteristics is essential to understanding the behavior of coastal areas in response to coastal structures and erosion mitigation projects. The...
Stauble, Donald K., Wise, Randall A., Smith, J. B.
The first National Shoreline Erosion Control Development and Demonstration project is located at Cape May Point, NJ, the southernmost beach along the New Jersey coast. This site was selected to...
Liselotte: Rauschenblattenknecht (1996)
Brooks, William, Goodbody, Axel, Smith, J. B., Yarrow, P. J.
Architecture of the Artifact-Based Collaboration System Matrix (1992)
Jeffay Lin, J. K. Lin, J. Menges, F. D. Smith, J. B. Smith
The UNC Collaboratory project is concerned with both the process of collaboration and with computer systems to support that process. Here, we describe a component of the Artifact-Based Collaboration...
PLASMA CORTISOL CONCENTRATIONS DURING CAESAREAN SECTION (1980)
NAMBA, Y., SMITH, J. B., FOX, G. S., CHALLIS, J. R. G.
The effects of extradural and general anaesthesia on the adrenocortical response to elective or emergency Caesarean section were studied in 72 patients. Maternal plasma concentrations of cortisol...
The geography and industries of Lawrence County, South Dakota / (1946)
Thesis (M.A.)--Colorado State College of Education, Dept. of Geography, 1946.
Lefer, A M, Stahl, G L, Lefer, D J, Brezinski, M E, Nicolaou, K C, Veale, C A, ...
Lipoxins A4 (LxA4) and B4 (LxB4), two lipoxygenase-generated icosanoids of arachidonic acid metabolism, were found to have a distinct biological profile. Both LxA4 and LxB4 slowly contracted...
Formation of Prostaglandins during the Aggregation of Human Blood Platelets
Smith, J. B., Ingerman, Carol, Kocsis, J. J., Silver, M. J.
Prostaglandins E2 and F2α were formed in response to ADP, L-epinephrine, or collagen by human platelets suspended in plasma containing citrate anticoagulant and stirred at 37°C. The prostaglandins...
Smith, J. B., Ingerman, Carol, Kocsis, J. J., Silver, M. J.
A compound that could be converted to prostaglandin F2α by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in...
Kraft, A S, Smith, J B, Berkow, R L
Phorbol esters bind to and activate a calcium phospholipid-dependent protein kinase (C kinase). Some researchers believe that activation of C kinase is necessary for the induction of phorbol ester...
Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
Smith, J B, Ingerman, C, Silver, M J
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the...
Antigenomic Hepatitis delta virus ribozymes self-cleave in 18 M formamide.
Smith, J B, Dinter-Gottlieb, G
The ribozymes derived from Hepatitis delta virus (HDV) RNA appear unique in their sequence requirements for self-cleavage. While truncating the 1679 nucleotide antigenomic HDV RNA, we have...
Brock, T A, Lewis, L J, Smith, J B
Angiotensin markedly altered the Na+ permeability of smooth muscle cells cultured from explants of rat aorta. The rate of net Na+ uptake was followed in the presence of ouabain in order to block Na+...
Lefer, A M, Smith, E F, Araki, H, Smith, J B, Aharony, D, Claremon, D A, ...
Carbocyclic thromboxane A2 [2 beta (Z),3 alpha- (1E,3R*)-3-(3-hydroxy(1-octenyl)-bicyclo[3.1.1]hept-2-yl-5-heptenoic acid], a stable analog of thromboxane A2, has been tested for its physiologic...
Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.
Ingerman-Wojenski, C, Silver, M J, Smith, J B, Macarak, E
Bovine aortic endothelial and smooth muscle cells in culture were incubated with arachidonic acid or prostaglandin H2. The amount of prostacyclin nd thromboxane A2 synthesized ws then determined by...
Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells.
Spector, A A, Hoak, J C, Fry, G L, Denning, G M, Stoll, L L, Smith, J B
We have investigated whether changes in cellular fatty acid saturation can influence prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. As compared to control cells,...
Czervionke, R L, Smith, J B, Fry, G L, Hoak, J C, Haycraft, D L
Aspirin treatment of cultured endothelial cells from the umbilical vein increased the adherence of 51Cr-platelets when thrombin was present. If the cyclooxygenase activity of endothelium was...
Bills, T K, Smith, J B, Silver, M J
Arachidonic acid is unique amongst human platelet fatty acids in that it is the precursor of prostaglandins and thromboxanes. Since a number of these oxygenated products of arachidonic acid have...
Nicolaou, K C, Magolda, R L, Smith, J B, Aharony, D, Smith, E F, Lefer, A M
Pinane-thromboxane A2 (PTA2, [1alpha,2 beta(Z),-3 alpha (1E,3R*),5 alpha]-7-(3-(3-hydroxy-1-octenyl)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)-5-heptenoic acid) has been synthesized and tested for...
Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin).
Chignard, M, Selak, M A, Smith, J B
Human neutrophils and platelets were loaded with the intracellular calcium indicator fura-2. The chemotactic peptide N-formyl-Met-Leu-Phe (fMet-Leu-Phe) induced a rapid elevation of cytosolic free...
Smith, J B, Smith, L, Brown, E R, Barnes, D, Sabir, M A, Davis, J S, ...
Smooth muscle cells were cultured from rat thoracic aorta and labeled to a stable specific activity with 45Ca2+, myo-[2-3H]inositol, or 32Pi. The efflux of 45Ca2+ was monitored over 10-sec intervals....
Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.
Two ionophores (monensin and gramicidin) that carry Na+ into 3T3 cells markedly enhance the rate of 86Rb+ uptake. Ouabain prevents both ionophores from increasing 86Rb+ uptake, indicating that the...
Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells.
Vanadyl sulfate and sodium orthovanadate in the concentration range between 5 and 50 microM are shown to be mitogenic for quiescent cultures of Swiss mouse 3T3 and 3T6 cells. The compounds caused a...
Van Oost, B A, Smith, J B, Holmsen, H, Vladutiu, G D
Thrombin induces partial secretion (up to 60%) of beta-N-acetyl-D-hexosaminidase (EC 3.2.1.52) from untreated platelets. Preincubation of platelets with 10 mM NH4Cl for up to 2 hr resulted in a...
Cyclic AMP does not inhibit collagen-induced platelet signal transduction.
Smith, J B, Dangelmaier, C, Selak, M A, Ashby, B, Daniel, J
The adhesion of platelets to collagen and their activation is the primary event in haemostasis. Following adhesion, platelet aggregation mediated by ADP, thromboxane A2 and thrombin leads to the...
Cathepsin G binding to human platelets. Evidence for a specific receptor.
We have shown previously that purified human neutrophil cathepsin G is a strong platelet agonist. We now demonstrate that cathepsin G exhibits saturable, reversible binding to human platelets which...
Cytosolic calcium as a second messenger for collagen-induced platelet responses.
Smith, J B, Selak, M A, Dangelmaier, C, Daniel, J L
We showed previously that direct platelet activation by collagen involves an increase in the platelet cytosolic free Ca2+ concentration ([Ca2+]i) but that this increase is not required for the...
Daniel, J L, Dangelmaier, C, Smith, J B
Adhesion of electrically permeabilized platelets to collagen was found to be essentially independent of free Ca2+ concentration in the medium. Addition of stable GTP analogues increased the...
The complete sequence of human lens gamma s-crystallin.
Smith, J B, Yang, Z, Lin, P, Zaidi, Z, Abbasi, A, Russell, P
The complete sequence of human gamma s-crystallin has been determined and confirmed using a combination of MS methods, peptide sequencing and cDNA sequencing. Regions 21-35 and 102-107, which were...
Zhou, Q, Smith, J B, Grossman, M H
A 50 kDa protein that inhibits platelet adhesion to collagen has been isolated from snake venom of Crotalus atrox (western diamondback rattlesnake) and has been named 'catrocollastatin'. The cDNA...
Daniel, J L, Dangelmaier, C, Smith, J B
(1) The non-specific protein kinase C inhibitor, staurosporine, inhibited collagen-induced increases in cytosolic free Ca2+ while having no effect on Ca2+ mobilization by other platelet agonists. A...
Mauco, G, Dangelmaier, C A, Smith, J B
Gel-filtered human platelets were stimulated with 5i.u. of thrombin/ml for times up to 1 min. The fatty acid composition of inositol-containing phospholipids, phosphatidic acid and diacylglycerol was...
Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets.
Daniel, J L, Dangelmaier, C A, Smith, J B
1. myo-[3H]Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], when added to lysed platelets, was rapidly converted into [3H]inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4], which was in turn converted...
Cathepsin G is a strong platelet agonist released by neutrophils.
Selak, M A, Chignard, M, Smith, J B
The present studies were undertaken to characterize a serine protease released by N-formyl-L-Met-L-Leu-L-Phe (fMet-Leu-Phe)-stimulated neutrophils that rapidly induces platelet calcium mobilization,...
Daniel, J L, Dangelmaier, C A, Smith, J B
We observed that more total inositol trisphosphate (InsP3) was formed when human platelets were stimulated with agonists (15-hydroxy-9,11-azo-prosta-5,13-dienoic acid or thrombin) in the presence of...
Stress and developmental regulation of the yeast C-type cyclin Ume3p (Srb11p/Ssn8p).
Cooper, K F, Mallory, M J, Smith, J B, Strich, R
The ume3-1 allele was identified as a mutation that allowed the aberrant expression of several meiotic genes (e.g. SPO11, SPO13) during mitotic cell division in Saccharomyces cerevisiae. Here we...
1. The involvement of intracellular 3′:5′-cyclic AMP in the inhibition of platelet aggregation by prostaglandin E1, isoprenaline and adenosine has been examined by a radiochemical technique....
Phospholipase A1 of human blood platelets (Short Communication)
Smith, J. B., Silver, M. J., Webster, G. R.
Substantial phospholipase A1 activity has been demonstrated in human blood platelets, and a rapid method for its measurement is described. The enzyme requires taurocholate for full activity and in...
Effects of d-amphetamine, chlorpromazine, and chlordiazepoxide on lever pressing under direct control of spaced-responding schedules were compared with effects on intercurrent drinking and wheel...
Smith, J B, Smith, L, Pijuan, V, Zhuang, Y, Chen, Y C
Cd2+ provokes an immediate production of inositol trisphosphate and the release of Ca2+ from internal stores in human fibroblasts and some other mammalian cells. Ni2+, Co2+, Fe2+, and Mn2+ evoke the...
Lefer, A M, Stahl, G L, Lefer, D J, Brezinski, M E, Nicolaou, K C, Veale, C A, ...
Lipoxins A4 (LxA4) and B4 (LxB4), two lipoxygenase-generated icosanoids of arachidonic acid metabolism, were found to have a distinct biological profile. Both LxA4 and LxB4 slowly contracted...
Formation of Prostaglandins during the Aggregation of Human Blood Platelets
Smith, J. B., Ingerman, Carol, Kocsis, J. J., Silver, M. J.
Prostaglandins E2 and F2α were formed in response to ADP, L-epinephrine, or collagen by human platelets suspended in plasma containing citrate anticoagulant and stirred at 37°C. The prostaglandins...
Smith, J. B., Ingerman, Carol, Kocsis, J. J., Silver, M. J.
A compound that could be converted to prostaglandin F2α by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in...
Kraft, A S, Smith, J B, Berkow, R L
Phorbol esters bind to and activate a calcium phospholipid-dependent protein kinase (C kinase). Some researchers believe that activation of C kinase is necessary for the induction of phorbol ester...
Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
Smith, J B, Ingerman, C, Silver, M J
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the...
Antigenomic Hepatitis delta virus ribozymes self-cleave in 18 M formamide.
Smith, J B, Dinter-Gottlieb, G
The ribozymes derived from Hepatitis delta virus (HDV) RNA appear unique in their sequence requirements for self-cleavage. While truncating the 1679 nucleotide antigenomic HDV RNA, we have...
Brock, T A, Lewis, L J, Smith, J B
Angiotensin markedly altered the Na+ permeability of smooth muscle cells cultured from explants of rat aorta. The rate of net Na+ uptake was followed in the presence of ouabain in order to block Na+...
Lefer, A M, Smith, E F, Araki, H, Smith, J B, Aharony, D, Claremon, D A, ...
Carbocyclic thromboxane A2 [2 beta (Z),3 alpha- (1E,3R*)-3-(3-hydroxy(1-octenyl)-bicyclo[3.1.1]hept-2-yl-5-heptenoic acid], a stable analog of thromboxane A2, has been tested for its physiologic...
Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.
Ingerman-Wojenski, C, Silver, M J, Smith, J B, Macarak, E
Bovine aortic endothelial and smooth muscle cells in culture were incubated with arachidonic acid or prostaglandin H2. The amount of prostacyclin nd thromboxane A2 synthesized ws then determined by...
Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells.
Spector, A A, Hoak, J C, Fry, G L, Denning, G M, Stoll, L L, Smith, J B
We have investigated whether changes in cellular fatty acid saturation can influence prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. As compared to control cells,...
Czervionke, R L, Smith, J B, Fry, G L, Hoak, J C, Haycraft, D L
Aspirin treatment of cultured endothelial cells from the umbilical vein increased the adherence of 51Cr-platelets when thrombin was present. If the cyclooxygenase activity of endothelium was...
Bills, T K, Smith, J B, Silver, M J
Arachidonic acid is unique amongst human platelet fatty acids in that it is the precursor of prostaglandins and thromboxanes. Since a number of these oxygenated products of arachidonic acid have...
Nicolaou, K C, Magolda, R L, Smith, J B, Aharony, D, Smith, E F, Lefer, A M
Pinane-thromboxane A2 (PTA2, [1alpha,2 beta(Z),-3 alpha (1E,3R*),5 alpha]-7-(3-(3-hydroxy-1-octenyl)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)-5-heptenoic acid) has been synthesized and tested for...
Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin).
Chignard, M, Selak, M A, Smith, J B
Human neutrophils and platelets were loaded with the intracellular calcium indicator fura-2. The chemotactic peptide N-formyl-Met-Leu-Phe (fMet-Leu-Phe) induced a rapid elevation of cytosolic free...
Smith, J B, Smith, L, Brown, E R, Barnes, D, Sabir, M A, Davis, J S, ...
Smooth muscle cells were cultured from rat thoracic aorta and labeled to a stable specific activity with 45Ca2+, myo-[2-3H]inositol, or 32Pi. The efflux of 45Ca2+ was monitored over 10-sec intervals....
Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.
Two ionophores (monensin and gramicidin) that carry Na+ into 3T3 cells markedly enhance the rate of 86Rb+ uptake. Ouabain prevents both ionophores from increasing 86Rb+ uptake, indicating that the...
Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells.
Vanadyl sulfate and sodium orthovanadate in the concentration range between 5 and 50 microM are shown to be mitogenic for quiescent cultures of Swiss mouse 3T3 and 3T6 cells. The compounds caused a...
Van Oost, B A, Smith, J B, Holmsen, H, Vladutiu, G D
Thrombin induces partial secretion (up to 60%) of beta-N-acetyl-D-hexosaminidase (EC 3.2.1.52) from untreated platelets. Preincubation of platelets with 10 mM NH4Cl for up to 2 hr resulted in a...
Cyclic AMP does not inhibit collagen-induced platelet signal transduction.
Smith, J B, Dangelmaier, C, Selak, M A, Ashby, B, Daniel, J
The adhesion of platelets to collagen and their activation is the primary event in haemostasis. Following adhesion, platelet aggregation mediated by ADP, thromboxane A2 and thrombin leads to the...
Cathepsin G binding to human platelets. Evidence for a specific receptor.
We have shown previously that purified human neutrophil cathepsin G is a strong platelet agonist. We now demonstrate that cathepsin G exhibits saturable, reversible binding to human platelets which...
Cytosolic calcium as a second messenger for collagen-induced platelet responses.
Smith, J B, Selak, M A, Dangelmaier, C, Daniel, J L
We showed previously that direct platelet activation by collagen involves an increase in the platelet cytosolic free Ca2+ concentration ([Ca2+]i) but that this increase is not required for the...
Daniel, J L, Dangelmaier, C, Smith, J B
Adhesion of electrically permeabilized platelets to collagen was found to be essentially independent of free Ca2+ concentration in the medium. Addition of stable GTP analogues increased the...
The complete sequence of human lens gamma s-crystallin.
Smith, J B, Yang, Z, Lin, P, Zaidi, Z, Abbasi, A, Russell, P
The complete sequence of human gamma s-crystallin has been determined and confirmed using a combination of MS methods, peptide sequencing and cDNA sequencing. Regions 21-35 and 102-107, which were...
Zhou, Q, Smith, J B, Grossman, M H
A 50 kDa protein that inhibits platelet adhesion to collagen has been isolated from snake venom of Crotalus atrox (western diamondback rattlesnake) and has been named 'catrocollastatin'. The cDNA...
Daniel, J L, Dangelmaier, C, Smith, J B
(1) The non-specific protein kinase C inhibitor, staurosporine, inhibited collagen-induced increases in cytosolic free Ca2+ while having no effect on Ca2+ mobilization by other platelet agonists. A...
Mauco, G, Dangelmaier, C A, Smith, J B
Gel-filtered human platelets were stimulated with 5i.u. of thrombin/ml for times up to 1 min. The fatty acid composition of inositol-containing phospholipids, phosphatidic acid and diacylglycerol was...
Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets.
Daniel, J L, Dangelmaier, C A, Smith, J B
1. myo-[3H]Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], when added to lysed platelets, was rapidly converted into [3H]inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4], which was in turn converted...
Cathepsin G is a strong platelet agonist released by neutrophils.
Selak, M A, Chignard, M, Smith, J B
The present studies were undertaken to characterize a serine protease released by N-formyl-L-Met-L-Leu-L-Phe (fMet-Leu-Phe)-stimulated neutrophils that rapidly induces platelet calcium mobilization,...
Daniel, J L, Dangelmaier, C A, Smith, J B
We observed that more total inositol trisphosphate (InsP3) was formed when human platelets were stimulated with agonists (15-hydroxy-9,11-azo-prosta-5,13-dienoic acid or thrombin) in the presence of...
Stress and developmental regulation of the yeast C-type cyclin Ume3p (Srb11p/Ssn8p).
Cooper, K F, Mallory, M J, Smith, J B, Strich, R
The ume3-1 allele was identified as a mutation that allowed the aberrant expression of several meiotic genes (e.g. SPO11, SPO13) during mitotic cell division in Saccharomyces cerevisiae. Here we...
1. The involvement of intracellular 3′:5′-cyclic AMP in the inhibition of platelet aggregation by prostaglandin E1, isoprenaline and adenosine has been examined by a radiochemical technique....
Phospholipase A1 of human blood platelets (Short Communication)
Smith, J. B., Silver, M. J., Webster, G. R.
Substantial phospholipase A1 activity has been demonstrated in human blood platelets, and a rapid method for its measurement is described. The enzyme requires taurocholate for full activity and in...
Effects of d-amphetamine, chlorpromazine, and chlordiazepoxide on lever pressing under direct control of spaced-responding schedules were compared with effects on intercurrent drinking and wheel...
Smith, J B, Smith, L, Pijuan, V, Zhuang, Y, Chen, Y C
Cd2+ provokes an immediate production of inositol trisphosphate and the release of Ca2+ from internal stores in human fibroblasts and some other mammalian cells. Ni2+, Co2+, Fe2+, and Mn2+ evoke the...
The frequency of occurrence in human peripheral blood of T cells able to proliferate in the autologous mixed lymphocyte reaction (AMLR), and in response to trinitrophenyl (TNP)-modified self...
We have examined autologous mixed lymphocyte culture (AMLC) reactions in patients with systemic lupus erythematosus (SLE), classical rheumatoid arthritis (RA), and in normal age and sex matched...
Purification and characterization of human liver specific F antigen.
This paper reports the properties of purified human F antigen (liver-specific antigen). Homogenates of liver in 0-25 M sucrose were centrifuged at 105,000 g. The supernatants were chromatographed on...
Occurrence of liver-specific antigen in adult human serum
A liver-specific, water-soluble autoantigen (F-antigen) was detected by double diffu-ion using specifically prepared antiserum in thirty of 285 adult serum samples tested. F-antigen was found most...
Bocchieri, M H, Smith, J B, Smith, J B, Staruch, M J, Wood, D D
NZB mice have previously been shown to be deficient in the production of interleukins 1 and 2 (IL-1, IL-2) during the development of autoimmune disease. One or both of these defects have been...
Effects of heparin on platelet aggregation and release and thromboxane A2 production.
Mohammad, S. F., Anderson, W. H., Smith, J. B., Chuang, H. Y., Mason, R. G.
Heparin, when added to citrated platelet-rich plasma (PRP), caused potentiation of platelet aggregation and the release reaction induced by the aggregating agents adenosine diphosphate (ADP),...
Uptake, metabolism and release of [3H]-adrenaline by human platelets
1. Measurements were made of the uptake, metabolism and release of [3H]-adrenaline by human platelets in citrated plasma or in an artificial medium.
Aksoy, M. O., Harakal, C., Smith, J. B., Stewart, G. J., Zerweck, C. R.
1. Canine jugular and femoral veins were studied to determine the possible importance of thromboxane (TXA2) and prostaglandin endoperoxides (prostaglandin H2, PGH2) in mediating...
Darius, H., Lefer, A. M., Leprán, I., Smith, J. B.
Prostacyclin (PGI2) inactivates platelets by stimulation of adenylate cyclase, and its effect can be potentiated in vitro by simultaneous inhibition of cyclic AMP phosphodiesterase. The interaction...
Pathophysiological mechanisms of sudden death induced by platelet activating factor.
Lefer, A. M., Müller, H. F., Smith, J. B.
Platelet activating factor (Paf) (15-40 micrograms-1) kills male rabbits within 3 to 5 min. Intravenous injection of Paf at a dose of 15 micrograms kg-1 is uniformly lethal, and the rabbits died...
Burke, S. E., Lefer, A. M., Nicolaou, K. C., Smith, G. M., Smith, J. B.
1--Platelet-rich plasma (PRP) from humans, cats, dogs (after addition of 10 microM adrenaline), rabbits and guinea-pigs aggregated in response to sodium arachidonate or 9,11-azo-prostaglandin H2,...
Smith, J. B., Sun, Y., Smith, D. L., Green, B.
A combination of mass spectrometric techniques has been used to investigate the amino acid sequence and post-translational modifications of alpha B-crystallin isolated from bovine lenses by gel...
In vivo acetylation identified at lysine 70 of human lens alphaA-crystallin.
Lin, P. P., Barry, R. C., Smith, D. L., Smith, J. B.
Posttranslational modification of protein lysyl residues that change the net charge of the molecule may alter the protein conformation. Such modifications are of particular significance among lens...
ANTIBODY FORMATION BY SINGLE CELLS FROM LYMPH NODES AND EFFERENT LYMPH OF SHEEP
Cunningham, A. J., Smith, J. B., Mercer, E. H.
The antibody-forming cells which appear in the popliteal lymph node and efferent lymph of the sheep following immunization with boiled Salmonella have been studied by light and electron microscopy....
The Impact of Pollution Charges on Productivity Growth in Canadian Brewing
This article presents an econometric analysis of the productivity impact of pollution charges on firms in the Canadian brewing industry. We estimate a translog cost function that allows for...
Prostaglandin levels in blood plasma during asthmatic attacks in patients with aspirin idiosyncrasy
Delaney, J. C., Smith, J. B., Silver, M. J.
It has been suggested that prostaglandin release is an important factor in the pathogenesis of bronchial asthma. Aspirin inhibits prostaglandin synthesis, yet there are a group of patients, with...
Receipt acknowledging $1500.00 from Babbitt Brothers to J.B. Smith dated September, 1886.
Record level- Receipt acknowledging $1500.00 from Babbitt Brothers to J.B. Smith dated September, 1886.
Record level- Document dismissing lawsuit against Babbitt Bros. over the amount of $75.00, dated September 20, 1887.
Estimates of the maternal mortality ratio in two districts of the Brong-Ahafo region, Ghana.
Smith, J. B., Fortney, J. A., Wong, E., Amatya, R., Coleman, N. A.
OBJECTIVE: To estimate the maternal mortality ratio (MMR) by the sisterhood method in two districts of the Brong-Ahafo region of Ghana, and to determine the impact of different assumptions and...
John Henry Smith was an LDS Church apostle and father of church president George Albert Smith. He also served as president of Utah's Constitutional Convention in 1895.
John Henry Smith was an LDS Church apostle and father of church president George Albert Smith. He also served as president of Utah's Constitutional Convention in 1895.