Priddle, J.D., Mattacks, C.A., Sadler, D.A., MacQueen, H.A., Pond, C.M.
Single-photon counting fluorimetry was used to record the time course of the expression of interleukin-10 receptors labelled with fluorescent antibodies on the surface of adipocytes over 24 hours,...
Rose, K, Priddle, J D, Offord, R E, Esnouf, M P
When a polypeptide containing gamma-carboxyglutamic acid is decarboxylated in 2H2O, residue of (gamma gamma-2H2)glutamic acid are formed. Subsequent proteolytic digestion produces peptides which...
Priddle, J D, Rose, K, Offord, R E
The use of g.l.c. coupled to mass spectrometry to separate and sequence permethylated acetyl- and trifluoroacetyl-peptides in a single operation is described. Both electron impact and chemical...
Furth, Anna J., Milman, J. D., Priddle, J. D., Offord, R. E.
1. Triose phosphate isomerase was prepared by chromatography on DEAE-cellulose of an (NH4)2SO4 fraction of an extract of homogenized chicken breast muscle. The product is homogeneous on gel...
De La Mare, Susan, Coulson, A. F. W., Knowles, J. R., Priddle, J. D., Offord, R. E.
Triose phosphate isomerase from chicken muscle reacts stoicheiometrically with the active-site-directed irreversible inhibitor bromohydroxyacetone phosphate with concomitant loss of all catalytic...
Rose, K, Priddle, J D, Offord, R E, Esnouf, M P
When a polypeptide containing gamma-carboxyglutamic acid is decarboxylated in 2H2O, residue of (gamma gamma-2H2)glutamic acid are formed. Subsequent proteolytic digestion produces peptides which...
Priddle, J D, Rose, K, Offord, R E
The use of g.l.c. coupled to mass spectrometry to separate and sequence permethylated acetyl- and trifluoroacetyl-peptides in a single operation is described. Both electron impact and chemical...
Furth, Anna J., Milman, J. D., Priddle, J. D., Offord, R. E.
1. Triose phosphate isomerase was prepared by chromatography on DEAE-cellulose of an (NH4)2SO4 fraction of an extract of homogenized chicken breast muscle. The product is homogeneous on gel...
De La Mare, Susan, Coulson, A. F. W., Knowles, J. R., Priddle, J. D., Offord, R. E.
Triose phosphate isomerase from chicken muscle reacts stoicheiometrically with the active-site-directed irreversible inhibitor bromohydroxyacetone phosphate with concomitant loss of all catalytic...
Lowes, J R, Radwan, P, Priddle, J D, Jewell, D P
Epithelial histocompatibility locus antigen (HLA) class II expression was studied to evaluate its induction by mucosal mononuclear cells in inflammatory bowel disease and to characterise the...
Production of epithelial cell growth factors by lamina propria mononuclear cells.
Lowes, J R, Priddle, J D, Jewell, D P
The effects of lamina propria mononuclear cell culture supernatant on epithelial cell DNA synthesis were studied using cells isolated from patients with inflammatory bowel disease and normal...
Mantzaris, G J, Karagiannis, J A, Priddle, J D, Jewell, D P
The human intestinal adenovirus serotype 12 (Ad12) may be implicated in the pathogenesis of coeliac disease by virtue of immunological cross reactivity between epitopes shared by its early region E1b...
Serum and tissue autoantibodies to colonic epithelium in ulcerative colitis.
Snook, J A, Lowes, J R, Wu, K C, Priddle, J D, Jewell, D P
Sera and colonic tissue-bound immunoglobulin extracts from patients with ulcerative colitis and disease controls were examined immunohistochemically and by killer cell cytotoxicity assay for the...
Ireland, A, Priddle, J D, Jewell, D P
Isolated human colonic epithelial cell suspensions were incubated with either 0.1 mM 5-aminosalicylic acid (5-ASA) or 0.1 mM acetylaminosalicylic acid (Ac-ASA) for up to two hours. Intra- and...
Effects of olsalazine in the jejunum of the rat.
Mohsen, A Q, Mulvey, D, Priddle, J D, Parsons, D S, Jewell, D P
Olsalazine (ADS) is the azo-linked dimer of 5-aminosalicylic acid (5-ASA). It is of value for the management of patients with ulcerative colitis but may be associated with increasing diarrhoea in a...
Cellular hypersensitivity to gluten derived peptides in coeliac disease.
Guan, R, Rawcliffe, P M, Priddle, J D, Jewell, D P
Wheat gluten derived antigens have been tested for their ability to inhibit the migration of leucocytes from healthy subjects and patients with coeliac disease. Three preparations of a water soluble...
Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.
Barr, G D, Hudson, M J, Priddle, J D, Jewell, D P
The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce...
Wu, K C, Mahida, Y R, Priddle, J D, Jewell, D P
We studied immunoglobulin production by isolated intestinal mononuclear cells from 25 patients with active inflammatory bowel disease (IBD) and 17 controls undergoing surgical resections for...
Wu, K C, Mahida, Y R, Priddle, J D, Jewell, D P
The effect of macrophages on spontaneous immunoglobulin production by isolated human intestinal mononuclear cells (MNC) is unknown. Depletion of macrophages by adherence to fibronectin or by panning...