Masako Ogura, J. Christian Perez, Hae-Kyung Lee, Geidrius Dailide, Shumin Tan, ...
Geographic partitioning is postulated to foster divergence of Helicobacter pylori populations as an adaptive response to local differences in predominant host physiology. H. pylori's ability to...
Acid pH activation of the PmrA/PmrB two-component regulatory system of Salmonella enterica
Perez, J Christian, Groisman, Eduardo A
Acid pH often triggers changes in gene expression. However, little is known about the identity of the gene products that sense fluctuations in extracytoplasmic pH. The Gram-negative pathogen...
Ogura, Masako, Perez, J. Christian, Mittl, Peer R. E, Lee, Hae-Kyung, Dailide, Geidrius, Tan, Shumin, ...
Geographic partitioning is postulated to foster divergence of Helicobacter pylori populations as an adaptive response to local differences in predominant host physiology. H. pylori's ability to...
Evolution of a Bacterial Regulon Controlling Virulence and Mg2+ Homeostasis
Perez, J. Christian, Shin, Dongwoo, Zwir, Igor, Latifi, Tammy, Hadley, Tricia J., Groisman, Eduardo A.
Related organisms typically rely on orthologous regulatory proteins to respond to a given signal. However, the extent to which (or even if) the targets of shared regulatory proteins are maintained...
Perez, J. Christian, Latifi, Tammy, Groisman, Eduardo A.
The acquisition of new traits through horizontal gene transfer depends on the ability of the recipient organism to express the incorporated genes. However, foreign DNA appears to be silenced by the...
Transcription factor function and promoter architecture govern the evolution of bacterial regulons
Perez, J. Christian, Groisman, Eduardo A.
Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences between related organisms. Studies of regulatory circuits in eukaryotes suggest that these modifications...