Singh, R., Campbell, B.J., Fernig, D.G., Milton, J.D., Goodlad, R.A., ...
Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose &bgr;1-3 N-acetylgalactosamine α-) occurs in colon cancer and colitis. This allows binding of...
Altered expression of mucins throughout the colon in ulcerative colitis. (1997)
Smithson, J. E., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., Jewell, D. P.
Altered expression of mucins throughout the colon in ulcerative colitis. (1997)
Smithson, J. E., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., Jewell, D. P.
Milton, J D, Eccleston, D, Parker, N, Raouf, A, Cubbin, C, Hoffman, J, ...
AIMS--To produce and characterise a monoclonal antibody specific for O-acetylated sialomucin and to assess its use in immunohistochemistry on a panel of normal and diseased intestinal tissue samples....
Milton, J D, Eccleston, D, Parker, N, Raouf, A, Cubbin, C, Hoffman, J, ...
AIMS--To produce and characterise a monoclonal antibody specific for O-acetylated sialomucin and to assess its use in immunohistochemistry on a panel of normal and diseased intestinal tissue samples....
Immunosuppressive properties of a ribonuclease-containing fraction from bacterial cultures
Carpenter, C. B., Milton, J. D., Mowbray, J. F., Butterworth, A. E.
The supernatant fluid from cultures of an organism resembling Bacillus cereus is immunosuppressive to mice given intravenous sheep red blood cells, and inhibits the proliferative response in vitro of...
Reversible loss of surface receptors on lymphocytes
An α-2-glycoprotein from bovine serum (Fraction C) with immunosuppressive properties in vivo and anti-proliferative activity in vitro has been shown to reversibly inhibit the synthesis of cell...
A serum α-2-glycoprotein (Fraction C) which has previously been shown to have immunosuppressive properties and to possess ribonuclease activity, has an inhibitory effect on the in vitro...
The localization of allogeneic lymphoid cells in relation to antibody-mediated immunosuppression.
Carbon blockade of mice did not affect cytotoxic antibody production after immunization with allogeneic cells, nor did it affect the immunosuppressive activity of alloantibody. Though it inhibited...
The effect of glutaraldehyde fixation on the immunogenicity of allogeneic lymphoid and tumour cells.
When CBA mice were injected with allogeneic (DBA/2) lymph node cells treated with glutaraldehyde at concentrations of 0.13% and 0.013% they failed to produce a primary cytotoxic antibody response;...
Ultraviolet (u.v.) irradiation was found to have only a modest inhibitory effect on the alloimmunogenecity of murine lymphoid cells in vivo when the response was assessed by the primary cytotoxic...
Singh, B, Milton, J D, Woodrow, J C
Twenty three anti-Klebsiella antisera were tested for their cytotoxic activity and four for their binding capacity for peripheral blood lymphocytes (PBL) from patients with HLA-B27 positive...
Altered expression of mucins throughout the colon in ulcerative colitis.
Smithson, J E, Campbell, A, Andrews, J M, Milton, J D, Pigott, R, Jewell, D P
BACKGROUND/AIMS: Regional differences in the biology of the colonic epithelium may determine the extent of involvement by ulcerative colitis. Novel monoclonal antibodies (MAbs) were used in this...
Raouf, A, Parker, N, Iddon, D, Ryder, S, Langdon-Brown, B, Milton, J D, ...
Previous reports of a selective mucin subclass defect in ulcerative colitis have been reassessed using high performance chromatography (Superose 6 and Mono Q) for mucin purification and fractionation...
Increased faecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment.
Tsai, H H, Dwarakanath, A D, Hart, C A, Milton, J D, Rhodes, J M
Colonic mucin is heavily sulphated and it has been shown that enzymatic desulphation by faecal bacterial sulphatases greatly increases its susceptibility to degradation by faecal glycosidases. A...
Immune responsiveness in chronic fatigue syndrome.
Milton, J. D., Clements, G. B., Edwards, R. H.
We have endeavoured to find immunological indications of chronic virus infection in patients with chronic fatigue syndrome (myalgic encephalomyelitis) and to investigate immune responsiveness to...