Post-repolarization block of cardiac sodium channels by saxitoxin.
Makielski, J C, Satin, J, Fan, Z
Phasic block of rat cardiac Na+ current by saxitoxin was assessed using pulse trains and two-pulse voltage clamp protocols, and the results were fit to several kinetic models. For brief...
Satin, J, Kyle, J W, Fan, Z, Rogart, R, Fozzard, H A, Makielski, J C
Sodium channels expressed in oocytes exhibited isoform differences in phasic block by saxitoxin (STX). Neuronal channels (rat IIa co-expressed with beta 1 subunit, Br2a + beta 1) had slower kinetics...
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Zhou, Z, Gong, Q, Ye, B, Fan, Z, Makielski, J C, Robertson, G A, ...
We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether-a go-go-related gene (HERG) channels. We used these cells to study biochemical...
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
Makielski, J C, Sheets, M F, Hanck, D A, January, C T, Fozzard, H A
Study of the excitatory sodium current (INa) intact heart muscle has been hampered by the limitations of voltage clamp methods in multicellular preparations that result from the presence of large...
Open sodium channel properties of single canine cardiac Purkinje cells.
Sheets, M F, Scanley, B E, Hanck, D A, Makielski, J C, Fozzard, H A
Open channel properties of canine cardiac Purkinje cell Na+ channels were studied with single channel cell-attached recording and with whole cell macroscopic current recording in internally perfused...
Fan, Z, George, A L, Kyle, J W, Makielski, J C
1. Two mutant human skeletal muscle voltage-gated Na+ channel alpha-subunits (hSkM1), with mutations found in patients with hereditary paramyotonia congenita (T1313M on the III-IV linker and R1448C...
Brill, D M, Fozzard, H A, Makielski, J C, Wasserstrom, J A
1. Twitch tension and intracellular Na+ activity (aiNa) were measured in voltage-clamped sheep cardiac Purkinje fibres. aiNa was measured using Na+-sensitive micro-electrodes filled with the liquid...
Fan, Z, George, A L, Kyle, J W, Makielski, J C
1. Two mutant human skeletal muscle voltage-gated Na+ channel alpha-subunits (hSkM1), with mutations found in patients with hereditary paramyotonia congenita (T1313M on the III-IV linker and R1448C...
Brill, D M, Fozzard, H A, Makielski, J C, Wasserstrom, J A
1. Twitch tension and intracellular Na+ activity (aiNa) were measured in voltage-clamped sheep cardiac Purkinje fibres. aiNa was measured using Na+-sensitive micro-electrodes filled with the liquid...
Post-repolarization block of cardiac sodium channels by saxitoxin.
Makielski, J C, Satin, J, Fan, Z
Phasic block of rat cardiac Na+ current by saxitoxin was assessed using pulse trains and two-pulse voltage clamp protocols, and the results were fit to several kinetic models. For brief...
Satin, J, Kyle, J W, Fan, Z, Rogart, R, Fozzard, H A, Makielski, J C
Sodium channels expressed in oocytes exhibited isoform differences in phasic block by saxitoxin (STX). Neuronal channels (rat IIa co-expressed with beta 1 subunit, Br2a + beta 1) had slower kinetics...
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Zhou, Z, Gong, Q, Ye, B, Fan, Z, Makielski, J C, Robertson, G A, ...
We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether-a go-go-related gene (HERG) channels. We used these cells to study biochemical...
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
Makielski, J C, Sheets, M F, Hanck, D A, January, C T, Fozzard, H A
Study of the excitatory sodium current (INa) intact heart muscle has been hampered by the limitations of voltage clamp methods in multicellular preparations that result from the presence of large...
Open sodium channel properties of single canine cardiac Purkinje cells.
Sheets, M F, Scanley, B E, Hanck, D A, Makielski, J C, Fozzard, H A
Open channel properties of canine cardiac Purkinje cell Na+ channels were studied with single channel cell-attached recording and with whole cell macroscopic current recording in internally perfused...