J. C. Philcox

Publication List Details

Period

1995 - 2003

Number

54

Co-Authors

Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine (2003)

Tran, C. D., Howarth, Gordon Stanley, Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N.

Background: Oral administration of zinc or bovine whey-derived growth factor extract (WGFE) is known to reduce intestinal permeability and ameliorate methotrexate (MTX)-induced mucositis,...

Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine (2003)

Tran, C. D., Howarth, Gordon Stanley, Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N.

Background: Oral administration of zinc or bovine whey-derived growth factor extract (WGFE) is known to reduce intestinal permeability and ameliorate methotrexate (MTX)-induced mucositis,...

Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies.

Coyle, P, Philcox, J C, Rofe, A M

Hepatic zinc uptake and accumulation were compared in freshly isolated and cultured hepatocytes prepared from control (MT+/+) and metallothionein (MT)-null (MT-/-) mice. In freshly isolated...

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.

Philcox, J C, Coyle, P, Michalska, A, Choo, K H, Rofe, A M

The action of endotoxin lipopolysaccharide (LPS) on hepatic Zn uptake was examined in mice lacking expression of metallothionein (MT)-1 and MT-II genes. Hepatic Zn concentrations, which in normal...

Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc.

Coyle, P, Zalewski, P D, Philcox, J C, Forbes, I J, Ward, A D, Lincoln, S F, ...

Zinquin [ethyl (2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetate], a new intracellular zinc fluorophore, was used to reveal and to measure Zn in cultured rat hepatocytes before and after...

Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice.

Rofe, A M, Philcox, J C, Coyle, P

Accumulation of hepatic zinc via metallothionein (MT) induction during infection/inflammation is postulated to benefit a range of metabolic processes. The metabolic consequences of two doses of...

Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies.

Coyle, P, Philcox, J C, Rofe, A M

Hepatic zinc uptake and accumulation were compared in freshly isolated and cultured hepatocytes prepared from control (MT+/+) and metallothionein (MT)-null (MT-/-) mice. In freshly isolated...

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.

Philcox, J C, Coyle, P, Michalska, A, Choo, K H, Rofe, A M

The action of endotoxin lipopolysaccharide (LPS) on hepatic Zn uptake was examined in mice lacking expression of metallothionein (MT)-1 and MT-II genes. Hepatic Zn concentrations, which in normal...

Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc.

Coyle, P, Zalewski, P D, Philcox, J C, Forbes, I J, Ward, A D, Lincoln, S F, ...

Zinquin [ethyl (2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetate], a new intracellular zinc fluorophore, was used to reveal and to measure Zn in cultured rat hepatocytes before and after...

Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice.

Rofe, A M, Philcox, J C, Coyle, P

Accumulation of hepatic zinc via metallothionein (MT) induction during infection/inflammation is postulated to benefit a range of metabolic processes. The metabolic consequences of two doses of...

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma

Coyle, P, Mathew, G, Game, P A, Myers, J C, Philcox, J C, Rofe, A M, ...

The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively...