John Ruskin's criticism of English writers. (1942)
"A thesis submitted in partial requirement for the degree of Master of Arts."
Identification of an RNA binding site for human thymidylate synthase.
Chu, E, Voeller, D, Koeller, D M, Drake, J C, Takimoto, C H, Maley, G F, ...
Previous studies from this laboratory have shown that human TS mRNA translation is regulated by its protein product in a negative autoregulatory manner. In this paper, we identify an RNA binding site...
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
Chu, E, Koeller, D M, Casey, J L, Drake, J C, Chabner, B A, Elwood, P C, ...
Thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) is essential for the de novo synthesis of thymidylate, a precursor of DNA. Previous studies have shown...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Kovacs, J A, Allegra, C J, Swan, J C, Drake, J C, Parrillo, J E, Chabner, B A, ...
Piritrexim, a lipid-soluble antifolate, was evaluated for its activity against Pneumocystis carinii and Toxoplasma gondii. The concentration of piritrexim needed to inhibit 50% of the catalytic...
Mechanism of pyrimethamine resistance in recent isolates of Plasmodium falciparum.
McCutchan, T F, Welsh, J A, Dame, J B, Quakyi, I A, Graves, P M, Drake, J C, ...
Clones of Plasmodium falciparum prepared from recent isolates of infected blood were studied to determine the molecular mechanism of naturally occurring pyrimethamine resistance. Total DNA, as well...
Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR)...
Polyglutamation of methotrexate. Is methotrexate a prodrug?
Chabner, B A, Allegra, C J, Curt, G A, Clendeninn, N J, Baram, J, Koizumi, S, ...
Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.
Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, ...
We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known...
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Allegra, C J, Kovacs, J A, Drake, J C, Swan, J C, Chabner, B A, Masur, H
Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from...
Identification of an RNA binding site for human thymidylate synthase.
Chu, E, Voeller, D, Koeller, D M, Drake, J C, Takimoto, C H, Maley, G F, ...
Previous studies from this laboratory have shown that human TS mRNA translation is regulated by its protein product in a negative autoregulatory manner. In this paper, we identify an RNA binding site...
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
Chu, E, Koeller, D M, Casey, J L, Drake, J C, Chabner, B A, Elwood, P C, ...
Thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) is essential for the de novo synthesis of thymidylate, a precursor of DNA. Previous studies have shown...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Kovacs, J A, Allegra, C J, Swan, J C, Drake, J C, Parrillo, J E, Chabner, B A, ...
Piritrexim, a lipid-soluble antifolate, was evaluated for its activity against Pneumocystis carinii and Toxoplasma gondii. The concentration of piritrexim needed to inhibit 50% of the catalytic...
Mechanism of pyrimethamine resistance in recent isolates of Plasmodium falciparum.
McCutchan, T F, Welsh, J A, Dame, J B, Quakyi, I A, Graves, P M, Drake, J C, ...
Clones of Plasmodium falciparum prepared from recent isolates of infected blood were studied to determine the molecular mechanism of naturally occurring pyrimethamine resistance. Total DNA, as well...
Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR)...
Polyglutamation of methotrexate. Is methotrexate a prodrug?
Chabner, B A, Allegra, C J, Curt, G A, Clendeninn, N J, Baram, J, Koizumi, S, ...
Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.
Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, ...
We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known...
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Allegra, C J, Kovacs, J A, Drake, J C, Swan, J C, Chabner, B A, Masur, H
Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from...
In vitro correlates of clinical response to methotrexate in actue leukaemia and Burkitt's lymphoma.
Bender, R. A., Bleyer, W. A., Drake, J. C., Ziegler, J. L.
The response of drug-resistant patients with acute leukaemia and Burkitt's lymphoma to treatment with a 24 h infusion of methotrexate (MTX) followed, in some cases,by cytosine arabinoside was...
Drake, J. C., Voeller, D. M., Allegra, C. J., Johnston, P. G.
We examined the importance of dosing interval between leucovorin (LCV) and 5-fluorouracil (5-FU) on intracellular thymidylate synthase (TS) ternary complex, free TS and total TS protein levels in...
Pestalozzi, B. C., McGinn, C. J., Kinsella, T. J., Drake, J. C., Glennon, M. C., Allegra, C. J., ...
We have analysed cell cycle variations in thymidylate synthase (TS) protein in asynchronously growing NCl H630 and HT 29 colon cancer and MCF-7 breast cancer cell lines. Western immunoblot analysis...