Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.
Böhme, G A, Bon, C, Lemaire, M, Reibaud, M, Piot, O, Stutzmann, J M, ...
Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term...
Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
Garret, C, Carruette, A, Fardin, V, Moussaoui, S, Peyronel, J F, Blanchard, J C, ...
We describe here the pharmacological properties of RP 67580 [(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one], a nonpeptide antagonist of substance P (SP). In...
Cyclic cholecystokinin analogues with high selectivity for central receptors.
Charpentier, B, Pelaprat, D, Durieux, C, Dor, A, Reibaud, M, Blanchard, J C, ...
Taking as a model the N-terminal folding of the cholecystokinin tyrosine-sulfated octapeptide [CCK-8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2] deduced from conformational studies, two cyclic...
Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.
Böhme, G A, Bon, C, Lemaire, M, Reibaud, M, Piot, O, Stutzmann, J M, ...
Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term...
Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
Garret, C, Carruette, A, Fardin, V, Moussaoui, S, Peyronel, J F, Blanchard, J C, ...
We describe here the pharmacological properties of RP 67580 [(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one], a nonpeptide antagonist of substance P (SP). In...
Cyclic cholecystokinin analogues with high selectivity for central receptors.
Charpentier, B, Pelaprat, D, Durieux, C, Dor, A, Reibaud, M, Blanchard, J C, ...
Taking as a model the N-terminal folding of the cholecystokinin tyrosine-sulfated octapeptide [CCK-8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2] deduced from conformational studies, two cyclic...
Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist
Doble, A., Girdlestone, D., Piot, O., Allam, D., Betschart, J., Boireau, A., ...
1 RP 62203 (2-[3-(4-(4-fluorophenyl)-piperazinyl)propyl]naphto[1,8-cd]isothiazole-1, 1-dioxide) is a novel naphtosultam derivative which shows very high affinity for 5-HT2 receptors in the rat...
Piot, O., Betschart, J., Grall, I., Ravard, S., Garret, C., Blanchard, J. C.
1. The NK1 tachykinin receptor agonists, septide, [Sar9,Met(O2)11]SP and [Pro9]SP produced locomotor hyperactivity (10-20 min) when injected intracerebroventricularly (i.c.v.) in the guinea-pig. The...
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
Moussaoui, S. M., Montier, F., Carruette, A., Blanchard, J. C., Laduron, P. M., Garret, C.
1. The non-peptide neurokinin NK1-receptor antagonist, RP 67580 (3aR, 7aR), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind paw skin induced by local application...