Carmichael, J., Larson, M., Marlow, J., Newman, E., Clough, P., Oomen, J., ...
This paper describes a multimedia multimodal information access sub-system (MIAS) for digital audio-visual documents, typically presented in streaming media format. The system is designed to provide...
This is a discussion of the complications of disseminating the work of a large-scale research project, and the difficulties in making research relevant to practitioners. It argues that making real...
The Literacies for Learning in FE research project: a workshop (2007)
This article describes a workshop designed to explore the theoretical perspectives brought to the learning process from the body of work on literacies as social practices. It first describes the...
Researching literacy for learning in the vocational curriculum, chapter 7, pp 79-89 (2007)
Carmichael, J, Edwards, R, Miller, K, Smith, J, Osborne, M, Houston, M, ...
This chapter starts by mapping out the theoretical and methodological terrain of the literacies for Learning in Further Education project, and giving two extended examples of the sort of data...
Literacies for Learning in FE in the UK: a symposium. (2006)
Brzeski, A, Carmichael, J, Edwards, R, Fowler, Z, Miller, K, ...
The symposium examines some of the challenges and findings from the first eighteen months of the project. The first paper explores some of the findings regarding the literacy practices required of...
Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., ...
Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the anti-idiotypic network, to stimulate immune...
An examination of the advantages of practitioner research and some of the difficulties that have arisen as a result of an ongoing collaborative project between two institutions of HE and four...
Piccart, MJ, Sledge, G, Carmichael, J, Luck, HJ, Mackey, JR, Nabholtz, JM, ...
Inst Jules Bordet, B-1000 Brussels, Belgium. Limburgs Univ Ctr, Diepenbeek, Belgium. IDDI, Brussels, Belgium.
Piccart, MJ, Sledge, G, Carmichael, J, Luck, HJ, Mackey, JR, Nabholtz, JM, ...
Limburgs Univ Centrum, Diepenbeek, Belgium. Inst Jules Bordet, B-1000 Brussels, Belgium. IDDI, Brussels, Belgium.
Piccart, MJ, BURZYKOWSKI, Tomasz, Sledge, G, Luck, HJ, Mackey, JR, Nabholtz, JM, ...
Inst Jules Bordet, B-1000 Brussels, Belgium. Limburgs Univ Ctr, Diepenbeek, Belgium. IDDI, Brussels, Belgium.
Piccart, MJ, Sledge, G, Carmichael, J, Luck, HJ, Mackey, JR, Nabholtz, JM, ...
Limburgs Univ Centrum, Diepenbeek, Belgium. Inst Jules Bordet, B-1000 Brussels, Belgium. IDDI, Brussels, Belgium.
Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., ...
Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the anti-idiotypic network, to stimulate immune...
Austomatic Speech Recognition with Sparse Training Data for Dysarthric Speakers (2003)
Green, PD, Carmichael, J, Hatzis, A, Enderby, PM, Hawley, M, Parker, M
Molife, R, Verrill, M, Bales, C, Millwater, C, Hewitt, P, ...
Modulation of polyglutamine-induced cell death by genes identified by expression profiling (2002)
Kita, H., Carmichael, J., Swartz, J., Muro, S., Wyttenbach, A., Matsubara, K., ...
The majority of triplet-repeat diseases are caused by mutated genes with an extended polyglutamine tract, exemplified by Huntington's disease (HD). In order to model HD pathogenesis in a controlled...
Wyttenbach, A., Sauvageot, O., Carmichael, J., Diaz-Latoud, C., Arrigo, A.P., Rubinsztein, D.C.
Neuronal loss and intraneuronal protein aggregates are characteristics of Huntington's disease (HD), which is one of 10 known neurodegenerative disorders caused by an expanded polyglutamine [poly(Q)]...
Wyttenbach, A., Sauvageot, O., Carmichael, J., Diaz-Latoud, C., Arrigo, A.P., Rubinsztein, D.C.
Neuronal loss and intraneuronal protein aggregates are characteristics of Huntington’s disease (HD), which is one of 10 known neurodegenerative disorders caused by an expanded polyglutamine...
Wyttenbach, A., Swartz, J., Kita, H., Thykjaer, T., Carmichael, J., Bradley, J., ...
Huntington’s disease (HD) is one of 10 known diseases caused by a (CAG)n trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract. We have developed stable...
The molecular biology of Huntington's disease (2001)
Ho, L.W., Carmichael, J., Swartz, J., Wyttenbach, A., Rankin, J., Rubinsztein, D.C.
Background. Huntington's disease (HD) is a fatal neurodegenerative disorder with an autosomal dominant mode of inheritance. It leads to progressive dementia, psychiatric symptoms and an...
A phase II trial of marimastat in advanced pancreatic cancer (2001)
Evans, J.D., Stark, A., Johnson, C.D., Daniel, F., Carmichael, J., Buckels, J., ...
Pancreatic cancer has a poor response to conventional chemotherapy and radiotherapy. Inhibition of matrix metalloproteinase activity involved in tumour invasion and metastases is a novel biological...
Wyttenbach, A., Swartz, J., Kita, H., Thykjaer, T., Carmichael, J., Bradley, J., ...
Huntington's disease (HD) is one of 10 known diseases caused by a (CAG)(n) trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract. We have developed stable...
The deleterious effect of polyglutamine aggregation in cell models of Huntington's disease. (2000)
Rubinsztein, D.C., Carmichael, J., Rankin, J., Chatellier, J., Woolfson, A., Wyttenbach, A., ...
Wyttenbach, A., Carmichael, J., Swartz, J.E., Furlong, R.A., Narain, Y., Rankin, J., ...
Huntington's disease (HD), spinocerebellar ataxias types 1 and 3 (SCA1, SCA3), and spinobulbar muscular atrophy (SBMA) are caused by CAG/polyglutamine expansion mutations. A feature of these diseases...
[Epithelial ovarian cancer (advanced stage): consensus conference (1998)] (2000)
Bertelsen, K, Du Bois, A, Brady, M F, Carmichael, J, Eisenhauer, E A, ...
Department of Internal Medicine, Utrecht University Hospital, The Netherlands.
Wyttenbach, A., Carmichael, J., Swartz, J., Furlong, R.A., Narain, Y., Rankin, J., ...
Huntington's disease (HD), spinocerebellar ataxias types 1 and 3 (SCA1, SCA3), and spinobulbar muscular atrophy (SBMA) are caused by CAG/polyglutamine expansion mutations. A feature of these diseases...
Advanced epithelial ovarian cancer : 1998 consensus statements (1999)
Berek, J, Bertelsen, K, Du Bois, A, Brady, M, Carmichael, J, Eisenhauer, E, ...
O'Brien, L, Carmichael, J, Lowrie, D B, Andrew, P W
The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in...
Corticosteroid resistance in chronic asthma.
Carmichael, J, Paterson, I C, Diaz, P, Crompton, G K, Kay, A B, Grant, I W
Fifty-eight patients with chronic asthma in whom airflow obstruction was relieved by bronchodilator aerosols but not by oral corticosteroids were compared with 58 other chronic asthmatics who...
Corticosteroid resistance in chronic asthma
Carmichael, J, Paterson, Ian C, Crompton, G K, Kay, A B, Grant, I W B
Bloomfield, P, Carmichael, J, Petrie, G R, Jewell, N P, Crompton, G K
A double-blind crossover trial was carried out during 22 episodes of life-threatening asthma in 19 patients to compare salbutamol given as a 500 microgram intravenous injection and as a 0 . 5%...
Carmichael, J, Duncan, D, Crompton, G K
In a double-blind study beclomethasone dipropionate inhaled as a dry powder in doses of 100 microgram four times daily and 150 microgram four times daily was compared with the conventional aerosol...
O'Brien, L, Carmichael, J, Lowrie, D B, Andrew, P W
The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in...
Corticosteroid resistance in chronic asthma.
Carmichael, J, Paterson, I C, Diaz, P, Crompton, G K, Kay, A B, Grant, I W
Fifty-eight patients with chronic asthma in whom airflow obstruction was relieved by bronchodilator aerosols but not by oral corticosteroids were compared with 58 other chronic asthmatics who...
Corticosteroid resistance in chronic asthma
Carmichael, J, Paterson, Ian C, Crompton, G K, Kay, A B, Grant, I W B
Bloomfield, P, Carmichael, J, Petrie, G R, Jewell, N P, Crompton, G K
A double-blind crossover trial was carried out during 22 episodes of life-threatening asthma in 19 patients to compare salbutamol given as a 500 microgram intravenous injection and as a 0 . 5%...
Carmichael, J, Duncan, D, Crompton, G K
In a double-blind study beclomethasone dipropionate inhaled as a dry powder in doses of 100 microgram four times daily and 150 microgram four times daily was compared with the conventional aerosol...
The serotonin type 3 receptor antagonist BRL 43694 and nausea and vomiting induced by cisplatin.
Carmichael, J., Cantwell, B. M., Edwards, C. M., Rapeport, W. G., Harris, A. L.
Thromboses and thromboemboli in patients with lymphoma during cytotoxic chemotherapy.
Cantwell, B. M., Carmichael, J., Ghani, S. E., Harris, A. L.
Fergusson, R J, Carmichael, J, Smyth, J F
Xenografts from eight human bronchial carcinomas have been established in CBA/Lac mice rendered immunodeficient by neonatal thymectomy followed three weeks later by whole body irradiation (7.35 Gy...
The Supply Price of Capital: An Empirical Reformulation and Some Points of Clarification
No abstract available
Inflation in Industrial Countries: Two Theoretical Views
A. Blundell-Wignall, J. Carmichael
No abstract available
Cancer chemotherapy: identifying novel anticancer drugs.
There are now around 60 cytotoxic drugs licensed for use in cancer therapy in the United Kingdom. For certain malignancies such as childhood cancers, haematological malignancies, and germ cell...
One of the cornerstones of the modern welfare approach to international trade theory is the compensation principle due to Samuelson. The difficulty with the compensation principle is that it pays...
Preclinical, phase I and pharmacokinetic studies with the dimethyl phenyltriazene CB10-277.
Foster, B. J., Newell, D. R., Carmichael, J., Harris, A. L., Gumbrell, L. A., Jones, M., ...
Decarbazine is an imidazole dimethyltriazene with reproducible activity in patients with metastatic melanoma. CB10-277 is a phenyl dimethyltriazene which, like dacarbazine, requires metabolic...
Philip, P. A., Carmichael, J., Tonkin, K., Buamah, P. K., Britton, J., Dowsett, M., ...
Eighteen consecutive patients with measurable locally advanced or metastatic pancreatic adenocarcinoma were treated with goserelin (Zoladex) 3.6 mg subcutaneously every 4 weeks. Hydrocortisone 20...
Philip, P. A., Kaklamanis, L., Carmichael, J., Tonkin, K., Morrison, H., Gatter, K., ...
Resistance to cytotoxics precludes the successful treatment of many solid tumours. Inhibition of DNA synthesis in normal tissues with antimetabolites such as hydroxyurea (HU) may be a useful means of...
Kirk, J., Houlbrook, S., Stuart, N. S., Stratford, I. J., Harris, A. L., Carmichael, J.
The ability of the anti-oestrogens tamoxifen, toremifene and their 4-hydroxy and N-desmethyl metabolites to modify doxorubicin (dox) toxicity to intrinsically resistant and multidrug resistant cell...
Kirk, J., Carmichael, J., Stratford, I. J., Harris, A. L.
The sensitivity of human breast and lung cancer cell lines to TGF-alpha-PE40, a novel chimeric recombinant cytotoxin composed of two independent domains, (i) TGF-alpha and (ii) a 40 kDa segment of...
Carmichael, J., Cantwell, B. M., Mannix, K. A., Veale, D., Elford, H. L., Blackie, R., ...
Twelve patients were treated with didox, a new ribonucleotide reductase inhibitor, by 36 h infusion. The maximum tolerated dose was 6 g m-2, above which dose-limiting hepatic toxicity was observed....
A phase II trial of goserelin (Zoladex) in relapsed epithelial ovarian cancer.
Lind, M. J., Cantwell, B. M., Millward, M. J., Robinson, A., Proctor, M., Simmons, D., ...
Thirty patients with advanced epithelial ovarian cancer were treated with the luteinising hormone releasing agonist, goserelin. There were two partial responses lasting 40 and 105 weeks respectively....
A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide.
Philip, P. A., Joel, S., Monkman, S. C., Dolega-Ossowski, E., Tonkin, K., Carmichael, J., ...
Multidrug resistance (MDR) is one of the mechanisms of resistance to multiple cytotoxic drugs and is mediated by the expression of a membrane pump called the P-glycoprotein. Nifedipine is one of the...
Stuart, N. S., Philip, P., Harris, A. L., Tonkin, K., Houlbrook, S., Kirk, J., ...
Twenty-six patients with relapsed or drug-resistant cancer were treated with a combination of oral etoposide (300 mg day-1 for 3 days) and high-dose oral tamoxifen as a potential modulator of drug...
Carmichael, J., Bessell, E. M., Harris, A. L., Hutcheon, A. W., Dawes, P. J., Daniels, S., ...
Two hundred and seventy-eight adult chemonaive patients, receiving moderately emetogenic chemotherapy were randomly allocated to receive either intravenous (i.v.) granisetron 3 mg plus i.v....
Houlbrook, S., Addison, C. M., Davies, S. L., Carmichael, J., Stratford, I. J., Harris, A. L., ...
Topoisomerase II is a key target for many anti-cancer drugs used to treat breast cancer. In human cells there are two closely related, but differentially expressed, topoisomerase II isoforms,...
The role of gemcitabine in the treatment of other tumours.
Gemcitabine (GEMZAR) is a novel nucleoside analogue with activity in a range of preclinical models both in vitro and in vivo. It is highly schedule dependent, with weekly x3 every 4 weeks being the...
Chemotherapy for ovarian cancer--a consensus statement on standard practice.
Adams, M., A'Hern, R. P., Calvert, A. H., Carmichael, J., Clark, P. I., Coleman, R. E., ...
Phase II study of gemcitabine in patients with advanced pancreatic cancer.
Carmichael, J., Fink, U., Russell, R. C., Spittle, M. F., Harris, A. L., Spiessi, G., ...
The efficacy and safety of gemcitabine at a starting dose of 800 mg m2 administered once a week for 3 weeks with 1 week's rest was investigated in chemonaive patients with advanced and/or metastatic...
Dobbs, S. P., Hewett, P. W., Johnson, I. R., Carmichael, J., Murray, J. C.
Squamous cell carcinoma of the cervix (SCC) is preceded by a premalignant condition known as cervical intraepithelial neoplasia (CIN). The majority of cases of CIN regress spontaneously; however,...
Chemosensitivity testing of human lung cancer cell lines using the MTT assay.
Carmichael, J., Mitchell, J. B., DeGraff, W. G., Gamson, J., Gazdar, A. F., Johnson, B. E., ...
Thirty human lung cancer cell lines were tested for chemosensitivity using the semi-automated, non-clonogenic MTT assay. The tumour cell lines came from three major categories of patients: untreated...
A phase 1 and pharmacokinetic study of didox: a ribonucleotide reductase inhibitor.
Veale, D., Carmichael, J., Cantwell, B. M., Elford, H. L., Blackie, R., Kerr, D. J., ...
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the drug by slow i.v. injection. Thirty-four patients with unresponsive...
Glutathione and related enzyme activity in human lung cancer cell lines.
Carmichael, J., Mitchell, J. B., Friedman, N., Gazdar, A. F., Russo, A.
Glutathione levels were measured in 30 human lung cancer lines. Lower levels were detected in cell lines derived from small cell lung cancer specimens compared to non-small cell lines (mean 42 vs....
Zoladex: endocrine and therapeutic effects in post-menopausal breast cancer.
Harris, A. L., Carmichael, J., Cantwell, B. M., Dowsett, M.
The endocrine and therapeutic effects of the LHRH agonist Zoladex have been assessed in 28 post-menopausal women with advanced breast cancer. Fourteen had responded to previous hormone therapy and 14...
Arginine vasopressin--a mediator of chemotherapy induced emesis?
Edwards, C. M., Carmichael, J., Baylis, P. H., Harris, A. L.
Concentrations of plasma arginine vasopressin (AVP) were studied in patients receiving chemotherapy. Of the 18 patients studied, nine experienced nausea and vomiting and the remaining nine were...
Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines.
Lewis, A. D., Forrester, L. M., Hayes, J. D., Wareing, C. J., Carmichael, J., Harris, A. L., ...
An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs. In view of the wide use of tumour cell...
Mukherjee, A, Westwell, A D, Bradshaw, T D, Stevens, M F G, Carmichael, J, Martin, S G
AW464 (NSC 706704) is a novel benzothiazole substituted quinol compound active against colon, renal and certain breast cancer cell lines. NCI COMPARE analysis indicates possible interaction with...
Maxwell-Armstrong, C A, Durrant, L G, Buckley, T J D, Scholefield, J H, Robins, R A, Fielding, K, ...
The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in...
A phase II trial of marimastat in advanced pancreatic cancer
Evans, J D, Stark, A, Johnson, C D, Daniel, F, Carmichael, J, Buckels, J, ...
Pancreatic cancer has a poor response to conventional chemotherapy and radiotherapy. Inhibition of matrix metalloproteinase activity involved in tumour invasion and metastases is a novel biological...
Anderson, H, Hopwood, P, Stephens, R J, Thatcher, N, Cottier, B, Nicholson, M, ...
Three hundred patients with symptomatic, locally advanced or metastatic NSCLC not requiring immediate radiotherapy were enrolled into this randomized multicentre trial comparing gemcitabine + BSC vs...