Coffee Consumption and Coronary Calcification: The Rotterdam Coronary Calcification Study (2008)
Geleijnse, J.M., Vliegenthart, R., Witteman, J.C.
Background: Diet and lifestyle play an important role in the development of coronary heart disease (CHD). The role of coffee in the cardiovascular system is not yet clear. We examined whether coffee...
Geleijnse, J.M., Vliegenthart, R., Witteman, J.C.
Background: Diet and lifestyle play an important role in the development of coronary heart disease (CHD). The role of coffee in the cardiovascular system is not yet clear. We examined whether coffee...
Beulens, J.W.J., Bots, M.L., Atsma, F., Bartelink, M.L., Prokop, M., Geleijnse, J.M., ...
Background Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. This may be due to different effects of...
Ikram, M.K., Janssen, J.A., Roos, A.M., Rietveld, I., Witteman, J.C., Breteler, M.M., ...
The association between a smaller retinal arteriolar-to-venular ratio (AVR) and incident diabetes may be due to arteriolar narrowing, venular dilatation, or both. We investigated associations between...
Alcohol intake and aortic stiffness in young men and women (2005)
Sierksma, A., Oren, A., Vos, L.E., Witteman, J.C., Grobbee, D.E., ...
The increase in cholestrol with menopause is associated with the apolipoprotein E genotype (2004)
Hak, A.E., Witteman, J.C., Hugens, W., Keyzer, J.J., Pop, V.J.M., Uitterlinden, A.G., ...
Homocysteine levels and the risk of osteoporotic fracture (2004)
Meurs, J.B. Van, Jonge, R. De, Lindemans, J., Groot, L.C., Uitterlinden, A.G., Hofman, A., ...
BACKGROUND: Very high plasma homocysteine levels are characteristic of homocystinuria, a rare autosomal recessive disease accompanied by the early onset of generalized osteoporosis. We therefore...
Oei, H.H., Vliegenthart, R., Hofman, A., Oudkerk, M., Witteman, J.C.
AIMS: We examined associations between cardiovascular risk factors and coronary calcification assessed by electron-beam tomography (EBT) in an unselected population of older subjects. METHODS AND...
Sayed-Tabatabaei, F.A., Schut, A.F., Hofman, A., Bertoli-Avella, A.M., Vergeer, J., Witteman, J.C., ...
INTRODUCTION: Studies on the role of the insertion/deletion (I/D) polymorphism of the gene coding for angiotensin converting enzyme (ACE) in atherosclerosis have been inconsistent. In a...
Ikram, M.K., Jong, F.J. De, Vingerling, J.R., Witteman, J.C., Hofman, A., Breteler, M.M., ...
PURPOSE: A lower retinal arteriolar-to-venular ratio (AVR) has been suggested to reflect generalized arteriolar narrowing and to predict the risk of cardiovascular diseases. The contribution of the...
Geleijnse, J.M., Vermeer, C., Grobbee, D.E., Schurgers, L.J., Knapen, M.H., ...
Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation depends on the availability of vitamin K....
UGT1A1*28 allele and coronary heart disease: The Rotterdam study (2003)
Bosma, P.J., Bakker, C.T.M., Hofman, A., Paul-Abrahamse, M., Witteman, J.C.
Spatial QRS-T angle predicts cardiac death in a general population (2003)
Kardys, I., Kors, J.A., Hofman, A., Witteman, J.C.
AIMS: The aim of this study was to assess the prognostic importance of the spatial QRS-T angle for fatal and non-fatal cardiac events. METHODS AND RESULTS: Electrocardiograms (ECGs) were recorded in...
Leeuwen, R. Van, Ikram, M.K., Vingerling, J.R., Witteman, J.C., Hofman, A., Jong, P.T. De
PURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a...
Vliegenthart, R., Hollander, M., Breteler, M.M., Hofman, A., Oudkerk, M., ...
BACKGROUND AND PURPOSE: Coronary calcification as detected by electron-beam CT measures the atherosclerotic plaque burden and has been reported to predict coronary events. Because atherosclerosis is...
Alcohol consumption and risk of peripheral arterial disease: the Rotterdam study (2002)
Vliegenthart, R., Geleijnse, J.M., Hofman, A., Meijer, W.T., Rooij, F.J. Van, Grobbee, D.E., ...
Moderate alcohol consumption is associated with a reduced risk of cardiovascular disease. Data on alcohol consumption and atherosclerosis are scarce. To determine the association between alcohol...
Hypertension and cerebral white matter lesions in a prospective cohort study (2002)
Leeuw, F.E. De, Groot, J.C. De, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. Van, ...
White matter lesions are frequently found on cerebral MRI scans of elderly people and are thought to be important in the pathogenesis of dementia. Hyper tension has been associated with the presence...
Geleijnse, J.M., Launer, L.J., Hofman, A., Witteman, J.C.
BACKGROUND: Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations. OBJECTIVE: The association...
Maat, M.P. De, Bots, M.L., Breteler, M.M., Meijer, J., Kiliaan, A.J., ...
Inflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease. Within the Rotterdam...
Hollander, M., Bots, M.L., Del Sol, A.I., Koudstaal, P.J., Witteman, J.C., Grobbee, D.E., ...
BACKGROUND: Few studies have quantified the relation between carotid plaques and stroke in asymptomatic patients, and limited data exist on the importance of location of plaques or the association...
Dietary intake of antioxidants and risk of Alzheimer disease (2002)
Engelhart, M.J., Geerlings, M.I., Ruitenberg, A., Swieten, J.C. Van, Hofman, A., Witteman, J.C., ...
CONTEXT: Laboratory findings have suggested that oxidative stress may contribute to the pathogenesis of Alzheimer disease. Therefore, the risk of Alzheimer disease might be reduced by intake of...
Hak, A.E., Witteman, J.C., Jong, F.H. De, Geerlings, M.I., Hofman, A., Pols, H.A.
In both men and women, circulating androgen levels decline with advancing age. Until now, results of several small studies on the relationship between endogenous androgen levels and atherosclerosis...
Vliegenthart, R., Oudkerk, M., Song, B., Hofman, A., Witteman, J.C.
AIMS: Available data are insufficient to determine the relation between coronary calcification and coronary events in the general population. We cross-sectionally examined the association between...
Mutations in the hemochromatosis gene (HFE) and stroke (2002)
Njajou, O.T., Hollander, M., Koudstaal, P.J., Hofman, A., Witteman, J.C., Breteler, M.M., ...
BACKGROUND AND PURPOSE: Increased serum iron is found to be a risk factor for stroke. Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for...
Maat, M.P. De, Hak, A.E., Kiliaan, A.J., Del Sol, A.I., ...
Background and Purpose- C-reactive protein (CRP) predicts myocardial infarction and stroke. Its role as a predictor of the progression of subclinical atherosclerosis is not yet known. We investigated...
Is open-angle glaucoma associated with early menopause? The Rotterdam Study (2001)
Hulsman, C.A., Westendorp, J.C., Ramrattan, R.S., Wolfs, R.C., Witteman, J.C., Vingerling, J.R., ...
Association between arterial stiffness and atherosclerosis: the Rotterdam Study (2001)
Popele, N.M. Van, Grobbee, D.E., Bots, M.L., Asmar, R., Topouchian, J., Reneman, R.S., ...
BACKGROUND AND PURPOSE: Studies of the association between arterial stiffness and atherosclerosis are contradictory. We studied stiffness of the aorta and the common carotid artery in relation to...
Vaessen, N., Heutink, P., Janssen, J.A., Witteman, J.C., Testers, L., Hofman, A., ...
Evidence is accumulating that low levels of IGF-I play a role in the pathogenesis of type 2 diabetes and cardiovascular diseases. We examined the role of a genetic polymorphism in the promoter region...
Reproductive period and risk of dementia in postmenopausal women (2001)
Geerlings, M.I., Ruitenberg, A., Witteman, J.C., Swieten, J.C. Van, Hofman, A., Duijn, C.M. Van, ...
CONTEXT: Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but...
Del Sol, A.I., Moons, K.G., Hollander, M., Hofman, A., Koudstaal, P.J., Grobbee, D.E., ...
BACKGROUND AND PURPOSE: We determined the contribution of common carotid intima-media thickness (IMT) in the prediction of future coronary heart disease and cerebrovascular disease when added to...
Dietary antioxidants and peripheral arterial disease : the Rotterdam Study (2001)
Klipstein-Grobusch, K., Breeijen, J.H. Den, Grobbee, D.E., Boeing, H., Hofman, A., Witteman, J.C.
This study examined cross-sectionally the association of dietary beta-carotene, vitamin C, and vitamin E with peripheral arterial disease in Rotterdam, the Netherlands (1990--1993). The 4,367...
Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam study (2001)
Slooter, A.J., Bots, M.L., Havekes, L.M., Del Sol, A.I., Cruts, M., Grobbee, D.E., ...
BACKGROUND AND PURPOSE: Carotid artery atherosclerosis is a strong predictor for future stroke. It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the...
Hak, A.E., Pols, H.A., Stehouwer, C.D., Meijer, J., Kiliaan, A.J., Hofman, A., ...
Insulin resistance, which is highly prevalent in the elderly, is suggested to be accompanied by an increased acute phase response. Until now, it is unclear whether cellular adhesion molecules are...
Tea and coronary heart disease : protection through estrogenlike activity? (2000)
Geleijnse, J.M., Witteman, J.C., Launer, L.J., Lamberts, S.J., Pols, H.A.
Tea drinking appears to be protective against coronary heart disease in a number of epidemiologic studies. It has been suggested that tea flavonols with antioxidative activity, including quercetin,...
Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly (2000)
Leeuw, F.E. De, Groot, J.C. De, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. Van, ...
BACKGROUND AND PURPOSE: MRI scans of the brains of elderly people frequently show white matter lesions. Clinically, these lesions are associated with cognitive impairment and dementia. A relation...
Hak, A.E., Pols, H.A., Visser, T.J., Drexhage, H.A., Hofman, A., Witteman, J.C.
BACKGROUND: Overt hypothyroidism has been found to be associated with cardiovascular disease. Whether subclinical hypothyroidism and thyroid autoimmunity are also risk factors for cardiovascular...
Rossum, C.T. Van, Mheen, H. Van De, Witteman, J.C., Hofman, A., Mackenbach, J.P., Grobbee, D.E.
The study objective was to assess the prevalence, level of treatment, and control of hypertension in a general elderly population according to age and sociodemographic factors. We conducted a...
Hak, A.E., Pols, H.A., Hemert, A.M. Van, Hofman, A., Witteman, J.C.
offerosclerosis and osteoporosis are major causes of morbidity and mortality in postmenopausal women and have been suggested to be associated. No study has examined whether progression of...
Popele, N.M. Van, Bos, W.J., Beer, N.A. De, Hofman, A., Grobbee, D.E., ...
Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that...
Estrogen use and early onset Alzheimer's disease: a population-based study (1999)
Slooter, A.J., Bronzova, J., Witteman, J.C., Broeckhoven, C. Van, Hofman, A., Duijn, C.M. Van
Estrogen use may be protective for Alzheimer's disease with late onset. However, the effects on early onset Alzheimer's disease are unclear. This issue was studied in a population based setting. For...
Dietary antioxidants and risk of myocardial infarction in the elderly: the Rotterdam Study (1999)
Klipstein-Grobusch, K., Geleijnse, J.M., Breeijen, J.H. Den, Boeing, H., Hofman, A., Grobbee, D.E., ...
BACKGROUND: Epidemiologic studies have shown dietary antioxidants to be inversely correlated with ischemic heart disease. OBJECTIVE: We investigated whether dietary beta-carotene, vitamin C, and...
Menopausal status and distensibility of the common carotid artery (1999)
Westendorp, I.C., Bots, M.L., Grobbee, D.E., Reneman, R.S., Hoeks, A.P., Popele, N.M. Van, ...
Although several studies have shown that exogenous estrogens have beneficial effects on arterial characteristics, the effect of endogenous estrogen on the vascular system is still unknown. In this...
Performance of a predictive model to identify undiagnosed diabetes in a health care setting (1999)
Baan, C.A., Ruige, J.B., Stolk, R.P., Witteman, J.C., Dekker, J.M., Heine, R.J., ...
OBJECTIVE: To develop a predictive model to identify individuals with an increased risk for undiagnosed diabetes, allowing for the availability of information within the health care system. RESEARCH...
Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study (1999)
Klipstein-Grobusch, K., Koster, J.F., Grobbee, D.E., Lindemans, J., Boeing, H., Hofman, A., ...
BACKGROUND: Elevated body iron stores have been suggested to be a risk factor for ischemic heart disease. OBJECTIVE: We examined whether elevated serum ferritin concentrations, other indicators of...
Hak, A.E., Stehouwer, C.D., Bots, M.L., Polderman, K.H., Schalkwijk, C.G., Westendorp, I.C., ...
Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response. In this study, we examined the relationship of...
Westendorp, I.C., Bots, M.L., Akkerhuis, J.M., Hofman, A., Grobbee, D.E., ...
BACKGROUND AND PURPOSE: Observational data suggest that hormone replacement therapy (HRT) reduces morbidity and mortality from cardiovascular disease in healthy postmenopausal women. The mechanisms...
J-shaped relation between blood pressure and stroke in treated hypertensives (1999)
Voko, Z., Bots, M.L., Hofman, A., Koudstaal, P.J., Witteman, J.C., Breteler, M.M.
The objective of this study was to investigate the relationship between hypertension and risk of stroke in the elderly. The study was performed within the framework of the Rotterdam Study, a...
Increased risk of atherosclerosis in women after the menopause.
Witteman, J. C., Grobbee, D. E., Kok, F. J., Hofman, A., Valkenburg, H. A.
An increase in the incidence of cardiovascular disease has generally been observed in postmenopausal women, but there have been few studies of the association between menopausal state and...
Physical activity, calcium intake, and bone mineral content in children in The Netherlands.
VandenBergh, M F, DeMan, S A, Witteman, J C, Hofman, A, Trouerbach, W T, Grobbee, D E
STUDY OBJECTIVE--To examine the relation between physical activity, calcium intake, and bone mineral content in children. DESIGN--Population based, cross sectional study. SETTING--Primary schools in...
An RBP4 promoter polymorphism increases risk of type 2 diabetes
Van Hoek, M., Dehghan, A., Zillikens, M. C., Hofman, A., Witteman, J. C., Sijbrands, E. J.G.
Geleijnse, J. M., Witteman, J. C., Bak, A. A., Den Breeijen, J. H., Grobbee, D. E.
OBJECTIVE--To examine the effect of a reduced sodium and increased potassium and magnesium intake on blood pressure. DESIGN--Randomised double blind placebo controlled trial. SETTING--General...