First-pass metabolism of cyclosporin by the gut (1991)
Kolars, J. C., Watkins, P. B., Merion, R. M., Awni, W. M.
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin...
Omeprazole and aryl hydrocarbon hydroxylases: Should we be worried? (1991)
Kolars, J. C., Turgeon, D. K., Watkins, P. B.
Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P-450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in...
Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA (1990)
Lucey, M. R., Kolars, J. C., Merion, R. M., Campbell, Darrel A., Aldrich, M., Watkins, P. B.
A 40-year-old male liver allograft recipient had neurological dysfunction and renal failure while his cyclosporin blood levels were in the therapeutic range; these features recurred on rechallenge....
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.
Kolars, J C, Schmiedlin-Ren, P, Schuetz, J D, Fang, C, Watkins, P B
Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass" metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes are expressed in...
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.
Kolars, J C, Schmiedlin-Ren, P, Schuetz, J D, Fang, C, Watkins, P B
Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass" metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes are expressed in...