Hepatoblastoma and Familial Adenomatous Polyposis (1988)
Garber, J. E., Li, F. P., Kingston, J. E., Krush, A. J., Strong, L. C., Finegold, M. J., ...
Eleven children have been identified as having hepatoblastoma and a family history of adenomatous polyposis, and 14 additional instances of this association have been collected from the literature....
Hawkins, M. M., Wilson, L. M., Stovall, M. A., Marsden, H. B., Potok, M. H., Kingston, J. E., ...
OBJECTIVE--To investigate the incidence and aetiology of secondary leukaemia after childhood cancer in Britain. DESIGN--Cohort study and a case-control study. SETTING--Britain and population based...
Relationship of regression pattern to recurrence in retinoblastoma.
Singh, A D, Garway-Heath, D, Love, S, Plowman, P N, Kingston, J E, Hungerford, J L
A retrospective analysis has been conducted of regression patterns following treatment of retinoblastoma by external beam irradiation. There were 180 tumours in 105 eyes of 83 patients. Type I...
External beam radiotherapy for retinoblastoma: I. Whole eye technique.
Hungerford, J L, Toma, N M, Plowman, P N, Kingston, J E
A retrospective analysis has been performed of the results of external beam radiotherapy for retinoblastoma using a whole eye technique. Local tumour control has been assessed in a consecutive series...
External beam radiotherapy for retinoblastoma: II. Lens sparing technique.
Toma, N M, Hungerford, J L, Plowman, P N, Kingston, J E, Doughty, D
A retrospective analysis is presented of the results of external beam radiotherapy for retinoblastoma utilising an accurate lens sparing technique. Local tumour control has been assessed in a...
Ectopic intracranial retinoblastoma in childhood.
Kingston, J E, Plowman, P N, Hungerford, J L
Twelve out of a series of 630 children with retinoblastoma, treated in the ocular oncology units at St Bartholomew's and Moorfields Eye Hospitals during the past 30 years, have developed ectopic...
Retinoblastoma in Great Britain 1969-80: incidence, treatment, and survival.
Sanders, B M, Draper, G J, Kingston, J E
Patients with retinoblastoma diagnosed from 1969 to 1980 have been followed up for periods of up to 17 years. Data from a previous study of patients diagnosed from 1962 to 1968 have been included for...
123I metaiodobenzylguanidine (MIBG) scintigraphy of retinoblastoma: preliminary experience.
Bomanji, J, Hungerford, J L, Kingston, J E, Levison, D A, Britton, K E
123I metaiodobenzylguanidine (MIBG) is a radiopharmaceutical used for imaging neural crest tumours. The possibility of using 123I MIBG for imaging retinoblastomas has been assessed in this pilot...
Orbital recurrence of retinoblastoma successfully treated by combined therapy.
Goble, R R, McKenzie, J, Kingston, J E, Plowman, P N, Hungerford, J L
Five children with an orbital recurrence of retinoblastoma have been successfully treated by a combination of excision biopsy of the tumour mass, radical orbital radiotherapy, and systemic...
Globe conserving treatment of the only eye in bilateral retinoblastoma
Lee, V, Hungerford, J L, Bunce, C, Ahmed, F, Kingston, J E, Plowman, P N
Aims: To quantify the rates of eye preservation and patient survival, local tumour relapse and recurrence, and development of new tumours in the remaining eye of children with bilateral...
Platinum-based chemotherapy for recurrent CNS tumours in young patients.
Douek, E, Kingston, J E, Malpas, J S, Plowman, P N
Twenty nine patients (median age 12 years) with a CNS tumour, received platinum-based chemotherapy for assessable disease. In 23 patients there was an objective response with improvement lasting for...
Association between hepatoblastoma and polyposis coli.
Kingston, J E, Herbert, A, Draper, G J, Mann, J R
We have identified five children with hepatoblastoma who have a family history of polyposis coli affecting the mother and maternal relatives. We believe that the familial association of these two...
Efficacy of varicella vaccine in patients with solid tumours.
Heath, R B, Malpas, J S, Kangro, H O, Ward, A, McEniery, J M, Kingston, J E
Thirty nine children with malignant disease and without antibodies to varicella zoster virus were immunised with a live Oka strain varicella vaccine. Seroconversion was shown in 24 of those who were...
Late deaths after treatment for childhood cancer.
Hawkins, M M, Kingston, J E, Kinnier Wilson, L M
An investigation of 749 deaths occurring among 4082 patients surviving at least five years after the diagnosis of childhood cancer in Britain before 1971 has been undertaken. Of the 738 with...
Causes of death in children diagnosed with non-Hodgkin's lymphoma between 1974 and 1985.
Robertson, C M, Stiller, C A, Kingston, J E
An investigation has been undertaken of 479 deaths occurring up to the end of 1990 among 883 patients diagnosed with non-Hodgkin's lymphoma from 1974 to 1985 who were included in the population based...
Late deaths and survival after childhood cancer: implications for cure.
Robertson, C. M., Hawkins, M. M., Kingston, J. E.
OBJECTIVES--To investigate causes of death and survival in subjects who had survived at least five years after diagnosis of childhood cancer; to compare observed mortality with that expected in the...
Testicular function following the treatment of Hodgkin's disease in childhood.
Shafford, E. A., Kingston, J. E., Malpas, J. S., Plowman, P. N., Pritchard, J., Savage, M. O., ...
Testicular function was studied in 40 males treated in childhood for Hodgkin's disease at St Bartholomew's Hospital, and the Hospital for Sick Children, London, between 1971-1985. All patients were...
Outcome of children with resistant and relapsed Hodgkin's disease.
James, N. D., Kingston, J. E., Plowman, P. N., Meller, S., Pinkerton, R., Barrett, A., ...
During the period 1974-89, 169 children with Hodgkin's disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew's Hospitals. The overall actuarial survival for...
Second primary neoplasms in patients with retinoblastoma.
Draper, G. J., Sanders, B. M., Kingston, J. E.
In a series of 882 retinoblastoma patients, 384 known to have the genetic form of the disease and 498 others, 30 patients developed second primary neoplasms. The spectrum of these second neoplasms is...
Incidence of second primary tumours among childhood cancer survivors.
Hawkins, M. M., Draper, G. J., Kingston, J. E.
Among a cohort of 10,106 three-year survivors of childhood cancer, 90 second primary tumours (SPTs) were observed. Within 25 years of 3-year survival about 4% developed a SPT, about 6-fold expected,...
Patterns of multiple primary tumours in patients treated for cancer during childhood.
Kingston, J. E., Hawkins, M. M., Draper, G. J., Marsden, H. B., Kinnier Wilson, L. M.
One hundred and sixty one children who have developed more than one primary neoplasm have been identified. Children with tumours of the central nervous system, retinoblastoma and leukaemia were those...
Childhood rhabdomyosarcoma: experience of the Children's Solid Tumour Group.
Kingston, J. E., McElwain, T. J., Malpas, J. S.
Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major...
The RB1 gene mutation in a child with ectopic intracranial retinoblastoma.
Onadim, Z., Woolford, A. J., Kingston, J. E., Hungerford, J. L.
The RB1 gene mutation was investigated in a child with ectopic intracranial retinoblastoma using DNA obtained from both the pineal and retinal tumours of the patient. A nonsense mutation in exon 17...
Thyroid nodular disease after radiotherapy to the neck for childhood Hodgkin's disease
Shafford, E A, Kingston, J E, Healy, J C, Webb, J A W, Plowman, P N, Reznek, R H
Lillington, D M, Goff, L K, Kingston, J E, Onadim, Z, Price, E, Domizio, P, ...
Twenty-five primary retinoblastoma tumours were analysed by real-time quantitative polymerase chain reaction to determine the genomic copy number of the N-MYC gene (2p24) relative to the copy number...